The role of GABA in anxiety disordersR Bruce Lydiard
Medical University of South Carolina, Charleston, USA
J Clin Psychiatry 64:21-7. 2003
..The article concludes with further support for the role of the GABA system in anxiety by summarizing the current evidence supporting the use of novel GABAergic agents including tiagabine in the treatment of anxiety disorders...
Comparative efficacy of pregabalin and benzodiazepines in treating the psychic and somatic symptoms of generalized anxiety disorderR Bruce Lydiard
Psychiatry Mental Health Ralph H Johnson VA Medical Center, Charleston, SC 29401 5799, USA
Int J Neuropsychopharmacol 13:229-41. 2010
..A dose-response effect was evident for PGB that reached a plateau at a dose of 300 mg/d...
- Impact of gastrointestinal symptom severity on response to venlafaxine extended-release in patients with generalized anxiety disorder
R Bruce Lydiard
Southeast Health Consultants, LLC, Charleston, SC 59407, USA
J Clin Psychiatry 65:838-44. 2004
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- Increased prevalence of functional gastrointestinal disorders in panic disorder: clinical and theoretical implications
R Bruce Lydiard
Department of Neuropsychiatry and Behavioral Science, University of South Carolina, Columbia, SC, USA
CNS Spectr 10:899-908. 2005
..Less is known about the prevalence of other FGID in individuals with panic disorder...
- Efficacy and tolerability of modified-release indiplon in elderly patients with chronic insomnia: results of a 2-week double-blind, placebo-controlled trial
R Bruce Lydiard
Department of Neuropsychiatny and Behavioral Science University of South Carolina, Columbia, SC, USA
J Clin Sleep Med 2:309-15. 2006
..The aim of the present study was to evaluate the efficacy and safety of a 15-mg nightly dose of modified-release indiplon tablets in elderly patients with primary insomnia characterized by sleep-maintenance difficulties...
- A preliminary investigation of the effects of cognitive behavioral therapy for panic disorder on gastrointestinal distress in patients with comorbid panic disorder and irritable bowel syndrome
Daniel F Gros
Mental Health Service, Ralph H Johnson VAMC, Charleston, South Carolina 29401, USA
Depress Anxiety 28:1027-33. 2011
..This study was a preliminary investigation of the influence of cognitive behavioral therapy (CBT) for PD/A on PD/A patients with and without comorbid IBS...
- Recognition and treatment of panic disorder
R Bruce Lydiard
Southeast Health Consultants, Charleston, SC, USA
J Clin Psychiatry 68:e26. 2007
..This presentation discusses the importance of collaboration between doctor and patient and details available treatment options, including antidepressants, benzodiazepines, and cognitive-behavioral therapy...
- Worried sick: antidepressants, stress, and inflammation
R Bruce Lydiard
Southeast Health Consultants, LLC, Charleston, SC, USA
J Clin Psychiatry 68:1613-4. 2007
- Anxiety disorders and comorbid medical illness
Peter P Roy-Byrne
University of Washington School of Medicine, Seattle, WA 98195, USA
Gen Hosp Psychiatry 30:208-25. 2008
..To provide an overview of the role of anxiety disorders in medical illness...
- Citalopram treatment of paroxetine-intolerant depressed patients
Michael E Thase
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute Clinic, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
Depress Anxiety 16:128-33. 2002
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- Pregabalin for treatment of generalized anxiety disorder: a 4-week, multicenter, double-blind, placebo-controlled trial of pregabalin and alprazolam
Karl Rickels
Department of Psychiatry, University of Pennsylvania, Philadelphia 19104 3309, USA
Arch Gen Psychiatry 62:1022-30. 2005
..Pregabalin inhibits release of excess excitatory neurotransmitters, presumably by binding to the alpha2-delta subunit protein of widely distributed voltage-dependent calcium channels in the brain and spinal cord...
- The effectiveness of St. John's Wort in major depressive disorder: a naturalistic phase 2 follow-up in which nonresponders were provided alternate medication
Alan J Gelenberg
University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
J Clin Psychiatry 65:1114-9. 2004
..A continuation study of an extract of St. John's wort (Hypericum perforatum) for depression was performed in follow-up to an acute study that found no significant difference between St. John's wort extract and placebo...
- Efficacy of the novel anxiolytic pregabalin in social anxiety disorder: a placebo-controlled, multicenter study
Atul C Pande
Pfizer Global Research and Development, New London, CT 06320, USA
J Clin Psychopharmacol 24:141-9. 2004
..Somnolence and dizziness were the most frequently occurring adverse events among patients receiving pregabalin 600 mg/d. In conclusion, pregabalin 600 mg/d was an effective and well-tolerated treatment of social anxiety disorder...
- Pharmacological and pharmacokinetic aspects of functional gastrointestinal disorders
Michael Camilleri
Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Gastroenterology 130:1421-34. 2006
..It is anticipated that the interaction between investigators of basic science, basic and applied pharmacology, and clinical trials will lead to better treatment of these disorders...
- Recognition and treatment of obsessive-compulsive disorder
Wayne K Goodman
Department of Psychiatry, University of Florida College of Medicine, Gainesville, USA
J Clin Psychiatry 68:e30. 2007
..Neurosurgery, such as deep brain stimulation, has also been shown to be effective in select patients with debilitating and refractory OCD...
- Posttraumatic stress disorder: characteristics and treatment
Thomas Mellman
Department of Psychiatry, Howard University Hospital, Washington, DC, USA
J Clin Psychiatry 69:e2. 2008
..Treatment often involves multiple modalities...
- The Social Thoughts and Beliefs Scale: a new inventory for assessing cognitions in social phobia
Samuel M Turner
Maryland Center for Anxiety Disorders, Department of Psychology, University of Maryland, College Park, Maryland 20742 4411, USA
Psychol Assess 15:384-91. 2003
..Potential usefulness of the STABS for assessing cognitions associated with social phobia is discussed...
- A randomized, double-blind, active-control study of sertraline versus venlafaxine XR in major depressive disorder
Richard C Shelton
Department of Psychiatry, Vanderbilt University Medical Center, Nashville, Tenn, USA
J Clin Psychiatry 67:1674-81. 2006
..The objective of the current multisite study was to compare relatively higher doses of sertraline (i.e., 150 mg/day) and venlafaxine extended release (XR) (225 mg/day) in outpatients with major depressive disorder...
