Hiten Madhani

Summary

Publications

  1. pmc Nonredundant requirement for multiple histone modifications for the early anaphase release of the mitotic exit regulator Cdc14 from nucleolar chromatin
    William W Hwang
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, USA
    PLoS Genet 5:e1000588. 2009
  2. pmc Coordinate control of gene expression noise and interchromosomal interactions in a MAP kinase pathway
    Emma McCullagh
    Department of Biochemistry and Biophysics, University of California, San Francisco, 600 16th Street, San Francisco, California 94158, USA
    Nat Cell Biol 12:954-62. 2010
  3. pmc Approaching the functional annotation of fungal virulence factors using cross-species genetic interaction profiling
    Jessica C S Brown
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 8:e1003168. 2012
  4. doi request reprint The frustrated gene: origins of eukaryotic gene expression
    Hiten D Madhani
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA Electronic address
    Cell 155:744-9. 2013
  5. doi request reprint snRNA catalysts in the spliceosome's ancient core
    Hiten D Madhani
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA Electronic address
    Cell 155:1213-5. 2013

Research Grants

Detail Information

Publications7

  1. pmc Nonredundant requirement for multiple histone modifications for the early anaphase release of the mitotic exit regulator Cdc14 from nucleolar chromatin
    William W Hwang
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, USA
    PLoS Genet 5:e1000588. 2009
    ..The nonredundant role for these modifications in this context contrasts with the notion of a highly combinatorial code by which histone marks act to control biological processes...
  2. pmc Coordinate control of gene expression noise and interchromosomal interactions in a MAP kinase pathway
    Emma McCullagh
    Department of Biochemistry and Biophysics, University of California, San Francisco, 600 16th Street, San Francisco, California 94158, USA
    Nat Cell Biol 12:954-62. 2010
    ..Consequently, cells may have evolved mechanisms to suppress noise by controlling these interactions...
  3. pmc Approaching the functional annotation of fungal virulence factors using cross-species genetic interaction profiling
    Jessica C S Brown
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 8:e1003168. 2012
    ....
  4. doi request reprint The frustrated gene: origins of eukaryotic gene expression
    Hiten D Madhani
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA Electronic address
    Cell 155:744-9. 2013
    ..Their evolution may have been driven by the need to defend against parasitic nucleic acids. ..
  5. doi request reprint snRNA catalysts in the spliceosome's ancient core
    Hiten D Madhani
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA Electronic address
    Cell 155:1213-5. 2013
    ..Remarkably, these correspond precisely to metal-binding phosphates in a homologous structure of Group II self-splicing introns, long proposed to be the ribozyme progenitor of spliceosome. ..

Research Grants21

  1. Mechanisms of Signal Transduction Specificity in Yeast
    Hiten Madhani; Fiscal Year: 2001
    ....
  2. Mechanisms of Signal Transduction Specificity in Yeast
    Hiten Madhani; Fiscal Year: 2009
    ....
  3. Systematic Genetic Analysis of Fungal Virulence
    Hiten Madhani; Fiscal Year: 2009
    ..By systematically identifying molecules produced by C. neoformans important for virulence and by understanding how they function, we hope to lay the groundwork for the discovery of new therapies to treat fungal infections. ..
  4. Mechanisms of Signal Transduction Specificity in Yeast
    Hiten D Madhani; Fiscal Year: 2010
    ....
  5. MECHANISMS OF GENE SILENCING
    Hiten D Madhani; Fiscal Year: 2010
    ..Our hope is that this will open up new avenues for the development of therapies that reactivate the expression of tumor suppressor genes and arrest growth and/or induce death of malignant cells. ..
  6. Mechanisms of Signal Transduction Specificity in Yeast
    Hiten Madhani; Fiscal Year: 2009
    ....
  7. Mechanisms of Signal Transduction Specificity in Yeast
    Hiten Madhani; Fiscal Year: 2007
    ....
  8. Systematic Genetic Analysis of Fungal Virulence
    Hiten Madhani; Fiscal Year: 2007
    ..By systematically identifying molecules produced by C. neoformans important for virulence and by understanding how they function, we hope to lay the groundwork for the discovery of new therapies to treat fungal infections. ..
  9. Epigenetic Regulation by Histone Substitution
    Hiten Madhani; Fiscal Year: 2007
    ..Indeed, chemical inhibitors of histone deacetylases, which are required for epigenetic gene silencing in all systems characterized from yeast to humans, are in clinical trials as anticancer drugs. ..
  10. Mechanisms of Signal Transduction Specificity in Yeast
    Hiten Madhani; Fiscal Year: 2002
    ....
  11. Mechanisms of Signal Transduction Specificity in Yeast
    Hiten Madhani; Fiscal Year: 2003
    ....
  12. Mechanisms of Signal Transduction Specificity in Yeast
    Hiten Madhani; Fiscal Year: 2004
    ....
  13. Mechanisms of Signal Transduction Specificity in Yeast
    Hiten Madhani; Fiscal Year: 2005
    ....
  14. Epigenetic Regulation by Histone Substitution
    Hiten Madhani; Fiscal Year: 2005
    ..Indeed, chemical inhibitors of histone deacetylases, which are required for epigenetic gene silencing in all systems characterized from yeast to humans, are in clinical trials as anticancer drugs. ..
  15. Systematic Genetic Analysis of Fungal Virulence
    Hiten Madhani; Fiscal Year: 2005
    ..By systematically identifying molecules produced by C. neoformans important for virulence and by understanding how they function, we hope to lay the groundwork for the discovery of new therapies to treat fungal infections. ..
  16. Epigenetic Regulation by Histone Substitution
    Hiten Madhani; Fiscal Year: 2006
    ..Indeed, chemical inhibitors of histone deacetylases, which are required for epigenetic gene silencing in all systems characterized from yeast to humans, are in clinical trials as anticancer drugs. ..
  17. Systematic Genetic Analysis of Fungal Virulence
    Hiten Madhani; Fiscal Year: 2006
    ..By systematically identifying molecules produced by C. neoformans important for virulence and by understanding how they function, we hope to lay the groundwork for the discovery of new therapies to treat fungal infections. ..
  18. MECHANISMS OF GENE SILENCING
    Hiten D Madhani; Fiscal Year: 2011
    ..Our hope is that this will open up new avenues for the development of therapies that reactivate the expression of tumor suppressor genes and arrest growth and/or induce death of malignant cells. ..