- Direct cell-to-cell spread of a pathogenic yeast
Molecular Pathobiology, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK
BMC Immunol 8:15. 2007
..This intracellular phase is thought to underlie the ability of the pathogen to remain latent for long periods of time within infected individuals...
- Expulsion of live pathogenic yeast by macrophages
Molecular Pathobiology, School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
Curr Biol 16:2156-60. 2006
- Mitochondria and the regulation of hypervirulence in the fatal fungal outbreak on Vancouver Island
University of Birmingham, School of Biosciences, Edgbaston, Birmingham, West Midlands, UK
Virulence 1:197-201. 2010
..In this addendum, the potential role of mitochondria in determining virulence in eukaryotic pathogens is discussed along with future experiments that may lead to an improved understanding of this topic...
- Transmission of Hypervirulence traits via sexual reproduction within and between lineages of the human fungal pathogen cryptococcus gattii
Institute of Microbiology and Infection and School of Biosciences, University of Birmingham, Birmingham, United Kingdom The National Institute of Health Research Surgical Reconstruction and Microbiology Research Centre, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom
PLoS Genet 9:e1003771. 2013
..gattii lineages VGII and VGIII, potentially creating novel hypervirulent genotypes, and that current models of uniparental mitochondrial inheritance in the Cryptococcus genus may not be universal. ..
- Virulence in Cryptococcus species
School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Adv Appl Microbiol 67:131-90. 2009
..We discuss the molecular basis of cryptococcal virulence and the interaction between these pathogens and the host immune system. Finally, we discuss future challenges in the study and treatment of cryptococcosis...
- The fatal fungal outbreak on Vancouver Island is characterized by enhanced intracellular parasitism driven by mitochondrial regulation
School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
Proc Natl Acad Sci U S A 106:12980-5. 2009
..Our data thus demonstrate that the intracellular parasitism of macrophages is a key driver of a human disease outbreak, a finding that has significant implications for a wide range of other human pathogens...
- Sex-dependent resistance to the pathogenic fungus Cryptococcus neoformans
Maaike C W van den Berg
Department of Molecular Pathobiology, University of Birmingham, UK
Genetics 173:677-83. 2006
..Our results hint at an overlap between the pathways controlling immunity and longevity and raise the possibility that differential regulation of these pathways may contribute to sex-dependent and species-dependent variation...