Haiching Ma

Summary

Publications

  1. ncbi request reprint Nanoliter homogenous ultra-high throughput screening microarray for lead discoveries and IC50 profiling
    Haiching Ma
    Reaction Biology Corporation, Malvern, PA 19355, USA
    Assay Drug Dev Technol 3:177-87. 2005
  2. pmc Chemical microarray: a new tool for drug screening and discovery
    Haiching Ma
    Reaction Biology Corporation, One Great Valley Parkway, Suite 8, Malvern, PA 19355, USA
    Drug Discov Today 11:661-8. 2006
  3. doi request reprint Chemical microarrays: a new tool for discovery enzyme inhibitors
    Shuguang Liang
    Reaction Biology Corporation, Malvern, PA, USA
    Methods Mol Biol 572:149-60. 2009
  4. ncbi request reprint Microarrays for the functional analysis of the chemical-kinase interactome
    Kurumi Y Horiuchi
    Reaction Biology Corporation, Malvern, PA 19355, USA
    J Biomol Screen 11:48-56. 2006
  5. ncbi request reprint Biochemical microarrays for studying chemical biology interaction: DiscoveryDot technology
    Kurumi Y Horiuchi
    Reaction Biology Corporation, One Great Valley Parkway, Suite 8, Malvern, PA 19355, USA
    Chem Biol Drug Des 67:87-8. 2006
  6. pmc Assay development for histone methyltransferases
    Kurumi Y Horiuchi
    Department of Biochemistry, Reaction Biology Corporation, One Great Valley Parkway, Suite 2, Malvern, PA 19355, USA
    Assay Drug Dev Technol 11:227-36. 2013
  7. doi request reprint Fluorescence polarization and time-resolved fluorescence resonance energy transfer techniques for PI3K assays
    Kurumi Y Horiuchi
    Reaction Biology Corporation, Malvern, PA, USA
    Methods Mol Biol 572:161-76. 2009

Research Grants

  1. Enzyme Assay Chips for Apoptosis Discovery
    Haiching Ma; Fiscal Year: 2002
  2. Microarraying and Screening Chemical Libraries
    Haiching Ma; Fiscal Year: 2009
  3. High throughput ELISA chip for drug toxicity screening
    Haiching Ma; Fiscal Year: 2007
  4. Kinome Drug Bioassay Platform
    Haiching Ma; Fiscal Year: 2007
  5. Microarraying and Screening Chemical Libraries
    Haiching Ma; Fiscal Year: 2007
  6. Enzyme Assay Chips for Apoptosis Discovery
    Haiching Ma; Fiscal Year: 2006
  7. Prostate Cancer Chip
    Haiching Ma; Fiscal Year: 2002

Collaborators

  • S L Diamond
  • Wei Xu
  • Kurumi Y Horiuchi
  • Yuan Wang
  • Shuguang Liang
  • Mia M Eason
  • Joseph J Ferry
  • Colin P Walsh
  • Konrad T Howitz
  • Robert F Smith
  • Jamie L Planck

Detail Information

Publications7

  1. ncbi request reprint Nanoliter homogenous ultra-high throughput screening microarray for lead discoveries and IC50 profiling
    Haiching Ma
    Reaction Biology Corporation, Malvern, PA 19355, USA
    Assay Drug Dev Technol 3:177-87. 2005
    ....
  2. pmc Chemical microarray: a new tool for drug screening and discovery
    Haiching Ma
    Reaction Biology Corporation, One Great Valley Parkway, Suite 8, Malvern, PA 19355, USA
    Drug Discov Today 11:661-8. 2006
    ..The success of chemical microarray technology will provide unprecedented possibilities and capabilities for parallel functional analysis of tremendous amounts of chemical compounds...
  3. doi request reprint Chemical microarrays: a new tool for discovery enzyme inhibitors
    Shuguang Liang
    Reaction Biology Corporation, Malvern, PA, USA
    Methods Mol Biol 572:149-60. 2009
    ..Sample assays for kinases, proteases, histone deacetylases, and phosphatases are demonstrated...
  4. ncbi request reprint Microarrays for the functional analysis of the chemical-kinase interactome
    Kurumi Y Horiuchi
    Reaction Biology Corporation, Malvern, PA 19355, USA
    J Biomol Screen 11:48-56. 2006
    ..All results indicate that this platform is well suited for kinetic analysis, HTS, large-scale IC50 determinations, and selectivity profiling...
  5. ncbi request reprint Biochemical microarrays for studying chemical biology interaction: DiscoveryDot technology
    Kurumi Y Horiuchi
    Reaction Biology Corporation, One Great Valley Parkway, Suite 8, Malvern, PA 19355, USA
    Chem Biol Drug Des 67:87-8. 2006
    ..The success of this chemical microarray technology will provide unprecedented possibility and capability for parallel functional analysis of hundreds of thousands of chemical compounds...
  6. pmc Assay development for histone methyltransferases
    Kurumi Y Horiuchi
    Department of Biochemistry, Reaction Biology Corporation, One Great Valley Parkway, Suite 2, Malvern, PA 19355, USA
    Assay Drug Dev Technol 11:227-36. 2013
    ..After hit confirmation and profiling, we found that suramin inhibited DOT1L, NSD2, and PRMT4 with IC₅₀ values at a low μM range...
  7. doi request reprint Fluorescence polarization and time-resolved fluorescence resonance energy transfer techniques for PI3K assays
    Kurumi Y Horiuchi
    Reaction Biology Corporation, Malvern, PA, USA
    Methods Mol Biol 572:161-76. 2009
    ..The application of FP and TR-FRET techniques for PI3K HTS will be described and advantages and disadvantages of these assays will be discussed...

Research Grants11

  1. Enzyme Assay Chips for Apoptosis Discovery
    Haiching Ma; Fiscal Year: 2002
    ..This technology can have research, medical, and industrial uses with respoect to the monitoring of intracellular enzyme states and identifying potential drug targets. ..
  2. Microarraying and Screening Chemical Libraries
    Haiching Ma; Fiscal Year: 2009
    ..Overall, this instrumentation allows a large number of wild type or recombinant protein targets, each obtained in miniscule quantity, to be screened against 100,000 to 500,000 compounds of the NIH repository. ..
  3. High throughput ELISA chip for drug toxicity screening
    Haiching Ma; Fiscal Year: 2007
    ....
  4. Kinome Drug Bioassay Platform
    Haiching Ma; Fiscal Year: 2007
    ..Rapid HTS implementation for proprietary customer kinases using small amounts of purified protein is also a significant opportunity. ..
  5. Microarraying and Screening Chemical Libraries
    Haiching Ma; Fiscal Year: 2007
    ..Overall, this instrumentation allows a large number of wild type or recombinant protein targets, each obtained in miniscule quantity, to be screened against 100,000 to 500,000 compounds of the NIH repository. ..
  6. Enzyme Assay Chips for Apoptosis Discovery
    Haiching Ma; Fiscal Year: 2006
    ..New inhibitors of caspases may lead to advances in the treatment of neurodegenerative processes during acute injury or in chronic disease. ..
  7. Prostate Cancer Chip
    Haiching Ma; Fiscal Year: 2002
    ..The Phase I activities will lead toward establishing chip chemistries and microfluidic technologies for a commercialized chip to aid in prostate cancer diagnostics. ..