Ayman M Mahmoud
Mahmoud A, Germoush M, Al Anazi K, Mahmoud A, Farah M, Allam A. Commiphora molmol protects against methotrexate-induced nephrotoxicity by up-regulating Nrf2/ARE/HO-1 signaling. Biomed Pharmacother. 2018;106:499-509 pubmed publisher
..In conclusion, C. molmol resin provided protection against MTX-induced AKI via activation of Nrf2 signaling and mitigation of oxidative stress. ..
Al Hroob A, Abukhalil M, Alghonmeen R, Mahmoud A. Ginger alleviates hyperglycemia-induced oxidative stress, inflammation and apoptosis and protects rats against diabetic nephropathy. Biomed Pharmacother. 2018;106:381-389 pubmed publisher
..In conclusion, this study strongly suggests that Z. officinale rhizome extract exerts a protective role against diabetes-induced renal injury by ameliorating oxidative stress, inflammation and apoptosis. ..
Al Rasheed N, Al Rasheed N, Bassiouni Y, Hasan I, Al Amin M, Al Ajmi H, et al
. Simvastatin ameliorates diabetic nephropathy by attenuating oxidative stress and apoptosis in a rat model of streptozotocin-induced type 1 diabetes. Biomed Pharmacother. 2018;105:290-298 pubmed publisher
..In conclusion, SIM can protect against diabetic nephropathy by attenuating oxidative stress and apoptosis. ..
Al Basher G, Aljabal H, Almeer R, Allam A, Mahmoud A. Perinatal exposure to energy drink induces oxidative damage in the liver, kidney and brain, and behavioral alterations in mice offspring. Biomed Pharmacother. 2018;102:798-811 pubmed publisher
..Therefore, the consumption of EDs during pregnancy and lactation has a negative impact on the newborns and should be treated as a significant health problem that warrants attention. ..
Germoush M, Othman S, Al Qaraawi M, Al Harbi H, Hussein O, Al Basher G, et al
. Umbelliferone prevents oxidative stress, inflammation and hematological alterations, and modulates glutamate-nitric oxide-cGMP signaling in hyperammonemic rats. Biomed Pharmacother. 2018;102:392-402 pubmed publisher
..UMB prevents hyperammonemia associated hematological alterations and therefore represents a promising protective agent against the deleterious effects of excess ammonia. ..
Al Samhari M, Al Rasheed N, Al Rejaie S, Al Rasheed N, Hasan I, Mahmoud A, et al
. Possible involvement of the JAK/STAT signaling pathway in N-acetylcysteine-mediated antidepressant-like effects. Exp Biol Med (Maywood). 2016;241:509-18 pubmed publisher
..Therefore, depression research may target the JAK/STAT signaling pathway to provide a novel effective therapy. ..
Mahmoud A, Al Dera H. 18Î²-Glycyrrhetinic acid exerts protective effects against cyclophosphamide-induced hepatotoxicity: potential role of PPARÎ³ and Nrf2 upregulation. Genes Nutr. 2015;10:41 pubmed publisher
..This report also confers new information that 18Î²-GA protects liver against the toxic effect of chemotherapeutic alkylating agents via activation of Nrf2 and PPARÎ³. ..
Mahmoud A, Abd El Twab S, Abdel Reheim E. Consumption of polyphenol-rich Morus alba leaves extract attenuates early diabetic retinopathy: the underlying mechanism. Eur J Nutr. 2017;56:1671-1684 pubmed publisher
..alba has protective effect on diabetic retinopathy with possible mechanisms of inhibiting hyperglycemia-induced oxidative stress, apoptosis, inflammation, polyol pathway activation, and VEGF expression in the retina. ..
Kamel E, Mahmoud A, Ahmed S, Lamsabhi A. A phytochemical and computational study on flavonoids isolated from Trifolium resupinatum L. and their novel hepatoprotective activity. Food Funct. 2016;7:2094-106 pubmed publisher
..Therefore, the present study provides the first clarification of the detailed antioxidant SARs of T. resupinatum flavonoids and points to the involvement of Nrf2 in their hepatoprotective activity. ..