Henning Madry

Summary

Publications

  1. doi request reprint The basic science of the subchondral bone
    Henning Madry
    Institute for Experimental Orthopaedics, Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg, Germany
    Knee Surg Sports Traumatol Arthrosc 18:419-33. 2010
  2. doi request reprint Transplanted articular chondrocytes co-overexpressing IGF-I and FGF-2 stimulate cartilage repair in vivo
    Patrick Orth
    Experimental Orthopaedics and Osteoarthritis Research, Saarland University, Kirrbergerstrasse, Building 37, 66421, Homburg, Germany
    Knee Surg Sports Traumatol Arthrosc 19:2119-30. 2011
  3. doi request reprint Reliability, reproducibility, and validation of five major histological scoring systems for experimental articular cartilage repair in the rabbit model
    Patrick Orth
    Experimental Orthopaedics and Osteoarthritis Research, Saarland University, Homburg Saar, Germany
    Tissue Eng Part C Methods 18:329-39. 2012
  4. ncbi request reprint Nasu-Hakola disease (PLOSL): report of five cases and review of the literature
    Henning Madry
    Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg Saar, Germany
    Clin Orthop Relat Res 454:262-9. 2007
  5. ncbi request reprint Efficacy of cationic liposome-mediated gene transfer to mesangial cells in vitro and in vivo
    H Madry
    Department of Orthopaedic Surgery, Saarland University Medical Center, Saarland University, Homburg, Germany
    J Mol Med (Berl) 79:184-9. 2001
  6. ncbi request reprint [Tissue engineering for articular cartilage repair improved by gene transfer. Current concepts]
    H Madry
    Labor für Experimentelle Orthopädie, Klinik fur Orthopadie und Orthopadische Chirurgie, Universitatsklinikum des Saarlandes, 66421, Homburg
    Orthopade 36:236-47. 2007
  7. doi request reprint Acceleration of articular cartilage repair by combined gene transfer of human insulin-like growth factor I and fibroblast growth factor-2 in vivo
    Henning Madry
    Institute for Experimental Orthopaedics and Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg, Germany
    Arch Orthop Trauma Surg 130:1311-22. 2010
  8. ncbi request reprint [Gene therapy in orthopaedic surgery]
    H Madry
    Labor für Experimentelle Orthopädie Klinik für Orthopädie und Orthopädische Chirurgie, Universitatsklinikum des Saarlandes, 66421, Homburg
    Orthopade 35:1193-202; quiz 1203. 2006
  9. doi request reprint [Autologous chondrocyte transplantation]
    H Madry
    Klinik fur Orthopadie und Orthopadische Chirurgie, Universitat des Saarlandes, Kirrberger Strasse 1, 66421, Homburg
    Orthopade 37:756-63. 2008
  10. ncbi request reprint Menisci are efficiently transduced by recombinant adeno-associated virus vectors in vitro and in vivo
    Henning Madry
    Laboratory for Experimental Orthopaedics, Department of Orthopaedic Surgery, Saarland University, Homburg, Germany
    Am J Sports Med 32:1860-5. 2004

Collaborators

Detail Information

Publications45

  1. doi request reprint The basic science of the subchondral bone
    Henning Madry
    Institute for Experimental Orthopaedics, Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg, Germany
    Knee Surg Sports Traumatol Arthrosc 18:419-33. 2010
    ....
  2. doi request reprint Transplanted articular chondrocytes co-overexpressing IGF-I and FGF-2 stimulate cartilage repair in vivo
    Patrick Orth
    Experimental Orthopaedics and Osteoarthritis Research, Saarland University, Kirrbergerstrasse, Building 37, 66421, Homburg, Germany
    Knee Surg Sports Traumatol Arthrosc 19:2119-30. 2011
    ..Here, the hypothesis that co-overexpression of IGF-I and FGF-2 by transplanted articular chondrocytes enhances the early repair of cartilage defects in vivo and protects the neighbouring cartilage from degeneration was tested...
  3. doi request reprint Reliability, reproducibility, and validation of five major histological scoring systems for experimental articular cartilage repair in the rabbit model
    Patrick Orth
    Experimental Orthopaedics and Osteoarthritis Research, Saarland University, Homburg Saar, Germany
    Tissue Eng Part C Methods 18:329-39. 2012
    ..Histological and biochemical evaluations may serve as complementary tools to assess articular cartilage repair in vivo...
  4. ncbi request reprint Nasu-Hakola disease (PLOSL): report of five cases and review of the literature
    Henning Madry
    Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg Saar, Germany
    Clin Orthop Relat Res 454:262-9. 2007
    ..A biopsy is not needed to confirm the diagnosis of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy because of the unique combination of radiographic and neurologic features...
  5. ncbi request reprint Efficacy of cationic liposome-mediated gene transfer to mesangial cells in vitro and in vivo
    H Madry
    Department of Orthopaedic Surgery, Saarland University Medical Center, Saarland University, Homburg, Germany
    J Mol Med (Berl) 79:184-9. 2001
    ..The current limitation of the evaluated liposomes for an efficient in vivo gene transfer to mesangial cells is the toxicity upon intrarenal arterial administration...
  6. ncbi request reprint [Tissue engineering for articular cartilage repair improved by gene transfer. Current concepts]
    H Madry
    Labor für Experimentelle Orthopädie, Klinik fur Orthopadie und Orthopadische Chirurgie, Universitatsklinikum des Saarlandes, 66421, Homburg
    Orthopade 36:236-47. 2007
    ..The combination of cartilage tissue engineering with overexpression of potential therapeutic genes using gene transfer technologies provides a basis for the development of novel molecular therapies for the repair of cartilage defects...
  7. doi request reprint Acceleration of articular cartilage repair by combined gene transfer of human insulin-like growth factor I and fibroblast growth factor-2 in vivo
    Henning Madry
    Institute for Experimental Orthopaedics and Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg, Germany
    Arch Orthop Trauma Surg 130:1311-22. 2010
    ....
  8. ncbi request reprint [Gene therapy in orthopaedic surgery]
    H Madry
    Labor für Experimentelle Orthopädie Klinik für Orthopädie und Orthopädische Chirurgie, Universitatsklinikum des Saarlandes, 66421, Homburg
    Orthopade 35:1193-202; quiz 1203. 2006
    ..Current data indicate that gene-based therapies are effective in promoting the repair of articular cartilage, and bone defects. Such strategies may lead to the development of novel molecular therapies treatments in orthopaedic surgery...
  9. doi request reprint [Autologous chondrocyte transplantation]
    H Madry
    Klinik fur Orthopadie und Orthopadische Chirurgie, Universitat des Saarlandes, Kirrberger Strasse 1, 66421, Homburg
    Orthopade 37:756-63. 2008
    ..Long-term studies are needed to determine the effect of ACT on the development of osteoarthritis...
  10. ncbi request reprint Menisci are efficiently transduced by recombinant adeno-associated virus vectors in vitro and in vivo
    Henning Madry
    Laboratory for Experimental Orthopaedics, Department of Orthopaedic Surgery, Saarland University, Homburg, Germany
    Am J Sports Med 32:1860-5. 2004
    ..Gene transfer is a potential approach to enhancing meniscal repair. Recombinant adeno-associated virus is a method of gene transfer that has advantages over previously used approaches to this problem...
  11. ncbi request reprint Recombinant adeno-associated virus vectors efficiently and persistently transduce chondrocytes in normal and osteoarthritic human articular cartilage
    Henning Madry
    Orthopedic Research Laboratories, Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Gene Ther 14:393-402. 2003
    ..Finally, the data demonstrate that these rAAV vectors are capable of effectively delivering recombinant genes to chondral and osteochondral defects in vivo...
  12. ncbi request reprint Overexpression of human fibroblast growth factor 2 stimulates cell proliferation in an ex vivo model of articular chondrocyte transplantation
    Henning Madry
    Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg, Germany
    J Gene Med 6:238-45. 2004
    ..In the present study, we tested the hypothesis that human FGF-2 (hFGF-2) gene transfer into articular chondrocytes modulates cell proliferation in an ex vivo model of chondrocyte transplantation...
  13. ncbi request reprint [Gene transfer in cruciate ligament surgery. Natural science-based principles and possible clinical applications]
    H Madry
    Labor für Experimentelle Orthopädie, Orthopadische Universitats und Poliklinik, Universitatskliniken des Saarlandes, 66421 Homburg
    Orthopade 31:799-809. 2002
    ..Special characteristics that dictate the experimental strategies will be outlined...
  14. ncbi request reprint Sustained transgene expression in cartilage defects in vivo after transplantation of articular chondrocytes modified by lipid-mediated gene transfer in a gel suspension delivery system
    Henning Madry
    Laboratory for Experimental Orthopaedics, Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg, Germany
    J Gene Med 5:502-9. 2003
    ..We tested the hypothesis that a recombinant gene can be delivered to sites of cartilage damage in vivo using chondrocytes transfected by a lipid-mediated gene transfer method...
  15. doi request reprint Effective, safe nonviral gene transfer to preserve the chondrogenic differentiation potential of human mesenchymal stem cells
    Sebastian Elsler
    Center of Experimental Orthopaedics, Saarland University Medical Center, Saarland University, Homburg Saar, Germany
    J Gene Med 14:501-11. 2012
    ....
  16. ncbi request reprint Improved tissue repair in articular cartilage defects in vivo by rAAV-mediated overexpression of human fibroblast growth factor 2
    Magali Cucchiarini
    Laboratory for Experimental Orthopaedics, Department of Orthopaedics and Orthopaedic Surgery, Saarland University Medical Center, D 66421 Homburg, Germany
    Mol Ther 12:229-38. 2005
    ..This process may further benefit from cosupplementation with other factors. These results provide a basis for rAAV application to sites of articular cartilage damage to deliver agents that promote tissue repair...
  17. ncbi request reprint Local stimulation of articular cartilage repair by transplantation of encapsulated chondrocytes overexpressing human fibroblast growth factor 2 (FGF-2) in vivo
    Gunter Kaul
    Laboratory for Experimental Orthopaedics, Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg, Germany
    J Gene Med 8:100-11. 2006
    ....
  18. doi request reprint In vitro and in vivo characterization of nonbiomedical- and biomedical-grade alginates for articular chondrocyte transplantation
    Susanne Heiligenstein
    Experimental Orthopaedics and Osteoarthritis Research, Saarland University, Homburg, Germany
    Tissue Eng Part C Methods 17:829-42. 2011
    ..The individual characteristics of these alginates may be valuable to tailor specific experimental and clinical strategies for cartilage tissue engineering...
  19. doi request reprint Direct FGF-2 gene transfer via recombinant adeno-associated virus vectors stimulates cell proliferation, collagen production, and the repair of experimental lesions in the human ACL
    Henning Madry
    Center of Experimental Orthopaedics, Saarland University Medical Center, Homburg, Germany
    Am J Sports Med 41:194-202. 2013
    ..Basic fibroblast growth factor (FGF-2) is a powerful stimulator of fibroblast proliferation and type I/III collagen production...
  20. doi request reprint Metabolic activities and chondrogenic differentiation of human mesenchymal stem cells following recombinant adeno-associated virus-mediated gene transfer and overexpression of fibroblast growth factor 2
    Magali Cucchiarini
    Experimental Orthopaedics and Osteoarthritis Research, Saarland University Medical Center, Saarland University, Homburg Saar, Germany
    Tissue Eng Part A 17:1921-33. 2011
    ....
  21. doi request reprint Human mesenchymal stem cells overexpressing therapeutic genes: from basic science to clinical applications for articular cartilage repair
    Magali Cucchiarini
    Center of Experimental Orthopaedics, Saarland University Medical Center, University of the Saarland, Homburg Saar, Germany
    Biomed Mater Eng 22:197-208. 2012
    ..Here, we propose an overview of the current approaches employed for cell- and gene-based treatment of articular cartilage disorders using mesenchymal stem cells...
  22. pmc Benefits of recombinant adeno-associated virus (rAAV)-mediated insulinlike growth factor I (IGF-I) overexpression for the long-term reconstruction of human osteoarthritic cartilage by modulation of the IGF-I axis
    Anja Weimer
    Center of Experimental Orthopaedics, Saarland University Medical Center, Homburg Saar, Germany
    Mol Med 18:346-58. 2012
    ..These findings show the benefits of directly providing an IGF-I sequence to articular cartilage via rAAV for the future treatment of human osteoarthritis...
  23. doi request reprint Remodelling of human osteoarthritic cartilage by FGF-2, alone or combined with Sox9 via rAAV gene transfer
    Magali Cucchiarini
    Laboratory for Experimental Orthopaedics, Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg, Germany
    J Cell Mol Med 13:2476-88. 2009
    ..These data provide further motivation to develop coupled gene transfer approaches via rAAV for the treatment of human OA...
  24. ncbi request reprint Restoration of the extracellular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor SOX9
    Magali Cucchiarini
    Saarland University Medical Center, Homburg, Germany
    Arthritis Rheum 56:158-67. 2007
    ..The purpose of this study was to investigate the ability of rAAV-mediated SOX9 overexpression to restore major ECM components in human OA articular cartilage...
  25. doi request reprint Evaluation of nonbiomedical and biomedical grade alginates for the transplantation of genetically modified articular chondrocytes to cartilage defects in a large animal model in vivo
    Susanne Heiligenstein
    Experimental Orthopaedics and Osteoarthritis Research, Saarland University Medical Center, Homburg, Germany
    J Gene Med 13:230-42. 2011
    ..In the present study, we tested the hypothesis that the alginate system allows for sustained transgene expression in cartilage defects in a preclinical large animal model in vivo...
  26. doi request reprint Effect of open wedge high tibial osteotomy on the lateral compartment in sheep. Part I: Analysis of the lateral meniscus
    Henning Madry
    Center of Experimental Orthopaedics, Saarland University, Kirrbergerstr 1, Bldg 37, 66421, Homburg, Saar, Germany
    Knee Surg Sports Traumatol Arthrosc 21:39-48. 2013
    ..To evaluate whether medial open wedge high tibial osteotomy (HTO) results in structural and biochemical changes in the lateral meniscus in adult sheep...
  27. doi request reprint Failed cartilage repair for early osteoarthritis defects: a biochemical, histological and immunohistochemical analysis of the repair tissue after treatment with marrow-stimulation techniques
    Gunter Kaul
    Experimental Orthopaedics and Osteoarthritis Research, Saarland University Medical Center and Saarland University, Kirrbergerstr 1, Bldg 37, 66421, Homburg Saar, Germany
    Knee Surg Sports Traumatol Arthrosc 20:2315-24. 2012
    ..To examine the entire repair tissue resulting from marrow-stimulation techniques in patients with early osteoarthritis...
  28. ncbi request reprint Gene therapy for cartilage defects
    Magali Cucchiarini
    Laboratory for Experimental Orthopaedics, Department of Orthopaedic Surgery, Saarland University Medical Center, 66421 Homburg Saar, Germany
    J Gene Med 7:1495-509. 2005
    ..The first experimental steps provide reason for cautious optimism...
  29. doi request reprint Analysis of novel nonviral gene transfer systems for gene delivery to cells of the musculoskeletal system
    Patrick Orth
    Laboratory for Experimental Orthopaedics, Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg, Germany
    Mol Biotechnol 38:137-44. 2008
    ..These results indicate that relatively high levels of transfection can be achieved using novel nonviral gene transfer methods...
  30. pmc rAAV Vectors as Safe and Efficient Tools for the Stable Delivery of Genes to Primary Human Chondrosarcoma Cells In Vitro and In Situ
    Henning Madry
    Center of Experimental Orthopaedics, Saarland University Medical Center, Saarland, 66421 Homburg, Germany
    Sarcoma 2012:347417. 2012
    ....
  31. pmc Clinical potential and challenges of using genetically modified cells for articular cartilage repair
    Henning Madry
    Experimental Orthopaedics and Osteoarthritis Research, Saarland University Medical Center, Homburg Saar, Germany
    Croat Med J 52:245-61. 2011
    ..This, in turn, may provide an important step toward the unanswered question of articular cartilage regeneration...
  32. doi request reprint Effect of subchondral drilling on the microarchitecture of subchondral bone: analysis in a large animal model at 6 months
    Patrick Orth
    Center of Experimental Orthopaedics, Saarland University, Homburg, Germany
    Am J Sports Med 40:828-36. 2012
    ..Marrow stimulation techniques such as subchondral drilling are clinically important treatment options for symptomatic small cartilage defects. Little is known about whether they induce deleterious changes in the subchondral bone...
  33. pmc A low morbidity surgical approach to the sheep femoral trochlea
    Patrick Orth
    Center of Experimental Orthopaedics and Osteoarthritis Research, Saarland University, Saar, Germany
    BMC Musculoskelet Disord 14:5. 2013
    ..Here, we describe a low morbidity surgical exposure of the ovine trochlea without the necessity for intraoperative patellar luxation...
  34. doi request reprint Biological aspects of early osteoarthritis
    Henning Madry
    Experimental Orthopaedics and Osteoarthritis Research, Saarland University, Kirrbergerstrasse, Building 37, 66421, Homburg, Germany
    Knee Surg Sports Traumatol Arthrosc 20:407-22. 2012
    ..The aim of this review is to highlight the molecular basis and histopathological features of early OA...
  35. ncbi request reprint Gene transfer of a human insulin-like growth factor I cDNA enhances tissue engineering of cartilage
    Henning Madry
    Department of Orthopedic Surgery, Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA
    Hum Gene Ther 13:1621-30. 2002
    ....
  36. ncbi request reprint Enhanced repair of articular cartilage defects in vivo by transplanted chondrocytes overexpressing insulin-like growth factor I (IGF-I)
    H Madry
    Laboratory for Experimental Orthopaedics, Department of Orthopaedic Surgery, Saarland University, Homburg, Germany
    Gene Ther 12:1171-9. 2005
    ..These results suggest that therapeutic growth factor gene delivery using encapsulated and transplanted genetically modified chondrocytes may be applicable to sites of focal articular cartilage damage...
  37. ncbi request reprint Overexpression of human insulin-like growth factor-I promotes new tissue formation in an ex vivo model of articular chondrocyte transplantation
    H Madry
    Orthopaedic Research Laboratories, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Gene Ther 8:1443-9. 2001
    ..The data further suggest that therapeutic growth factor gene transfer may be applicable to articular cartilage...
  38. doi request reprint [Molecular tools to remodel osteoarthritic articular cartilage : growth, transcription, and signaling factors]
    M Cucchiarini
    Labor für Experimentelle Orthopädie, Klinik fur Orthopadie und Orthopadische Chirurgie, Universitatsklinikum des Saarlandes, Kirrbergerstrasse 37, 66421, Homburg Saar, Deutschland
    Orthopade 38:1063-70. 2009
    ..In conclusion, recent experimental findings permit cautious optimism, holding promise for treating human OA in the future...
  39. doi request reprint rAAV-mediated overexpression of FGF-2 promotes cell proliferation, survival, and alpha-SMA expression in human meniscal lesions
    M Cucchiarini
    Department of Orthopaedic Surgery, Laboratory for Experimental Orthopaedics, Saarland University Medical Center, Homburg Saar, Germany
    Gene Ther 16:1363-72. 2009
    ..Such a direct gene-based approach may have value in options aiming at treating human meniscal defects...
  40. ncbi request reprint Enamel matrix derivative inhibits proteoglycan production and articular cartilage repair, delays the restoration of the subchondral bone and induces changes of the synovial membrane in a lapine osteochondral defect model in vivo
    Alice Kiss
    Department of Operative Dentistry and Periodontology, Saarland University Medical Centre, Homburg Saar, Germany
    J Tissue Eng Regen Med . 2012
    ..These data suggest that EMD inhibits the early repair of the osteochondral unit in vivo. Copyright © 2012 John Wiley & Sons, Ltd...
  41. pmc Cartilage repair and joint preservation: medical and surgical treatment options
    Henning Madry
    Lehrstuhl für Experimentelle Orthopädie und Arthroseforschung, Universitat des Saarlandes, 66421 Homburg, Germany
    Dtsch Arztebl Int 108:669-77. 2011
    ..Reconstructive surgical treatment strategies aim to form a repair tissue or to unload compartments of the joint with articular cartilage damage...
  42. doi request reprint Direct rAAV SOX9 administration for durable articular cartilage repair with delayed terminal differentiation and hypertrophy in vivo
    Magali Cucchiarini
    Center of Experimental Orthopaedics, Saarland University Medical Center, Kirrbergerstr Bldg 37, 66421, Homburg Saar, Germany
    J Mol Med (Berl) 91:625-36. 2013
    ..These findings show the potential of direct rAAV gene delivery as an efficient tool to treat cartilage lesions...
  43. pmc The subchondral bone in articular cartilage repair: current problems in the surgical management
    Andreas H Gomoll
    Department of Orthopaedic Surgery, Brigham and Women s Hospital, Harvard Medical School, Chestnut Hill, MA 02467, USA
    Knee Surg Sports Traumatol Arthrosc 18:434-47. 2010
    ..Lastly, since this area remains in constant evolution, the requirements for prospective studies needed to evaluate these emerging technologies will be reviewed...
  44. doi request reprint Genetic modification of mesenchymal stem cells for cartilage repair
    Magali Cucchiarini
    Experimental Orthopaedics and Osteoarthritis Research, Saarland University Medical Center, Homburg Saar, Germany
    Biomed Mater Eng 20:135-43. 2010
    ..The aim of this report is to provide an overview of the most recent therapeutic approaches developed in experimental orthopaedic research...
  45. ncbi request reprint Gene therapy for articular cartilage repair
    S Trippel
    Department of Orthopaedic Surgery, Indiana University School of Medicine, 541 Clinical Drive, Suite 600, Indianapolis, IP 46202 5111, USA
    Proc Inst Mech Eng H 221:451-9. 2007
    ..Although preliminary, data from in-vitro and in-vivo studies suggest that gene therapy can deliver such potentially therapeutic agents to protect existing cartilage and to build new cartilage...