Involvement of hypothalamic pituitary adrenal axis on the nifedipine-induced antinociception and tolerance in ratsSaeed Esmaeili Mahani
Department of Physiology and Pharmacology, Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Pharmacol Biochem Behav 85:422-7. 2006
..Both effects are reversed by corticosterone replacement...
- Nifedipine suppresses morphine-induced thermal hyperalgesia: evidence for the role of corticosterone
Saeed Esmaeili Mahani
Department of Physiology, Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Eur J Pharmacol 567:95-101. 2007
....
- Low-dose morphine induces hyperalgesia through activation of G alphas, protein kinase C, and L-type Ca 2+ channels in rats
Saeed Esmaeili-Mahani
Department of Physiology, Neuroscience Research Center, Shahid Beheshti Medical University, Tehran, Iran
J Neurosci Res 86:471-9. 2008
..Activation of ordinary G(alphas) signaling through cAMP levels did not appear to play a major role in the induction of hyperalgesia by low-dose of morphine...
L-type calcium channel blockade attenuates morphine withdrawal: in vivo interaction between L-type calcium channels and corticosteroneSaeed Esmaeili-Mahani
Department of Biology, Faculty of Sciences, Shahid Bahonar University, Kerman, Iran
Horm Behav 53:351-7. 2008
..Thus, we have shown the involvement of the HPA axis in the effect of nifedipine on the development of morphine dependency and additionally demonstrated an in vivo interaction between the L-type Ca2+ channels and corticosterone...
- Post-adrenalectomy changes in the gene expression of specific G-protein subunits involved in morphine sensitization
Saeed Esmaeili-Mahani
Department of Biology, Faculty of Sciences, Shahid Bahonar University, Kerman, Iran
Neuropeptides 42:169-75. 2008
..This may be at least partly responsible for adrenalectomy-induced morphine sensitization...
- Exercise-induced morphine insensitivity is accompanied with a decrease in specific G-protein subunits gene expression in rats
Saeed Esmaeili-Mahani
Laboratory of Molecular Neuroscience, Kerman Neuroscience Research Center KNRC, Kerman University of Medical Sciences, Kerman, Iran Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran Electronic address
Pharmacol Biochem Behav 105:128-33. 2013
..In conclusion, our results reveal that the expression patterns of the opioid receptor signaling elements change in exercise training animals. This may be, at least partly, responsible for exercise-induced morphine insensitivity...
- Involvement of hypothalamic pituitary adrenal axis on the analgesic cross-tolerance between morphine and nifedipine
Saeed Esmaeili-Mahani
Departments of Physiology and Pharmacology, Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Pharmacol Biochem Behav 86:806-12. 2007
..Based on these results, we can conclude that HPA axis is involved in the induction of cross-tolerance between morphine and nifedipine due to chronic morphine and not nifedipine treatment...
- Olive (Olea europaea L.) leaf extract elicits antinociceptive activity, potentiates morphine analgesia and suppresses morphine hyperalgesia in rats
Saeed Esmaeili-Mahani
Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran
J Ethnopharmacol 132:200-5. 2010
..Recently, it has been shown that olive leaf extract (OLE) has calcium channel blocker property; however, its influences on nociceptive threshold and morphine effects have not yet been clarified...
- Ginger (Zingiber officinale Roscoe) elicits antinociceptive properties and potentiates morphine-induced analgesia in the rat radiant heat tail-flick test
Reza Sepahvand
Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khoramabad, Iran
J Med Food 13:1397-401. 2010
..Thus, the data indicate that ginger extract has a beneficial influence on morphine analgesia and can be an efficacious adjunct for pain management...
