Research Topics
| Claude P MullerSummaryAffiliation: Laboratoire National de Sant Country: Luxembourg Publications
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Detail Information
Publications
Immunogenic measles antigens expressed in plants: role as an edible vaccine for adultsClaude P Muller
Department of Immunology and WHO Collaborative Center for Measles, Laboratoire National de Santé, PO Box 1102, 20A rue Auguste Lumière, L 1950, Luxembourg, Luxembourg
Vaccine 21:816-9. 2003..Strategies for the vaccination of adults, the potential of an oral measles vaccine produced in edible plants and the design of suitable antigens are discussed...
Characterization of conserved properties of hemagglutinin of H5N1 and human influenza viruses: possible consequences for therapy and infection controlVeljko Veljkovic
Center for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, P O Box 522, 11001 Belgrade, Serbia
BMC Struct Biol 9:21. 2009..Here we compare informational and structural properties of the hemagglutinin (HA) of H5N1 virus and human influenza virus subtypes, which are important for the receptor/virus interaction...- Identification of hemagglutinin structural domain and polymorphisms which may modulate swine H1N1 interactions with human receptorVeljko Veljkovic
Center for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, PO Box 522, 11001 Belgrade, Serbia
BMC Struct Biol 9:62. 2009..Here we have studied properties of hemagglutinin of A/H1N1 which may modulate virus/receptor interaction... - Evidence of recombination among early-vaccination era measles virus strainsMikkel H Schierup
Bioinformatics Research Center BiRC, University of Aarhus, Hoegh Guldbergs Gade 10, DK 8000 Aarhus C, Denmark
BMC Evol Biol 5:52. 2005.... - The proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infectionsKonstantin H Müller
Institute of Immunology, Centre de Recherche Public Santé Laboratoire National de Santé, Luxembourg, Luxembourg
Br J Pharmacol 164:344-57. 2011.... - Reducing global disease burden of measles and rubella: report of the WHO Steering Committee on research related to measles and rubella vaccines and vaccination, 2005Claude P Muller
Institute of Immunology and WHO Collaborative Center for Measles and WHO European Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Santé, Luxemburg
Vaccine 25:1-9. 2007..However further validation of these methods in different settings is required before their routine use can be recommended... - A high variability of mixed infections and recent recombinations of hepatitis B virus in LaosIris E Andernach
Institute of Immunology, Centre de Recherche Public Santé National Public Health Laboratory, Luxembourg, Luxembourg
PLoS ONE 7:e30245. 2012..In conclusion, our analyses revealed a high variability of mixed infections as a very probable breeding ground of multiple variable recombination events in Laos that so far have not led to new dominant strains... 
Hepatitis B virus genotype E variability in AfricaJudith M Hübschen
Institute of Immunology, Laboratoire National de Santé, L 1950 Luxembourg, Luxembourg
J Clin Virol 43:376-80. 2008..Despite its wide geographic distribution and the high prevalence throughout this genotype E crescent, this genotype has a very low genetic diversity...- Phylogenetic analysis of human parvovirus b19 sequences from eleven different countries confirms the predominance of genotype 1 and suggests the spread of genotype 3bJudith M Hübschen
Institute of Immunology, Laboratoire National de Santé, 20A, rue Auguste Lumiere, L 1950 Luxembourg
J Clin Microbiol 47:3735-8. 2009..57% to genotype 1, 5.42% to genotype 3b, and 3.01% to genotype 3a. Very similar viruses of genotype 1 circulated widely in Europe and Israel. Genotype 3b seems to show an increasing spread outside of Africa... - Revealing new measles virus transmission routes by use of sequence analysis of phosphoprotein and hemagglutinin genesJulia R Kessler
Institute of Immunology, Centre de Recherche Public Santé Laboratoire National de Santé, WHO Regional Reference Laboratory for Measles and Rubella and WHO Collaboration Centre for Measles Research, Luxembourg, Luxembourg
J Clin Microbiol 49:677-83. 2011..Thus, a longer sequencing window has true benefits both for the epidemiological surveillance of measles and for the better monitoring of viral evolution... - Differential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmedSimone R Alt
Institute of Immunology, Laboratoire National de Santé Centre de Recherche Public de la Santé, 20A rue Auguste Lumière, L 1950 Luxembourg
Psychoneuroendocrinology 35:544-56. 2010..However, this should be further confirmed in dedicated studies in larger cohorts... - A multiplex TaqMan PCR assay for the detection of measles and rubella virusJudith M Hübschen
Institute of Immunology and WHO Collaborative Centre for Measles and WHO European Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1950 Luxembourg, Luxembourg
J Virol Methods 149:246-50. 2008..The performance of the assay is similar to a conventional nested PCR and generates cDNA with random primers which can be used directly for virus genotyping... - Immunogenicity of a promiscuous T cell epitope peptide based conjugate vaccine against benzo[a]pyrene: redirecting antibodies to the haptenMario T Schellenberger
Centre de Recherche Public Santé National Public Health Laboratory, Institute of Immunology, Luxembourg, Grand Duchy of Luxembourg
PLoS ONE 7:e38329. 2012..Further studies to demonstrate a long-term protection of an immunoprophylactic immunisation against B[a]P are warranted... - Glucocorticoid sensitivity in fibromyalgia patients: decreased expression of corticosteroid receptors and glucocorticoid-induced leucine zipperJoana A Macedo
Institute of Immunology, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1011, Luxembourg
Psychoneuroendocrinology 33:799-809. 2008.... - Exceptional genetic variability of hepatitis B virus indicates that Rwanda is east of an emerging African genotype E/A1 divideJudith M Hübschen
Institute of Immunology, Laboratoire National de Santé Centre de Recherche Public de Santé, Luxembourg, Luxembourg
J Med Virol 81:435-40. 2009..Despite this exceptional genetic variability, not a single genotype E virus was found indicating that this country does not belong to the genotype E crescent, but is east of an emerging African genotype E/A1 divide... - Genotyping of recent measles virus strains from Russia and Vietnam by nucleotide-specific multiplex PCRJacques R Kremer
Institute of Immunology and WHO Collaborative Centre for Measles and WHO European Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Santé, L 1011, Luxembourg
J Med Virol 79:987-94. 2007.... - Modulation of benzo[a]pyrene induced immunotoxicity in mice actively immunized with a B[a]P-diphtheria toxoid conjugateMario T Schellenberger
Institute of Immunology, LNS CRP Santé, Luxembourg, Grand Duchy of Luxembourg
Toxicol Appl Pharmacol 240:37-45. 2009..Thus, we demonstrate that vaccination with a B[a]P conjugate vaccine based on a carrier protein used in licensed human vaccines reduces immunotoxicity and possibly other detrimental effects associated with B[a]P... - Modulation of carcinogen bioavailability by immunisation with benzo[a]pyrene-conjugate vaccinesNathalie Grova
Institute of Immunology, LNS CRP Santé, Grand Duchy of Luxembourg, Luxembourg
Vaccine 27:4142-51. 2009..Our results showed that this immune prophylactic strategy influences the pharmacokinetic of B[a]P and further studies to investigate their effects on chemical carcinogenesis are warranted... - Hepatitis B virus genotype E surface antigen detection with different immunoassays and diagnostic impact of mutations in the preS/S geneChristophe M Olinger
Institute of Immunology, National Public Health Laboratory, 20A, rue Auguste Lumiere, 1950, Luxembourg, Luxembourg
Med Microbiol Immunol 196:247-52. 2007..4-100%) but differed considerably in specificity (84-99%). Failure to detect HBsAg antigen and differences in signal intensity were mainly associated with mutations in the preS/S gene outside the "a" determinant... - Slave trade and hepatitis B virus genotypes and subgenotypes in Haiti and AfricaIris E Andernach
Institute of Immunology, Luxembourg
Emerg Infect Dis 15:1222-8. 2009..The high prevalence of HBV genotype E in much of Africa further suggests that HBV hyperendemicity is a recent phenomenon, probably resulting from extensive use of unsafe needles... - Effects of antibodies induced by a conjugate vaccine on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone absorptive transport, metabolism, and proliferation of human lung cellsStefan S De Buck
Institute of Immunology, LNS CRP Santé, Luxembourg, Grand Duchy of Luxembourg
Int J Cancer 127:513-20. 2010..These in vitro data therefore suggest that a prophylactic antibody response may be associated with a reduced risk of cancer... - Transcriptional control of the glucocorticoid receptor: CpG islands, epigenetics and moreJonathan D Turner
Institute of Immunology, CRP Santé Laboratoire National de Santé, 20A rue Auguste Lumière, L 1950, Luxembourg
Biochem Pharmacol 80:1860-8. 2010..Dissecting how tissue-specific GR levels are regulated, in particular in the brain, is a first step to understand the significance of aberrant GR levels in disease and behaviour... - Highly individual methylation patterns of alternative glucocorticoid receptor promoters suggest individualized epigenetic regulatory mechanismsJonathan D Turner
Institute of Immunology, Laboratoire National de Santé, Luxembourg, Germany
Nucleic Acids Res 36:7207-18. 2008.... - Possible new hepatitis B virus genotype, southeast AsiaChristophe M Olinger
National Public Health Laboratory Centre de Recherche Public Santé, Luxembourg, Luxembourg
Emerg Infect Dis 14:1777-80. 2008..This emerging new genotype likely developed outside Southeast Asia and is now found in mixed infections and in recombinations with local strains in a geographically confined region... - Experimental vaccines against measles in a world of changing epidemiologyMike M Putz
Department of Immunology, Laboratoire National de Santé, 20A rue Auguste Lumière, 1950 Luxembourg, Luxembourg
Int J Parasitol 33:525-45. 2003..While some of these candidate vaccines have proven their efficacy in monkey studies, aerosol formulated live attenuated measles vaccine are evaluated in clinical trials... - Humoral immune responses to a protective peptide-conjugate against measles after different prime-boost regimensMike M Putz
Institute of Immunology, Laboratoire National de Santé, 20A rue Auguste Lumière, 1950 Luxembourg, Luxembourg, Germany
Vaccine 22:4173-82. 2004..These results underline the potential of these peptide-based conjugates as vaccine candidates for use in early infancy to close the window of susceptibility before the live-attenuated vaccine can be administered... - Measles virus strain diversity, Nigeria and Democratic Republic of the CongoJacques R Kremer
Centre de Recherche Publique Sante Laboratoire National de Sante, Luxembourg, Luxembourg
Emerg Infect Dis 16:1724-30. 2010..In contrast, the relatively low genetic diversity of MV in DRC and the genotype replacement in Kinshasa reflect a notable improvement in local measles control... - EPs® 7630 (Umckaloabo®), an extract from Pelargonium sidoides roots, exerts anti-influenza virus activity in vitro and in vivoLinda L Theisen
Institute of Immunology, Centre de Recherche Public de la Sante Laboratoire National de Sante, Luxembourg, Luxembourg
Antiviral Res 94:147-56. 2012..In addition, EPs® 7630 administered by inhalation significantly improved survival, body weight and body temperature of influenza-infected mice, without obvious toxicity, demonstrating the benefit of EPs® 7630 in treatment of influenza... - Co-circulation of multiple rubella virus strains in Belarus forming novel genetic groups within clade 1Judith M Hübschen
Institute of Immunology and WHO Collaborative Centre for Measles and WHO European Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1011 Luxembourg
J Gen Virol 88:1960-6. 2007..As there currently seem to be misattributions of strains to genotypes and unclear phylogenetic relationships, criteria for genotyping of RUBV should be clarified further... - Proteomic profiling of rapid non-genomic and concomitant genomic effects of acute restraint stress on rat thymocytesAnja M Billing
Institute of Immunology, Centre de Recherche Public de la Santé National Public Health Laboratory, 20A, rue Auguste Lumiere, L 1950 Luxembourg, Luxembourg
J Proteomics 75:2064-79. 2012..This is the first study investigating rapid effects of stress-induced HPA activation in vivo at the proteome level... - Newcastle disease virus in West Africa: new virulent strains identified in non-commercial farmsChantal J Snoeck
National Public Health Laboratory, Institute of Immunology, 20A rue Auguste Lumière, 1950, Luxembourg, Luxembourg
Arch Virol 154:47-54. 2009..5 to 17.3%. Their high genetic diversity and their presence in three different Sub-Saharan countries suggest that these new sublineages represent the NDV variants indigenous to West Africa... - High genetic diversity of measles virus, World Health Organization European Region, 2005-2006Jacques R Kremer
World Health Organization WHO Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Santé Immunology 20A, rue Auguste Lumiere, Luxembourg, Luxembourg
Emerg Infect Dis 14:107-14. 2008..Thus, despite the reduction of endemic MV circulation, importation of MV from other continents caused prolonged circulation and large outbreaks after their introduction into unvaccinated and highly mobile communities... - Rubella seroprevalence among pregnant women in Burkina FasoMarc C Tahita
Institute of Immunology, Centre de Recherche Public de la Sante Laboratoire National de Sante, 20A rue Auguste Lumière, Luxembourg, L, 1950, Luxembourg
BMC Infect Dis 13:164. 2013..Despite the serious consequences of rubella infection during early pregnancy, very little is known about the rubella seroprevalence in a number of African countries including Burkina Faso... - Phylogenetic analysis of the precore/core gene of hepatitis B virus genotypes E and A in West Africa: new subtypes, mixed infections and recombinationsChristophe M Olinger
Institute of Immunology, National Public Health Laboratory, Luxembourg
J Gen Virol 87:1163-73. 2006..The low genetic variability in the preC/C gene of genotype E supports our previous speculation about a relatively short evolutionary history of this genotype, in contrast to the subtype-rich African genotype A strains... - Characterization of a new genotype and serotype of infectious bronchitis virus in Western AfricaMariette F Ducatez
Institute of Immunology, National Public Health Laboratory, CRP Sante, 20A rue Auguste Lumière, L 1950 Luxembourg
J Gen Virol 90:2679-85. 2009..Despite the absence of obvious clinical signs in poultry infected by IBADAN strains, it is important to test the cross-protection of current vaccine strains... - A new transcript splice variant of the human glucocorticoid receptor: identification and tissue distribution of hGR Delta 313-338, an alternative exon 2 transactivation domain isoformJonathan D Turner
Institute of Immunology, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1011 Luxembourg, Grand Duchy of Luxembourg
Ann N Y Acad Sci 1095:334-41. 2007..It is thought that phosphorylation plays an important role in transactivation action of hGR. Thus, we hypothesize that hGRDelta313-338 represents a hGR isoform with an altered glucocorticoid-induced transactivation profile... - Sub-acute administration of benzo[a]pyrene (B[a]P) reduces anxiety-related behaviour in adult mice and modulates regional expression of N-methyl-D-aspartate (NMDA) receptors genes in relevant brain regionsNathalie Grova
Institute of Immunology, Laboratoire National de Santé, 20A rue Auguste Lumière, P O Box 1102, L 1011 Luxembourg, Luxembourg
Chemosphere 73:S295-302. 2008..In conclusion, a sub-acute exposure to B[a]P (20 and 200 mg kg(-1)) reduced anxiety-related behaviour in adult mice and concomitantly impaired NMDA receptor gene expression in relevant brain regions... - Interplay of measles virus with early induced cytokines reveals different wild type phenotypesJulia R Kessler
Laboratoire National de Santé, Institute of Immunology, Centre de Recherche Public Santé WHO Regional Reference, 20A rue Auguste Lumière, L 1950 Luxembourg, Luxembourg
Virus Res 155:195-202. 2011..The present data show that MV wt strains differ in their sensitivity and their ability to temper with the innate immune response, which may result in differences in virulence... - Transcriptional control of the human glucocorticoid receptor: identification and analysis of alternative promoter regionsLei Cao-Lei
Institute of Immunology, CRP Santé Laboratoire National de Santé, 20A rue Auguste Lumière, Luxembourg, Grand Duchy of Luxembourg
Hum Genet 129:533-43. 2011..This complexity within the CpG island helps to explain the variable, tissue-specific transcriptional control of the GR, and provides insight into the mechanisms underlying tissue specific deregulation of GR levels... - Evaluation of adjuvants for a candidate conjugate vaccine against benzo[a]pyreneMario T Schellenberger
Institute of Immunology, CRP Santé LNS, Luxembourg, Grand Duchy of Luxembourg
Hum Vaccin 7:166-73. 2011..Our findings demonstrate that a vaccination against B[a]P is feasible in combination with adjuvants licensed in humans... - Structure of the glucocorticoid receptor (NR3C1) gene 5' untranslated region: identification, and tissue distribution of multiple new human exon 1Jonathan D Turner
Institute of Immunology, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1011, Luxembourg
J Mol Endocrinol 35:283-92. 2005.... - Detection of new Francisella-like tick endosymbionts in Hyalomma spp. and Rhipicephalus spp. (Acari: Ixodidae) from BulgariaIvan N Ivanov
National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria
Appl Environ Microbiol 77:5562-5. 2011..The FLEs were characterized by 16S rRNA and tul4 gene sequencing and seem to lack the molecular marker RD1. These two new taxa seem to be facultative secondary endosymbionts of ticks... - Differential effects of NS1 proteins of human pandemic H1N1/2009, avian highly pathogenic H5N1, and low pathogenic H5N2 influenza A viruses on cellular pre-mRNA polyadenylation and mRNA translationDenis E Kainov
Institute of Immunology, Centre de Recherche Public Santé Laboratoire National de Santé, L 1011, Luxembourg
J Biol Chem 286:7239-47. 2011..Thus, we identified strain-specific differences between influenza virus NS1 proteins in pre-mRNA polyadenylation and mRNA translation... - Low genetic diversity despite hyperendemicity of hepatitis B virus genotype E throughout West AfricaMick N Mulders
Institute of Immunology, National Public Health Laboratory, Luxembourg, Luxembourg
J Infect Dis 190:400-8. 2004.... - Limited diversity of measles field isolates after a national immunization day in Burkina Faso: progress from endemic to epidemic transmission?Mick N Mulders
Laboratoire National de Santé, Department of Immunology, and World Health Organization Collaborating Center for Measles, Luxembourg, Grand Duchy of Luxembourg
J Infect Dis 187:S277-82. 2003.... - Hepatitis B virus: the genotype E puzzleIris E Andernach
Institute of Immunology, Laboratoire National de Santé CRP Santé, 20A rue Auguste Lumière, L 1950 Luxembourg, Luxembourg
Rev Med Virol 19:231-40. 2009.... - Cortisol is a potent modulator of lipopolysaccharide-induced interferon signaling in macrophagesAnja M Billing
Institute of Immunology, CRP Santé National Public Health Laboratory, 20A rue Auguste Lumière, Luxembourg, Grand Duchy of Luxembourg
Innate Immun 17:302-20. 2011..They were all suppressed by CORT. This is the first proteomics study to investigate the effects of CORT on activated immune cells... - Reassortant low-pathogenic avian influenza H5N2 viruses in African wild birdsChantal J Snoeck
Institute of Immunology, CRP Santé and Laboratoire National de Santé, Luxembourg
J Gen Virol 92:1172-83. 2011.... - Pathogen prevalence in ticks collected from the vegetation and livestock in NigeriaAnna L Reye
Institute of Immunology, Centre de Recherche Public de la Santé National Public Health Laboratory, Luxembourg, Luxembourg
Appl Environ Microbiol 78:2562-8. 2012..6% for a Rickettsia africae-like species, 27% for Coxiella burnetii, and 8.5% for Anaplasma marginale/centrale suggest that these pathogens may have considerable implications for human and animal health... - Adhesion molecules and cytokine expression in fibromyalgia patients: increased L-selectin on monocytes and neutrophilsJoana A Macedo
Institute of Immunology, Laboratoire National de Santé, Luxembourg
J Neuroimmunol 188:159-66. 2007..This study shows a slight disturbance in the innate immune system of FM patients, and suggests an enhanced adhesion and recruitment of leukocytes to inflammatory sites... - Synthesis of 4-[2-aminoethyl(nitrosamino)]-1-pyridin-3-yl-butan-1-one, a new NNK hapten for the induction of N-nitrosamine-specific antibodiesEmmanuel J F Prodhomme
Institute of Immunology, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1011, Luxembourg, Luxembourg
Bioconjug Chem 18:2045-53. 2007..Therefore, such antibodies detect NNK and NNAL and may have the potential to modulate their redistribution in vivo, perhaps reducing some detrimental effects of smoking... - Emergence of oseltamivir-resistant influenza A H1N1 virus during the 2007-2008 winter season in Luxembourg: clinical characteristics and epidemiologyJoel Mossong
Microbiology, National Health Laboratory, PO Box 1102, L 1011 Luxembourg, Luxembourg
Antiviral Res 84:91-4. 2009..Following initial local seeding, oseltamivir-resistant strains spread synchronously to sensitive strains causing a similar epidemiology and clinical symptoms... - Neutralising immunogenicity of a polyepitope antigen expressed in a transgenic food plant: a novel antigen to protect against measlesFabienne B Bouche
Laboratoire National de Sant, Department of Immunology, WHO Collaborative Center for Measles, , L-1950 Luxembourg, Luxembourg
Vaccine 21:2065-72. 2003..The combined features of the selected epitopes and the potential of the plant expression system may pave the way towards new vaccines against measles... - Prevalence of tick-borne pathogens in Ixodes ricinus and Dermacentor reticulatus ticks from different geographical locations in BelarusAnna L Reye
Institute of Immunology, Centre de Recherche Public de la Santé National Public Health Laboratory, Luxembourg, Luxembourg
PLoS ONE 8:e54476. 2013..Identified hotspots of infected ticks should be included in future surveillance studies, especially when F. tularensis ssp. and C. burnetii are involved... - Characterization of newcastle disease viruses in wild and domestic birds in Luxembourg from 2006 to 2008Chantal J Snoeck
Institute of Immunology, Centre de Recherche Public Santé Laboratoire National de Santé, Luxembourg, Luxembourg
Appl Environ Microbiol 79:639-45. 2013..The circulation of NDV in wild and free-ranging domestic birds warrants continuous surveillance because of increased concern that low-virulence wild-bird viruses could become more virulent in domestic populations... - Epidemiology of chicken anemia virus in Central African Republic and CameroonChantal J Snoeck
Institute of Immunology, Centre de Recherche Public de la Santé National Public Health Laboratory, 20A rue Auguste Lumière, L 1950, Luxembourg, Luxembourg
Virol J 9:189. 2012..Although chicken anemia virus (CAV) has been detected on all continents, little is known about this virus in sub-Saharan Africa. This study aimed to detect and characterize CAV for the first time in Central African Republic and in Cameroon... - Modulation of behavior and NMDA-R1 gene mRNA expression in adult female mice after sub-acute administration of benzo(a)pyreneNathalie Grova
Institute of Immunology, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1011 Luxembourg, Luxembourg
Neurotoxicology 28:630-6. 2007.... - The rationale of a peptide-conjugate vaccine against measlesMike M Putz
Department of Immunology, PO Box 1102, 20A rue Auguste Lumière, 1950, Luxembourg, Luxembourg
Vaccine 21:663-6. 2003..Such a vaccine induces carrier-specific T cells, avoiding measles-specific Th2 cells associated with the risk of atypical measles. This article discusses the rationale of such a strategy and its future potential... - Modelling measles re-emergence as a result of waning of immunity in vaccinated populationsJoel Mossong
Laboratoire National de Santé, P O Box 1102, L 1011 Luxembourg, Luxembourg
Vaccine 21:4597-603. 2003..Although waning of humoral immunity in vaccinees is widely observed, re-emergence of measles in highly vaccinated populations depends on parameters for which better estimates are needed... - Prevalence and seasonality of tick-borne pathogens in questing Ixodes ricinus ticks from LuxembourgAnna L Reye
Institute of Immunology, National Public Health Laboratory CRP Santé, Luxembourg, Luxembourg
Appl Environ Microbiol 76:2923-31. 2010..We also found Hepatozoon canis (0.1%) and Bartonella henselae (0.3%), which so far have not been found in questing Ixodes ricinus ticks in Central Europe... - Immunopropylactic approaches against chemical carcinogenesisStefan S De Buck
Institute of Immunology, Laboratoire National de Sant, , L-1011 Luxembourg, Luxembourg
Vaccine 23:2403-6. 2005..Studies at immunoprophylactic intervention in carcinogenicity are discussed... - Neutralizing B cell response in measlesFabienne B Bouche
Department of Immunology and WHO Collaborating Center for Measles, Laboratoire National de Sant, Luxembourg, Luxembourg
Viral Immunol 15:451-71. 2002..Major neutralizing epitopes have been mapped mainly on the hemagglutinin protein with monoclonal antibodies, producing an increasingly comprehensive map of functional domains... - Tissue specific glucocorticoid receptor expression, a role for alternative first exon usage?Jonathan D Turner
Institute of Immunology, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1950 Luxembourg, Grand Duchy of Luxembourg
Biochem Pharmacol 72:1529-37. 2006..Spreading the necessary promoter elements over multiple promoter regions, each with an associated alternative transcription initiation site would appear to vastly increase the capacity for transcriptional control of GR... - Modulation of the metabolism and adverse effects of benzo[a]pyrene by a specific antibody: a novel host factor in environmental carcinogenesis?Stefan S De Buck
Institute of Immunology, Laboratoire National de Santé, Rue Auguste Lumière 20A, L 1011 Luxembourg, Luxembourg, Belgium
Carcinogenesis 26:835-44. 2005..These in vitro data also suggest that a natural or prophylactic antibody response against carcinogens may be associated with a reduced risk of cancer... - Proteomic analysis of the cortisol-mediated stress response in THP-1 monocytes using DIGE technologyAnja M Billing
Institute of Immunology, National Public Health Laboratory, 20A, rue Auguste Lumiere, L 1950 Luxembourg, Grand Duchy of Luxembourg
J Mass Spectrom 42:1433-44. 2007..FKBP51 isoforms found on the gel map were linked to alternative promoter usage on the genetic level, successfully correlating both the specific proteomic and genomic findings... - Prevalence of antibodies against canine distemper virus among red foxes in LuxembourgBenjamin C Damien
Department of Immunology, Laboratoire National de Sant, , L-1011 Luxembourg, Luxembourg
J Wildl Dis 38:856-9. 2002..About 9 to 13% of the Luxembourg red fox population is positive for antibodies against CDV. Thus a sizeable proportion of red foxes has been exposed to CDV in the wild. The significance of CDV in red foxes is discussed... - Induction of broadly neutralizing antibodies against measles virus mutants using a polyepitope vaccine strategyFabienne B Bouche
Institute of Immunology and WHO Collaborative Center for Measles, Laboratoire National de Sant, , L-1950 Luxembourg, Luxembourg
Vaccine 23:2074-7. 2005..These results suggest that the multiple copies of the L epitope fold into different conformations that induce a repertoire of B cells diverse enough to overcome the genetic diversity of field viruses... - Central African Republic is part of the West-African hepatitis B virus genotype E crescentClaudine Bekondi
Laboratoire de Virologie, Unité des Rétrovirus et des Hépatites virales, Institut Pasteur de Bangui, rue Pasteur, BP 923 Bangui, Republique Centrafricaine
J Clin Virol 40:31-7. 2007..Recent studies have shown that Hepatitis B virus (HBV) genotype E predominates in a vast crescent in West-Africa spanning from Senegal to Angola... - Waning antibodies in measles and rubella vaccinees--a longitudinal studyJacques R Kremer
Institute of Immunology and WHO Collaborative Centre for Measles and WHO European Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Sant, 20A, , L-1011, Luxembourg
Vaccine 24:2594-601. 2006..However, as a result of a more rapid decay of high-titre (> 1500 mIU) antibodies (-2.4%/year), many vaccinees may eventually become susceptible to vaccine-modified measles (VMM) and consequently complicate measles control strategies... - Identification of a second major site for CD46 binding in the hemagglutinin protein from a laboratory strain of measles virus (MV): potential consequences for wild-type MV infectionNicolas Masse
INSERM U404, Immunité et Vaccination, CERVI, IFR 74, 21 Avenue Tony Garnier, 69365 Lyon Cedex 07, France
J Virol 76:13034-8. 2002..Our results suggest that although wt MV interacts with SLAM with high affinity, it also possesses the capacity to interact with CD46 with low affinity... - Determination of hepatitis B virus genotype by flow-through reverse dot blotRen Zhang
Department of Human Anatomy and DaAn Gene Diagnostic Center of Sun Yat Sen University, Guangzhou, PR China
J Clin Virol 39:94-100. 2007..Most methods of determining the viral genotype are relatively time-consuming and costly. Moreover, the results of some methods are influenced by single nucleotide mutations... - Genetic characterization of HPAI (H5N1) viruses from poultry and wild vultures, Burkina FasoMariette F Ducatez
National Public Health Laboratory, Luxembourg
Emerg Infect Dis 13:611-3. 2007..Hooded vultures could potentially be vectors or sentinels of influenza subtype H5N1, as are cats and swans elsewhere... - High-performance microtiter plates for immunosorbent assays made of renewable resources: polylactic acid biopolymer as a substitute for synthetic polystyreneFabienne B Bouche
Laboratoire National de Sant, PO Box 1102, L-1011 Luxembourg, Luxembourg. pab productions, , D-85241 Hebertshausen, Germany
Clin Chem 48:378-80. 2002 - Re-exposure to wild-type virus stabilizes measles-specific antibody levels in late convalescent patientsJacques R Kremer
Institute of Immunology and WHO Collaborative Centre for Measles and WHO European Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Sant, , L-1011 Luxembourg
J Clin Virol 35:95-8. 2006..3% to +0.1%) during 2.5 years but significance was low (p=0.08). CONCLUSION: The maintenance of antibody levels in convalescent measles patients is at least partially dependant on recurrent exposure to circulating wt virus... - Immunogenicity of peptides of measles virus origin and influence of adjuvantsBeata Halassy
Institute of Immunology, Research and Development Department, Rockefellerova 10, HR 10000 Zagreb, Croatia
Vaccine 24:185-94. 2006..Further improvement of immune response was obtained after incorporation of such a peptide mixture into oil-based adjuvants... - Evaluation of commercial assay detecting specific immunoglobulin g in oral fluid for determining measles immunity in vaccineesJacques R Kremer
Institute of Immunology, WHO Collaborative Centre for Measles, WHO European Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Sant, L-1011 Luxembourg
Clin Diagn Lab Immunol 12:668-70. 2005..4%; confidence interval: -1.5 to -13.2%; P = 0.01) due to a reduced sensitivity when antibody levels were low... - Measles virus genotyping by nucleotide-specific multiplex PCRJacques R Kremer
Department of Immunology and WHO Collaborative Centre for Measles, Laboratoire National de Sant, 20A, , L-1011 Luxembourg, Luxembourg
J Clin Microbiol 42:3017-22. 2004.... - Improved antiviral activity in vitro of ribavirin against measles virus after complexation with cyclodextrinsNicolas Grancher
Groupe d Etude des Vecteurs Supramoléculaires du Médicament, Unité Mixte de Recherche Université CNRS 7565, Structure et Réactivité des Systèmes Moléculaires Complexes, Universite Henri Poincare, Nancy 1, France
Antiviral Res 62:135-7. 2004..Complexation of RBV with alpha-CD or beta-CD lead to a five-fold or a two-fold decrease in the 50% inhibitory concentration, respectively, against both MEV strains. In contrast, gamma-CD complexation showed no modification... - Functional fine-mapping and molecular modeling of a conserved loop epitope of the measles virus hemagglutinin proteinMike M Putz
Department of Immunology, Laboratoire National de Santé, Luxembourg Fakultät für Chemie und Pharmazie, Universitat Tubingen, Germany
Eur J Biochem 270:1515-27. 2003....