A comparison of three highly active antiretroviral treatment strategies consisting of non-nucleoside reverse transcriptase inhibitors, protease inhibitors, or both in the presence of nucleoside reverse transcriptase inhibitors as initial therapy (CPCRA 05Rodger D MacArthur
Wayne State University, Detroit, MI, USA
Lancet 368:2125-35. 2006
..Here, we report results from the FIRST trial, which compared initial treatment strategies for clinical, immunological, and virological outcomes...
- A self-learning fuzzy discrete event system for HIV/AIDS treatment regimen selection
Hao Ying
Department of Electrical and Computer Engineering, Wayne State University, Detroit, MI 48202, USA
IEEE Trans Syst Man Cybern B Cybern 37:966-79. 2007
..This learning and prediction approach, as well as our original FDESs theory, is general purpose and can be applied to other medical or nonmedical problems...
- Understanding HIV phenotypic resistance testing: usefulness in managing treatment-experienced patients
Rodger D MacArthur
Wayne State University School of Medicine, Division of Infectious Diseases, Detroit, Michigan 48201, USA
AIDS Rev 11:223-30. 2009
..An understanding of the basic principles of phenotypic resistance testing is crucial for providing optimal care, particularly for antiretroviral-experienced patients...
Reviews of anti-infective agents: maraviroc: the first of a new class of antiretroviral agentsRodger D MacArthur
Wayne State University, Detroit, Michigan, USA
Clin Infect Dis 47:236-41. 2008
..HIV-1 mechanisms of resistance to maraviroc, assays to determine viral coreceptor use (tropism), drug safety, and clinical use of maraviroc are discussed at length...
- Comparison of prognostic importance of latest CD4+ cell count and HIV RNA levels in patients with advanced HIV infection on highly active antiretroviral therapy
Rodger D MacArthur
Wayne State University, University Health Center, Detroit, Michigan 48201, USA
HIV Clin Trials 6:127-35. 2005
..The comparative prognostic importance of latest plasma HIV RNA levels (viral loads) and CD4+ cell counts among patients prescribed highly active antiretroviral therapy (HAART) has not been well characterized...
Discordance between viral loads determined by Roche COBAS AMPLICOR human immunodeficiency virus type 1 monitor (version 1.5) Standard and ultrasensitive assays caused by freezing patient plasma in centrifuged becton-dickinson vacutainer brand plasma prepaHossein Salimnia
Department of Pathology, Detroit, MI 48201, USA
J Clin Microbiol 43:4635-9. 2005
..If the plasma was transferred from the centrifuged plasma preparation tubes before freezing, standard and ultrasensitive results were concordant with each other and with values determined on plasma from lavender-topped EDTA tubes...
- Etiology and pharmacologic management of noninfectious diarrhea in HIV-infected individuals in the highly active antiretroviral therapy era
Rodger D MacArthur
Division of Infectious Diseases, Wayne State University, Detroit, Michigan 48201, USA
Clin Infect Dis 55:860-7. 2012
..New therapies targeting the pathogenic mechanisms of noninfectious diarrheas are needed...
- A fuzzy discrete event system approach to determining optimal HIV/AIDS treatment regimens
Hao Ying
Department of Electrical and Computer Engineering, Wayne State University, Detroit, MI 48202, USA
IEEE Trans Inf Technol Biomed 10:663-76. 2006
..These are practically important features to medical applications in general, and HIV/AIDS treatment in particular, as national HIV/AIDS treatment guidelines are modified several times per year...
- Darunavir: promising initial results
Rodger D MacArthur
Wayne State University, Detroit, MI 48201, USA
Lancet 369:1143-4. 2007
- An updated guide to genotype interpretation
Rodger D MacArthur
Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, Michigan, USA
AIDS Read 14:256-8, 261-4, 266. 2004
..This report gives an update about important new developments in the area of antiretroviral resistance and provides a guide to interpreting genotype reports...
- Aerobic exercise training fails to lower hypertriglyceridemia levels in persons with advanced HIV-1 infection
Thomas J Birk
Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA
J Assoc Nurses AIDS Care 13:20-4. 2002
..The results suggest that long-term exercise training cannot correct lipid profile abnormality, particularly hypertriglyceridemia, common to individuals with advanced HIV-1 infection...
- Repair type I aortic dissection in a patient with human immunodeficiency virus infection
Frank A Baciewicz
Department of Cardiothoracic Surgery, Harper University Hospital, Wayne State University, Detroit, Michigan 48201, USA
Ann Thorac Surg 76:917-9. 2003
..The thoracic and abdominal aorta diameters have remained stable. Select patients with type I aortic dissection and HIV infection are candidates for surgical repair...
- Acetylator phenotype and genotype in HIV-infected patients with and without sulfonamide hypersensitivity
Rodger D MacArthur
Department of Pharmaceutical Sciences, Wayne State University, Detroit, Michigan 48202, USA
J Clin Pharmacol 42:613-9. 2002
....
- Episodic antiretroviral therapy increases HIV transmission risk compared with continuous therapy: results of a randomized controlled trial
William Burman
Denver Public Health, 605 Bannock Street, Denver, CO 80204, USA
J Acquir Immune Defic Syndr 49:142-50. 2008
..To compare the HIV transmission risk among patients randomized to episodic versus continuous antiretroviral therapy...
- Poor initial CD4+ recovery with antiretroviral therapy prolongs immune depletion and increases risk for AIDS and non-AIDS diseases
Jason V Baker
Department of Biostatistics, University of Minnesota, Minneapolis, MN, USA
J Acquir Immune Defic Syndr 48:541-6. 2008
..Low CD4+ increases risk for both AIDS- and non-AIDS-related morbidity and mortality. The magnitude of CD4+ recovery early after initial antiretroviral therapy (ART) is important in the ultimate duration of immune depletion...
- CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infection
Jason V Baker
University of Minnesota, Minneapolis, USA
AIDS 22:841-8. 2008
..Reductions in AIDS-related morbidity and mortality following the advent of combination antiretroviral therapy have coincided with relative increases in chronic non-AIDS end-organ diseases among HIV+ patients...
- Mild-to-moderate symptoms during the first year of antiretroviral therapy worsen quality of life in HIV-infected individuals
Sharon B Mannheimer
Division of Infectious Diseases, Harlem Hospital Center, New York, New York, USA
Clin Infect Dis 46:941-5. 2008
..Quality of life was inversely related to the number of symptoms and in the change in the number of symptoms from baseline...
- Differential adherence to combination antiretroviral therapy is associated with virological failure with resistance
Edward M Gardner
Denver Public Health, Denver, Colorado 80204, USA
AIDS 22:75-82. 2008
..To investigate the occurrence of differential adherence to components of combination antiretroviral therapy and assess its predictors and association with virological failure and antiretroviral medication resistance...
- Beta-glucuronidase activity in patients infected with HIV
Robert K Drobitch
AIDS 17:269-70. 2003
- The Incidence of HIV drug resistance and its impact on progression of HIV disease among antiretroviral-naïve participants started on three different antiretroviral therapy strategies
Michael J Kozal
Yale University School of Medicine and VA CT Healthcare System, New Haven, Connecticut 06510, USA
HIV Clin Trials 8:357-70. 2007
..The strategies were compared for drug resistance at first virologic failure (VF; HIV RNA >1000 copies/mL). The impact of resistance on AIDS or death was determined...
- A randomized clinical trial comparing nelfinavir and ritonavir in patients with advanced HIV disease (CPCRA 042/CTN 102)
George Perez
North Jersey Community Research Initiative, Newark, NJ 07103, USA
HIV Clin Trials 5:7-18. 2004
..To compare the long-term clinical efficacy and toxicity of initial strategies of nelfinavir (NFV) or ritonavir (RTV) in patients with CD4+ cells below 200/mm3...
- Prevalence and impact of HIV-1 protease codon 33 mutations and polymorphisms in treatment-naive and treatment-experienced patients
Michael J Kozal
Yale University Et VA CT Healthcare System, New Haven, CT, USA
Antivir Ther 11:457-63. 2006
..Little is known about the difference in prevalence of codon 33 mutations and polymorphisms between treatment-naive and treatment-experienced patients, and the effect of codon 33F on PI phenotypic resistance patterns...
- Prevalence of antiretroviral drug resistance mutations in chronically HIV-infected, treatment-naive patients: implications for routine resistance screening before initiation of antiretroviral therapy
Richard M Novak
University of Illinois, Chicago, IL 60612, USA
Clin Infect Dis 40:468-74. 2005
..However, it is unclear to what extent these mutations persist in chronically infected, treatment-naive patients...
