Loch R Macdonald

Summary

Publications

  1. ncbi request reprint Intracranial drug delivery for subarachnoid hemorrhage
    Robert Loch Macdonald
    Division of Neurosurgery, St Michael s Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    Ther Deliv 3:91-103. 2012
  2. pmc Simvastatin re-couples dysfunctional endothelial nitric oxide synthase in experimental subarachnoid hemorrhage
    Mohammed Sabri
    Division of Neurosurgery, St Michael s Hospital, Toronto, Ontario, Canada
    PLoS ONE 6:e17062. 2011
  3. pmc Acute microvascular changes after subarachnoid hemorrhage and transient global cerebral ischemia
    Michael K Tso
    Division of Neurosurgery, St Michael s Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre of the Li Ka Shing Knowledge Institute of St Michael s Hospital, Department of Surgery, University of Toronto, Toronto, ON, Canada M5B 1W8
    Stroke Res Treat 2013:425281. 2013
  4. pmc Early brain injury: a common mechanism in subarachnoid hemorrhage and global cerebral ischemia
    Mohammed Sabri
    Division of Neurosurgery, St Michael s Hospital, 30 Bond Street, Toronto, ON, Canada M5B 1W8 Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, 209 Victoria Street, Toronto, ON, Canada M5B 1T8
    Stroke Res Treat 2013:394036. 2013
  5. doi request reprint SAHIT Investigators--on the outcome of some subarachnoid hemorrhage clinical trials
    R Loch MacDonald
    St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Transl Stroke Res 4:286-96. 2013
  6. doi request reprint Subarachnoid Hemorrhage International Trialists data repository (SAHIT)
    R Loch MacDonald
    St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    World Neurosurg 79:418-22. 2013
  7. doi request reprint Randomised trial of clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid hemorrhage undergoing surgical clipping (CONSCIOUS-2)
    R Loch MacDonald
    St Michael s Hospital, Toronto, ON, Canada
    Acta Neurochir Suppl 115:27-31. 2013
  8. doi request reprint History and definition of delayed cerebral ischemia
    R Loch MacDonald
    St Michael s Hospital, Toronto, ON, M5B 1W8, Canada
    Acta Neurochir Suppl 115:3-7. 2013
  9. doi request reprint Electrocardiographic changes predict angiographic vasospasm after aneurysmal subarachnoid hemorrhage
    George M Ibrahim
    Division of Neurosurgery, St Michael s Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre of the Li Ka Shing Knowledge Institute of St Michael s Hospital and Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    Stroke 43:2102-7. 2012
  10. doi request reprint Randomized trial of clazosentan in patients with aneurysmal subarachnoid hemorrhage undergoing endovascular coiling
    R Loch MacDonald
    Division of Neurosurgery, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada
    Stroke 43:1463-9. 2012

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Intracranial drug delivery for subarachnoid hemorrhage
    Robert Loch Macdonald
    Division of Neurosurgery, St Michael s Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    Ther Deliv 3:91-103. 2012
    ....
  2. pmc Simvastatin re-couples dysfunctional endothelial nitric oxide synthase in experimental subarachnoid hemorrhage
    Mohammed Sabri
    Division of Neurosurgery, St Michael s Hospital, Toronto, Ontario, Canada
    PLoS ONE 6:e17062. 2011
    ..The data suggest that simvastatin re-couples eNOS after SAH, leading to decreased secondary complications such as vasospasm, microthromboemboli and neuronal injury...
  3. pmc Acute microvascular changes after subarachnoid hemorrhage and transient global cerebral ischemia
    Michael K Tso
    Division of Neurosurgery, St Michael s Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre of the Li Ka Shing Knowledge Institute of St Michael s Hospital, Department of Surgery, University of Toronto, Toronto, ON, Canada M5B 1W8
    Stroke Res Treat 2013:425281. 2013
    ....
  4. pmc Early brain injury: a common mechanism in subarachnoid hemorrhage and global cerebral ischemia
    Mohammed Sabri
    Division of Neurosurgery, St Michael s Hospital, 30 Bond Street, Toronto, ON, Canada M5B 1W8 Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, 209 Victoria Street, Toronto, ON, Canada M5B 1T8
    Stroke Res Treat 2013:394036. 2013
    ..In this paper, we highlight the importance of cerebral hypoperfusion and other mechanisms that occur in tandem in both pathologies and underline their possible roles in triggering brain injury after hemorrhagic or ischemic strokes...
  5. doi request reprint SAHIT Investigators--on the outcome of some subarachnoid hemorrhage clinical trials
    R Loch MacDonald
    St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Transl Stroke Res 4:286-96. 2013
    ..Key issues moving forward will be to use common definitions (common data elements), outcomes analysis, and to prioritize research questions, among others...
  6. doi request reprint Subarachnoid Hemorrhage International Trialists data repository (SAHIT)
    R Loch MacDonald
    St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    World Neurosurg 79:418-22. 2013
    ..We welcome collaboration with other investigators...
  7. doi request reprint Randomised trial of clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid hemorrhage undergoing surgical clipping (CONSCIOUS-2)
    R Loch MacDonald
    St Michael s Hospital, Toronto, ON, Canada
    Acta Neurochir Suppl 115:27-31. 2013
    ..The results showed that clazosentan nonsignificantly decreased mortality/vasospasm-related morbidity and nonsignificantly increased poor functional outcome in patients with aneurysmal SAH undergoing surgical clipping...
  8. doi request reprint History and definition of delayed cerebral ischemia
    R Loch MacDonald
    St Michael s Hospital, Toronto, ON, M5B 1W8, Canada
    Acta Neurochir Suppl 115:3-7. 2013
    ..Selected advances in knowledge in the field and some controversies are described. A proposal for definitions of neurological deterioration due to delayed cerebral ischemia, of cerebral infarction, and of vasospasm is reviewed...
  9. doi request reprint Electrocardiographic changes predict angiographic vasospasm after aneurysmal subarachnoid hemorrhage
    George M Ibrahim
    Division of Neurosurgery, St Michael s Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre of the Li Ka Shing Knowledge Institute of St Michael s Hospital and Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    Stroke 43:2102-7. 2012
    ..Here, we perform the first study to determine the association between ECG changes and angiographic vasospasm after SAH...
  10. doi request reprint Randomized trial of clazosentan in patients with aneurysmal subarachnoid hemorrhage undergoing endovascular coiling
    R Loch MacDonald
    Division of Neurosurgery, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada
    Stroke 43:1463-9. 2012
    ..CONSCIOUS-3 assessed whether clazosentan reduced vasospasm-related morbidity and all-cause mortality postaSAH secured by endovascular coiling...
  11. ncbi request reprint Cisternal sustained release dihydropyridines for subarachnoid hemorrhage
    Douglas J Cook
    Division of Neurosurgery, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre in the Li Ka Shing Knowledge, St Michael s Hospital, Toronto, Ontario, Canada
    Curr Neurovasc Res 9:139-48. 2012
    ..Since nimodipine improves outcome in patients with SAH without necessarily preventing vasospasm, further studies are warranted...
  12. doi request reprint Quality of life and healthcare resource use associated with angiographic vasospasm after aneurysmal subarachnoid hemorrhage
    R Loch MacDonald
    Division of Neurosurgery, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada
    Stroke 43:1082-8. 2012
    ..In this analysis of data from a large clinical trial in aneurysmal subarachnoid hemorrhage, the impact of angiographic vasospasm (aVSP) on specific patient outcomes and inpatient healthcare resource use was assessed...
  13. pmc Red blood cell transfusion in patients with subarachnoid hemorrhage: a multidisciplinary North American survey
    Andreas H Kramer
    Department of Critical Care Medicine, Hotchkiss Brain Institute, Foothills Medical Center, University of Calgary, 1403 29th Street NW, Calgary, AB T2N 2T9, Canada
    Crit Care 15:R30. 2011
    ..It remains unclear whether this association can be modified with more aggressive use of red blood cell (RBC) transfusions. The degree to which restrictive thresholds have been adopted in neurocritical care patients remains unknown...
  14. ncbi request reprint Circulatory and vascular changes after aneurysmal subarachnoid hemorrhage
    H Wan
    Department of Surgery, University of Toronto, ON, Canada
    J Neurosurg Sci 55:329-41. 2011
    ..This purpose of this review was then to juxtapose macrovascular and microvascular changes after SAH, and provide an overview of current and prospective treatments...
  15. doi request reprint Preventing vasospasm improves outcome after aneurysmal subarachnoid hemorrhage: rationale and design of CONSCIOUS-2 and CONSCIOUS-3 trials
    R Loch MacDonald
    Division of Neurosurgery, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, M5B 1W8, Canada
    Neurocrit Care 13:416-24. 2010
    ..Results are expected at the end of 2010 and 2011 for CONSCIOUS-2 and CONSCIOUS-3, respectively...
  16. doi request reprint Attributing hypodensities on CT to angiographic vasospasm is not sensitive and unreliable
    George M Ibrahim
    Division of Neurosurgery, St Michael s Hospital, Toronto, ON M5B 1W8, Canada
    Stroke 43:109-12. 2012
    ..We assess the interobserver variability in attributing hypodensities on CT to angiographic vasospasm-related delayed ischemic neurological deficit...
  17. doi request reprint Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, double-blind, placebo-controlled phase 3 trial (CONSCIOUS-2)
    R Loch MacDonald
    St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Lancet Neurol 10:618-25. 2011
    ..We investigated whether clazosentan reduced vasospasm-related morbidity and all-cause mortality...
  18. doi request reprint Impact of systemic inflammatory response syndrome on vasospasm, cerebral infarction, and outcome after subarachnoid hemorrhage: exploratory analysis of CONSCIOUS-1 database
    Alan K H Tam
    Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, 30 Bond Street, Toronto, ON, M5B 1W8, Canada
    Neurocrit Care 13:182-9. 2010
    ....
  19. doi request reprint Different effects of clazosentan on consequences of subarachnoid hemorrhage in rats
    Gang Chen
    Division of Neurosurgery, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre in the Li Ka Shing Knowledge, St Michael s Hospital, Toronto M5B 1W8, Ontario, Canada
    Brain Res 1392:132-9. 2011
    ....
  20. doi request reprint Anterior circulation mouse model of subarachnoid hemorrhage
    Mohammed Sabri
    Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Brain Res 1295:179-85. 2009
    ..The model is simple to perform and may be useful for investigating the pathophysiology of SAH...
  21. doi request reprint Dissociation of vasospasm and secondary effects of experimental subarachnoid hemorrhage by clazosentan
    Mohammed Sabri
    Division of Neurosurgery, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, Canada, M5B 1W8
    Stroke 42:1454-60. 2011
    ....
  22. doi request reprint Clazosentan to overcome neurological ischemia and infarction occurring after subarachnoid hemorrhage (CONSCIOUS-1): randomized, double-blind, placebo-controlled phase 2 dose-finding trial
    R Loch MacDonald
    St Michael s Hospital, Division of Neurosurgery, Toronto, Ontario, Canada
    Stroke 39:3015-21. 2008
    ....
  23. ncbi request reprint Clazosentan: an endothelin receptor antagonist for treatment of vasospasm after subarachnoid hemorrhage
    R Loch MacDonald
    University of Toronto, St Michael Hospital, Division of Neurosurgery, Keenan Research Centre, Toronto, Ontario, Canada
    Expert Opin Investig Drugs 17:1761-7. 2008
    ..All patients will undergo neurosurgical aneurysm clipping and outcome will be assessed primarily based on mortality and vasospasm-related morbidity...
  24. doi request reprint Angiographic vasospasm is strongly correlated with cerebral infarction after subarachnoid hemorrhage
    R Webster Crowley
    Department of Neurological Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA
    Stroke 42:919-23. 2011
    ..We used data from the CONSCIOUS-1 trial to determine the relationship between angiographic vasospasm and cerebral infarction after subarachnoid hemorrhage...
  25. doi request reprint Metaanalysis of tirilazad mesylate in patients with aneurysmal subarachnoid hemorrhage
    Yeon Gyoe Jang
    Division of Neurosurgery, University of Toronto, Toronto, ON, Canada, M5B 1W8
    Neurocrit Care 10:141-7. 2009
    ..We performed a meta-analysis of these trials to assess the effect of tirilazad on unfavorable outcome, symptomatic vasospasm, and cerebral infarction after SAH...
  26. doi request reprint Statins: a potential therapeutic addition to treatment for aneurysmal subarachnoid hemorrhage?
    Mohammed Sabri
    Division of Neurosurgery, St Michael s Hospital, Toronto, Ontario, Canada
    World Neurosurg 73:646-53. 2010
    ..Statins have been studied in patients with aneurysmal subarachnoid hemorrhage (SAH) but the history, pharmacology, and studies have not been reviewed recently...
  27. doi request reprint Nitric oxide related pathophysiological changes following subarachnoid haemorrhage
    Mohammed Sabri
    Division of Neurosurgery, Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, and Department of Surgery, University of Toronto, Toronto, ON, Canada
    Acta Neurochir Suppl 110:105-9. 2011
    ....
  28. pmc Effect of pharmaceutical treatment on vasospasm, delayed cerebral ischemia, and clinical outcome in patients with aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis
    Nima Etminan
    Division of Neurosurgery, St Michael s Hospital, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 31:1443-51. 2011
    ..This dissociation between vasospasm and clinical outcome could result from methodological problems, sample size, insensitivity of clinical outcome measures, or from mechanisms other than vasospasm that also contribute to poor outcome...
  29. doi request reprint Cerebral infarction after subarachnoid hemorrhage contributes to poor outcome by vasospasm-dependent and -independent effects
    Mervyn D I Vergouwen
    Department of Medicine, Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Stroke 42:924-9. 2011
    ....
  30. pmc Neuronal and astrocytic apoptosis after subarachnoid hemorrhage: a possible cause for poor prognosis
    Mohammed Sabri
    Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s, Toronto, Ontario, Canada
    Brain Res 1238:163-71. 2008
    ..These changes coupled with neurological deterioration seen in patients may present a possible reason for the poor outcome in SAH patients...
  31. ncbi request reprint Effect of country or continent of treatment on outcome after aneurysmal subarachnoid hemorrhage. Clinical article
    Nir Lipsman
    Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre, Li Ka Shing Knowledge Institute, and Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    J Neurosurg 111:67-74. 2009
    ..Because treatment can vary between countries and continents, the authors used a large database of patients with SAH to determine the effect of the geographic location of treatment on outcome...
  32. pmc Neurological and neurobehavioral assessment of experimental subarachnoid hemorrhage
    Hyojin Jeon
    Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital and Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    BMC Neurosci 10:103. 2009
    ..Only a few studies in rats examined learning and memory. It is concluded that more studies are needed to fully characterize neurobehavioral performance in animals with SAH and assess effects of treatment...
  33. ncbi request reprint Cognitive and functional outcome after aneurysmal subarachnoid hemorrhage
    Timour Al-Khindi
    University of Toronto, Toronto, Ontario, Canada
    Stroke 41:e519-36. 2010
    ..The acute treatment of aSAH is well documented but less is known about the long-term effects of aSAH on cognition and day-to-day functioning...
  34. doi request reprint Interobserver variability in the interpretation of computed tomography following aneurysmal subarachnoid hemorrhage
    George M Ibrahim
    Division of Neurosurgery, St Michael s Hospital, Keenan Research Centre of the Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada
    J Neurosurg 115:1191-6. 2011
    ..Numerous abnormal findings may be evident on CT scans after aneurysmal subarachnoid hemorrhage (SAH). Here, the authors assess the interobserver variability in the radiological interpretation of the initial CT scan following SAH...
  35. doi request reprint Developing a model of chronic subdural hematoma
    Jingyang Tang
    Division of Neurosurgery, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, and Department of Surgery, University of Toronto, 30 Bond Street, Toronto, ON, M5B 1W8, Canada
    Acta Neurochir Suppl 111:25-9. 2011
    ..Thus, it is possible that an easily reproducible and representative animal model of CSDH would facilitate research in the pathogenesis of CSDH and aid with development of treatment options...