Kalana Maduwage

Summary

Publications

  1. doi request reprint Procoagulant snake venoms have differential effects in animal plasmas: Implications for antivenom testing in animal models
    Kalana P Maduwage
    Clinical Toxicology Research Group, University of Newcastle, Newcastle, Australia South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, Sri Lanka Electronic address
    Thromb Res 137:174-7. 2016
  2. doi request reprint Epidemiology and clinical effects of hump-nosed pit viper (Genus: Hypnale) envenoming in Sri Lanka
    Kalana Maduwage
    Department of Biochemistry, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
    Toxicon 61:11-5. 2013
  3. doi request reprint Venom Concentrations and Clotting Factor Levels in a Prospective Cohort of Russell's Viper Bites with Coagulopathy
    Geoffrey K Isbister
    School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, New South Wales, Australia South Asian Clinical Toxicology Research Collaboration SACTRC, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
    PLoS Negl Trop Dis 9:e0003968. 2015
  4. pmc Detection of venom after antivenom is not associated with persistent coagulopathy in a prospective cohort of Russell's viper (Daboia russelii) envenomings
    Kalana Maduwage
    School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
    PLoS Negl Trop Dis 8:e3304. 2014
  5. doi request reprint Victims' response to snakebite and socio-epidemiological factors of 1018 snakebites in a tertiary care hospital in Sri Lanka
    Abeysinghe M Kularatne
    Department of Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka Drs Kularatne and C Ratnayake
    Wilderness Environ Med 25:35-40. 2014
  6. doi request reprint Coagulopthy, acute kidney injury and death following Hypnale zara envenoming: the first case report from Sri Lanka
    Kalana Maduwage
    Department of Biochemistry, University of Peradeniya, Sri Lanka
    Toxicon 58:641-3. 2011
  7. doi request reprint Population Pharmacokinetics of an Indian F(ab')2 Snake Antivenom in Patients with Russell's Viper (Daboia russelii) Bites
    Geoffrey K Isbister
    Clinical Toxicology Research Group, University of Newcastle, Newcastle, New South Wales, Australia South Asian Clinical Toxicology Research Collaboration SACTRC, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
    PLoS Negl Trop Dis 9:e0003873. 2015
  8. pmc Diagnosis of snake envenomation using a simple phospholipase A2 assay
    Kalana Maduwage
    1 School of Medicine and Public Health, University of Newcastle, NSW 2308, Australia 2 Department of Biochemistry, Faculty of Medicine, University of Peradeniya, Sri Lanka
    Sci Rep 4:4827. 2014
  9. pmc Revisiting Russell's viper (Daboia russelii) bite in Sri Lanka: is abdominal pain an early feature of systemic envenoming?
    Senanayake A M Kularatne
    Department of Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
    PLoS ONE 9:e90198. 2014
  10. pmc Current treatment for venom-induced consumption coagulopathy resulting from snakebite
    Kalana Maduwage
    School of Medicine and Public Health, University of Newcastle, New South Wales, Australia South Asian Clinical Toxicology Research Collaboration, Peradeniya, Sri Lanka Department of Biochemistry, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
    PLoS Negl Trop Dis 8:e3220. 2014

Collaborators

Detail Information

Publications11

  1. doi request reprint Procoagulant snake venoms have differential effects in animal plasmas: Implications for antivenom testing in animal models
    Kalana P Maduwage
    Clinical Toxicology Research Group, University of Newcastle, Newcastle, Australia South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, Sri Lanka Electronic address
    Thromb Res 137:174-7. 2016
    ..However, venoms that cause clinically relevant coagulopathy in humans may have differential effects in animals. We aimed to investigate the effect of different procoagulant snake venoms on various animal plasmas...
  2. doi request reprint Epidemiology and clinical effects of hump-nosed pit viper (Genus: Hypnale) envenoming in Sri Lanka
    Kalana Maduwage
    Department of Biochemistry, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
    Toxicon 61:11-5. 2013
    ..This study confirms that hump-nosed viper bites cause only minor effects in most cases. Future studies need to undertake formal coagulation studies and identify important early indicators of renal impairment...
  3. doi request reprint Venom Concentrations and Clotting Factor Levels in a Prospective Cohort of Russell's Viper Bites with Coagulopathy
    Geoffrey K Isbister
    School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia Department of Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, New South Wales, Australia South Asian Clinical Toxicology Research Collaboration SACTRC, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
    PLoS Negl Trop Dis 9:e0003968. 2015
    ..Russell's viper envenoming is a major problem in South Asia and causes venom induced consumption coagulopathy. This study aimed to investigate the kinetics and dynamics of venom and clotting function in Russell's viper envenoming...
  4. pmc Detection of venom after antivenom is not associated with persistent coagulopathy in a prospective cohort of Russell's viper (Daboia russelii) envenomings
    Kalana Maduwage
    School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
    PLoS Negl Trop Dis 8:e3304. 2014
    ..We compare the recovery of coagulopathy to the recurrence or persistence of venom in patients with Russell's viper envenoming...
  5. doi request reprint Victims' response to snakebite and socio-epidemiological factors of 1018 snakebites in a tertiary care hospital in Sri Lanka
    Abeysinghe M Kularatne
    Department of Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka Drs Kularatne and C Ratnayake
    Wilderness Environ Med 25:35-40. 2014
    ..Although snake bite remains a major health problem in Sri Lanka, there is a dearth of baseline information that would be useful in education about and prevention of snakebite...
  6. doi request reprint Coagulopthy, acute kidney injury and death following Hypnale zara envenoming: the first case report from Sri Lanka
    Kalana Maduwage
    Department of Biochemistry, University of Peradeniya, Sri Lanka
    Toxicon 58:641-3. 2011
    ..This report describes an authenticated fatal case of a 47 years old male due to coagulopthy and acute kidney injury following envenoming by H. zara in Sri Lanka...
  7. doi request reprint Population Pharmacokinetics of an Indian F(ab')2 Snake Antivenom in Patients with Russell's Viper (Daboia russelii) Bites
    Geoffrey K Isbister
    Clinical Toxicology Research Group, University of Newcastle, Newcastle, New South Wales, Australia South Asian Clinical Toxicology Research Collaboration SACTRC, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
    PLoS Negl Trop Dis 9:e0003873. 2015
    ..There is limited information on antivenom pharmacokinetics. This study aimed to investigate the pharmacokinetics of an Indian snake antivenom in humans with Russell's viper bites...
  8. pmc Diagnosis of snake envenomation using a simple phospholipase A2 assay
    Kalana Maduwage
    1 School of Medicine and Public Health, University of Newcastle, NSW 2308, Australia 2 Department of Biochemistry, Faculty of Medicine, University of Peradeniya, Sri Lanka
    Sci Rep 4:4827. 2014
    ..Using a simple assay, potentially a bedside test, we detected high phospholipase activity in sera of patients with viper and elapid envenomation compared to minimal activity in non-envenomed patients. ..
  9. pmc Revisiting Russell's viper (Daboia russelii) bite in Sri Lanka: is abdominal pain an early feature of systemic envenoming?
    Senanayake A M Kularatne
    Department of Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
    PLoS ONE 9:e90198. 2014
    ..2%. Thus, abdominal pain is an early clinical feature of systemic Russell's viper bite envenoming in Sri Lanka. However, it is best to judge abdominal pain together with other clinical manifestations on decision making. ..
  10. pmc Current treatment for venom-induced consumption coagulopathy resulting from snakebite
    Kalana Maduwage
    School of Medicine and Public Health, University of Newcastle, New South Wales, Australia South Asian Clinical Toxicology Research Collaboration, Peradeniya, Sri Lanka Department of Biochemistry, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
    PLoS Negl Trop Dis 8:e3220. 2014
    ..Studies of heparin did not demonstrate it improved outcomes in VICC. Fresh frozen plasma appeared to speed the recovery of coagulopathy and should be considered in bleeding patients. ..
  11. doi request reprint Parallels between Russell's viper (Daboia russelii) and hump-nosed viper (Hypnale species) bites in the central hills of Sri Lanka amidst the heavy burden of unidentified snake bites
    Keerthi Kularatne
    Teaching Hospital, Peradeniya, Sri Lanka
    Asian Pac J Trop Med 4:564-7. 2011
    ..To describe the epidemiology of snake bite in the region and attempt to compare proven Russell's viper with hump-nosed viper bites...