Megan K L Macleod

Summary

Publications

  1. pmc Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity
    Amy S McKee
    Howard Hughes Medical Institute, Denver, CO 80206, USA
    J Immunol 183:4403-14. 2009
  2. pmc Memory CD4 T cells: generation, reactivation and re-assignment
    Megan K L Macleod
    Howard Hughes Medical Institute, Denver, CO, USA
    Immunology 130:10-5. 2010
  3. pmc Memory CD4 T cells that express CXCR5 provide accelerated help to B cells
    Megan K L Macleod
    Integrated Department of Immunology, Howard Hughes Medical Institute, National Jewish Health, Denver, CO 80206, USA
    J Immunol 186:2889-96. 2011
  4. pmc Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells
    Megan K L Macleod
    The Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 108:7914-9. 2011
  5. pmc Immune mechanisms of protection: can adjuvants rise to the challenge?
    Amy S McKee
    Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    BMC Biol 8:37. 2010
  6. pmc CD4 memory T cells divide poorly in response to antigen because of their cytokine profile
    Megan K L Macleod
    Howard Hughes Medical Institute and Department of Immunology, National Jewish Medical and Research Center and University of Colorado Health Science Center, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 105:14521-6. 2008
  7. pmc CD4 memory T cells: what are they and what can they do?
    Megan K L Macleod
    Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
    Semin Immunol 21:53-61. 2009
  8. pmc Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza A virus that expresses an altered nucleoprotein sequence
    Megan K L Macleod
    Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Health, Denver, Colorado, United States of America
    PLoS ONE 8:e61775. 2013
  9. pmc Antigen-specific suppression of humoral immunity by anergic Ars/A1 B cells
    Katja Aviszus
    Integrated Department of Immunology, National Jewish Health and University of Colorado School of Medicine, Denver, CO 80206, USA
    J Immunol 189:4275-83. 2012

Collaborators

Detail Information

Publications9

  1. pmc Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity
    Amy S McKee
    Howard Hughes Medical Institute, Denver, CO 80206, USA
    J Immunol 183:4403-14. 2009
    ..These data suggest that activation of the inflammasome and the type 2 innate response orchestrated by macrophages and mast cells in vivo are not required for adjuvant effect of alum on endogenous T and B cell responses...
  2. pmc Memory CD4 T cells: generation, reactivation and re-assignment
    Megan K L Macleod
    Howard Hughes Medical Institute, Denver, CO, USA
    Immunology 130:10-5. 2010
    ..In light of this, we will discuss how CD4 T memory T cells respond to reactivation in vivo and whether they are malleable to a re-assignment of their effector response...
  3. pmc Memory CD4 T cells that express CXCR5 provide accelerated help to B cells
    Megan K L Macleod
    Integrated Department of Immunology, Howard Hughes Medical Institute, National Jewish Health, Denver, CO 80206, USA
    J Immunol 186:2889-96. 2011
    ....
  4. pmc Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells
    Megan K L Macleod
    The Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 108:7914-9. 2011
    ..CD8 memory T cells generated by antigen delivered with both aluminum salts and MPL provided significant protection from influenza A challenge. These adjuvants could be used in human vaccines to prime protective memory CD8 T cells...
  5. pmc Immune mechanisms of protection: can adjuvants rise to the challenge?
    Amy S McKee
    Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA
    BMC Biol 8:37. 2010
    ..For many diseases vaccines are lacking or only partly effective. Research on protective immunity and adjuvants that generate vigorous immune responses may help generate effective vaccines against such pathogens...
  6. pmc CD4 memory T cells divide poorly in response to antigen because of their cytokine profile
    Megan K L Macleod
    Howard Hughes Medical Institute and Department of Immunology, National Jewish Medical and Research Center and University of Colorado Health Science Center, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 105:14521-6. 2008
    ..Both these factors affected the low proliferation of the memory cells, because either exogenous IL-2 or inhibition of IFNgamma increased the proliferation of the memory cells...
  7. pmc CD4 memory T cells: what are they and what can they do?
    Megan K L Macleod
    Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA
    Semin Immunol 21:53-61. 2009
    ..Here we discuss the different systems used to study CD4 memory cells and ask whether, and in what circumstances, memory CD4 cells could provide protection against infections...
  8. pmc Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza A virus that expresses an altered nucleoprotein sequence
    Megan K L Macleod
    Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Health, Denver, Colorado, United States of America
    PLoS ONE 8:e61775. 2013
    ..Together, these data point towards a vaccine solution for all influenza A subtypes...
  9. pmc Antigen-specific suppression of humoral immunity by anergic Ars/A1 B cells
    Katja Aviszus
    Integrated Department of Immunology, National Jewish Health and University of Colorado School of Medicine, Denver, CO 80206, USA
    J Immunol 189:4275-83. 2012
    ..This Ag-specific suppressive activity implicates the autoreactive anergic B cell as an enforcer of immunological tolerance to self-Ags...