Michael Maes

Summary

Publications

  1. ncbi Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression
    Michael Maes
    Maes 998 Rimklongsamsen Road, Piyavate Hospital, Bangkok 10310, Thailand
    Prog Neuropsychopharmacol Biol Psychiatry 35:664-75. 2011
  2. ncbi Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways
    Michael Maes
    Maes Clinics TRIA, Piyavate Hospital, 998 Rimklongsamsen Road, Bangkok 10310, Thailand
    BMC Med 10:66. 2012
  3. ncbi Depression's multiple comorbidities explained by (neuro)inflammatory and oxidative & nitrosative stress pathways
    Michael Maes
    Maes Clinics TRIA, Bangkok, Thailand, Thailand
    Neuro Endocrinol Lett 32:7-24. 2011
  4. ncbi Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: another pathway that may be associated with coronary artery disease and neuroprogression in depression
    Michael Maes
    Piyavate Hospital, Bangkok, Thailand, Thailand
    Neuro Endocrinol Lett 32:133-40. 2011
  5. ncbi Increased autoimmune activity against 5-HT: a key component of depression that is associated with inflammation and activation of cell-mediated immunity, and with severity and staging of depression
    Michael Maes
    Maes Clinics TRIA, Piyavate Hospital, Bangkok, Thailand
    J Affect Disord 136:386-92. 2012
  6. ncbi Myalgic Encephalomyelitis (ME), Chronic Fatigue Syndrome (CFS), and Chronic Fatigue (CF) are distinguished accurately: results of supervised learning techniques applied on clinical and inflammatory data
    Michael Maes
    Maes Clinics TRIA, Piyavate Hospital, 998 Rimklongsamsen Road, Bangkok 10310, Thailand
    Psychiatry Res 200:754-60. 2012
  7. ncbi IgM-mediated autoimmune responses directed against anchorage epitopes are greater in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) than in major depression
    Michael Maes
    Maes Clinics TRIA, Piyavate Hospital, 998 Rimklongsamsen Road, Bangkok, 10310, Thailand
    Metab Brain Dis 27:415-23. 2012
  8. ncbi New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates--Nrf2 activators and GSK-3 inhibitors
    Michael Maes
    Maes 998 Rimklongsamsen Road, Bangkok 10310, Thailand
    Inflammopharmacology 20:127-50. 2012
  9. ncbi An intriguing and hitherto unexplained co-occurrence: Depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways
    Michael Maes
    Maes Clinics TRIA, 998 Rimklongsamsen Road, Bangkok 10310, Thailand
    Prog Neuropsychopharmacol Biol Psychiatry 35:784-94. 2011

Detail Information

Publications9

  1. ncbi Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression
    Michael Maes
    Maes 998 Rimklongsamsen Road, Piyavate Hospital, Bangkok 10310, Thailand
    Prog Neuropsychopharmacol Biol Psychiatry 35:664-75. 2011
    ..This review shows that inflammation and cell-mediated immune activation are key factors in depression...
  2. ncbi Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways
    Michael Maes
    Maes Clinics TRIA, Piyavate Hospital, 998 Rimklongsamsen Road, Bangkok 10310, Thailand
    BMC Med 10:66. 2012
    ....
  3. ncbi Depression's multiple comorbidities explained by (neuro)inflammatory and oxidative & nitrosative stress pathways
    Michael Maes
    Maes Clinics TRIA, Bangkok, Thailand, Thailand
    Neuro Endocrinol Lett 32:7-24. 2011
    ..This shows that depression belongs to the spectrum of inflammatory and degenerative disorders...
  4. ncbi Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: another pathway that may be associated with coronary artery disease and neuroprogression in depression
    Michael Maes
    Piyavate Hospital, Bangkok, Thailand, Thailand
    Neuro Endocrinol Lett 32:133-40. 2011
    ..Moreover, depression is accompanied by disorders in inflammatory and neuroprogressive (IN-PRO) pathways...
  5. ncbi Increased autoimmune activity against 5-HT: a key component of depression that is associated with inflammation and activation of cell-mediated immunity, and with severity and staging of depression
    Michael Maes
    Maes Clinics TRIA, Piyavate Hospital, Bangkok, Thailand
    J Affect Disord 136:386-92. 2012
    ..g. lowering the 5-HT precursor tryptophan, and upregulating 5-HT receptor mRNA. This study has been undertaken to examine autoimmune activity directed against 5-HT in relation to CMI activation and inflammation...
  6. ncbi Myalgic Encephalomyelitis (ME), Chronic Fatigue Syndrome (CFS), and Chronic Fatigue (CF) are distinguished accurately: results of supervised learning techniques applied on clinical and inflammatory data
    Michael Maes
    Maes Clinics TRIA, Piyavate Hospital, 998 Rimklongsamsen Road, Bangkok 10310, Thailand
    Psychiatry Res 200:754-60. 2012
    ..e. "malaise-sickness" and "malaise-hyperalgesia". Fukuda's criteria are adequate to make a distinction between ME/CFS and CF, but ME/CFS patients should be subdivided into ME (with PEM) and CFS (without PEM)...
  7. ncbi IgM-mediated autoimmune responses directed against anchorage epitopes are greater in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) than in major depression
    Michael Maes
    Maes Clinics TRIA, Piyavate Hospital, 998 Rimklongsamsen Road, Bangkok, 10310, Thailand
    Metab Brain Dis 27:415-23. 2012
    ..g. intracellular signal transduction, cellular differentiation and apoptosis, but their impact may be more important in ME/CFS than in depression...
  8. ncbi New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates--Nrf2 activators and GSK-3 inhibitors
    Michael Maes
    Maes 998 Rimklongsamsen Road, Bangkok 10310, Thailand
    Inflammopharmacology 20:127-50. 2012
    ..Nrf2 activators and GSK-3 inhibitors have the potential to be advanced to phase-2 clinical trials to examine whether they augment the efficacy of antidepressants or are useful as monotherapy...
  9. ncbi An intriguing and hitherto unexplained co-occurrence: Depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways
    Michael Maes
    Maes Clinics TRIA, 998 Rimklongsamsen Road, Bangkok 10310, Thailand
    Prog Neuropsychopharmacol Biol Psychiatry 35:784-94. 2011
    ..Depression and ME/CFS are not 'comorbid' disorders, but should be regarded as 'co-associated disorders' that are clinical manifestations of shared pathways...