A Machens

Summary

Publications

  1. doi request reprint Benefit-risk balance of reoperation for persistent medullary thyroid cancer
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, D 06097 Halle Saale, Germany
    Ann Surg 257:751-7. 2013
  2. doi request reprint Molecular epidemiology of multiple endocrine neoplasia 2: implications for RET screening in the new millenium
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Straße 40, D 06097 Halle Saale, Germany
    Eur J Endocrinol 168:307-14. 2013
  3. doi request reprint Prognostic impact of N staging in 715 medullary thyroid cancer patients: proposal for a revised staging system
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Ann Surg 257:323-9. 2013
  4. doi request reprint Peak incidence of pheochromocytoma and primary hyperparathyroidism in multiple endocrine neoplasia 2: need for age-adjusted biochemical screening
    Andreas Machens
    MD, Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    J Clin Endocrinol Metab 98:E336-45. 2013
  5. doi request reprint Correlation between the number of lymph node metastases and lung metastasis in papillary thyroid cancer
    Andreas Machens
    Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    J Clin Endocrinol Metab 97:4375-82. 2012
  6. pmc Multiple endocrine neoplasia type 2: achievements and current challenges
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle, Germany
    Clinics (Sao Paulo) 67:113-8. 2012
  7. doi request reprint Clinical relevance of RET variants G691S, L769L, S836S and S904S to sporadic medullary thyroid cancer
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Clin Endocrinol (Oxf) 76:691-7. 2012
  8. doi request reprint Biological relevance of medullary thyroid microcarcinoma
    Andreas Machens
    Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    J Clin Endocrinol Metab 97:1547-53. 2012
  9. doi request reprint Germline RET sequence variation I852M and occult medullary thyroid cancer: harmless polymorphism or causative mutation?
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Clin Endocrinol (Oxf) 75:801-5. 2011
  10. doi request reprint Modification of multiple endocrine neoplasia 2A phenotype by cell membrane proximity of RET mutations in exon 10
    Andreas Machens
    Department of General, Visceral and Vascular Surgery Pathology, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle, Germany
    Endocr Relat Cancer 16:171-7. 2009

Detail Information

Publications74

  1. doi request reprint Benefit-risk balance of reoperation for persistent medullary thyroid cancer
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, D 06097 Halle Saale, Germany
    Ann Surg 257:751-7. 2013
    ....
  2. doi request reprint Molecular epidemiology of multiple endocrine neoplasia 2: implications for RET screening in the new millenium
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Straße 40, D 06097 Halle Saale, Germany
    Eur J Endocrinol 168:307-14. 2013
    ..MEN2-associated signs, taking time to manifest, can be subtle. This study sought to clarify to what extent conventional estimates of 1:200 000-500 000 underestimate the incidence of RET mutations in the population...
  3. doi request reprint Prognostic impact of N staging in 715 medullary thyroid cancer patients: proposal for a revised staging system
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Ann Surg 257:323-9. 2013
    ..This institutional study aimed at quantifying a medullary thyroid cancer (MTC) patient's risk of lung, liver, or bone metastasis...
  4. doi request reprint Peak incidence of pheochromocytoma and primary hyperparathyroidism in multiple endocrine neoplasia 2: need for age-adjusted biochemical screening
    Andreas Machens
    MD, Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    J Clin Endocrinol Metab 98:E336-45. 2013
    ..Conclusions: These data, revealing phases of greater amidst phases of lower penetrance, support adjustment of biochemical screening to carrier age and ATA class...
  5. doi request reprint Correlation between the number of lymph node metastases and lung metastasis in papillary thyroid cancer
    Andreas Machens
    Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    J Clin Endocrinol Metab 97:4375-82. 2012
    ..A prognostic classification system based on aggregate numbers of lymph node metastases may better estimate the risk of distant metastasis...
  6. pmc Multiple endocrine neoplasia type 2: achievements and current challenges
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle, Germany
    Clinics (Sao Paulo) 67:113-8. 2012
    ..In this setting, functional characterization of mutant cells in vitro may generate helpful ancillary evidence with regard to the pathogenicity of gene variants in comparison with established mutations...
  7. doi request reprint Clinical relevance of RET variants G691S, L769L, S836S and S904S to sporadic medullary thyroid cancer
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Clin Endocrinol (Oxf) 76:691-7. 2012
    ....
  8. doi request reprint Biological relevance of medullary thyroid microcarcinoma
    Andreas Machens
    Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    J Clin Endocrinol Metab 97:1547-53. 2012
    ..The clinical relevance of medullary thyroid microcarcinoma, a calcitonin-secreting malignancy, as a valid target for biochemical screening programs has been called into doubt...
  9. doi request reprint Germline RET sequence variation I852M and occult medullary thyroid cancer: harmless polymorphism or causative mutation?
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Clin Endocrinol (Oxf) 75:801-5. 2011
    ..This study aimed to clarify whether RET I852M represents a harmless polymorphism or a pathogenic mutation...
  10. doi request reprint Modification of multiple endocrine neoplasia 2A phenotype by cell membrane proximity of RET mutations in exon 10
    Andreas Machens
    Department of General, Visceral and Vascular Surgery Pathology, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle, Germany
    Endocr Relat Cancer 16:171-7. 2009
    ..Although limited in numbers, these data suggested that membrane proximity is an important determinant of tumor development in carriers of RET mutations in exon 10...
  11. doi request reprint Medullary thyroid cancer responsiveness to pentagastrin stimulation: an early surrogate parameter of tumor dissemination?
    Andreas Machens
    Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, Halle Saale, Germany
    J Clin Endocrinol Metab 93:2234-8. 2008
    ..Because of its outstanding sensitivity, stimulation of calcitonin secretion with iv injection of pentagastrin is widely used for biochemical diagnosis of medullary thyroid cancer...
  12. ncbi request reprint Multiple endocrine neoplasia type 2 and the RET protooncogene: from bedside to bench to bedside
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    Mol Cell Endocrinol 247:34-40. 2006
    ....
  13. ncbi request reprint Age-related penetrance of endocrine tumours in multiple endocrine neoplasia type 1 (MEN1): a multicentre study of 258 gene carriers
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University, Halle Saale, Germany
    Clin Endocrinol (Oxf) 67:613-22. 2007
    ..This study was conducted to examine whether carriers of out-of-frame/truncating and in-frame MEN1 mutations differ in age-related tumour penetrance...
  14. doi request reprint Prediction of mediastinal lymph node metastasis in papillary thyroid cancer
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, 06097, Halle Saale, Germany
    Ann Surg Oncol 16:171-6. 2009
    ....
  15. ncbi request reprint Locoregional recurrence and death from medullary thyroid carcinoma in a contemporaneous series: 5-year results
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    Eur J Endocrinol 157:85-93. 2007
    ..This study was designed to investigate cancer-specific event rates after initial neck resection in contemporaneous patients recruited within less than a decade...
  16. doi request reprint Prediction of lateral lymph node metastases in medullary thyroid cancer
    A Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Br J Surg 95:586-91. 2008
    ..In medullary thyroid cancer (MTC), there is a concordance between central and lateral neck involvement, but this relationship has not been assessed quantitatively...
  17. ncbi request reprint Disparities between male and female patients with thyroid cancers: sex difference or gender divide?
    Andreas Machens
    Departments of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle, Saale, Germany
    Clin Endocrinol (Oxf) 65:500-5. 2006
    ..This investigation was undertaken to quantify histopathological disparities between male and female patients with sporadic and hereditary thyroid cancers, which may reflect a biological 'sex difference' or a behavioural 'gender divide'...
  18. ncbi request reprint Familial prevalence and age of RET germline mutations: implications for screening
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Clin Endocrinol (Oxf) 69:81-7. 2008
    ..The current investigation was undertaken to provide such natural history data which are urgently needed to enable factual decision-making about DNA-based screening programmes for RET germline mutations...
  19. ncbi request reprint Abnormal carcinoembryonic antigen levels and medullary thyroid cancer progression: a multivariate analysis
    Andreas Machens
    Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Arch Surg 142:289-93; discussion 294. 2007
    ..Medullary thyroid cancer cells are capable of secreting carcinoembyronic antigen (CEA). An abnormal preoperative CEA level may have important implications for the management of this condition...
  20. ncbi request reprint Genotype-phenotype based surgical concept of hereditary medullary thyroid carcinoma
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, D 06097, Halle Saale, Germany
    World J Surg 31:957-68. 2007
    ..A comprehensive appraisal of this body of evidence using evidence-based methodology is pending...
  21. ncbi request reprint Referral bias in thyroid cancer surgery: direction and magnitude
    A Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    Eur J Surg Oncol 34:556-62. 2008
    ..This study was conducted to clarify the impact of referral bias in thyroid cancer surgery...
  22. ncbi request reprint Increased risk of lymph node metastasis in multifocal hereditary and sporadic medullary thyroid cancer
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, D 06097, Halle Saale, Germany
    World J Surg 31:1960-5. 2007
    ..In sporadic and hereditary medullary thyroid cancer, tumor multifocality may constitute an independent risk factor of lymph node metastasis on top of primary tumor size when the diameter of the largest primary tumor is the same...
  23. doi request reprint Lymph node dissection in the lateral neck for completion in central node-positive papillary thyroid cancer
    Andreas Machens
    Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle, Germany
    Surgery 145:176-81. 2009
    ..In papillary thyroid cancer, quantitative relationships may exist between central and lateral neck lymph node metastases, which may be of clinical usefulness...
  24. doi request reprint Constitutive RET tyrosine kinase activation in hereditary medullary thyroid cancer: clinical opportunities
    A Machens
    The Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, Halle Saale D 06097, Germany
    J Intern Med 266:114-25. 2009
    ..Better comprehension of RET function should enable the design of targeted therapies for RET carriers beyond surgical cure in whom the DNA-based 'window of opportunity' has been missed...
  25. doi request reprint Age disparities in referrals to specialist surgical care for papillary thyroid cancer
    A Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle, Saale, Germany
    Eur J Surg Oncol 35:1312-7. 2009
    ..This study sought to clarify whether younger patients with papillary thyroid cancer are referred more often because of their more frequent and more numerous lymph node metastases or because of age alone...
  26. doi request reprint Simultaneous medullary and papillary thyroid cancer: a novel entity?
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Ann Surg Oncol 19:37-44. 2012
    ..The causes underlying the phenomenon of simultaneous medullary (MTC) and papillary thyroid cancer (PTC) are unclear...
  27. doi request reprint Papillary thyroid cancer in children and adolescents does not differ in growth pattern and metastatic behavior
    Andreas Machens
    Department of General Surgery, Martin Luther University, Halle Saale, Germany
    J Pediatr 157:648-52. 2010
    ..To provide comprehensive clinicopathologic data, comparing the growth pattern and metastatic behavior of papillary thyroid cancer between children and adolescents...
  28. doi request reprint Decreasing tumor size of thyroid cancer in Germany: institutional experience 1995-2009
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle, Saale, Germany
    Eur J Endocrinol 163:111-9. 2010
    ..Nonetheless, thyroid cancer size is rarely analyzed as a function of time. This study aimed to explore secular trends of thyroid cancer diameter in Germany...
  29. doi request reprint Biomarker-based risk stratification for previously untreated medullary thyroid cancer
    Andreas Machens
    Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    J Clin Endocrinol Metab 95:2655-63. 2010
    ..If not cleared promptly, cervical lymph node metastases may emerge subsequently. Reoperations entail an excess risk of surgical morbidity and may be avoidable...
  30. doi request reprint Outcome after thyroid surgery for metastasis from renal cell cancer
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle, Germany
    Surgery 147:65-71. 2010
    ..Owing to their rarity, the prognostic ramifications of thyroid metastases from renal cell cancer are unclear...
  31. doi request reprint Importance of gender-specific calcitonin thresholds in screening for occult sporadic medullary thyroid cancer
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Endocr Relat Cancer 16:1291-8. 2009
    ..These findings indicate that gender-specific calcitonin thresholds predict sporadic occult medullary thyroid cancer better than unisex thresholds...
  32. doi request reprint Individualization of lymph node dissection in RET (rearranged during transfection) carriers at risk for medullary thyroid cancer: value of pretherapeutic calcitonin levels
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Germany
    Ann Surg 250:305-10. 2009
    ..This study sought to define the need for lymph node dissection in Rearranged during Transfection (RET) carriers at risk for hereditary medullary thyroid cancer...
  33. ncbi request reprint Advances in the management of hereditary medullary thyroid cancer
    A Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    J Intern Med 257:50-9. 2005
    ..Uncovering molecular pathways from RET genotype to MEN 2 phenotype should provide treatment options for RET mutation carriers whose MTC currently is too advanced for cure...
  34. ncbi request reprint Simultaneously occurring liver metastases of pheochromocytoma and medullary thyroid carcinoma--a diagnostic pitfall with clinical implications for patients with multiple endocrine neoplasia type 2a
    R Hinze
    Institute of Pathology, Martin Luther University, Halle, Germany
    Pathol Res Pract 196:477-81. 2000
    ..A misinterpretation could lead to harmful clinical complications, as shown in the present case...
  35. ncbi request reprint Skip metastases in thyroid cancer leaping the central lymph node compartment
    Andreas Machens
    Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle, Germany
    Arch Surg 139:43-5. 2004
    ..Discontinuous nodal metastasis, or skip metastasis, in thyroid cancer may display clinicopathologic features different from those seen in continuous nodal metastasis and thus may have a different prognosis...
  36. ncbi request reprint Malignant progression from C-cell hyperplasia to medullary thyroid carcinoma in 167 carriers of RET germline mutations
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University, Halle Wittenberg, Halle Saale, Germany
    Surgery 134:425-31. 2003
    ..The study objective was to investigate the impact of RET genotype on disease progression from C-cell hyperplasia (CCH) to MTC...
  37. ncbi request reprint Surgery on the cervicovisceral axis for invasive thyroid cancer
    A Machens
    Department of General Surgery, Martin Luther University, Halle Wittenberg, Ernst Grube Strasse 40, 06097 Halle Saale, Germany
    Langenbecks Arch Surg 386:318-23. 2001
    ..Invasion of the cervicovisceral axis (i.e., larynx trachea esophagus) by thyroid cancers still poses a surgical challenge...
  38. ncbi request reprint Pattern of nodal metastasis for primary and reoperative thyroid cancer
    Andreas Machens
    Department of General Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    World J Surg 26:22-8. 2002
    ..This concept rests on the joint resection of cervicocentral and ipsilateral cervicolateral compartments. Depending on tumor entity, surgical status, and primary tumor diameter, additional compartments may have to be cleared...
  39. ncbi request reprint Early malignant progression of hereditary medullary thyroid cancer
    Andreas Machens
    Klinik fUr Allgemein, Viszeral, und Gefässchirurgie, Martin Luther Universitat Halle Wittenberg, Halle, Saale, Germany
    N Engl J Med 349:1517-25. 2003
    ....
  40. doi request reprint [Hereditary thyroid cancer]
    H Dralle
    Universitätsklinik für Allgemein, Viszeral und Gefässchirurgie, Universitätsklinikum Halle, Medizinische Fakultät der Martin Luther Universität Halle Wittenberg, Halle Saale, Ernst Grube Strasse 40, 06097, Halle
    Chirurg 79:1017-28. 2008
    ..Regarding time and extent of prophylactic thyroidectomy (without or with lymph node dissection) a combined molecular-biochemical concept including the use of pentagastrin-stimulated calcitonin values is therefore recommended...
  41. ncbi request reprint Genotype-phenotype correlations in hereditary medullary thyroid carcinoma: oncological features and biochemical properties
    A Machens
    Department of General Surgery, Martin Luther University Halle Wittenberg, D 06097 Halle Saale, Germany
    J Clin Endocrinol Metab 86:1104-9. 2001
    ..The current data demonstrate that there is a significant genotype-phenotype correlation, allowing for a more individualized approach to the timing and extent of prophylactic surgery...
  42. ncbi request reprint Prophylactic completion thyroidectomy for differentiated thyroid carcinoma: prediction of extrathyroidal soft tissue infiltrates
    A Machens
    Department of General Surgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Thyroid 11:381-4. 2001
    ..Selective lymph node dissection alone does not seem capable of eliminating these soft tissue infiltrates from the cervicocentral compartment...
  43. ncbi request reprint Differential diagnosis of calcitonin-secreting neuroendocrine carcinoma of the foregut by pentagastrin stimulation
    A Machens
    Department of General Surgery, Martin Luther University Halle Wittenberg, Germany
    Langenbecks Arch Surg 385:398-401. 2000
    ..This study assessed the suitability of pentagastrin stimulation in hypercalcitoninaemia for differential diagnosis of neuroendocrine carcinoma of the foregut...
  44. doi request reprint Loss of the nerve monitoring signal during bilateral thyroid surgery
    H Dralle
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle, Germany
    Br J Surg 99:1089-95. 2012
    ..It explored the willingness of surgeons to change strategy after loss of signal (LOS) on the first side of resection...
  45. ncbi request reprint Thyroid carcinoma invading the cervicovisceral axis: routes of invasion and clinical implications
    A Machens
    Department of General Surgery, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany
    Surgery 129:23-8. 2001
    ..To keep nodal metastasis from encroaching onto the cervicovisceral axis, paratracheal and paraesophageal lymph nodes should be cleared from the cervicocentral compartment at the primary operation...
  46. ncbi request reprint DNA-based window of opportunity for curative pre-emptive therapy of hereditary medullary thyroid cancer
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    Surgery 139:279-82. 2006
  47. ncbi request reprint Multivariate analysis of clinicopathologic parameters for the insular subtype of differentiated thyroid carcinoma
    A Machens
    Department of General Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Str 40, D 06097 Halle Saale, Germany
    Arch Surg 136:941-4. 2001
    ..Insular carcinoma represents a more aggressive subtype of differentiated thyroid cancer on multivariate analysis after controlling for various clinicopathologic parameters...
  48. ncbi request reprint Extended surgery and early postoperative radiotherapy for undifferentiated thyroid carcinoma
    A Machens
    Department of General Surgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Thyroid 11:373-80. 2001
    ..Because pN1 and R2 patients with radiotherapy of 30 Gy or less comprised most UTC patients, only 1-year, but not median, survival improved compared to literature controls...
  49. ncbi request reprint Prediction of mediastinal lymph node metastasis in medullary thyroid carcinoma
    A Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    Br J Surg 91:709-12. 2004
    ....
  50. ncbi request reprint Enhancement of lymph node metastasis and distant metastasis of thyroid carcinoma
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    Cancer 98:712-9. 2003
    ..The mechanisms of local and distant metastases are imperfectly understood. The goal of the current study was to add to the body of knowledge regarding local and distant metastases of thyroid malignancies...
  51. ncbi request reprint Mycotic aneurysm of common carotid artery induced by Staphylococcus aureus infection after cervical reoperation
    A Machens
    Department of General Surgery, Martin Luther University, Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    World J Surg 25:1113-6. 2001
    ..It is important to recognize this novel type of mycotic aneurysm, as it must be repaired immediately to anticipate imminent rupture...
  52. ncbi request reprint The tall-cell variant of papillary thyroid carcinoma: a multivariate analysis of clinical risk factors
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University of Halle Wittenberg, Ernst Grube Strasse 40, 06097 Halle Saale, Germany
    Langenbecks Arch Surg 389:278-82. 2004
    ..The biological behaviour of the tall-cell variant (TCV) of papillary thyroid carcinoma (PTC) remains to be clarified in a multivariate analysis that controls for all relevant clinicopathological parameters...
  53. ncbi request reprint Codon-specific development of pheochromocytoma in multiple endocrine neoplasia type 2
    Andreas Machens
    Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    J Clin Endocrinol Metab 90:3999-4003. 2005
    ..Recent data suggest a codon-specific, age-related development of multiple endocrine neoplasia type 2...
  54. doi request reprint Surgical approaches in thyroid cancer and lymph-node metastases
    Henning Dralle
    Department of General, Visceral and Vascular Surgery, Medical Faculty, University of Halle Wittenberg, University Hospital, Ernst Grube Strabetae 40, D 06097 Halle Saale, Germany
    Best Pract Res Clin Endocrinol Metab 22:971-87. 2008
    ....
  55. doi request reprint Intraoperative monitoring of the recurrent laryngeal nerve in thyroid surgery
    H Dralle
    Department of General, Visceral and Vascular Surgery, Martin Luther University of Halle, Ernst Grube Str 40, D 06097 Halle Saale, Germany
    World J Surg 32:1358-66. 2008
    ..Nevertheless, a systematic evidence-based assessment of this novel health technology has not been performed...
  56. ncbi request reprint Prospects of remission in medullary thyroid carcinoma according to basal calcitonin level
    Andreas Machens
    Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, 06097 Halle Saale, Germany
    J Clin Endocrinol Metab 90:2029-34. 2005
    ..Preoperative basal calcitonin levels may thus help individualize the extent of surgery and postoperative follow-up intervals for MTC...
  57. doi request reprint European endocrine surgery in the 150-year history of Langenbeck's Archives of Surgery
    Henning Dralle
    Department of General, Visceral and Vascular Surgery, University Hospital, Ernst Grube Strasse 40, Halle Saale, Germany
    Langenbecks Arch Surg 395:43-55. 2010
    ....
  58. doi request reprint Premonitory symptoms preceding metastatic medullary thyroid cancer in MEN 2B: An exploratory analysis
    Michael Brauckhoff
    Department of General, Visceral and Vascular Surgery, Martin Luther University, Halle Wittenberg, Germany
    Surgery 144:1044-50; discussion 1050-3. 2008
    ..Little information exists about the presence of these symptoms in infancy...
  59. ncbi request reprint The prognostic value of primary tumor size in papillary and follicular thyroid carcinoma
    Andreas Machens
    Department of General, Visceral, and Vascular Surgery, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Cancer 103:2269-73. 2005
    ..Threshold tumor diameters for extrathyroidal growth, lymph node spread, and distant metastasis in papillary (PTC) and follicular thyroid carcinoma (FTC) remain to be defined...
  60. ncbi request reprint Contralateral cervical and mediastinal lymph node metastasis in medullary thyroid cancer: systemic disease?
    Andreas Machens
    Departments of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Salle, Germany
    Surgery 139:28-32. 2006
    ....
  61. ncbi request reprint Primary surgery for differentiated thyroid cancer in the new millennium
    H Dralle
    Department of General, Visceral and Vascular Surgery, Medical Faculty, University of Halle Wittenberg, University Hospital, Ernst Grube Strasse 40, Halle Saale, Germany
    J Endocrinol Invest 35:10-5. 2012
    ....
  62. ncbi request reprint Risk-oriented approach to hereditary adrenal pheochromocytoma
    Andreas Machens
    Department of General, Visceral and Vascular Surgery, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, D 06097 Halle Saale, Germany
    Ann N Y Acad Sci 1073:417-28. 2006
    ..Grouping hereditary pheochromocytoma into preliminary risk categories may improve the management of gene carriers at risk of developing pheochromocytomas...
  63. ncbi request reprint Emergence of medullary thyroid carcinoma in a family with the Cys630Arg RET germline mutation
    Andreas Machens
    Department of General Surgery, Internal Medicine, Division of Endocrinology, Martin Luther University Halle Wittenberg, D 06097 Halle Saale, Germany
    Surgery 136:1083-7. 2004
    ..Limited information exists on the Cys630 RET genotype. Most of the few published carriers of this genotype who developed medullary thyroid carcinomas (MTCs) were in their mid-30s...
  64. ncbi request reprint The impact of surgical technique on postoperative hypoparathyroidism in bilateral thyroid surgery: a multivariate analysis of 5846 consecutive patients
    Oliver Thomusch
    Department of General Surgery, Albert Ludwigs University Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    Surgery 133:180-5. 2003
    ..Limited information exists about risk factors for postoperative hypoparathyroidism after bilateral thyroid surgery...
  65. ncbi request reprint Validity of intra-operative neuromonitoring signals in thyroid surgery
    Oliver Thomusch
    Department of General, Visceral and Vascular Surgery, Martin Luther University of Halle Wittenberg, Halle, Germany
    Langenbecks Arch Surg 389:499-503. 2004
    ..Although intra-operative neuromonitoring (IONM) is widely used in thyroid surgery, the validity of the received IONM signals are still unknown...
  66. ncbi request reprint Intraoperative neuromonitoring of surgery for benign goiter
    Oliver Thomusch
    Department of General Surgery, Martin Luther University Halle, Wittenberg, Germany
    Am J Surg 183:673-8. 2002
    ..Recurrent laryngeal nerve (RLN) palsy is one of the most serious complications in thyroid surgery. No prospective studies are available that evaluate if the additional use of intraoperative neuromonitoring reduces the rate of RLN palsy...
  67. doi request reprint Pheochromocytoma penetrance varies by RET mutation in MEN 2A
    Andreas Machens
    Surgery 143:696; author reply 697. 2008
  68. doi request reprint Introduction of bias by merging patients with initial surgery and reoperations in analysis of survival
    Andreas Machens
    Ann Surg 248:137; author reply 137-8. 2008
  69. ncbi request reprint Pretargeted anti-carcinoembryonic-antigen radioimmunotherapy for medullary thyroid carcinoma
    Andreas Machens
    J Clin Oncol 24:e37; author reply e38. 2006
  70. ncbi request reprint Early malignant progression of hereditary medullary thyroid cancer
    Andreas Machens
    N Engl J Med 350:943. 2004
  71. ncbi request reprint Adjuvant mitotane in adrenocortical carcinoma
    Andreas Machens
    N Engl J Med 357:1258-9; author reply 1259. 2007
  72. ncbi request reprint Very early manifestation of hereditary medullary thyroid cancer in carriers of intracellular-domain RET mutations
    Andreas Machens
    J Pediatr Surg 42:1153; author reply 1154. 2007
  73. ncbi request reprint Association of HLA DQ4-DR8 haplotype with papillary thyroid carcinomas
    Andreas Machens
    Clin Endocrinol (Oxf) 64:715. 2006
  74. ncbi request reprint Bronchoalveolar lavage for diagnosis of miliary lung metastases from papillary thyroid carcinoma
    Andreas Machens
    J Clin Oncol 25:2495-6; author reply 2496. 2007