Claude P Muller

Summary

Affiliation: Laboratoire National de Sant
Country: Luxembourg

Publications

  1. ncbi Immunogenic measles antigens expressed in plants: role as an edible vaccine for adults
    Claude P Muller
    Department of Immunology and WHO Collaborative Center for Measles, Laboratoire National de Santé, PO Box 1102, 20A rue Auguste Lumière, L 1950, Luxembourg, Luxembourg
    Vaccine 21:816-9. 2003
  2. pmc Genetic characterization of HPAI (H5N1) viruses from poultry and wild vultures, Burkina Faso
    Mariette F Ducatez
    National Public Health Laboratory, Luxembourg
    Emerg Infect Dis 13:611-3. 2007
  3. pmc Possible new hepatitis B virus genotype, southeast Asia
    Christophe M Olinger
    National Public Health Laboratory Centre de Recherche Public Santé, Luxembourg, Luxembourg
    Emerg Infect Dis 14:1777-80. 2008
  4. pmc Measles virus strain diversity, Nigeria and Democratic Republic of the Congo
    Jacques R Kremer
    Centre de Recherche Publique Sante Laboratoire National de Sante, Luxembourg, Luxembourg
    Emerg Infect Dis 16:1724-30. 2010
  5. pmc Slave trade and hepatitis B virus genotypes and subgenotypes in Haiti and Africa
    Iris E Andernach
    Institute of Immunology, Luxembourg
    Emerg Infect Dis 15:1222-8. 2009
  6. pmc Replacement of sublineages of avian influenza (H5N1) by reassortments, sub-Saharan Africa
    Ademola A Owoade
    University of Ibadan, Ibadan, Nigeria
    Emerg Infect Dis 14:1731-5. 2008
  7. pmc Swine influenza virus antibodies in humans, western Europe, 2009
    Nancy A Gerloff
    Centre de Recherche Public de la Sante Laboratoire National de Sante, Luxembourg, Grand Duchy of Luxembourg
    Emerg Infect Dis 17:403-11. 2011
  8. pmc Characterization of conserved properties of hemagglutinin of H5N1 and human influenza viruses: possible consequences for therapy and infection control
    Veljko Veljkovic
    Center for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, P O Box 522, 11001 Belgrade, Serbia
    BMC Struct Biol 9:21. 2009
  9. pmc Identification of hemagglutinin structural domain and polymorphisms which may modulate swine H1N1 interactions with human receptor
    Veljko Veljkovic
    Center for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, PO Box 522, 11001 Belgrade, Serbia
    BMC Struct Biol 9:62. 2009
  10. pmc Evidence of recombination among early-vaccination era measles virus strains
    Mikkel H Schierup
    Bioinformatics Research Center BiRC, University of Aarhus, Hoegh Guldbergs Gade 10, DK 8000 Aarhus C, Denmark
    BMC Evol Biol 5:52. 2005

Collaborators

Detail Information

Publications93

  1. ncbi Immunogenic measles antigens expressed in plants: role as an edible vaccine for adults
    Claude P Muller
    Department of Immunology and WHO Collaborative Center for Measles, Laboratoire National de Santé, PO Box 1102, 20A rue Auguste Lumière, L 1950, Luxembourg, Luxembourg
    Vaccine 21:816-9. 2003
    ..Strategies for the vaccination of adults, the potential of an oral measles vaccine produced in edible plants and the design of suitable antigens are discussed...
  2. pmc Genetic characterization of HPAI (H5N1) viruses from poultry and wild vultures, Burkina Faso
    Mariette F Ducatez
    National Public Health Laboratory, Luxembourg
    Emerg Infect Dis 13:611-3. 2007
    ..Hooded vultures could potentially be vectors or sentinels of influenza subtype H5N1, as are cats and swans elsewhere...
  3. pmc Possible new hepatitis B virus genotype, southeast Asia
    Christophe M Olinger
    National Public Health Laboratory Centre de Recherche Public Santé, Luxembourg, Luxembourg
    Emerg Infect Dis 14:1777-80. 2008
    ..This emerging new genotype likely developed outside Southeast Asia and is now found in mixed infections and in recombinations with local strains in a geographically confined region...
  4. pmc Measles virus strain diversity, Nigeria and Democratic Republic of the Congo
    Jacques R Kremer
    Centre de Recherche Publique Sante Laboratoire National de Sante, Luxembourg, Luxembourg
    Emerg Infect Dis 16:1724-30. 2010
    ..In contrast, the relatively low genetic diversity of MV in DRC and the genotype replacement in Kinshasa reflect a notable improvement in local measles control...
  5. pmc Slave trade and hepatitis B virus genotypes and subgenotypes in Haiti and Africa
    Iris E Andernach
    Institute of Immunology, Luxembourg
    Emerg Infect Dis 15:1222-8. 2009
    ..The high prevalence of HBV genotype E in much of Africa further suggests that HBV hyperendemicity is a recent phenomenon, probably resulting from extensive use of unsafe needles...
  6. pmc Replacement of sublineages of avian influenza (H5N1) by reassortments, sub-Saharan Africa
    Ademola A Owoade
    University of Ibadan, Ibadan, Nigeria
    Emerg Infect Dis 14:1731-5. 2008
    ..If the high prevalence of reassortants was typical for West Africa in 2007, the absence of such reassortants anywhere else suggests that reintroductions of influenza A (H5N1) from Africa into Eurasia must be rare...
  7. pmc Swine influenza virus antibodies in humans, western Europe, 2009
    Nancy A Gerloff
    Centre de Recherche Public de la Sante Laboratoire National de Sante, Luxembourg, Grand Duchy of Luxembourg
    Emerg Infect Dis 17:403-11. 2011
    ..Further studies are needed to determine the extent to which serologic responses correlate with infection...
  8. pmc Characterization of conserved properties of hemagglutinin of H5N1 and human influenza viruses: possible consequences for therapy and infection control
    Veljko Veljkovic
    Center for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, P O Box 522, 11001 Belgrade, Serbia
    BMC Struct Biol 9:21. 2009
    ..Here we compare informational and structural properties of the hemagglutinin (HA) of H5N1 virus and human influenza virus subtypes, which are important for the receptor/virus interaction...
  9. pmc Identification of hemagglutinin structural domain and polymorphisms which may modulate swine H1N1 interactions with human receptor
    Veljko Veljkovic
    Center for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, PO Box 522, 11001 Belgrade, Serbia
    BMC Struct Biol 9:62. 2009
    ..Here we have studied properties of hemagglutinin of A/H1N1 which may modulate virus/receptor interaction...
  10. pmc Evidence of recombination among early-vaccination era measles virus strains
    Mikkel H Schierup
    Bioinformatics Research Center BiRC, University of Aarhus, Hoegh Guldbergs Gade 10, DK 8000 Aarhus C, Denmark
    BMC Evol Biol 5:52. 2005
    ....
  11. pmc The proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infections
    Konstantin H Müller
    Institute of Immunology, Centre de Recherche Public Santé Laboratoire National de Santé, Luxembourg, Luxembourg
    Br J Pharmacol 164:344-57. 2011
    ....
  12. ncbi Reducing global disease burden of measles and rubella: report of the WHO Steering Committee on research related to measles and rubella vaccines and vaccination, 2005
    Claude P Muller
    Institute of Immunology and WHO Collaborative Center for Measles and WHO European Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Santé, Luxemburg
    Vaccine 25:1-9. 2007
    ..However further validation of these methods in different settings is required before their routine use can be recommended...
  13. pmc High genetic diversity of Newcastle disease virus in poultry in West and Central Africa: cocirculation of genotype XIV and newly defined genotypes XVII and XVIII
    Chantal J Snoeck
    Institute of Immunology, Centre de Recherche Public de la Sante Laboratoire National de Sante, Luxembourg, Luxembourg
    J Clin Microbiol 51:2250-60. 2013
    ....
  14. ncbi Induction of broadly neutralizing antibodies against measles virus mutants using a polyepitope vaccine strategy
    Fabienne B Bouche
    Institute of Immunology and WHO Collaborative Center for Measles, Laboratoire National de Santé, 20 A rue Auguste Lumière, L 1950 Luxembourg, Luxembourg
    Vaccine 23:2074-7. 2005
    ..These results suggest that the multiple copies of the L epitope fold into different conformations that induce a repertoire of B cells diverse enough to overcome the genetic diversity of field viruses...
  15. pmc Revealing new measles virus transmission routes by use of sequence analysis of phosphoprotein and hemagglutinin genes
    Julia R Kessler
    Institute of Immunology, Centre de Recherche Public Santé Laboratoire National de Santé, WHO Regional Reference Laboratory for Measles and Rubella and WHO Collaboration Centre for Measles Research, Luxembourg, Luxembourg
    J Clin Microbiol 49:677-83. 2011
    ..Thus, a longer sequencing window has true benefits both for the epidemiological surveillance of measles and for the better monitoring of viral evolution...
  16. doi Modulation of benzo[a]pyrene induced neurotoxicity in female mice actively immunized with a B[a]P-diphtheria toxoid conjugate
    Mario T Schellenberger
    Institute of Immunology, Centre de Recherche Public de la Sante Laboratoire National de Sante, 20A rue Auguste Lumière, L 1950 Luxembourg, Grand Duchy of Luxembourg
    Toxicol Appl Pharmacol 271:175-83. 2013
    ..Thus active immunization against B[a]P with a B[a]P-DT conjugate vaccine had a protective effect and attenuated the pharmacological and neurotoxic effects even of high concentrations of B[a]P. ..
  17. pmc A high variability of mixed infections and recent recombinations of hepatitis B virus in Laos
    Iris E Andernach
    Institute of Immunology, Centre de Recherche Public Santé National Public Health Laboratory, Luxembourg, Luxembourg
    PLoS ONE 7:e30245. 2012
    ..In conclusion, our analyses revealed a high variability of mixed infections as a very probable breeding ground of multiple variable recombination events in Laos that so far have not led to new dominant strains...
  18. doi Glucocorticoid sensitivity in fibromyalgia patients: decreased expression of corticosteroid receptors and glucocorticoid-induced leucine zipper
    Joana A Macedo
    Institute of Immunology, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1011, Luxembourg
    Psychoneuroendocrinology 33:799-809. 2008
    ....
  19. pmc Genetic diversity of newcastle disease virus in wild birds and pigeons in West Africa
    Chantal J Snoeck
    Institute of Immunology, Centre de Recherche Public de la Sante Laboratoire National de Sante, Luxembourg, Luxembourg
    Appl Environ Microbiol 79:7867-74. 2013
    ....
  20. doi Hepatitis B virus genotype E variability in Africa
    Judith M Hübschen
    Institute of Immunology, Laboratoire National de Santé, L 1950 Luxembourg, Luxembourg
    J Clin Virol 43:376-80. 2008
    ..Despite its wide geographic distribution and the high prevalence throughout this genotype E crescent, this genotype has a very low genetic diversity...
  21. pmc Phylogenetic analysis of human parvovirus b19 sequences from eleven different countries confirms the predominance of genotype 1 and suggests the spread of genotype 3b
    Judith M Hübschen
    Institute of Immunology, Laboratoire National de Santé, 20A, rue Auguste Lumiere, L 1950 Luxembourg
    J Clin Microbiol 47:3735-8. 2009
    ..57% to genotype 1, 5.42% to genotype 3b, and 3.01% to genotype 3a. Very similar viruses of genotype 1 circulated widely in Europe and Israel. Genotype 3b seems to show an increasing spread outside of Africa...
  22. ncbi Characterization of a new genotype and serotype of infectious bronchitis virus in Western Africa
    Mariette F Ducatez
    Institute of Immunology, National Public Health Laboratory, CRP Sante, 20A rue Auguste Lumière, L 1950 Luxembourg
    J Gen Virol 90:2679-85. 2009
    ..Despite the absence of obvious clinical signs in poultry infected by IBADAN strains, it is important to test the cross-protection of current vaccine strains...
  23. ncbi Phylogenetic analysis of the precore/core gene of hepatitis B virus genotypes E and A in West Africa: new subtypes, mixed infections and recombinations
    Christophe M Olinger
    Institute of Immunology, National Public Health Laboratory, Luxembourg
    J Gen Virol 87:1163-73. 2006
    ..The low genetic variability in the preC/C gene of genotype E supports our previous speculation about a relatively short evolutionary history of this genotype, in contrast to the subtype-rich African genotype A strains...
  24. ncbi Low genetic diversity despite hyperendemicity of hepatitis B virus genotype E throughout West Africa
    Mick N Mulders
    Institute of Immunology, National Public Health Laboratory, Luxembourg, Luxembourg
    J Infect Dis 190:400-8. 2004
    ....
  25. pmc Characterization of newcastle disease viruses in wild and domestic birds in Luxembourg from 2006 to 2008
    Chantal J Snoeck
    Institute of Immunology, Centre de Recherche Public Santé Laboratoire National de Santé, Luxembourg, Luxembourg
    Appl Environ Microbiol 79:639-45. 2013
    ..The circulation of NDV in wild and free-ranging domestic birds warrants continuous surveillance because of increased concern that low-virulence wild-bird viruses could become more virulent in domestic populations...
  26. ncbi Genotyping of recent measles virus strains from Russia and Vietnam by nucleotide-specific multiplex PCR
    Jacques R Kremer
    Institute of Immunology and WHO Collaborative Centre for Measles and WHO European Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Santé, L 1011, Luxembourg
    J Med Virol 79:987-94. 2007
    ....
  27. pmc Immunogenicity of a promiscuous T cell epitope peptide based conjugate vaccine against benzo[a]pyrene: redirecting antibodies to the hapten
    Mario T Schellenberger
    Centre de Recherche Public Santé National Public Health Laboratory, Institute of Immunology, Luxembourg, Grand Duchy of Luxembourg
    PLoS ONE 7:e38329. 2012
    ..Further studies to demonstrate a long-term protection of an immunoprophylactic immunisation against B[a]P are warranted...
  28. ncbi Waning antibodies in measles and rubella vaccinees--a longitudinal study
    Jacques R Kremer
    Institute of Immunology and WHO Collaborative Centre for Measles and WHO European Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Santé, 20A, rue Auguste Lumiere, L 1011, Luxembourg
    Vaccine 24:2594-601. 2006
    ..However, as a result of a more rapid decay of high-titre (> 1500 mIU) antibodies (-2.4%/year), many vaccinees may eventually become susceptible to vaccine-modified measles (VMM) and consequently complicate measles control strategies...
  29. doi Differential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed
    Simone R Alt
    Institute of Immunology, Laboratoire National de Santé Centre de Recherche Public de la Santé, 20A rue Auguste Lumière, L 1950 Luxembourg
    Psychoneuroendocrinology 35:544-56. 2010
    ..However, this should be further confirmed in dedicated studies in larger cohorts...
  30. doi A multiplex TaqMan PCR assay for the detection of measles and rubella virus
    Judith M Hübschen
    Institute of Immunology and WHO Collaborative Centre for Measles and WHO European Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1950 Luxembourg, Luxembourg
    J Virol Methods 149:246-50. 2008
    ..The performance of the assay is similar to a conventional nested PCR and generates cDNA with random primers which can be used directly for virus genotyping...
  31. doi Newcastle disease virus in West Africa: new virulent strains identified in non-commercial farms
    Chantal J Snoeck
    National Public Health Laboratory, Institute of Immunology, 20A rue Auguste Lumière, 1950, Luxembourg, Luxembourg
    Arch Virol 154:47-54. 2009
    ..5 to 17.3%. Their high genetic diversity and their presence in three different Sub-Saharan countries suggest that these new sublineages represent the NDV variants indigenous to West Africa...
  32. ncbi Neutralising immunogenicity of a polyepitope antigen expressed in a transgenic food plant: a novel antigen to protect against measles
    Fabienne B Bouche
    Laboratoire National de Santé, Department of Immunology, WHO Collaborative Center for Measles, 20A rue Auguste Lumière, L 1950 Luxembourg, Luxembourg
    Vaccine 21:2065-72. 2003
    ..The combined features of the selected epitopes and the potential of the plant expression system may pave the way towards new vaccines against measles...
  33. doi Exceptional genetic variability of hepatitis B virus indicates that Rwanda is east of an emerging African genotype E/A1 divide
    Judith M Hübschen
    Institute of Immunology, Laboratoire National de Santé Centre de Recherche Public de Santé, Luxembourg, Luxembourg
    J Med Virol 81:435-40. 2009
    ..Despite this exceptional genetic variability, not a single genotype E virus was found indicating that this country does not belong to the genotype E crescent, but is east of an emerging African genotype E/A1 divide...
  34. ncbi Co-circulation of multiple rubella virus strains in Belarus forming novel genetic groups within clade 1
    Judith M Hübschen
    Institute of Immunology and WHO Collaborative Centre for Measles and WHO European Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1011 Luxembourg
    J Gen Virol 88:1960-6. 2007
    ..As there currently seem to be misattributions of strains to genotypes and unclear phylogenetic relationships, criteria for genotyping of RUBV should be clarified further...
  35. ncbi Proteomic analysis of the cortisol-mediated stress response in THP-1 monocytes using DIGE technology
    Anja M Billing
    Institute of Immunology, National Public Health Laboratory, 20A, rue Auguste Lumiere, L 1950 Luxembourg, Grand Duchy of Luxembourg
    J Mass Spectrom 42:1433-44. 2007
    ..FKBP51 isoforms found on the gel map were linked to alternative promoter usage on the genetic level, successfully correlating both the specific proteomic and genomic findings...
  36. ncbi Limited diversity of measles field isolates after a national immunization day in Burkina Faso: progress from endemic to epidemic transmission?
    Mick N Mulders
    Laboratoire National de Santé, Department of Immunology, and World Health Organization Collaborating Center for Measles, Luxembourg, Grand Duchy of Luxembourg
    J Infect Dis 187:S277-82. 2003
    ....
  37. doi Proteomic profiling of rapid non-genomic and concomitant genomic effects of acute restraint stress on rat thymocytes
    Anja M Billing
    Institute of Immunology, Centre de Recherche Public de la Santé National Public Health Laboratory, 20A, rue Auguste Lumiere, L 1950 Luxembourg, Luxembourg
    J Proteomics 75:2064-79. 2012
    ..This is the first study investigating rapid effects of stress-induced HPA activation in vivo at the proteome level...
  38. ncbi Humoral immune responses to a protective peptide-conjugate against measles after different prime-boost regimens
    Mike M Putz
    Institute of Immunology, Laboratoire National de Santé, 20A rue Auguste Lumière, 1950 Luxembourg, Luxembourg, Germany
    Vaccine 22:4173-82. 2004
    ..These results underline the potential of these peptide-based conjugates as vaccine candidates for use in early infancy to close the window of susceptibility before the live-attenuated vaccine can be administered...
  39. pmc Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid effects
    Sara Vernocchi
    Institute of Immunology, Centre de Recherche Public de la Sante Laboratoire National de Sante, Luxembourg, Grand Duchy of Luxembourg
    Mol Cell Proteomics 12:1764-79. 2013
    ..However, if expressed, this membrane protein dimerizes with the mGR modulating its function. ..
  40. pmc Prevalence of tick-borne pathogens in Ixodes ricinus and Dermacentor reticulatus ticks from different geographical locations in Belarus
    Anna L Reye
    Institute of Immunology, Centre de Recherche Public de la Santé National Public Health Laboratory, Luxembourg, Luxembourg
    PLoS ONE 8:e54476. 2013
    ..Identified hotspots of infected ticks should be included in future surveillance studies, especially when F. tularensis ssp. and C. burnetii are involved...
  41. doi Modulation of benzo[a]pyrene induced immunotoxicity in mice actively immunized with a B[a]P-diphtheria toxoid conjugate
    Mario T Schellenberger
    Institute of Immunology, LNS CRP Santé, Luxembourg, Grand Duchy of Luxembourg
    Toxicol Appl Pharmacol 240:37-45. 2009
    ..Thus, we demonstrate that vaccination with a B[a]P conjugate vaccine based on a carrier protein used in licensed human vaccines reduces immunotoxicity and possibly other detrimental effects associated with B[a]P...
  42. doi Modulation of carcinogen bioavailability by immunisation with benzo[a]pyrene-conjugate vaccines
    Nathalie Grova
    Institute of Immunology, LNS CRP Santé, Grand Duchy of Luxembourg, Luxembourg
    Vaccine 27:4142-51. 2009
    ..Our results showed that this immune prophylactic strategy influences the pharmacokinetic of B[a]P and further studies to investigate their effects on chemical carcinogenesis are warranted...
  43. doi EPs® 7630 (Umckaloabo®), an extract from Pelargonium sidoides roots, exerts anti-influenza virus activity in vitro and in vivo
    Linda L Theisen
    Institute of Immunology, Centre de Recherche Public de la Sante Laboratoire National de Sante, Luxembourg, Luxembourg
    Antiviral Res 94:147-56. 2012
    ..In addition, EPs® 7630 administered by inhalation significantly improved survival, body weight and body temperature of influenza-infected mice, without obvious toxicity, demonstrating the benefit of EPs® 7630 in treatment of influenza...
  44. doi Cortisol is a potent modulator of lipopolysaccharide-induced interferon signaling in macrophages
    Anja M Billing
    Institute of Immunology, CRP Santé National Public Health Laboratory, 20A rue Auguste Lumière, Luxembourg, Grand Duchy of Luxembourg
    Innate Immun 17:302-20. 2011
    ..They were all suppressed by CORT. This is the first proteomics study to investigate the effects of CORT on activated immune cells...
  45. doi Neutralizing antibodies against influenza A in pigs before and after the 2009 pandemic, Luxembourg
    Nina Lütteke
    Institute of Immunology, Centre de Recherche Public de la Sante Laboratoire National de Sante, 20A rue Auguste Lumière, L 1950 Luxembourg, Luxembourg
    Vet Microbiol 169:96-101. 2014
    ..While in 2009 neutralization of the pandemic virus could be explained by cross-reaction with swine influenza viruses this was not the case in at least 2 farms in 2012. ..
  46. pmc Measles virus genotyping by nucleotide-specific multiplex PCR
    Jacques R Kremer
    Department of Immunology and WHO Collaborative Centre for Measles, Laboratoire National de Santé, 20A, rue Auguste Lumiere, L 1011 Luxembourg, Luxembourg
    J Clin Microbiol 42:3017-22. 2004
    ....
  47. pmc Epidemiology of chicken anemia virus in Central African Republic and Cameroon
    Chantal J Snoeck
    Institute of Immunology, Centre de Recherche Public de la Santé National Public Health Laboratory, 20A rue Auguste Lumière, L 1950, Luxembourg, Luxembourg
    Virol J 9:189. 2012
    ..Although chicken anemia virus (CAV) has been detected on all continents, little is known about this virus in sub-Saharan Africa. This study aimed to detect and characterize CAV for the first time in Central African Republic and in Cameroon...
  48. ncbi Re-exposure to wild-type virus stabilizes measles-specific antibody levels in late convalescent patients
    Jacques R Kremer
    Institute of Immunology and WHO Collaborative Centre for Measles and WHO European Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1011 Luxembourg
    J Clin Virol 35:95-8. 2006
    ..Infection with wild-type (wt) measles virus strains induces high antibody levels believed to provide life-long protection against disease...
  49. doi Transcriptional control of the glucocorticoid receptor: CpG islands, epigenetics and more
    Jonathan D Turner
    Institute of Immunology, CRP Santé Laboratoire National de Santé, 20A rue Auguste Lumière, L 1950, Luxembourg
    Biochem Pharmacol 80:1860-8. 2010
    ..Dissecting how tissue-specific GR levels are regulated, in particular in the brain, is a first step to understand the significance of aberrant GR levels in disease and behaviour...
  50. pmc Highly individual methylation patterns of alternative glucocorticoid receptor promoters suggest individualized epigenetic regulatory mechanisms
    Jonathan D Turner
    Institute of Immunology, Laboratoire National de Santé, Luxembourg, Germany
    Nucleic Acids Res 36:7207-18. 2008
    ....
  51. ncbi Effects of antibodies induced by a conjugate vaccine on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone absorptive transport, metabolism, and proliferation of human lung cells
    Stefan S De Buck
    Institute of Immunology, LNS CRP Santé, Luxembourg, Grand Duchy of Luxembourg
    Int J Cancer 127:513-20. 2010
    ..These in vitro data therefore suggest that a prophylactic antibody response may be associated with a reduced risk of cancer...
  52. ncbi Hepatitis B virus genotype E surface antigen detection with different immunoassays and diagnostic impact of mutations in the preS/S gene
    Christophe M Olinger
    Institute of Immunology, National Public Health Laboratory, 20A, rue Auguste Lumiere, 1950, Luxembourg, Luxembourg
    Med Microbiol Immunol 196:247-52. 2007
    ..4-100%) but differed considerably in specificity (84-99%). Failure to detect HBsAg antigen and differences in signal intensity were mainly associated with mutations in the preS/S gene outside the "a" determinant...
  53. doi Extensive phosphorylation flanking the C-terminal functional domains of the measles virus nucleoprotein
    Emmanuel J F Prodhomme
    Institute of Immunology, Laboratoire National de Santé and Centre de Recherche Public Santé, L 1011 Luxembourg, Grand Duchy of Luxembourg
    J Proteome Res 9:5598-609. 2010
    ..They clustered around functional domains involved in transcription and replication, as well as in sequences interacting with host-cell proteins. This underlines the importance of these post-translational modifications...
  54. doi Diurnal redistribution of human lymphocytes and their temporal associations with salivary cortisol
    Slavena T Trifonova
    Institute of Immunology, Centre de Recherche Public de la Sante Laboratoire National de Sante, Luxembourg, Grand Duchy of Luxembourg
    Chronobiol Int 30:669-81. 2013
    ..In conclusion, our results suggest that cortisol and the HPA axis orchestrate tidal waves of immune cells that are alternatively based toward innate and acquired immune surveillance...
  55. doi Interplay of measles virus with early induced cytokines reveals different wild type phenotypes
    Julia R Kessler
    Laboratoire National de Santé, Institute of Immunology, Centre de Recherche Public Santé WHO Regional Reference, 20A rue Auguste Lumière, L 1950 Luxembourg, Luxembourg
    Virus Res 155:195-202. 2011
    ..The present data show that MV wt strains differ in their sensitivity and their ability to temper with the innate immune response, which may result in differences in virulence...
  56. pmc Evaluation of commercial assay detecting specific immunoglobulin g in oral fluid for determining measles immunity in vaccinees
    Jacques R Kremer
    Institute of Immunology, WHO Collaborative Centre for Measles, WHO European Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Santé, L 1011 Luxembourg
    Clin Diagn Lab Immunol 12:668-70. 2005
    ..4%; confidence interval: -1.5 to -13.2%; P = 0.01) due to a reduced sensitivity when antibody levels were low...
  57. ncbi Experimental vaccines against measles in a world of changing epidemiology
    Mike M Putz
    Department of Immunology, Laboratoire National de Santé, 20A rue Auguste Lumière, 1950 Luxembourg, Luxembourg
    Int J Parasitol 33:525-45. 2003
    ..While some of these candidate vaccines have proven their efficacy in monkey studies, aerosol formulated live attenuated measles vaccine are evaluated in clinical trials...
  58. pmc High genetic diversity of measles virus, World Health Organization European Region, 2005-2006
    Jacques R Kremer
    World Health Organization WHO Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Santé Immunology 20A, rue Auguste Lumiere, Luxembourg, Luxembourg
    Emerg Infect Dis 14:107-14. 2008
    ..Thus, despite the reduction of endemic MV circulation, importation of MV from other continents caused prolonged circulation and large outbreaks after their introduction into unvaccinated and highly mobile communities...
  59. pmc Differential effects of NS1 proteins of human pandemic H1N1/2009, avian highly pathogenic H5N1, and low pathogenic H5N2 influenza A viruses on cellular pre-mRNA polyadenylation and mRNA translation
    Denis E Kainov
    Institute of Immunology, Centre de Recherche Public Santé Laboratoire National de Santé, L 1011, Luxembourg
    J Biol Chem 286:7239-47. 2011
    ..Thus, we identified strain-specific differences between influenza virus NS1 proteins in pre-mRNA polyadenylation and mRNA translation...
  60. doi Emergence of oseltamivir-resistant influenza A H1N1 virus during the 2007-2008 winter season in Luxembourg: clinical characteristics and epidemiology
    Joel Mossong
    Microbiology, National Health Laboratory, PO Box 1102, L 1011 Luxembourg, Luxembourg
    Antiviral Res 84:91-4. 2009
    ..Following initial local seeding, oseltamivir-resistant strains spread synchronously to sensitive strains causing a similar epidemiology and clinical symptoms...
  61. ncbi Hepatitis B virus: the genotype E puzzle
    Iris E Andernach
    Institute of Immunology, Laboratoire National de Santé CRP Santé, 20A rue Auguste Lumière, L 1950 Luxembourg, Luxembourg
    Rev Med Virol 19:231-40. 2009
    ....
  62. doi Reassortant low-pathogenic avian influenza H5N2 viruses in African wild birds
    Chantal J Snoeck
    Institute of Immunology, CRP Santé and Laboratoire National de Santé, Luxembourg
    J Gen Virol 92:1172-83. 2011
    ....
  63. ncbi Neutralizing B cell response in measles
    Fabienne B Bouche
    Department of Immunology and WHO Collaborating Center for Measles, Laboratoire National de Santé, Luxembourg, Luxembourg
    Viral Immunol 15:451-71. 2002
    ..Major neutralizing epitopes have been mapped mainly on the hemagglutinin protein with monoclonal antibodies, producing an increasingly comprehensive map of functional domains...
  64. pmc Rubella seroprevalence among pregnant women in Burkina Faso
    Marc C Tahita
    Institut de recherche en sciences de la sante, 399 Avenue de la liberté, Bobo Dioulasso BP 545, Burkina Faso
    BMC Infect Dis 13:164. 2013
    ..Despite the serious consequences of rubella infection during early pregnancy, very little is known about the rubella seroprevalence in a number of African countries including Burkina Faso...
  65. ncbi A new transcript splice variant of the human glucocorticoid receptor: identification and tissue distribution of hGR Delta 313-338, an alternative exon 2 transactivation domain isoform
    Jonathan D Turner
    Institute of Immunology, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1011 Luxembourg, Grand Duchy of Luxembourg
    Ann N Y Acad Sci 1095:334-41. 2007
    ..It is thought that phosphorylation plays an important role in transactivation action of hGR. Thus, we hypothesize that hGRDelta313-338 represents a hGR isoform with an altered glucocorticoid-induced transactivation profile...
  66. ncbi Sub-acute administration of benzo[a]pyrene (B[a]P) reduces anxiety-related behaviour in adult mice and modulates regional expression of N-methyl-D-aspartate (NMDA) receptors genes in relevant brain regions
    Nathalie Grova
    Institute of Immunology, Laboratoire National de Santé, 20A rue Auguste Lumière, P O Box 1102, L 1011 Luxembourg, Luxembourg
    Chemosphere 73:S295-302. 2008
    ..In conclusion, a sub-acute exposure to B[a]P (20 and 200 mg kg(-1)) reduced anxiety-related behaviour in adult mice and concomitantly impaired NMDA receptor gene expression in relevant brain regions...
  67. doi Transcriptional control of the human glucocorticoid receptor: identification and analysis of alternative promoter regions
    Lei Cao-Lei
    Institute of Immunology, CRP Santé Laboratoire National de Santé, 20A rue Auguste Lumière, Luxembourg, Grand Duchy of Luxembourg
    Hum Genet 129:533-43. 2011
    ..This complexity within the CpG island helps to explain the variable, tissue-specific transcriptional control of the GR, and provides insight into the mechanisms underlying tissue specific deregulation of GR levels...
  68. ncbi Evaluation of adjuvants for a candidate conjugate vaccine against benzo[a]pyrene
    Mario T Schellenberger
    Institute of Immunology, CRP Santé LNS, Luxembourg, Grand Duchy of Luxembourg
    Hum Vaccin 7:166-73. 2011
    ..Our findings demonstrate that a vaccination against B[a]P is feasible in combination with adjuvants licensed in humans...
  69. ncbi Structure of the glucocorticoid receptor (NR3C1) gene 5' untranslated region: identification, and tissue distribution of multiple new human exon 1
    Jonathan D Turner
    Institute of Immunology, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1011, Luxembourg
    J Mol Endocrinol 35:283-92. 2005
    ....
  70. pmc Detection of new Francisella-like tick endosymbionts in Hyalomma spp. and Rhipicephalus spp. (Acari: Ixodidae) from Bulgaria
    Ivan N Ivanov
    National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria
    Appl Environ Microbiol 77:5562-5. 2011
    ..The FLEs were characterized by 16S rRNA and tul4 gene sequencing and seem to lack the molecular marker RD1. These two new taxa seem to be facultative secondary endosymbionts of ticks...
  71. ncbi Glucocorticoid receptor gene expression and promoter CpG modifications throughout the human brain
    Lei Cao-Lei
    Institute of Immunology, Centre de Recherche Public de la Santé, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1950 Luxembourg, Luxembourg Department of Immunology, Research Institute of Psychobiology, University of Trier, D 54290 Trier, Germany
    J Psychiatr Res 47:1597-607. 2013
    ..In both promoters 1F and 1H modification levels correlated with GRα expression suggesting that 5-mC and 5-hmC play an important role in fine tuning GR expression levels throughout the brain. ..
  72. pmc Epigenetic regulation of the glucocorticoid receptor promoter 1(7) in adult rats
    Simone R Witzmann
    Institute of Immunology, Centre de Recherche Public de la Santé and National Public Health Laboratory, Luxembourg, Luxembourg
    Epigenetics 7:1290-301. 2012
    ..Differences in methylation susceptibility between the PVN in the perinatal period and the peripheral HPA axis tissues in adulthood may represent an important "trait" vs. "state" regulation of the Gr gene...
  73. ncbi Modulation of behavior and NMDA-R1 gene mRNA expression in adult female mice after sub-acute administration of benzo(a)pyrene
    Nathalie Grova
    Institute of Immunology, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1011 Luxembourg, Luxembourg
    Neurotoxicology 28:630-6. 2007
    ....
  74. ncbi Modelling measles re-emergence as a result of waning of immunity in vaccinated populations
    Joel Mossong
    Laboratoire National de Santé, P O Box 1102, L 1011 Luxembourg, Luxembourg
    Vaccine 21:4597-603. 2003
    ..Although waning of humoral immunity in vaccinees is widely observed, re-emergence of measles in highly vaccinated populations depends on parameters for which better estimates are needed...
  75. ncbi Adhesion molecules and cytokine expression in fibromyalgia patients: increased L-selectin on monocytes and neutrophils
    Joana A Macedo
    Institute of Immunology, Laboratoire National de Santé, Luxembourg
    J Neuroimmunol 188:159-66. 2007
    ..This study shows a slight disturbance in the innate immune system of FM patients, and suggests an enhanced adhesion and recruitment of leukocytes to inflammatory sites...
  76. pmc Pathogen prevalence in ticks collected from the vegetation and livestock in Nigeria
    Anna L Reye
    Institute of Immunology, Centre de Recherche Public de la Santé National Public Health Laboratory, Luxembourg, Luxembourg
    Appl Environ Microbiol 78:2562-8. 2012
    ..6% for a Rickettsia africae-like species, 27% for Coxiella burnetii, and 8.5% for Anaplasma marginale/centrale suggest that these pathogens may have considerable implications for human and animal health...
  77. ncbi Synthesis of 4-[2-aminoethyl(nitrosamino)]-1-pyridin-3-yl-butan-1-one, a new NNK hapten for the induction of N-nitrosamine-specific antibodies
    Emmanuel J F Prodhomme
    Institute of Immunology, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1011, Luxembourg, Luxembourg
    Bioconjug Chem 18:2045-53. 2007
    ..Therefore, such antibodies detect NNK and NNAL and may have the potential to modulate their redistribution in vivo, perhaps reducing some detrimental effects of smoking...
  78. pmc Interindividual variability and co-regulation of DNA methylation differ among blood cell populations
    Monique Jacoby
    Institute of Immunology, Centre de Recherche Public de la Sante Laboratoire National de Sante, Luxembourg, Luxembourg
    Epigenetics 7:1421-34. 2012
    ..Taken together, our data suggest that unsorted mononuclear cells are reasonable surrogates of CD8+ and, to a lesser extent, CD4+ T cell methylation in adult peripheral, but not in neonatal, cord blood...
  79. ncbi The rationale of a peptide-conjugate vaccine against measles
    Mike M Putz
    Department of Immunology, PO Box 1102, 20A rue Auguste Lumière, 1950, Luxembourg, Luxembourg
    Vaccine 21:663-6. 2003
    ..Such a vaccine induces carrier-specific T cells, avoiding measles-specific Th2 cells associated with the risk of atypical measles. This article discusses the rationale of such a strategy and its future potential...
  80. pmc Prevalence and seasonality of tick-borne pathogens in questing Ixodes ricinus ticks from Luxembourg
    Anna L Reye
    Institute of Immunology, National Public Health Laboratory CRP Santé, Luxembourg, Luxembourg
    Appl Environ Microbiol 76:2923-31. 2010
    ..We also found Hepatozoon canis (0.1%) and Bartonella henselae (0.3%), which so far have not been found in questing Ixodes ricinus ticks in Central Europe...
  81. ncbi Immunopropylactic approaches against chemical carcinogenesis
    Stefan S De Buck
    Institute of Immunology, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1011 Luxembourg, Luxembourg
    Vaccine 23:2403-6. 2005
    ..Studies at immunoprophylactic intervention in carcinogenicity are discussed...
  82. doi The use of saliva for assessment of cortisol pulsatile secretion by deconvolution analysis
    Slavena T Trifonova
    Institute of Immunology, Centre de Recherche Public de la Sante Laboratoire National de Sante, Luxembourg, Luxembourg
    Psychoneuroendocrinology 38:1090-101. 2013
    ....
  83. ncbi Tissue specific glucocorticoid receptor expression, a role for alternative first exon usage?
    Jonathan D Turner
    Institute of Immunology, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1950 Luxembourg, Grand Duchy of Luxembourg
    Biochem Pharmacol 72:1529-37. 2006
    ..Spreading the necessary promoter elements over multiple promoter regions, each with an associated alternative transcription initiation site would appear to vastly increase the capacity for transcriptional control of GR...
  84. ncbi Modulation of the metabolism and adverse effects of benzo[a]pyrene by a specific antibody: a novel host factor in environmental carcinogenesis?
    Stefan S De Buck
    Institute of Immunology, Laboratoire National de Santé, Rue Auguste Lumière 20A, L 1011 Luxembourg, Luxembourg, Belgium
    Carcinogenesis 26:835-44. 2005
    ..These in vitro data also suggest that a natural or prophylactic antibody response against carcinogens may be associated with a reduced risk of cancer...
  85. ncbi Prevalence of antibodies against canine distemper virus among red foxes in Luxembourg
    Benjamin C Damien
    Department of Immunology, Laboratoire National de Santé, 20A rue Auguste Lumière, L 1011 Luxembourg, Luxembourg
    J Wildl Dis 38:856-9. 2002
    ..About 9 to 13% of the Luxembourg red fox population is positive for antibodies against CDV. Thus a sizeable proportion of red foxes has been exposed to CDV in the wild. The significance of CDV in red foxes is discussed...
  86. ncbi Central African Republic is part of the West-African hepatitis B virus genotype E crescent
    Claudine Bekondi
    Laboratoire de Virologie, Unité des Rétrovirus et des Hépatites virales, Institut Pasteur de Bangui, rue Pasteur, BP 923 Bangui, Republique Centrafricaine
    J Clin Virol 40:31-7. 2007
    ..Recent studies have shown that Hepatitis B virus (HBV) genotype E predominates in a vast crescent in West-Africa spanning from Senegal to Angola...
  87. ncbi Immunogenicity of peptides of measles virus origin and influence of adjuvants
    Beata Halassy
    Institute of Immunology, Research and Development Department, Rockefellerova 10, HR 10000 Zagreb, Croatia
    Vaccine 24:185-94. 2006
    ..Further improvement of immune response was obtained after incorporation of such a peptide mixture into oil-based adjuvants...
  88. ncbi Functional fine-mapping and molecular modeling of a conserved loop epitope of the measles virus hemagglutinin protein
    Mike M Putz
    Department of Immunology, Laboratoire National de Santé, Luxembourg Fakultät für Chemie und Pharmazie, Universitat Tubingen, Germany
    Eur J Biochem 270:1515-27. 2003
    ....
  89. ncbi Improved antiviral activity in vitro of ribavirin against measles virus after complexation with cyclodextrins
    Nicolas Grancher
    Groupe d Etude des Vecteurs Supramoléculaires du Médicament, Unité Mixte de Recherche Université CNRS 7565, Structure et Réactivité des Systèmes Moléculaires Complexes, Universite Henri Poincare, Nancy 1, France
    Antiviral Res 62:135-7. 2004
    ..Complexation of RBV with alpha-CD or beta-CD lead to a five-fold or a two-fold decrease in the 50% inhibitory concentration, respectively, against both MEV strains. In contrast, gamma-CD complexation showed no modification...
  90. pmc Identification of a second major site for CD46 binding in the hemagglutinin protein from a laboratory strain of measles virus (MV): potential consequences for wild-type MV infection
    Nicolas Masse
    INSERM U404, Immunité et Vaccination, CERVI, IFR 74, 21 Avenue Tony Garnier, 69365 Lyon Cedex 07, France
    J Virol 76:13034-8. 2002
    ..Our results suggest that although wt MV interacts with SLAM with high affinity, it also possesses the capacity to interact with CD46 with low affinity...
  91. ncbi Determination of hepatitis B virus genotype by flow-through reverse dot blot
    Ren Zhang
    Department of Human Anatomy and DaAn Gene Diagnostic Center of Sun Yat Sen University, Guangzhou, PR China
    J Clin Virol 39:94-100. 2007
    ..Most methods of determining the viral genotype are relatively time-consuming and costly. Moreover, the results of some methods are influenced by single nucleotide mutations...
  92. ncbi High-performance microtiter plates for immunosorbent assays made of renewable resources: polylactic acid biopolymer as a substitute for synthetic polystyrene
    Fabienne B Bouche
    Laboratoire National de Santé, PO Box 1102, L 1011 Luxembourg, Luxembourg pab productions, Bürgermeister Herzog Strasse 5, D 85241 Hebertshausen, Germany
    Clin Chem 48:378-80. 2002