Subarachnoid Hemorrhage International Trialists Data Repository (SAHIT)R Loch MacDonald
St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada Electronic address
World Neurosurg 79:418-22. 2013
..We welcome collaboration with other investigators...
- Randomised trial of clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid hemorrhage undergoing surgical clipping (CONSCIOUS-2)
R Loch MacDonald
St Michael s Hospital, Toronto, ON, Canada
Acta Neurochir Suppl 115:27-31. 2013
..The results showed that clazosentan nonsignificantly decreased mortality/vasospasm-related morbidity and nonsignificantly increased poor functional outcome in patients with aneurysmal SAH undergoing surgical clipping...
- History and definition of delayed cerebral ischemia
R Loch MacDonald
St Michael s Hospital, Toronto, ON, M5B 1W8, Canada
Acta Neurochir Suppl 115:3-7. 2013
..Selected advances in knowledge in the field and some controversies are described. A proposal for definitions of neurological deterioration due to delayed cerebral ischemia, of cerebral infarction, and of vasospasm is reviewed...
Intracranial drug delivery for subarachnoid hemorrhageRobert Loch Macdonald
Division of Neurosurgery, St Michael s Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
Ther Deliv 3:91-103. 2012
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- Electrocardiographic changes predict angiographic vasospasm after aneurysmal subarachnoid hemorrhage
George M Ibrahim
Division of Neurosurgery, St Michael s Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre of the Li Ka Shing Knowledge Institute of St Michael s Hospital and Department of Surgery, University of Toronto, Toronto, Ontario, Canada
Stroke 43:2102-7. 2012
..Here, we perform the first study to determine the association between ECG changes and angiographic vasospasm after SAH...
- Randomized trial of clazosentan in patients with aneurysmal subarachnoid hemorrhage undergoing endovascular coiling
R Loch MacDonald
Division of Neurosurgery, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada
Stroke 43:1463-9. 2012
..CONSCIOUS-3 assessed whether clazosentan reduced vasospasm-related morbidity and all-cause mortality postaSAH secured by endovascular coiling...
- Cisternal sustained release dihydropyridines for subarachnoid hemorrhage
Douglas J Cook
Division of Neurosurgery, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre in the Li Ka Shing Knowledge, St Michael s Hospital, Toronto, Ontario, Canada
Curr Neurovasc Res 9:139-48. 2012
..Since nimodipine improves outcome in patients with SAH without necessarily preventing vasospasm, further studies are warranted...
- Quality of life and healthcare resource use associated with angiographic vasospasm after aneurysmal subarachnoid hemorrhage
R Loch MacDonald
Division of Neurosurgery, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada
Stroke 43:1082-8. 2012
..In this analysis of data from a large clinical trial in aneurysmal subarachnoid hemorrhage, the impact of angiographic vasospasm (aVSP) on specific patient outcomes and inpatient healthcare resource use was assessed...
Red blood cell transfusion in patients with subarachnoid hemorrhage: a multidisciplinary North American surveyAndreas H Kramer
Department of Critical Care Medicine, Hotchkiss Brain Institute, Foothills Medical Center, University of Calgary, 1403 29th Street NW, Calgary, AB T2N 2T9, Canada
Crit Care 15:R30. 2011
..It remains unclear whether this association can be modified with more aggressive use of red blood cell (RBC) transfusions. The degree to which restrictive thresholds have been adopted in neurocritical care patients remains unknown...
- Attributing hypodensities on CT to angiographic vasospasm is not sensitive and unreliable
George M Ibrahim
Division of Neurosurgery, St Michael s Hospital, Toronto, ON M5B 1W8, Canada
Stroke 43:109-12. 2012
..We assess the interobserver variability in attributing hypodensities on CT to angiographic vasospasm-related delayed ischemic neurological deficit...
- Circulatory and vascular changes after aneurysmal subarachnoid hemorrhage
H Wan
Department of Surgery, University of Toronto, ON, Canada
J Neurosurg Sci 55:329-41. 2011
..This purpose of this review was then to juxtapose macrovascular and microvascular changes after SAH, and provide an overview of current and prospective treatments...
- Preventing vasospasm improves outcome after aneurysmal subarachnoid hemorrhage: rationale and design of CONSCIOUS-2 and CONSCIOUS-3 trials
R Loch MacDonald
Division of Neurosurgery, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, M5B 1W8, Canada
Neurocrit Care 13:416-24. 2010
..Results are expected at the end of 2010 and 2011 for CONSCIOUS-2 and CONSCIOUS-3, respectively...
- Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, double-blind, placebo-controlled phase 3 trial (CONSCIOUS-2)
R Loch MacDonald
St Michael s Hospital, University of Toronto, Toronto, ON, Canada
Lancet Neurol 10:618-25. 2011
..We investigated whether clazosentan reduced vasospasm-related morbidity and all-cause mortality...
- Impact of systemic inflammatory response syndrome on vasospasm, cerebral infarction, and outcome after subarachnoid hemorrhage: exploratory analysis of CONSCIOUS-1 database
Alan K H Tam
Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, 30 Bond Street, Toronto, ON, M5B 1W8, Canada
Neurocrit Care 13:182-9. 2010
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- Different effects of clazosentan on consequences of subarachnoid hemorrhage in rats
Gang Chen
Division of Neurosurgery, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre in the Li Ka Shing Knowledge, St Michael s Hospital, Toronto M5B 1W8, Ontario, Canada
Brain Res 1392:132-9. 2011
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- Anterior circulation mouse model of subarachnoid hemorrhage
Mohammed Sabri
Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
Brain Res 1295:179-85. 2009
..The model is simple to perform and may be useful for investigating the pathophysiology of SAH...
- Dissociation of vasospasm and secondary effects of experimental subarachnoid hemorrhage by clazosentan
Mohammed Sabri
Division of Neurosurgery, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada, M5B 1W8
Stroke 42:1454-60. 2011
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- Clazosentan to overcome neurological ischemia and infarction occurring after subarachnoid hemorrhage (CONSCIOUS-1): randomized, double-blind, placebo-controlled phase 2 dose-finding trial
R Loch MacDonald
St Michael s Hospital, Division of Neurosurgery, Toronto, Ontario, Canada
Stroke 39:3015-21. 2008
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- Clazosentan: an endothelin receptor antagonist for treatment of vasospasm after subarachnoid hemorrhage
R Loch MacDonald
University of Toronto, St Michael Hospital, Division of Neurosurgery, Keenan Research Centre, Toronto, Ontario, Canada
Expert Opin Investig Drugs 17:1761-7. 2008
..All patients will undergo neurosurgical aneurysm clipping and outcome will be assessed primarily based on mortality and vasospasm-related morbidity...
- Angiographic vasospasm is strongly correlated with cerebral infarction after subarachnoid hemorrhage
R Webster Crowley
Department of Neurological Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA
Stroke 42:919-23. 2011
..We used data from the CONSCIOUS-1 trial to determine the relationship between angiographic vasospasm and cerebral infarction after subarachnoid hemorrhage...
- Metaanalysis of tirilazad mesylate in patients with aneurysmal subarachnoid hemorrhage
Yeon Gyoe Jang
Division of Neurosurgery, University of Toronto, Toronto, ON, Canada, M5B 1W8
Neurocrit Care 10:141-7. 2009
..We performed a meta-analysis of these trials to assess the effect of tirilazad on unfavorable outcome, symptomatic vasospasm, and cerebral infarction after SAH...
- Statins: a potential therapeutic addition to treatment for aneurysmal subarachnoid hemorrhage?
Mohammed Sabri
Division of Neurosurgery, St Michael s Hospital, Toronto, Ontario, Canada
World Neurosurg 73:646-53. 2010
..Statins have been studied in patients with aneurysmal subarachnoid hemorrhage (SAH) but the history, pharmacology, and studies have not been reviewed recently...
- Nitric oxide related pathophysiological changes following subarachnoid haemorrhage
Mohammed Sabri
Division of Neurosurgery, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, and Department of Surgery, University of Toronto, Toronto, ON, Canada
Acta Neurochir Suppl 110:105-9. 2011
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- Simvastatin re-couples dysfunctional endothelial nitric oxide synthase in experimental subarachnoid hemorrhage
Mohammed Sabri
Division of Neurosurgery, St Michael s Hospital, Toronto, Ontario, Canada
PLoS ONE 6:e17062. 2011
..The data suggest that simvastatin re-couples eNOS after SAH, leading to decreased secondary complications such as vasospasm, microthromboemboli and neuronal injury...
- Effect of pharmaceutical treatment on vasospasm, delayed cerebral ischemia, and clinical outcome in patients with aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis
Nima Etminan
Division of Neurosurgery, St Michael s Hospital, Toronto, Ontario, Canada
J Cereb Blood Flow Metab 31:1443-51. 2011
..This dissociation between vasospasm and clinical outcome could result from methodological problems, sample size, insensitivity of clinical outcome measures, or from mechanisms other than vasospasm that also contribute to poor outcome...
- Cerebral infarction after subarachnoid hemorrhage contributes to poor outcome by vasospasm-dependent and -independent effects
Mervyn D I Vergouwen
Department of Medicine, Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
Stroke 42:924-9. 2011
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- Effect of country or continent of treatment on outcome after aneurysmal subarachnoid hemorrhage. Clinical article
Nir Lipsman
Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre, Li Ka Shing Knowledge Institute, and Department of Surgery, University of Toronto, Toronto, Ontario, Canada
J Neurosurg 111:67-74. 2009
..Because treatment can vary between countries and continents, the authors used a large database of patients with SAH to determine the effect of the geographic location of treatment on outcome...
- Neuronal and astrocytic apoptosis after subarachnoid hemorrhage: a possible cause for poor prognosis
Mohammed Sabri
Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s, Toronto, Ontario, Canada
Brain Res 1238:163-71. 2008
..These changes coupled with neurological deterioration seen in patients may present a possible reason for the poor outcome in SAH patients...
- Interobserver variability in the interpretation of computed tomography following aneurysmal subarachnoid hemorrhage
George M Ibrahim
Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre of the Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada
J Neurosurg 115:1191-6. 2011
..Numerous abnormal findings may be evident on CT scans after aneurysmal subarachnoid hemorrhage (SAH). Here, the authors assess the interobserver variability in the radiological interpretation of the initial CT scan following SAH...
- Cognitive and functional outcome after aneurysmal subarachnoid hemorrhage
Timour Al-Khindi
University of Toronto, Toronto, Ontario, Canada
Stroke 41:e519-36. 2010
..The acute treatment of aSAH is well documented but less is known about the long-term effects of aSAH on cognition and day-to-day functioning...
- Neurological and neurobehavioral assessment of experimental subarachnoid hemorrhage
Hyojin Jeon
Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital and Department of Surgery, University of Toronto, Toronto, Ontario, Canada
BMC Neurosci 10:103. 2009
..Only a few studies in rats examined learning and memory. It is concluded that more studies are needed to fully characterize neurobehavioral performance in animals with SAH and assess effects of treatment...
- Developing a model of chronic subdural hematoma
Jingyang Tang
Division of Neurosurgery, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, and Department of Surgery, University of Toronto, 30 Bond Street, Toronto, ON, M5B 1W8, Canada
Acta Neurochir Suppl 111:25-9. 2011
..Thus, it is possible that an easily reproducible and representative animal model of CSDH would facilitate research in the pathogenesis of CSDH and aid with development of treatment options...
