Giulio Maira

Summary

Publications

  1. pmc Gene expression profile of glioblastoma peritumoral tissue: an ex vivo study
    Annunziato Mangiola
    Institute of Neurosurgery, Faculty of Medicine, Catholic University of Rome, Rome, Italy
    PLoS ONE 8:e57145. 2013
  2. doi request reprint Radioimmunotherapy for high-grade glioma
    Pasquale De Bonis
    Department of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    Immunotherapy 5:647-59. 2013
  3. doi request reprint The impact of repeated surgery and adjuvant therapy on survival for patients with recurrent glioblastoma
    Pasquale De Bonis
    Institute of Neurosurgery, Catholic University School of Medicine, L go F Vito, 1 00168 Rome, Italy
    Clin Neurol Neurosurg 115:883-6. 2013
  4. doi request reprint High-grade glioma: elderly patients, older treatments
    Pasquale De Bonis
    Institute of Neurosurgery, Catholic University School of Medicine, Largo F Vito, 1, 00168, Rome, Italy
    Expert Rev Neurother 12:1293-6. 2012
  5. doi request reprint Post-traumatic hydrocephalus is a contraindication for endoscopic third-ventriculostomy: isn't it?
    Pasquale De Bonis
    Institute of Neurosurgery, Catholic University School of Medicine, Largo F Vito 1, 00168 Rome, Italy
    Clin Neurol Neurosurg 115:9-12. 2013
  6. doi request reprint CSF dynamics analysis in patients with post-traumatic ventriculomegaly
    Pasquale De Bonis
    Institute of Neurosurgery, Catholic University School of Medicine, Largo Agostino Gemelli, 8, 00168 Rome, Italy
    Clin Neurol Neurosurg 115:49-53. 2013
  7. doi request reprint The influence of surgery on recurrence pattern of glioblastoma
    Pasquale De Bonis
    Institute of Neurosurgery, Catholic University School of Medicine, L go F Vito, 1 00168, Rome, Italy
    Clin Neurol Neurosurg 115:37-43. 2013
  8. doi request reprint Safety and efficacy of Gliadel wafers for newly diagnosed and recurrent glioblastoma
    Pasquale De Bonis
    Institute of Neurosurgery, Catholic University School of Medicine, L go F Vito, 1 00168, Rome, Italy
    Acta Neurochir (Wien) 154:1371-8. 2012
  9. doi request reprint Adult idiopathic occlusion of the foramina of Monro: diagnostic tools and therapy
    Pasquale De Bonis
    Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    J Neuroimaging 18:101-4. 2008
  10. doi request reprint Decompressive craniectomy for elderly patients with traumatic brain injury: it's probably not worth the while
    Pasquale De Bonis
    Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    J Neurotrauma 28:2043-8. 2011

Detail Information

Publications69

  1. pmc Gene expression profile of glioblastoma peritumoral tissue: an ex vivo study
    Annunziato Mangiola
    Institute of Neurosurgery, Faculty of Medicine, Catholic University of Rome, Rome, Italy
    PLoS ONE 8:e57145. 2013
    ..Otherwise, the recurrent tumor may arise from both infiltrating tumor cells and from an interaction and recruitment of apparently normal cells in the peritumor tissue by infiltrating tumor cells...
  2. doi request reprint Radioimmunotherapy for high-grade glioma
    Pasquale De Bonis
    Department of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    Immunotherapy 5:647-59. 2013
    ..This review will provide an overview of preclinical and clinical studies to date and assess the effectiveness of radioimmunotherapy, focusing on possible future therapies for the treatment of HGG...
  3. doi request reprint The impact of repeated surgery and adjuvant therapy on survival for patients with recurrent glioblastoma
    Pasquale De Bonis
    Institute of Neurosurgery, Catholic University School of Medicine, L go F Vito, 1 00168 Rome, Italy
    Clin Neurol Neurosurg 115:883-6. 2013
    ..Treatment of glioblastoma recurrence can have a palliative aim, after considering risks and potential benefits. The aim of this study is to verify the impact of surgery and of palliative adjuvant treatments on survival after recurrence...
  4. doi request reprint High-grade glioma: elderly patients, older treatments
    Pasquale De Bonis
    Institute of Neurosurgery, Catholic University School of Medicine, Largo F Vito, 1, 00168, Rome, Italy
    Expert Rev Neurother 12:1293-6. 2012
    ..Ongoing trials evaluating RT plus TMZ, RT plus bevacizumab and other treatment modalities in the elderly population are going to change clinical practice in the near future...
  5. doi request reprint Post-traumatic hydrocephalus is a contraindication for endoscopic third-ventriculostomy: isn't it?
    Pasquale De Bonis
    Institute of Neurosurgery, Catholic University School of Medicine, Largo F Vito 1, 00168 Rome, Italy
    Clin Neurol Neurosurg 115:9-12. 2013
    ..Post-traumatic hydrocephalus (PTH) is commonly considered as a relative contraindication for endoscopic third-ventriculostomy (ETV). However, few studies are available on this topic...
  6. doi request reprint CSF dynamics analysis in patients with post-traumatic ventriculomegaly
    Pasquale De Bonis
    Institute of Neurosurgery, Catholic University School of Medicine, Largo Agostino Gemelli, 8, 00168 Rome, Italy
    Clin Neurol Neurosurg 115:49-53. 2013
    ..The purpose of this study is to analyze the CSF-dynamics in patients with PTV and, possibly, to identify parameters that correlate with prognosis...
  7. doi request reprint The influence of surgery on recurrence pattern of glioblastoma
    Pasquale De Bonis
    Institute of Neurosurgery, Catholic University School of Medicine, L go F Vito, 1 00168, Rome, Italy
    Clin Neurol Neurosurg 115:37-43. 2013
    ..Glioblastoma recurs within 2 cm from the primary tumor's margins in 90-95% of cases. Natural history of recurrence is not well defined. The aim of this study was to verify if pattern of recurrence can be influenced by the extent of surgery...
  8. doi request reprint Safety and efficacy of Gliadel wafers for newly diagnosed and recurrent glioblastoma
    Pasquale De Bonis
    Institute of Neurosurgery, Catholic University School of Medicine, L go F Vito, 1 00168, Rome, Italy
    Acta Neurochir (Wien) 154:1371-8. 2012
    ..We analyzed the efficacy and safety in patients with glioblastoma who underwent multimodal treatment with implantation of Gliadel wafers...
  9. doi request reprint Adult idiopathic occlusion of the foramina of Monro: diagnostic tools and therapy
    Pasquale De Bonis
    Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    J Neuroimaging 18:101-4. 2008
    ..The bilateral foramina of Monro occlusion is an extremely rare event in adults. To date, only six cases of adult hydrocephalus due to idiopatic obstruction of the bilateral foramina of Monro (including our patient) have been reported...
  10. doi request reprint Decompressive craniectomy for elderly patients with traumatic brain injury: it's probably not worth the while
    Pasquale De Bonis
    Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    J Neurotrauma 28:2043-8. 2011
    ..None of the 22 patients with a post-resuscitation GCS score of 3-5 had a good outcome, 2/10 (20%) patients with a post-resuscitation GCS score of 6-8 and 6/12 patients (50%) with a post-resuscitation GCS score ≥9 had a good outcome...
  11. doi request reprint Postoperative infection may influence survival in patients with glioblastoma: simply a myth?
    Pasquale De Bonis
    Institutes of Neuro surgery, Catholic University School of Medicine, Rome, Italy
    Neurosurgery 69:864-8; discussion 868-9. 2011
    ..This contention is based largely on anecdotal reports. Recently, a single-center study showed there was no survival advantage in those patients who had glioblastoma with postoperative infection...
  12. doi request reprint Post-traumatic hydrocephalus after decompressive craniectomy: an underestimated risk factor
    Pasquale De Bonis
    Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    J Neurotrauma 27:1965-70. 2010
    ..Craniectomy with a superior limit too close to the midline can predispose patients undergoing DC to the development of hydrocephalus. We therefore suggest performing wide DCs with the superior limit >25 mm from the midline...
  13. doi request reprint Decompressive craniectomy for the treatment of traumatic brain injury: does an age limit exist?
    Pasquale De Bonis
    Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    J Neurosurg 112:1150-3. 2010
    ..A literature search was performed to assess the level of evidence with respect to the effect of age on outcome in these cases...
  14. doi request reprint Teaching NeuroImage: spinal extradural arachnoid cyst: a rare cause of back pain
    P De Bonis
    Institute of Neurosurgery, Catholic University School of Medicine, L go A Gemelli 8, 00168 Rome, Italy
    Neurology 71:e24. 2008
  15. ncbi request reprint Assessment of angiogenesis by CD105 and nestin expression in peritumor tissue of glioblastoma
    Gigliola Sica
    Institute of Histology and Embryology, Faculty of Medicine, Catholic University of the Sacred Heart, Largo Francesco Vito 1, I 00168 Rome, Italy
    Int J Oncol 38:41-9. 2011
    ..These results demonstrate that a tumor neoangiogenesis occurs in GBM peritumor tissue with intimate involvement of pericytes. CD105-MVD in the area located at a greater distance from the tumor margin carries prognostic significance...
  16. doi request reprint Invasive tumor cells and prognosis in a selected population of patients with glioblastoma multiforme
    Annunziato Mangiola
    Department of Neurological Sciences, Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    Cancer 113:841-6. 2008
    ..After surgical resection, the residual, invasive glioblastoma (GBM) cells give rise to a recurrent tumor, which, in 96% of patients, arises adjacent to the resection margin...
  17. doi request reprint Communicating hydrocephalus following surgery and adjuvant radiochemotherapy for glioblastoma
    Nicola Montano
    Institute of Neurosurgery, Catholic University, Rome, Italy
    J Neurosurg 115:1126-30. 2011
    ..The authors evaluated the clinical and radiological factors associated with the onset of communicating hydrocephalus and the impact of ventriculoperitoneal (VP) shunt surgery on the outcome of these patients...
  18. ncbi request reprint Telomerase inhibition impairs tumor growth in glioblastoma xenografts
    Maria Laura Falchetti
    Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy
    Neurol Res 28:532-7. 2006
    ..On the contrary, development of tumors upon subcutaneously grafting of U87MG and TB10 cells and intracranial implantation of U87MG cells in nude athymic mice was strongly reduced by telomerase inhibition...
  19. ncbi request reprint Stem cell marker nestin and c-Jun NH2-terminal kinases in tumor and peritumor areas of glioblastoma multiforme: possible prognostic implications
    Annunziato Mangiola
    Institute of Neurosurgery, Catholic University of the Sacred Heart, Rome, Italy
    Clin Cancer Res 13:6970-7. 2007
    ..This study analyzes stem cell marker nestin and JNK expression in glioblastoma multiforme (GBM) and peritumor tissue and assesses their possible prognostic implications...
  20. doi request reprint Targeted therapy with bevacizumab and erlotinib tailored to the molecular profile of patients with recurrent glioblastoma. Preliminary experience
    Quintino Giorgio D'Alessandris
    Department of Neurosurgery, Universita Cattolica del Sacro Cuore, Largo Agostino Gemelli, 8, 00168, Rome, Italy
    Acta Neurochir (Wien) 155:33-40. 2013
    ..The aim of the present study was to evaluate the efficacy and safety of a targeted therapeutic approach in which administration of bevacizumab and erlotinib was tailored on the molecular profile of recurrent GBM...
  21. pmc Expression of EGFRvIII in glioblastoma: prognostic significance revisited
    Nicola Montano
    Istituti di Neurochirurgia, Universita Cattolica del Sacro Cuore, Rome, Italy
    Neoplasia 13:1113-21. 2011
    ..Depletion of EGFRvIII in recurrent GBMs as well as differential sensitivity to TMZ in vitro indicates that the EGFRvIII-negative cell fraction is involved in resistance to radio/chemotherapy and tumor repopulation...
  22. pmc Tumorigenic potential of olfactory bulb-derived human adult neural stem cells associates with activation of TERT and NOTCH1
    Patrizia Casalbore
    Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy
    PLoS ONE 4:e4434. 2009
    ..However, the constitutive activation of the cellular machinery required to bypass apoptosis and senescence places these cells at risk for malignant transformation...
  23. pmc Chemotherapy of skull base chordoma tailored on responsiveness of patient-derived tumor cells to rapamycin
    Lucia Ricci-Vitiani
    Department of Haematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    Neoplasia 15:773-82. 2013
    ..This is the first case of chordoma in whom chemotherapy was tailored on the basis of the sensitivity of patient-derived tumor cells. ..
  24. pmc Intracranial melanocytic meningeal tumours and melanosis oculi: case report and literature review
    Francesco Doglietto
    Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    BMC Cancer 12:220. 2012
    ..The importance of this association is discussed together with the diagnostic and therapeutic challenges of the case...
  25. ncbi request reprint Inhibition of telomerase in the endothelial cells disrupts tumor angiogenesis in glioblastoma xenografts
    Maria Laura Falchetti
    Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy
    Int J Cancer 122:1236-42. 2008
    ..Our data demonstrate that telomerase upregulation by the ECs is a key requisite for GBM tumor angiogenesis...
  26. doi request reprint In vivo laser assisted microvascular repair and end-to-end anastomosis by means of indocyanine green-infused chitosan patches: a pilot study
    Giuseppe Esposito
    Institute of Neurosurgery, Catholic University School of Medicine, Rome, 00100, Italy
    Lasers Surg Med 45:318-25. 2013
    ..All these procedures have been executed by the use of diode laser irradiation and chitosan-patches infused with Indocyanine Green (ICG)...
  27. doi request reprint Relevance of bleeding pattern on clinical appearance and outcome in patients with hemorrhagic brain arteriovenous malformations
    Carmelo Lucio Sturiale
    Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    J Neurol Sci 324:118-23. 2013
    ..In conclusion, our data emphasized the possibility that non-parenchymal bleeding may worsen the outcome of patients with hemorrhagic AVMs...
  28. ncbi request reprint Activated ERK1/2 expression in glioblastoma multiforme and in peritumor tissue
    Gina Lama
    Institute of Histology and Embryology, Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy
    Int J Oncol 30:1333-42. 2007
    ..In addition, a percentage > or = 10 of neoplastic elements in peritumor tissue was associated with an approximately 4-fold increased death risk...
  29. doi request reprint Association between the rs1333040 polymorphism on the chromosomal 9p21 locus and sporadic brain arteriovenous malformations
    Carmelo Lucio Sturiale
    Department of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    J Neurol Neurosurg Psychiatry 84:1059-62. 2013
    ..In this study, we tested the association between the rs1333040C>T polymorphism on the 9p21 locus and sporadic brain arteriovenous malformations (BAVMs)...
  30. doi request reprint Anterior subtemporal approach for posterolateral brainstem cavernomas: report of ten cases
    Giovanni Sabatino
    Neurosurgery Institute Catholic University School of Medicine, Largo F Vito, 00168 Rome, Italy
    Acta Neurochir (Wien) 154:2009-16. 2012
    ..Several nerve nuclei, ascending and descending fibers make this region at high risk of serious postoperative deficits...
  31. doi request reprint De novo malignant craniopharyngioma: case report and literature review
    Libero Lauriola
    Department of Pathology, Catholic University School of Medicine, Largo A Gemelli, 8, 00168, Rome, Italy
    J Neurooncol 103:381-6. 2011
    ..Malignant craniopharyngioma is a rare primary malignant tumor of the sellar region. This is the first case of de novo malignant craniopharyngioma with significant follow-up...
  32. ncbi request reprint Transplantation of foetal neural stem cells into the rat hippocampus during trimethyltin-induced neurodegeneration
    Maria Concetta Geloso
    Institute of Anatomy and Cell Biology, Universita Cattolica del Sacro Cuore, Largo F Vito 1, 00168, Rome, Italy
    Neurochem Res 32:2054-61. 2007
    ....
  33. ncbi request reprint Influence of local environment on the differentiation of neural stem cells engrafted onto the injured spinal cord
    Lucia Ricci-Vitiani
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    Neurol Res 28:488-92. 2006
    ..Here, we tested the hypothesis that inflammatory cytokines (ICs) may be involved in the restricted differentiation of NSCs after grafting onto the injured SC...
  34. ncbi request reprint Establishing tumor cell lines from aggressive telomerase-positive chordomas of the skull base. Technical note
    Lucia Ricci-Vitiani
    Department of Hematology, Oncology, and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy
    J Neurosurg 105:482-4. 2006
    ..In vitro, chordoma cells overexpressed telomerase, supporting the hypothesis that this enzyme is required for the immortalization process...
  35. ncbi request reprint Antibiotic-impregnated ventriculo-peritoneal shunts in patients at high risk of infection
    Alessio Albanese
    Institute of Neurosurgery, Catholic University School of Medicine, L go A Gemelli, 8, 00168 Rome, Italy
    Acta Neurochir (Wien) 151:1259-63. 2009
    ..To determine the efficacy of antibiotic impregnated shunts (AIS) in reducing shunt infections in a population at high risk of shunt infection...
  36. doi request reprint Simultaneously occurring tumours within the same cerebello-pontine angle: refining literature definitions and proposal for classification
    Paolo Frassanito
    Neurosurgery, Catholic University Medical School, Policlinico A Gemelli Largo A Gemelli, 8, 00168, Rome, Italy
    Acta Neurochir (Wien) 153:1989-93; discussion 1993. 2011
    ..The correct classification of these nosological entities will allow further more accurate evaluations of these cases in order to clarify the pathogenesis, prognosis and best treatment of each one...
  37. doi request reprint Clivus metastases: report of seven patients and literature review
    Roberto Pallini
    Institute of Neurosurgery, Catholic University School of Medicine, Roma, Italy
    Acta Neurochir (Wien) 151:291-6; discussion 296. 2009
    ..Here, we describe seven such examples and review the pertinent literature...
  38. doi request reprint Neural stem cells modified to express BDNF antagonize trimethyltin-induced neurotoxicity through PI3K/Akt and MAP kinase pathways
    Patrizia Casalbore
    Institute of Neurobiology and Molecular Medicine, National Research Council, Rome, Italy
    J Cell Physiol 224:710-21. 2010
    ..We demonstrate that overexpression of BDNF firmly regulate cell survival and differentiation of NSC and protects differentiated NSC against TMT-induced neurotoxicity through the PI3K/Akt and MAPK signaling pathways...
  39. ncbi request reprint Radically resected pituitary adenomas: prognostic role of Ki 67 labeling index in a monocentric retrospective series and literature review
    Sabrina Chiloiro
    Section of Endocrinology, Department of Internal Medicine, Universita Cattolica del Sacro Cuore, Policlinico Gemelli, Largo A Gemelli, 8, 00168, Rome, Italy
    Pituitary 17:267-76. 2014
    ..Ki-67 labeling index may be useful in postoperative management, even in patients who underwent radical PA removal. We suggest a Ki-67 cut-off value of 1.5% to plan an adequate clinical follow-up...
  40. ncbi request reprint Autologous dural substitutes: a prospective study
    Giovanni Sabatino
    Institute of Neurosurgery, Catholic University of Rome, Rome, Italy
    Clin Neurol Neurosurg 116:20-3. 2014
    ..In this prospective research we compared duraplasty using autologous galea-pericranium vs. dural patches in terms of postoperative long term results, ease/time required and costs...
  41. ncbi request reprint Cancer stem cell analysis and clinical outcome in patients with glioblastoma multiforme
    Roberto Pallini
    Department of Neurosurgery, Catholic University of Rome, Rome, Italy
    Clin Cancer Res 14:8205-12. 2008
    ..The stem cell antigen CD133 identifies such a tumorigenic population in a subset of glioblastoma patients. We conducted a prospective study to explore the prognostic potential of CSC analysis in glioblastoma patients...
  42. doi request reprint Minimally occlusive laser vascular anastomosis (MOLVA): experimental study
    Alfredo Puca
    Institute of Neurosurgery, Catholic University, Largo A Gemelli, Rome, Italy
    Acta Neurochir (Wien) 151:363-8; discussion 368. 2009
    ..A new laser vascular welding technique that minimizes the occlusion time of the recipient vessel has been developed and is described in this report...
  43. ncbi request reprint Homologous transplantation of neural stem cells to the injured spinal cord of mice
    Roberto Pallini
    Department of Neurosurgery, Laboratory for Neural Stem Cells, Center for Research on Regeneration of the Nervous System, Catholic University School of Medicine, Rome, Italy
    Neurosurgery 57:1014-25; discussion 1014-25. 2005
    ..In addition, we investigated whether transduced NSCs over-expressing vascular endothelial growth factor might exert any angiogenetic effect in the injured SC...
  44. ncbi request reprint A plasmid-encoded VEGF siRNA reduces glioblastoma angiogenesis and its combination with interleukin-4 blocks tumor growth in a xenograft mouse model
    Francesco Niola
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    Cancer Biol Ther 5:174-9. 2006
    ..These results suggest that our retroviral vector might be employed as a potential tool in future antiangiogenic gene therapy trials for glioblastoma...
  45. doi request reprint Treatment with octreotide LAR in clinically non-functioning pituitary adenoma: results from a case-control study
    Alessandra Fusco
    Division of Endocrinology, School of Medicine, Catholic University, Largo A Gemelli 8, 00168 Rome, Italy
    Pituitary 15:571-8. 2012
    ..This study indicates that SSTR5 and SSTR3 are the most frequently expressed SSTR subtypes in NFPAs and supports a potential role of SSTR subtypes in stabilization of tumor remnant from NFPAs...
  46. doi request reprint Large middle cerebral artery dissecting aneurysm mimicking hemorrhagic stroke
    Giuseppe Esposito
    Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    Clin Neurol Neurosurg 113:901-3. 2011
    ..We report a patient with middle cerebral artery dissection who developed a large middle cerebral artery dissecting aneurysm mimicking a hemorrhagic stroke...
  47. ncbi request reprint Pyrogenic cytokine interleukin-6 expression by a chordoid meningioma in an adult with a systemic inflammatory syndrome. Case report and review of the literature
    Luca Denaro
    Department of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    J Neurosurg 103:555-8. 2005
    ..The capacity of the tumor to produce this pyrogenic cytokine could explain both the patient's clinical presentation and her response to the surgical management...
  48. doi request reprint Microscopic and endoscopic extracranial approaches to the cavernous sinus: anatomic study
    Francesco Doglietto
    Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    Neurosurgery 64:413-21; discussion 421-2. 2009
    ..The aim of this study was to describe the distinctive anatomic features of these approaches and compare their efficacy in exposing the sella and parasellar areas...
  49. ncbi request reprint Association between Polymorphisms rs1333040 and rs7865618 of Chromosome 9p21 and Sporadic Brain Arteriovenous Malformations
    Carmelo Lucio Sturiale
    Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    Cerebrovasc Dis 37:290-5. 2014
    ..These results extend and strengthen the role of the 9p21 chromosomal region as a common risk factor for cerebrovascular diseases. © 2014 S. Karger AG, Basel. ..
  50. ncbi request reprint Hypothalamitis: a diagnostic and therapeutic challenge
    Antonio Bianchi
    Pituitary Unit, Departments of Endocrinology, Catholic University School of Medicine, Largo Agostino Gemelli, 8, 00168, Rome, Italy
    Pituitary 17:197-202. 2014
    ..Although steroid treatment is advisable as a first line therapy, immunosuppressive therapy with azathioprine might be necessary to achieve disease control. ..
  51. ncbi request reprint Single nucleotide polymorphisms associated with sporadic brain arteriovenous malformations: where do we stand?
    Carmelo Lucio Sturiale
    Department of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    Brain 136:665-81. 2013
    ..42; 95% confidence interval: 1.54-3.8) gene polymorphism and disease susceptibility...
  52. ncbi request reprint Primary empty sella syndrome in a series of 142 patients
    Giulio Maira
    Institute of Neurosurgery, Catholic University, Rome, Italy
    J Neurosurg 103:831-6. 2005
    ..An increase in intracranial pressure (ICP) is proposed to be one of the involved pathogenetic factors...
  53. ncbi request reprint Telomerase inhibition by stable RNA interference impairs tumor growth and angiogenesis in glioblastoma xenografts
    Roberto Pallini
    Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    Int J Cancer 118:2158-67. 2006
    ..Tumor xenografts that arose from telomerase-inhibited GBM cells also showed a less-malignant phenotype due both to the absence of massive necrosis and to reduced angiogenesis...
  54. pmc Endoscope-assisted microsurgical transoral approach to the anterior craniovertebral junction compressive pathologies
    Massimiliano Visocchi
    Istituto di Neurochirurgia, Catholic University School of Medicine, Policlinico A Gemelli, Largo A Gemelli, 8, 00168 Rome, Italy
    Eur Spine J 20:1518-25. 2011
    ..In our opinion, the endoscope deserves a role as "support" to the standard transoral microsurgical approach since 30° angulated endoscopy significantly increases the surgical area exposed at the level of the anterior CVJ...
  55. ncbi request reprint Calcified extra-axial cavernoma involving lower cranial nerves: technical case report
    Alessio Albanese
    Institute of Neurosurgery, Catholic University School of Medicine, Rome, Italy
    Neurosurgery 64:onsE135-6; discussion onsE136. 2009
    ..We report what is, to our knowledge, a unique case of a calcified extra-axial cerebellopontine angle (CPA) cavernoma involving the lower CNs...
  56. doi request reprint A rare bone-leptomeningeal metastasis from an adrenal cortical carcinoma
    Gennaro Capone
    Institute of Neurosurgery, Catholic University, Rome, Italy
    J Clin Neurosci 16:977-80. 2009
    ..In our opinion, surgery represents the most appropriate treatment for voluminous intracranial metastasis - even when there are no neurological signs...
  57. ncbi request reprint Idiopathic spinal cord herniation: diagnostic, surgical, and follow-up data obtained in five cases
    Giulio Maira
    Institutes of Neurosurgery and Radiology, Catholic University School of Medicine, Rome, Italy
    J Neurosurg Spine 4:10-9. 2006
    ..Based on the results and complications in these five cases, the authors now believe that ISCH should be treated, when feasible, by using a dural patch to close the dural defect at the site of the herniation...
  58. ncbi request reprint The PPARgamma ligands PGJ2 and rosiglitazone show a differential ability to inhibit proliferation and to induce apoptosis and differentiation of human glioblastoma cell lines
    Roberta Morosetti
    Division of Pediatric Oncology, Catholic University of Rome, 00168 Rome, Italy
    Int J Oncol 25:493-502. 2004
    ..By contrast, the modulation of differentiation-associated proteins by PGJ2, but not rosiglitazone, suggests that PGJ2 promotes differentiation of glioblastoma cells independently of PPARgamma activation...
  59. doi request reprint Anterior video-assisted approach to the craniovertebral junction: transnasal or transoral? A cadaver study
    Massimiliano Visocchi
    Institute of Neurosurgery, Catholic University of Rome, Largo Gemelli, 8, 00168, Rome, Italy
    Acta Neurochir (Wien) 156:285-92. 2014
    ..We compared the surgical exposition angle and the working channel volume of both the transnasal and transoral approaches in the cadaver...
  60. ncbi request reprint The role of transsphenoidal surgery in the treatment of craniopharyngiomas
    Giulio Maira
    Istituto di Neurochirurgia, Universita Cattolica del Sacro Cuore, Rome, Italy
    J Neurosurg 100:445-51. 2004
    ..Moreover, TSS was also performed in some cases of purely suprasellar craniopharyngiomas. In this study the surgical indications and the results obtained in all patients who had undergone TSS were analyzed...
  61. doi request reprint Efficacy of the combined cabergoline and octreotide treatment in a case of a dopamine-agonist resistant macroprolactinoma
    Alessandra Fusco
    Department of Internal Medicine, Universita Cattolica del Sacro Cuore, Rome, Italy
    Pituitary 14:351-7. 2011
    ..The expression and functionality of sstr should be investigated in these tumours since a combined therapy with cabergoline and octreotide may be a good therapeutic course of action for select cases...
  62. ncbi request reprint Treatment of intracranial aneurysms
    Giulio Maira
    Institute of Neurosurgery, Catholic University, Rome, Italy
    Clin Exp Hypertens 28:371-6. 2006
    ..The primary therapeutic target consists in prevention of rebleeding. At present, therapeutic opportunities for intracranial aneurysms are microsurgery and endovascular treatment...
  63. ncbi request reprint Osteosarcoma of craniovertebral junction
    Luca Denaro
    Department of Neurosurgery, Catholic University School of Medicine, Largo A Gemelli 8 Rome, Italy
    Lancet Oncol 6:1000. 2005
  64. doi request reprint Clinical Reasoning: A case of slowly progressive painful paraparesis
    Marzia Corbetto
    From the Institute of Neurology M C, F C, V D L, Department of Orthopaedic and Trauma Surgery V D, and Institute of Radiology C Q, Campus Bio Medico University of Rome Fondazione Alberto Sordi Research Institute for Ageing F C, V D L and the Institute of Radiology C C, Institute of Neurosurgery G M, Catholic University, Rome, Italy
    Neurology 82:1476-9. 2014
    ..The pain was not relieved in any position and was not preceded by fever or trauma. Her history was unremarkable. General examination including temperature, pulse, and blood pressure was normal. ..
  65. ncbi request reprint Long survival in an untreated solitary choroid plexus metastasis from renal cell carcinoma: case report and review of the literature
    Liverana Lauretti
    Department of Neurosurgery, Catholic University School of Medicine, Largo Agostino Gemelli 8, 00168, Rome, Italy
    J Neurooncol 71:157-60. 2005
    ..To our knowledge, this 46 months survival is the longest survival of a patient affected by a single choroid plexus metastasis from RCC...
  66. ncbi request reprint Diode laser-assisted carotid bypass surgery: an experimental study with morphological and immunohistochemical evaluations
    Alfredo Puca
    Institute of Neurosurgery, Catholic University, Rome, Italy
    Neurosurgery 59:1286-94; discussion 1294-5. 2006
    ..An experimental model of double end-to-side venous graft anastomosis on the common carotid artery was set up to compare conventional suturing methods with a low-power diode laser vascular welding technique...
  67. ncbi request reprint Pharmacokinetics of temozolomide given three times a day in pediatric and adult patients
    Anna Riccardi
    Division of Pediatric Oncology, Department of Pediatrics, Catholic University, Largo A Gemelli, 8, 00168 Rome, Italy
    Cancer Chemother Pharmacol 52:459-64. 2003
    ....
  68. ncbi request reprint Primary empty sella
    Laura De Marinis
    Departments of Endocrinology, Catholic University of Rome, 00168 Rome, Italy
    J Clin Endocrinol Metab 90:5471-7. 2005
    ..The term primary empty sella (PES) refers to a number of endocrine and/or neurological disturbances that may be caused by the herniation of subarachnoid space within the sella...
  69. ncbi request reprint Role of apoptosis in intracranial aneurysm rupture
    Luigi Pentimalli
    Department of Neurosurgery, Catholic University, Institute of Experimental Medicine and Biochemical Sciences, Rome, Italy
    J Neurosurg 101:1018-25. 2004
    ..The authors in this study focused on the comparative evaluation of apoptosis in ruptured and unruptured intracranial aneurysms. Peripheral arteries in patients harboring the aneurysms and in a group of controls were also analyzed...