Kathryn Maitland

Summary

Publications

  1. pmc Dosing regimens of oral ciprofloxacin for children with severe malnutrition: a population pharmacokinetic study with Monte Carlo simulation
    Nahashon Thuo
    KEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research Coast, PO Box 230, 80108 Kilifi, Kenya
    J Antimicrob Chemother 66:2336-45. 2011
  2. pmc Sequence variation does not confound the measurement of plasma PfHRP2 concentration in African children presenting with severe malaria
    Thiranut Ramutton
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 11:276. 2012
  3. pmc Endotoxaemia is common in children with Plasmodium falciparum malaria
    Peter Olupot-Olupot
    Department of Paediatrics, Mbale Regional Referral Hospital, Mbale, Uganda
    BMC Infect Dis 13:117. 2013
  4. pmc Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial
    Kathryn Maitland
    Wellcome Trust Centre for Clinical Tropical Medicine, Department of Paediatrics, Faculty of Medicine, St Marys Campus, Norfolk Place, Imperial College, London W2 1PG, UK
    BMC Med 11:68. 2013
  5. doi request reprint Mortality after fluid bolus in African children with severe infection
    Kathryn Maitland
    Kilifi Clinical Trials Facility, Kenya Medical Research Institute KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    N Engl J Med 364:2483-95. 2011
  6. ncbi request reprint Phase II trial on the use of Dextran 70 or starch for supportive therapy in Kenyan children with severe malaria
    Samuel O Akech
    KEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Crit Care Med 38:1630-6. 2010
  7. pmc Diarrhoea complicating severe acute malnutrition in Kenyan children: a prospective descriptive study of risk factors and outcome
    Alison Talbert
    Kenya Medical Research Institute Wellcome Trust Research Programme, Kilifi, Kenya
    PLoS ONE 7:e38321. 2012
  8. pmc Defining childhood severe falciparum malaria for intervention studies
    Philip Bejon
    Kenya Medical Research Institute KEMRI Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    PLoS Med 4:e251. 2007
  9. pmc Fraction of all hospital admissions and deaths attributable to malnutrition among children in rural Kenya
    Philip Bejon
    Kenyan Medical Research Institute Centre for Geographic Medicine Research, Kilifi, Kenya
    Am J Clin Nutr 88:1626-31. 2008
  10. pmc Progressive increase in antimicrobial resistance among invasive isolates of Haemophilus influenzae obtained from children admitted to a hospital in Kilifi, Kenya, from 1994 to 2002
    J Anthony G Scott
    Wellcome Trust Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, P O Box 230, Kilifi, Kenya
    Antimicrob Agents Chemother 49:3021-4. 2005

Collaborators

Detail Information

Publications52

  1. pmc Dosing regimens of oral ciprofloxacin for children with severe malnutrition: a population pharmacokinetic study with Monte Carlo simulation
    Nahashon Thuo
    KEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research Coast, PO Box 230, 80108 Kilifi, Kenya
    J Antimicrob Chemother 66:2336-45. 2011
    ..Oral ciprofloxacin is a potential alternative to the standard parenteral ampicillin/gentamicin combination, but its pharmacokinetics in malnourished children is unknown...
  2. pmc Sequence variation does not confound the measurement of plasma PfHRP2 concentration in African children presenting with severe malaria
    Thiranut Ramutton
    Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Malar J 11:276. 2012
    ..The Pfhrp2 gene is highly polymorphic, with deletion of the entire gene reported in both laboratory and field isolates. These issues potentially confound the interpretation of PFHRP2 measurements...
  3. pmc Endotoxaemia is common in children with Plasmodium falciparum malaria
    Peter Olupot-Olupot
    Department of Paediatrics, Mbale Regional Referral Hospital, Mbale, Uganda
    BMC Infect Dis 13:117. 2013
    ....
  4. pmc Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial
    Kathryn Maitland
    Wellcome Trust Centre for Clinical Tropical Medicine, Department of Paediatrics, Faculty of Medicine, St Marys Campus, Norfolk Place, Imperial College, London W2 1PG, UK
    BMC Med 11:68. 2013
    ..We hypothesize that boluses may cause excess deaths from neurological or respiratory events relating to fluid overload...
  5. doi request reprint Mortality after fluid bolus in African children with severe infection
    Kathryn Maitland
    Kilifi Clinical Trials Facility, Kenya Medical Research Institute KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    N Engl J Med 364:2483-95. 2011
    ..The role of fluid resuscitation in the treatment of children with shock and life-threatening infections who live in resource-limited settings is not established...
  6. ncbi request reprint Phase II trial on the use of Dextran 70 or starch for supportive therapy in Kenyan children with severe malaria
    Samuel O Akech
    KEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Crit Care Med 38:1630-6. 2010
    ..Human albumin solution is expensive and not readily available in Africa. We examined the safety and efficacy of the fluid resuscitation with two synthetic colloids, Dextran 70 and hydroxyethyl starch, to inform future trial design...
  7. pmc Diarrhoea complicating severe acute malnutrition in Kenyan children: a prospective descriptive study of risk factors and outcome
    Alison Talbert
    Kenya Medical Research Institute Wellcome Trust Research Programme, Kilifi, Kenya
    PLoS ONE 7:e38321. 2012
    ..We examined the clinical and laboratory features on admission and outcome of children with SAM and diarrhoea at a Kenyan district hospital...
  8. pmc Defining childhood severe falciparum malaria for intervention studies
    Philip Bejon
    Kenya Medical Research Institute KEMRI Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    PLoS Med 4:e251. 2007
    ....
  9. pmc Fraction of all hospital admissions and deaths attributable to malnutrition among children in rural Kenya
    Philip Bejon
    Kenyan Medical Research Institute Centre for Geographic Medicine Research, Kilifi, Kenya
    Am J Clin Nutr 88:1626-31. 2008
    ....
  10. pmc Progressive increase in antimicrobial resistance among invasive isolates of Haemophilus influenzae obtained from children admitted to a hospital in Kilifi, Kenya, from 1994 to 2002
    J Anthony G Scott
    Wellcome Trust Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, P O Box 230, Kilifi, Kenya
    Antimicrob Agents Chemother 49:3021-4. 2005
    ..In Africa, the increasing cost of treating resistant infections supports economic arguments for prevention through conjugate H. influenzae type b immunization...
  11. pmc Burden, features, and outcome of neurological involvement in acute falciparum malaria in Kenyan children
    Richard Idro
    Centre for Geographic Medicine Research, Kenya Medical Research Institute Wellcome Trust Research Labs, Kilifi, Kenya
    JAMA 297:2232-40. 2007
    ..Plasmodium falciparum appears to have a particular propensity to involve the brain but the burden, risk factors, and full extent of neurological involvement have not been systematically described...
  12. pmc HIV infection, malnutrition, and invasive bacterial infection among children with severe malaria
    James A Berkley
    Centre for Geographic Medicine Research, Kilifi, Kenya
    Clin Infect Dis 49:336-43. 2009
    ..However, it is unclear whether their cooccurrence with falciparum parasitization and severe disease happens by chance or by association among children in areas where malaria is endemic...
  13. pmc Haptoglobin HP2-2 genotype, alpha-thalassaemia and acute seizures in children living in a malaria-endemic area
    Richard Idro
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Epilepsy Res 81:114-8. 2008
    ..We conclude that the HP2-2 polymorphism and deletions in alpha-globin gene are not risk factors for acute seizures in children. Future studies should examine other susceptibility genes...
  14. ncbi request reprint Invasive Gram-negative bacilli are frequently resistant to standard antibiotics for children admitted to hospital in Kilifi, Kenya
    Philip Bejon
    Wellcome Trust Kenya Medical Research Institute KEMRI, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    J Antimicrob Chemother 56:232-5. 2005
    ....
  15. pmc Diagnostic performance of visible severe wasting for identifying severe acute malnutrition in children admitted to hospital in Kenya
    Polycarp Mogeni
    KEMRI Wellcome Trust Research Programme, Centre for Geographic Medical Research Coast, Kilifi, Kenya
    Bull World Health Organ 89:900-6. 2011
    ..To determine the diagnostic value of visible severe wasting in identifying severe acute malnutrition at two public hospitals in Kenya...
  16. pmc Survival and haematological recovery of children with severe malaria transfused in accordance to WHO guidelines in Kilifi, Kenya
    Samuel O Akech
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Malar J 7:256. 2008
    ..Few studies have reported outcome and haematological recovery of children with severe malaria where transfusion practice complies with WHO recommendations...
  17. pmc Children with severe malnutrition: can those at highest risk of death be identified with the WHO protocol?
    Kathryn Maitland
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    PLoS Med 3:e500. 2006
    ....
  18. pmc Use of clinical syndromes to target antibiotic prescribing in seriously ill children in malaria endemic area: observational study
    James A Berkley
    Centre for Geographic Medicine Research Coast, PO Box 230, Kilifi, Kenya
    BMJ 330:995. 2005
    ..To determine how well antibiotic treatment is targeted by simple clinical syndromes and to what extent drug resistance threatens affordable antibiotics...
  19. pmc Changing trends in blood transfusion in children and neonates admitted in Kilifi District Hospital, Kenya
    Rosalon Pedro
    Kenya Medical Research Institute Wellcome Trust Programme, PO Box 230, Kilifi, Kenya
    Malar J 9:307. 2010
    ..This study aimed to investigate whether this trend affected clinical burden, clinical severity of anaemia and requirements for paediatric transfusion...
  20. pmc The incidence, aetiology and outcome of acute seizures in children admitted to a rural Kenyan district hospital
    Richard Idro
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    BMC Pediatr 8:5. 2008
    ..We determined the incidence, aetiological factors and the immediate outcome of seizures in a rural malaria endemic area in coastal Kenya...
  21. doi request reprint Hypothermia in children with severe malnutrition: low prevalence on the tropical coast of Kenya
    Alison Talbert
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, PO Box 230, Kilifi, Kenya
    J Trop Pediatr 55:413-6. 2009
    ..Hypothermia was a rare marker of severity in our setting. We recommend that other observations be highlighted to identify high risk groups and that routine temperature observations be reduced wherever staff are few...
  22. pmc Decorticate, decerebrate and opisthotonic posturing and seizures in Kenyan children with cerebral malaria
    Richard Idro
    Centre for Geographic Medicine Research Coast, Kenya Medical Research, Kenya
    Malar J 4:57. 2005
    ..Abnormal motor posturing is often observed in children with cerebral malaria, but the aetiology and pathogenesis is poorly understood. This study examined the risk factors and outcome of posturing in Kenyan children with cerebral malaria...
  23. ncbi request reprint Assessment of severe malnutrition among hospitalized children in rural Kenya: comparison of weight for height and mid upper arm circumference
    James Berkley
    Kenya Medical Institute Centre for Geographic Medicine Research, Kilifi, Kenya
    JAMA 294:591-7. 2005
    ..Mid upper arm circumference (MUAC) and the clinical sign "visible severe wasting" are simple and inexpensive methods but have not been evaluated in this setting...
  24. pmc 'The words will pass with the blowing wind': staff and parent views of the deferred consent process, with prior assent, used in an emergency fluids trial in two African hospitals
    Sassy Molyneux
    Health Systems and Social Science Research Group, Kenya Medical Research Institute ellcome Trust Research Programme, Kilifi, Kenya
    PLoS ONE 8:e54894. 2013
    ....
  25. ncbi request reprint Perturbations in electrolyte levels in kenyan children with severe malaria complicated by acidosis
    Kathryn Maitland
    Centre for Geographic Medicine Research, Coast, Kenyan Medical Research Unit, Kilifi, Kenya
    Clin Infect Dis 40:9-16. 2005
    ..To date, information about the frequency of electrolyte disturbances among children with severe falciparum malaria is limited...
  26. pmc The quality of stored umbilical cord and adult-donated whole blood in Mombasa, Kenya
    Oliver Hassall
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute Wellcome Trust Research Programme, Kilifi, Kenya
    Transfusion 50:611-6. 2010
    ..Before clinical trials, evidence is needed that cord blood donations, which vary greatly in volume, can be collected and stored into a fixed volume of anticoagulant-preservative solution obviating the need for prestorage processing...
  27. pmc Choice of fluids for resuscitation in children with severe infection and shock: systematic review
    Samuel Akech
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute Wellcome Trust Programme, PO Box 230, Kilifi, Kenya
    BMJ 341:c4416. 2010
    ..To systemically review the evidence from clinical trials comparing the use of crystalloids and colloids for fluid resuscitation in children with severe infection...
  28. pmc Phase II trial of isotonic fluid resuscitation in Kenyan children with severe malnutrition and hypovolaemia
    Samuel O Akech
    KEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    BMC Pediatr 10:71. 2010
    ..We evaluated the safety and efficacy of this guideline compared to resuscitation with a standard isotonic solution...
  29. pmc Emergency triage assessment for hypoxaemia in neonates and young children in a Kenyan hospital: an observational study
    Michael K Mwaniki
    Centre for Geographic Medicine Research, Kenya Medical Research Institute, Kilifi, Kenya
    Bull World Health Organ 87:263-70. 2009
    ....
  30. doi request reprint Cardiac function and hemodynamics in Kenyan children with severe malaria
    Sophie Yacoub
    Department of Infectious Diseases and Immunity, Hammersmith Campus, Imperial College, London, UK
    Crit Care Med 38:940-5. 2010
    ..Several markers of cardiovascular compromise and metabolic acidosis correlate with mortality. The role of cardiac dysfunction in the pathogenesis of severe childhood malaria remains unknown...
  31. ncbi request reprint The prognostic value of dipstick urinalysis in children admitted to hospital with severe malnutrition
    Nahashon Thuo
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Arch Dis Child 95:422-6. 2010
    ..UTIs are common in SAM and can lead to secondary invasive bacterial sepsis. Very few studies have examined the usefulness of dipstick screening of urine specimens in SAM and none has explored its prognostic value...
  32. pmc Determination of ciprofloxacin in human plasma using high-performance liquid chromatography coupled with fluorescence detection: application to a population pharmacokinetics study in children with severe malnutrition
    Simon N Muchohi
    Kenya Medical Research Institute KEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research Coast, P O Box 230 80108, Kilifi, Kenya
    J Chromatogr B Analyt Technol Biomed Life Sci 879:146-52. 2011
    ..This method was successfully applied to measure plasma ciprofloxacin concentrations in a population pharmacokinetics study of ciprofloxacin in malnourished children...
  33. pmc Bacterial contamination of pediatric whole blood transfusions in a Kenyan hospital
    Oliver Hassall
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute Wellcome Trust Research Programme, Kilifi, Kenya
    Transfusion 49:2594-8. 2009
    ..The risk from bacterial contamination of blood for transfusion in sub-Saharan Africa is not known. This study assessed the frequency of bacterial contamination of pediatric whole blood transfusions at a referral hospital in Kenya...
  34. ncbi request reprint Severe malaria: lessons learned from the management of critical illness in children
    Kathryn Maitland
    The Centre for Geographic Medicine Research, Coast, KEMRI, Kenya, PO Box 230, Kilifi, Kenya
    Trends Parasitol 22:457-62. 2006
    ....
  35. ncbi request reprint Population pharmacokinetics of a single daily intramuscular dose of gentamicin in children with severe malnutrition
    Claire Seaton
    KEMRI Wellcome Research Programme, Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, PO Box 230, Kilifi, Kenya
    J Antimicrob Chemother 59:681-9. 2007
    ..5 mg/kg) in children with severe malnutrition and to evaluate clinical factors affecting pharmacokinetic parameters...
  36. pmc Incidence and clinical characteristics of group A rotavirus infections among children admitted to hospital in Kilifi, Kenya
    D James Nokes
    Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    PLoS Med 5:e153. 2008
    ..The study objective was to accurately define the incidence and severity of group A rotavirus disease in a resource-poor setting necessary to make informed decisions on the need for vaccine prevention...
  37. ncbi request reprint Randomized trial of volume expansion with albumin or saline in children with severe malaria: preliminary evidence of albumin benefit
    Kathryn Maitland
    The Centre for Geographic Medicine Research, Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Clin Infect Dis 40:538-45. 2005
    ..In an open-label, randomized, controlled trial, we compared the safety of resuscitation with albumin to saline in Kenyan children with severe malaria...
  38. pmc Management of severe malaria in children: proposed guidelines for the United Kingdom
    Kathryn Maitland
    Kenya Medical Research Institute Wellcome Trust Programme, Centre for Geographic Medicine Research Coast, PO Box 230, Kilifi, Kenya
    BMJ 331:337-43. 2005
  39. ncbi request reprint Fluid management of severe falciparum malaria in African children
    Allan Pamba
    The Centre for Geographic Medicine Research, Coast, Kenya Medical Research Institute KEMRI WellcomeTrust Unit, Kenya, PO Box 230, Kilifi, Kenya
    Trop Doct 34:67-70. 2004
    ..Early recognition and prompt treatment may lead to improvements in outcome. We discuss the new evidence supporting the role of hypovolaemia in severe malaria and potential treatment options whilst awaiting the results of clinical trials...
  40. ncbi request reprint Hypokalemia in children with severe falciparum malaria
    Kathryn Maitland
    Centre for Geographic Medicine Research, Coast, KEMRI, Kenya
    Pediatr Crit Care Med 5:81-5. 2004
    ..Alterations in plasma potassium concentrations are commonly associated with acidosis. To date, there is little information about the changes in potassium in severe malaria...
  41. pmc Hypoglycaemia in severe malaria, clinical associations and relationship to quinine dosage
    Gilbert N Ogetii
    Centre for Geographic Medicine Research, Kenya Medical Research Institute Wellcome Trust Programme, PO Box 230, Kilifi, Kenya
    BMC Infect Dis 10:334. 2010
    ..This presented us with the opportunity to examine whether there was any dose relationship of quinine and hypoglycaemia occurrence...
  42. ncbi request reprint Falciparum malaria: current therapeutic challenges
    Kathryn Maitland
    The Centre for Geographic Medicine Research, Coast, KEMRI, Kilifi, Kenya
    Curr Opin Infect Dis 17:405-12. 2004
    ..We then review some recent literature regarding the pathological processes involved in the aetiology of severe malaria that may lead to improvements in the management of children with severe disease...
  43. ncbi request reprint Pathophysiology of severe malaria in children
    Kathryn Maitland
    The Centre for Geographic Medicine Research Coast, KEMRI, Kenya, P O Box 230, Kilifi, Kenya
    Acta Trop 90:131-40. 2004
    ..Current therapeutic challenges are discussed and research priorities are highlighted...
  44. pmc Iron deficiency and acute seizures: results from children living in rural Kenya and a meta-analysis
    Richard Idro
    Department of Paediatrics and Child Health, Mulago Hospital Makerere University, Kampala, Uganda
    PLoS ONE 5:e14001. 2010
    ..There are conflicting reports on whether iron deficiency changes susceptibility to seizures. We examined the hypothesis that iron deficiency is associated with an increased risk of acute seizures in children in a malaria endemic area...
  45. ncbi request reprint Both heterozygous and homozygous alpha+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya
    Thomas N Williams
    Wellcome Trust Kenya Medical Research Institute KEMRI, Centre for Geographic Medicine Research, Kilifi, Kenya
    Blood 106:368-71. 2005
    ..Our study supports the conclusion that both heterozygotes and homozygotes enjoy a selective advantage against death from Plasmodium falciparum malaria...
  46. ncbi request reprint Response to volume resuscitation in children with severe malaria
    Kathryn Maitland
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Pediatr Crit Care Med 4:426-31. 2003
    ..To examine whether hypovolemia is an important cause of the acidosis in children with severe malaria...
  47. ncbi request reprint Joint BAPEN and Nutrition Society Symposium on 'Feeding size 0: the science of starvation'. Severe malnutrition: therapeutic challenges and treatment of hypovolaemic shock
    Kathryn Maitland
    KEMRI Wellcome Trust Programme, Kilifi, Kenya
    Proc Nutr Soc 68:274-80. 2009
    ..The present paper focuses on the identification of children with sepsis and on fluid management strategies...
  48. ncbi request reprint Malaria
    Kathryn Maitland
    The Center for Geographic Medicine Research, Coast, KEMRI, Kilifi, Kenya
    Adv Exp Med Biol 549:125-34. 2004
  49. ncbi request reprint Phase II trial of standard versus increased transfusion volume in Ugandan children with acute severe anemia
    Peter Olupot-Olupot
    Kilifi Clinical Trials Facility, KEMRI Wellcome Trust Research Programme, PO Box 230, Kilifi, Kenya
    BMC Med 12:67. 2014
    ..Please see related commentary article http://www.biomedcentral.com/1741-7015/12/68/abstract...
  50. ncbi request reprint Bacteremia among children admitted to a rural hospital in Kenya
    James A Berkley
    Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    N Engl J Med 352:39-47. 2005
    ..We studied every acute pediatric admission to a rural district hospital in Kenya to examine the prevalence, incidence, types, and outcome of community-acquired bacteremia...
  51. ncbi request reprint Acidosis of severe falciparum malaria: heading for a shock?
    Kathryn Maitland
    The Centre for Geographic Medicine Research, Coast, KEMRI, Kenya, PO Box 230, Kilifi, Kenya
    Trends Parasitol 21:11-6. 2005
    ..We summarize the results of recent clinical trials examining the safety and efficacy of volume expansion in children with 'cerebral malaria' complicated by acidosis...
  52. ncbi request reprint Malaria
    Kathryn Maitland
    The Centre for Geographic Medicine Research, Coast, KEMRI, Kilifi, Kenya
    Curr Opin Infect Dis 16:389-95. 2003
    ..This review addresses recent developments that relate to the pathogenesis of severe malaria and its treatment, and also highlights the increase in the global burden of malaria and provides a summary of clinical trials of malaria vaccines...