Michael Maes

Summary

Publications

  1. pmc Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
    Michael Maes
    Maes Bangkok, Thailand
    Med Sci Monit 17:SC11-5. 2011
  2. ncbi request reprint Case definitions and diagnostic criteria for Myalgic Encephalomyelitis and Chronic fatigue Syndrome: from clinical-consensus to evidence-based case definitions
    Gerwyn Morris
    Mumbles Head, Pembrey llanelli, UK
    Neuro Endocrinol Lett 34:185-99. 2013
  3. doi request reprint Targeting classical IL-6 signalling or IL-6 trans-signalling in depression?
    Michael Maes
    Deakin University, Department of Psychiatry, Geelong, Australia
    Expert Opin Ther Targets 18:495-512. 2014
  4. ncbi request reprint In myalgic encephalomyelitis/chronic fatigue syndrome, increased autoimmune activity against 5-HT is associated with immuno-inflammatory pathways and bacterial translocation
    Michael Maes
    Maes Clinics TRIA, Bangkok, Thailand
    J Affect Disord 150:223-30. 2013
  5. pmc A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior
    Gerwyn Morris
    Tir Na Nog, Bryn Road Seaside 87, Llanelli SA152LW, UK
    BMC Med 11:64. 2013
  6. doi request reprint In depression, bacterial translocation may drive inflammatory responses, oxidative and nitrosative stress (O&NS), and autoimmune responses directed against O&NS-damaged neoepitopes
    M Maes
    Maes Clinics TRIA, Bangkok, Thailand
    Acta Psychiatr Scand 127:344-54. 2013
  7. doi request reprint Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: implications for the pathways to chronic depression and neuroprogression
    Michael Maes
    Maes Clinics TRIA, Bangkok, Thailand
    J Affect Disord 149:23-9. 2013
  8. doi request reprint Diagnosis of myalgic encephalomyelitis: where are we now?
    Michael Maes
    Chulalongkorn University, Department of Psychiatry, Bangkok, Thailand
    Expert Opin Med Diagn 7:221-5. 2013
  9. doi request reprint Myalgic Encephalomyelitis (ME), Chronic Fatigue Syndrome (CFS), and Chronic Fatigue (CF) are distinguished accurately: results of supervised learning techniques applied on clinical and inflammatory data
    Michael Maes
    Maes Clinics TRIA, Piyavate Hospital, 998 Rimklongsamsen Road, Bangkok 10310, Thailand
    Psychiatry Res 200:754-60. 2012
  10. doi request reprint IgM-mediated autoimmune responses directed against anchorage epitopes are greater in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) than in major depression
    Michael Maes
    Maes Clinics TRIA, Piyavate Hospital, 998 Rimklongsamsen Road, Bangkok, 10310, Thailand
    Metab Brain Dis 27:415-23. 2012

Detail Information

Publications38

  1. pmc Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
    Michael Maes
    Maes Bangkok, Thailand
    Med Sci Monit 17:SC11-5. 2011
    ..The present study was carried out in order to examine whether ME/CFS is accompanied by increased levels of plasma peroxides and serum oxidized LDL (oxLDL) antibodies, two biomarkers of oxidative stress...
  2. ncbi request reprint Case definitions and diagnostic criteria for Myalgic Encephalomyelitis and Chronic fatigue Syndrome: from clinical-consensus to evidence-based case definitions
    Gerwyn Morris
    Mumbles Head, Pembrey llanelli, UK
    Neuro Endocrinol Lett 34:185-99. 2013
    ....
  3. doi request reprint Targeting classical IL-6 signalling or IL-6 trans-signalling in depression?
    Michael Maes
    Deakin University, Department of Psychiatry, Geelong, Australia
    Expert Opin Ther Targets 18:495-512. 2014
    ..Future research should delineate the effects of treatments with sgp130Fc in combination with antidepressants in various animal models of chronic depression. ..
  4. ncbi request reprint In myalgic encephalomyelitis/chronic fatigue syndrome, increased autoimmune activity against 5-HT is associated with immuno-inflammatory pathways and bacterial translocation
    Michael Maes
    Maes Clinics TRIA, Bangkok, Thailand
    J Affect Disord 150:223-30. 2013
    ..This study has been carried out to examine the autoimmune responses to 5-HT in ME/CFS in relation to inflammation and bacterial translocation...
  5. pmc A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior
    Gerwyn Morris
    Tir Na Nog, Bryn Road Seaside 87, Llanelli SA152LW, UK
    BMC Med 11:64. 2013
    ..It is concluded that sickness behavior and ME/CFS are two different conditions. ..
  6. doi request reprint In depression, bacterial translocation may drive inflammatory responses, oxidative and nitrosative stress (O&NS), and autoimmune responses directed against O&NS-damaged neoepitopes
    M Maes
    Maes Clinics TRIA, Bangkok, Thailand
    Acta Psychiatr Scand 127:344-54. 2013
    ..The latter suggests that bacterial translocation has caused IgM/IgA responses directed against LPS. Bacterial translocation may drive IO&NS responses...
  7. doi request reprint Increased autoimmune responses against auto-epitopes modified by oxidative and nitrosative damage in depression: implications for the pathways to chronic depression and neuroprogression
    Michael Maes
    Maes Clinics TRIA, Bangkok, Thailand
    J Affect Disord 149:23-9. 2013
    ..The aim of this study is to examine IgM-mediated autoimmune responses against a variety of modified neo-epitopes formed by O&NS damage to self-epitopes in chronic depression...
  8. doi request reprint Diagnosis of myalgic encephalomyelitis: where are we now?
    Michael Maes
    Chulalongkorn University, Department of Psychiatry, Bangkok, Thailand
    Expert Opin Med Diagn 7:221-5. 2013
    ..c) ME, where PEM is evident in CFS. Future research on this "chronic fatigue spectrum" should, therefore, use the abovementioned validated categories and novel tailored algorithms to classify patients into ME, CFS, or CF...
  9. doi request reprint Myalgic Encephalomyelitis (ME), Chronic Fatigue Syndrome (CFS), and Chronic Fatigue (CF) are distinguished accurately: results of supervised learning techniques applied on clinical and inflammatory data
    Michael Maes
    Maes Clinics TRIA, Piyavate Hospital, 998 Rimklongsamsen Road, Bangkok 10310, Thailand
    Psychiatry Res 200:754-60. 2012
    ..e. "malaise-sickness" and "malaise-hyperalgesia". Fukuda's criteria are adequate to make a distinction between ME/CFS and CF, but ME/CFS patients should be subdivided into ME (with PEM) and CFS (without PEM)...
  10. doi request reprint IgM-mediated autoimmune responses directed against anchorage epitopes are greater in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) than in major depression
    Michael Maes
    Maes Clinics TRIA, Piyavate Hospital, 998 Rimklongsamsen Road, Bangkok, 10310, Thailand
    Metab Brain Dis 27:415-23. 2012
    ..g. intracellular signal transduction, cellular differentiation and apoptosis, but their impact may be more important in ME/CFS than in depression...
  11. doi request reprint Targeting cyclooxygenase-2 in depression is not a viable therapeutic approach and may even aggravate the pathophysiology underpinning depression
    Michael Maes
    Maes Clinics TRIA, Piyavate Hospital 998 Rimklongsamsen Road, Bangkok, 10310, Thailand
    Metab Brain Dis 27:405-13. 2012
    ..Selectively targeting COX-2 may not be a viable therapeutic approach to treat depression. Multi-targeting of the different pathways that play a role in depression is more likely to yield good treatment results...
  12. doi request reprint Increased IgA and IgM responses against gut commensals in chronic depression: further evidence for increased bacterial translocation or leaky gut
    Michael Maes
    Maes Clinics TRIA, Bangkok, Thailand
    J Affect Disord 141:55-62. 2012
    ....
  13. pmc Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways
    Michael Maes
    Maes Clinics TRIA, Piyavate Hospital, 998 Rimklongsamsen Road, Bangkok 10310, Thailand
    BMC Med 10:66. 2012
    ....
  14. doi request reprint Diagnostic classifications in depression and somatization should include biomarkers, such as disorders in the tryptophan catabolite (TRYCAT) pathway
    Michael Maes
    Maes Clinics TRIA, Bangkok, Thailand
    Psychiatry Res 196:243-9. 2012
    ..Within the patient group, cluster analysis has generated a "pathway phenotype", i.e. aberrations in the TRYCAT pathway, which are associated with somatization rather than with depression...
  15. doi request reprint Activation of cell-mediated immunity in depression: association with inflammation, melancholia, clinical staging and the fatigue and somatic symptom cluster of depression
    Michael Maes
    Maes Clinics TRIA, Bangkok, Thailand
    Prog Neuropsychopharmacol Biol Psychiatry 36:169-75. 2012
    ..These PICs may induce depressive, melancholic and chronic fatigue (CF) symptoms...
  16. doi request reprint New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates--Nrf2 activators and GSK-3 inhibitors
    Michael Maes
    Maes 998 Rimklongsamsen Road, Bangkok 10310, Thailand
    Inflammopharmacology 20:127-50. 2012
    ..Nrf2 activators and GSK-3 inhibitors have the potential to be advanced to phase-2 clinical trials to examine whether they augment the efficacy of antidepressants or are useful as monotherapy...
  17. doi request reprint Increased IgA responses to the LPS of commensal bacteria is associated with inflammation and activation of cell-mediated immunity in chronic fatigue syndrome
    Michael Maes
    Maes Clinics TRIA, Bangkok, Thailand
    J Affect Disord 136:909-17. 2012
    ..g. increased plasma interleukin-(IL)1 and tumor necrosis factor (TNF)α; and c) activation of cell-mediated immunity (CMI), as demonstrated by increased neopterin...
  18. doi request reprint Evidence for inflammation and activation of cell-mediated immunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): increased interleukin-1, tumor necrosis factor-α, PMN-elastase, lysozyme and neopterin
    Michael Maes
    Maes Clinics TRIA, Bangkok, Thailand
    J Affect Disord 136:933-9. 2012
    ..Given the broad spectrum inflammatory state in ME/CFS, the aim of this study was to examine whether inflammatory and CMI biomarkers are increased in individuals with ME/CFS...
  19. doi request reprint Increased autoimmune activity against 5-HT: a key component of depression that is associated with inflammation and activation of cell-mediated immunity, and with severity and staging of depression
    Michael Maes
    Maes Clinics TRIA, Piyavate Hospital, Bangkok, Thailand
    J Affect Disord 136:386-92. 2012
    ..g. lowering the 5-HT precursor tryptophan, and upregulating 5-HT receptor mRNA. This study has been undertaken to examine autoimmune activity directed against 5-HT in relation to CMI activation and inflammation...
  20. doi request reprint A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness
    Michael Maes
    Clinics, Bangkok, Thailand
    Prog Neuropsychopharmacol Biol Psychiatry 35:676-92. 2011
    ..It is concluded that aberrations in O&NS pathways are--together with the inflammatory processes--key components of depression. All in all, the results suggest that depression belongs to the spectrum of (neuro)degenerative disorders...
  21. doi request reprint Multiple aberrations in shared inflammatory and oxidative & nitrosative stress (IO&NS) pathways explain the co-association of depression and cardiovascular disorder (CVD), and the increased risk for CVD and due mortality in depressed patients
    Michael Maes
    Maes Clinics TRIA, Bangkok, Thailand
    Prog Neuropsychopharmacol Biol Psychiatry 35:769-83. 2011
    ..It is advised that patients with (sub)chronic or recurrent major depression should routinely be assessed by serology tests to predict if they have an increased risk to cardiovascular disorders...
  22. doi request reprint The new '5-HT' hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to th
    M Maes
    Maes Clinics TRIA, Piyavate Hospital, 998 Rimklongsamsen Road, Bangkok 10310, Thailand
    Prog Neuropsychopharmacol Biol Psychiatry 35:702-21. 2011
    ....
  23. doi request reprint IgM-mediated autoimmune responses directed against multiple neoepitopes in depression: new pathways that underpin the inflammatory and neuroprogressive pathophysiology
    Michael Maes
    Maes Clinics TRIA, Bangkok, Thailand
    J Affect Disord 135:414-8. 2011
    ..e. palmitic and myristic acids and S-farnesyl-L-cysteine...
  24. ncbi request reprint Somatization, but not depression, is characterized by disorders in the tryptophan catabolite (TRYCAT) pathway, indicating increased indoleamine 2,3-dioxygenase and lowered kynurenine aminotransferase activity
    Michael Maes
    Maes Clinics TRIA, Bangkok, Thailand
    Neuro Endocrinol Lett 32:264-73. 2011
    ..Depression is accompanied by lowered kynurenic acid, a neuroprotectant, or increased kynurenine, a neurotoxic TRYCAT...
  25. ncbi request reprint Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: another pathway that may be associated with coronary artery disease and neuroprogression in depression
    Michael Maes
    Piyavate Hospital, Bangkok, Thailand, Thailand
    Neuro Endocrinol Lett 32:133-40. 2011
    ..Moreover, depression is accompanied by disorders in inflammatory and neuroprogressive (IN-PRO) pathways...
  26. doi request reprint An intriguing and hitherto unexplained co-occurrence: Depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways
    Michael Maes
    Maes Clinics TRIA, 998 Rimklongsamsen Road, Bangkok 10310, Thailand
    Prog Neuropsychopharmacol Biol Psychiatry 35:784-94. 2011
    ..Depression and ME/CFS are not 'comorbid' disorders, but should be regarded as 'co-associated disorders' that are clinical manifestations of shared pathways...
  27. doi request reprint Atopic disorders and depression: findings from a large, population-based study
    Livia Sanna
    Neurosciences, Mental Health and Sensory Organs Department NeSMOS, Unit of Psychiatry, Faculty of Medicine and Psychology, Sant Andrea Hospital, Sapienza University of Rome, Italy School of Medicine, Deakin University, Geelong, Australia Electronic address
    J Affect Disord 155:261-5. 2014
    ..We sought to determine the role of atopic disorders in depression using data from a randomly-selected, population-based study of men and women...
  28. ncbi request reprint Depression's multiple comorbidities explained by (neuro)inflammatory and oxidative & nitrosative stress pathways
    Michael Maes
    Maes Clinics TRIA, Bangkok, Thailand, Thailand
    Neuro Endocrinol Lett 32:7-24. 2011
    ..This shows that depression belongs to the spectrum of inflammatory and degenerative disorders...
  29. pmc Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness
    Michael Berk
    School of Medicine, Deakin University, 75 Pigdon s Road, Waurn Ponds, Geelong, Victoria 3216, Australia
    BMC Med 11:74. 2013
    ....
  30. pmc So depression is an inflammatory disease, but where does the inflammation come from?
    Michael Berk
    IMPACT Strategic Research Centre, School of Medicine, Deakin University, Geelong, Vic, Australia
    BMC Med 11:200. 2013
    ..It is similarly accompanied by increased oxidative and nitrosative stress (O&NS), which contribute to neuroprogression in the disorder. The obvious question this poses is 'what is the source of this chronic low-grade inflammation?'..
  31. doi request reprint Putative neuroprotective agents in neuropsychiatric disorders
    Seetal Dodd
    School of Medicine, Deakin University, Geelong, Victoria, Australia Department of Psychiatry, University of Melbourne, Parkville, Victoria, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 42:135-45. 2013
    ..These agents are putative neuroprotective agents for schizophrenia and mood disorders...
  32. doi request reprint Targeting IL-1 in depression
    Michael Maes
    Maes Clinics TRIA, Bangkok, Thailand
    Expert Opin Ther Targets 16:1097-112. 2012
    ..e., neurodegeneration, impaired plasticity and reduced neurogenesis). These pathways involve increased monocytic activation and interleukin-1 (IL-1) levels...
  33. ncbi request reprint Polyunsaturated fatty acids: do they have a role in the pathophysiology of autism?
    Sonja Sliwinski
    University Center of Child and Adolescent Psychiatry, ZNA Middelheim, University of Antwerp, Wilrijk, Belgium
    Neuro Endocrinol Lett 27:465-71. 2006
    ..The aim of the present study was to examine whether autism is accompanied by abnormalities in the composition of the polyunsaturated fatty acids (PUFAs) in plasma phospholipids...
  34. doi request reprint Inflammatory and cell-mediated immune biomarkers in myalgic encephalomyelitis/chronic fatigue syndrome and depression: inflammatory markers are higher in myalgic encephalomyelitis/chronic fatigue syndrome than in depression
    Michael Maes
    Maes Clinics, TRIA, Bangkok, Thailand dr michaelmaes hotmail com
    Psychother Psychosom 81:286-95. 2012
    ..The aim of the present study is to compare inflammatory and cell-mediated immune (CMI) responses between depression and ME/CFS...
  35. doi request reprint Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression
    Michael Maes
    Maes 998 Rimklongsamsen Road, Piyavate Hospital, Bangkok 10310, Thailand
    Prog Neuropsychopharmacol Biol Psychiatry 35:664-75. 2011
    ..This review shows that inflammation and cell-mediated immune activation are key factors in depression...
  36. doi request reprint Nutrient intakes and the common mental disorders in women
    Felice N Jacka
    Barwon Psychiatric Research Unit, School of Medicine, Deakin University, Australia
    J Affect Disord 141:79-85. 2012
    ..Magnesium, folate and zinc have all been implicated in depressive illness, however there are few data on these nutrients in anxiety disorders and the data from population-studies are limited...
  37. pmc Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways
    Michael Maes
    Maes Clinics TRIA, Piyavate Hospital, Bangkok, Thailand
    BMC Med 8:35. 2010
    ....
  38. ncbi request reprint In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation
    Michael Maes
    M Care4U Outpatient Clinics, and the Clinical Research Center for Mental Health, Antwerp, Belgium
    Neuro Endocrinol Lett 26:745-51. 2005
    ..The results suggest that patients with CFS should respond favourably to treatment with--amongst other things--omega3 PUFAs, such as EPA and DHA...