Isabella W Y Mak

Summary

Affiliation: McMaster University
Location: Hamilton, Canada
Summary:
Isabella W. Y. Mak, a female molecular biology scientist, graduated from the Biochemistry and Molecular Biology department at the University of British Columbia (UBC) in 2001 and 2005. Her thesis was on characterizing the effect of a novel drug on human leukemic cancer. After the completion of her degree requirements, she worked at the BC Cancer Research Centre as a research assistant to extend the scope of the project under the supervision of Dr. Victor Ling, Vice President of the BC Cancer Agency. Prior to the study of her degree, she was employed as an assistant throughout her undergraduate years in the laboratory of Dr. Christopher Overall in UBC. Currently, under the supervision of the clinician PI Dr. Michelle Ghert, Isabella is working on a project that studies giant cell tumour (GCT) in bone microenvironment. Moreover, she is also trained to work in the clinical trial research as a Certified Clinical Research Associate (CCRA) at McMaster University .

Publications

  1. ncbi The effect of the fungal metabolite radicicol analog A on mRNA degradation
    Isabella W Y Mak
    BC Cancer Research Centre, BC Cancer Agency, Vancouver, BC, Canada
    Genomics 90:723-32. 2007
  2. ncbi Upregulation of MMP-13 via Runx2 in the stromal cell of Giant Cell Tumor of bone
    Isabella W Y Mak
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    Bone 45:377-86. 2009
  3. pmc Collagenase expression and activity in the stromal cells from giant cell tumour of bone
    Robert W Cowan
    Faculty of Health Sciences, McMaster University and the Juravinski Cancer Centre, Hamilton, Ontario, Canada
    Bone 44:865-71. 2009
  4. doi Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone
    Isabella W Y Mak
    McMaster University, Hamilton, Ontario, Canada L8V 5C2
    Hum Pathol 41:1320-9. 2010
  5. pmc AP-1 as a Regulator of MMP-13 in the Stromal Cell of Giant Cell Tumor of Bone
    Isabella W Y Mak
    Department of Surgery, McMaster University, Hamilton, ON, Canada L8S 4L8
    Biochem Res Int 2011:164197. 2011
  6. doi The role of TWIST as a regulator in giant cell tumor of bone
    Shalini Singh
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    J Cell Biochem 112:2287-95. 2011
  7. pmc PTHrP induces autocrine/paracrine proliferation of bone tumor cells through inhibition of apoptosis
    Isabella W Y Mak
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 6:e19975. 2011
  8. doi Parathyroid hormone-related protein (PTHrP) modulates adhesion, migration and invasion in bone tumor cells
    Isabella W Y Mak
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    Bone 55:198-207. 2013

Detail Information

Publications8

  1. ncbi The effect of the fungal metabolite radicicol analog A on mRNA degradation
    Isabella W Y Mak
    BC Cancer Research Centre, BC Cancer Agency, Vancouver, BC, Canada
    Genomics 90:723-32. 2007
    ..Whereas all the destabilized mRNAs possessed at least one SK box, for transcripts not destabilized but nonetheless down-regulated, RAA appears to function by a SK box-independent mechanism not currently understood...
  2. ncbi Upregulation of MMP-13 via Runx2 in the stromal cell of Giant Cell Tumor of bone
    Isabella W Y Mak
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    Bone 45:377-86. 2009
    ..Our study provides the first evidence that Runx2 may play a crucial role in cytokine-mediated MMP-13 expression in GCT stromal cells...
  3. pmc Collagenase expression and activity in the stromal cells from giant cell tumour of bone
    Robert W Cowan
    Faculty of Health Sciences, McMaster University and the Juravinski Cancer Centre, Hamilton, Ontario, Canada
    Bone 44:865-71. 2009
    ..The spindle-like stromal cells from GCT may therefore actively participate in the bone destruction that is characteristic of the tumour...
  4. doi Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone
    Isabella W Y Mak
    McMaster University, Hamilton, Ontario, Canada L8V 5C2
    Hum Pathol 41:1320-9. 2010
    ..Future research will involve elucidation of the role of cell-cell/matrix communication pathways in bone resorption and tumorigenesis in GCT...
  5. pmc AP-1 as a Regulator of MMP-13 in the Stromal Cell of Giant Cell Tumor of Bone
    Isabella W Y Mak
    Department of Surgery, McMaster University, Hamilton, ON, Canada L8S 4L8
    Biochem Res Int 2011:164197. 2011
    ..We conclude that there was no synergy found between RUNX2 and AP-1 in the regulation of the MMP13 expression and that these transcription factors may be independently regulated in these cells...
  6. doi The role of TWIST as a regulator in giant cell tumor of bone
    Shalini Singh
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    J Cell Biochem 112:2287-95. 2011
    ....
  7. pmc PTHrP induces autocrine/paracrine proliferation of bone tumor cells through inhibition of apoptosis
    Isabella W Y Mak
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    PLoS ONE 6:e19975. 2011
    ..Thus PTHrP neutralizing immunotherapy is an intriguing potential therapeutic strategy for this tumor...
  8. doi Parathyroid hormone-related protein (PTHrP) modulates adhesion, migration and invasion in bone tumor cells
    Isabella W Y Mak
    Department of Surgery, McMaster University, Hamilton, Ontario, Canada
    Bone 55:198-207. 2013
    ..Based on the data presented herein, we conclude that PTHrP excreted by GCT stromal cells increases bone tumor cell local invasiveness and migration...