A Machens

Summary

Publications

  1. Machens A, Dralle H. Surgical cure rates of sporadic medullary thyroid cancer in the era of calcitonin screening. Eur J Endocrinol. 2016;175:219-28 pubmed publisher
    ..The independent contribution of routine calcitonin screening to these time-dependent changes warrants more research. ..
  2. Machens A, Lorenz K, Weber F, Dralle H. Geographic epidemiology of MTC families: unearthing European ancestral heritage. Endocr Relat Cancer. 2018;: pubmed publisher
    ..There is a clear need for additional geographical epidemiological studies, in particular to clarify the putative 'Germanic' ancestral heritage of RET p.L790F/c.2370G>T. ..
  3. Machens A, Dralle H. Advances in risk-oriented surgery for multiple endocrine neoplasia type 2. Endocr Relat Cancer. 2018;25:T41-T52 pubmed publisher
    ..The sweeping changes in the management of MEN2 since the new millenium hold the hope that death and major morbidity from this uncommon disease can be eliminated in our lifetime. ..
  4. request reprint
    Machens A, Ukkat J, Hauptmann S, Dralle H. Abnormal carcinoembryonic antigen levels and medullary thyroid cancer progression: a multivariate analysis. Arch Surg. 2007;142:289-93; discussion 294 pubmed
    ..Medullary thyroid cancer cells are capable of secreting carcinoembyronic antigen (CEA). An abnormal preoperative CEA level may have important implications for the management of this condition...
  5. request reprint
    Machens A, Dralle H. Genotype-phenotype based surgical concept of hereditary medullary thyroid carcinoma. World J Surg. 2007;31:957-68 pubmed
    ..A comprehensive appraisal of this body of evidence using evidence-based methodology is pending...
  6. request reprint
    Machens A, Schaaf L, Karges W, Frank Raue K, Bartsch D, Rothmund M, et al. Age-related penetrance of endocrine tumours in multiple endocrine neoplasia type 1 (MEN1): a multicentre study of 258 gene carriers. Clin Endocrinol (Oxf). 2007;67:613-22 pubmed
    ..This study was conducted to examine whether carriers of out-of-frame/truncating and in-frame MEN1 mutations differ in age-related tumour penetrance...
  7. request reprint
    Machens A, Dralle H. Familial prevalence and age of RET germline mutations: implications for screening. Clin Endocrinol (Oxf). 2008;69:81-7 pubmed
    ..The current investigation was undertaken to provide such natural history data which are urgently needed to enable factual decision-making about DNA-based screening programmes for RET germline mutations...
  8. Machens A, Hauptmann S, Dralle H. Modification of multiple endocrine neoplasia 2A phenotype by cell membrane proximity of RET mutations in exon 10. Endocr Relat Cancer. 2009;16:171-7 pubmed publisher
    ..Although limited in numbers, these data suggested that membrane proximity is an important determinant of tumor development in carriers of RET mutations in exon 10...
  9. Machens A, Frank Raue K, Lorenz K, Rondot S, Raue F, Dralle H. Clinical relevance of RET variants G691S, L769L, S836S and S904S to sporadic medullary thyroid cancer. Clin Endocrinol (Oxf). 2012;76:691-7 pubmed publisher
    ..This observation, along with the inconclusive evidence of previous association studies, calls for larger longitudinal association studies with age- and sex-matched external controls and additional functional studies of RET biology. ..
  10. Machens A, Elwerr M, Thanh P, Lorenz K, Schneider R, Dralle H. Impact of central node dissection on postoperative morbidity in pediatric patients with suspected or proven thyroid cancer. Surgery. 2016;160:484-92 pubmed publisher
    ..The notion that the experience of the center and surgeons may be more important than the age of the child requires validation in independent series across different health care settings. ..

Locale

Collaborators

Detail Information

Publications10

  1. Machens A, Dralle H. Surgical cure rates of sporadic medullary thyroid cancer in the era of calcitonin screening. Eur J Endocrinol. 2016;175:219-28 pubmed publisher
    ..The independent contribution of routine calcitonin screening to these time-dependent changes warrants more research. ..
  2. Machens A, Lorenz K, Weber F, Dralle H. Geographic epidemiology of MTC families: unearthing European ancestral heritage. Endocr Relat Cancer. 2018;: pubmed publisher
    ..There is a clear need for additional geographical epidemiological studies, in particular to clarify the putative 'Germanic' ancestral heritage of RET p.L790F/c.2370G>T. ..
  3. Machens A, Dralle H. Advances in risk-oriented surgery for multiple endocrine neoplasia type 2. Endocr Relat Cancer. 2018;25:T41-T52 pubmed publisher
    ..The sweeping changes in the management of MEN2 since the new millenium hold the hope that death and major morbidity from this uncommon disease can be eliminated in our lifetime. ..
  4. request reprint
    Machens A, Ukkat J, Hauptmann S, Dralle H. Abnormal carcinoembryonic antigen levels and medullary thyroid cancer progression: a multivariate analysis. Arch Surg. 2007;142:289-93; discussion 294 pubmed
    ..Medullary thyroid cancer cells are capable of secreting carcinoembyronic antigen (CEA). An abnormal preoperative CEA level may have important implications for the management of this condition...
  5. request reprint
    Machens A, Dralle H. Genotype-phenotype based surgical concept of hereditary medullary thyroid carcinoma. World J Surg. 2007;31:957-68 pubmed
    ..A comprehensive appraisal of this body of evidence using evidence-based methodology is pending...
  6. request reprint
    Machens A, Schaaf L, Karges W, Frank Raue K, Bartsch D, Rothmund M, et al. Age-related penetrance of endocrine tumours in multiple endocrine neoplasia type 1 (MEN1): a multicentre study of 258 gene carriers. Clin Endocrinol (Oxf). 2007;67:613-22 pubmed
    ..This study was conducted to examine whether carriers of out-of-frame/truncating and in-frame MEN1 mutations differ in age-related tumour penetrance...
  7. request reprint
    Machens A, Dralle H. Familial prevalence and age of RET germline mutations: implications for screening. Clin Endocrinol (Oxf). 2008;69:81-7 pubmed
    ..The current investigation was undertaken to provide such natural history data which are urgently needed to enable factual decision-making about DNA-based screening programmes for RET germline mutations...
  8. Machens A, Hauptmann S, Dralle H. Modification of multiple endocrine neoplasia 2A phenotype by cell membrane proximity of RET mutations in exon 10. Endocr Relat Cancer. 2009;16:171-7 pubmed publisher
    ..Although limited in numbers, these data suggested that membrane proximity is an important determinant of tumor development in carriers of RET mutations in exon 10...
  9. Machens A, Frank Raue K, Lorenz K, Rondot S, Raue F, Dralle H. Clinical relevance of RET variants G691S, L769L, S836S and S904S to sporadic medullary thyroid cancer. Clin Endocrinol (Oxf). 2012;76:691-7 pubmed publisher
    ..This observation, along with the inconclusive evidence of previous association studies, calls for larger longitudinal association studies with age- and sex-matched external controls and additional functional studies of RET biology. ..
  10. Machens A, Elwerr M, Thanh P, Lorenz K, Schneider R, Dralle H. Impact of central node dissection on postoperative morbidity in pediatric patients with suspected or proven thyroid cancer. Surgery. 2016;160:484-92 pubmed publisher
    ..The notion that the experience of the center and surgeons may be more important than the age of the child requires validation in independent series across different health care settings. ..