Michael Maes

Summary

Publications

  1. doi request reprint Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression
    Michael Maes
    Maes 998 Rimklongsamsen Road, Piyavate Hospital, Bangkok 10310, Thailand
    Prog Neuropsychopharmacol Biol Psychiatry 35:664-75. 2011
  2. doi request reprint New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates--Nrf2 activators and GSK-3 inhibitors
    Michael Maes
    Maes 998 Rimklongsamsen Road, Bangkok 10310, Thailand
    Inflammopharmacology 20:127-50. 2012
  3. doi request reprint Myalgic Encephalomyelitis (ME), Chronic Fatigue Syndrome (CFS), and Chronic Fatigue (CF) are distinguished accurately: results of supervised learning techniques applied on clinical and inflammatory data
    Michael Maes
    Maes Clinics TRIA, Piyavate Hospital, 998 Rimklongsamsen Road, Bangkok 10310, Thailand
    Psychiatry Res 200:754-60. 2012
  4. pmc Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways
    Michael Maes
    Maes Clinics TRIA, Piyavate Hospital, 998 Rimklongsamsen Road, Bangkok 10310, Thailand
    BMC Med 10:66. 2012
  5. ncbi request reprint Depression's multiple comorbidities explained by (neuro)inflammatory and oxidative & nitrosative stress pathways
    Michael Maes
    Maes Clinics TRIA, Bangkok, Thailand, Thailand
    Neuro Endocrinol Lett 32:7-24. 2011
  6. ncbi request reprint Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: another pathway that may be associated with coronary artery disease and neuroprogression in depression
    Michael Maes
    Piyavate Hospital, Bangkok, Thailand, Thailand
    Neuro Endocrinol Lett 32:133-40. 2011
  7. doi request reprint Increased autoimmune activity against 5-HT: a key component of depression that is associated with inflammation and activation of cell-mediated immunity, and with severity and staging of depression
    Michael Maes
    Maes Clinics TRIA, Piyavate Hospital, Bangkok, Thailand
    J Affect Disord 136:386-92. 2012
  8. doi request reprint IgM-mediated autoimmune responses directed against anchorage epitopes are greater in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) than in major depression
    Michael Maes
    Maes Clinics TRIA, Piyavate Hospital, 998 Rimklongsamsen Road, Bangkok, 10310, Thailand
    Metab Brain Dis 27:415-23. 2012
  9. doi request reprint An intriguing and hitherto unexplained co-occurrence: Depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways
    Michael Maes
    Maes Clinics TRIA, 998 Rimklongsamsen Road, Bangkok 10310, Thailand
    Prog Neuropsychopharmacol Biol Psychiatry 35:784-94. 2011

Detail Information

Publications9

  1. doi request reprint Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression
    Michael Maes
    Maes 998 Rimklongsamsen Road, Piyavate Hospital, Bangkok 10310, Thailand
    Prog Neuropsychopharmacol Biol Psychiatry 35:664-75. 2011
    ..This review shows that inflammation and cell-mediated immune activation are key factors in depression...
  2. doi request reprint New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates--Nrf2 activators and GSK-3 inhibitors
    Michael Maes
    Maes 998 Rimklongsamsen Road, Bangkok 10310, Thailand
    Inflammopharmacology 20:127-50. 2012
    ..Nrf2 activators and GSK-3 inhibitors have the potential to be advanced to phase-2 clinical trials to examine whether they augment the efficacy of antidepressants or are useful as monotherapy...
  3. doi request reprint Myalgic Encephalomyelitis (ME), Chronic Fatigue Syndrome (CFS), and Chronic Fatigue (CF) are distinguished accurately: results of supervised learning techniques applied on clinical and inflammatory data
    Michael Maes
    Maes Clinics TRIA, Piyavate Hospital, 998 Rimklongsamsen Road, Bangkok 10310, Thailand
    Psychiatry Res 200:754-60. 2012
    ..e. "malaise-sickness" and "malaise-hyperalgesia". Fukuda's criteria are adequate to make a distinction between ME/CFS and CF, but ME/CFS patients should be subdivided into ME (with PEM) and CFS (without PEM)...
  4. pmc Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways
    Michael Maes
    Maes Clinics TRIA, Piyavate Hospital, 998 Rimklongsamsen Road, Bangkok 10310, Thailand
    BMC Med 10:66. 2012
    ....
  5. ncbi request reprint Depression's multiple comorbidities explained by (neuro)inflammatory and oxidative & nitrosative stress pathways
    Michael Maes
    Maes Clinics TRIA, Bangkok, Thailand, Thailand
    Neuro Endocrinol Lett 32:7-24. 2011
    ..This shows that depression belongs to the spectrum of inflammatory and degenerative disorders...
  6. ncbi request reprint Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: another pathway that may be associated with coronary artery disease and neuroprogression in depression
    Michael Maes
    Piyavate Hospital, Bangkok, Thailand, Thailand
    Neuro Endocrinol Lett 32:133-40. 2011
    ..Moreover, depression is accompanied by disorders in inflammatory and neuroprogressive (IN-PRO) pathways...
  7. doi request reprint Increased autoimmune activity against 5-HT: a key component of depression that is associated with inflammation and activation of cell-mediated immunity, and with severity and staging of depression
    Michael Maes
    Maes Clinics TRIA, Piyavate Hospital, Bangkok, Thailand
    J Affect Disord 136:386-92. 2012
    ..g. lowering the 5-HT precursor tryptophan, and upregulating 5-HT receptor mRNA. This study has been undertaken to examine autoimmune activity directed against 5-HT in relation to CMI activation and inflammation...
  8. doi request reprint IgM-mediated autoimmune responses directed against anchorage epitopes are greater in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) than in major depression
    Michael Maes
    Maes Clinics TRIA, Piyavate Hospital, 998 Rimklongsamsen Road, Bangkok, 10310, Thailand
    Metab Brain Dis 27:415-23. 2012
    ..g. intracellular signal transduction, cellular differentiation and apoptosis, but their impact may be more important in ME/CFS than in depression...
  9. doi request reprint An intriguing and hitherto unexplained co-occurrence: Depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways
    Michael Maes
    Maes Clinics TRIA, 998 Rimklongsamsen Road, Bangkok 10310, Thailand
    Prog Neuropsychopharmacol Biol Psychiatry 35:784-94. 2011
    ..Depression and ME/CFS are not 'comorbid' disorders, but should be regarded as 'co-associated disorders' that are clinical manifestations of shared pathways...