Use of an inspiratory impedance valve improves neurologically intact survival in a porcine model of ventricular fibrillationKeith G Lurie
Cardiac Arrhythmia Center, Department of Medicine, University of Minnesota, Minneapolis 55455, USA
Circulation 105:124-9. 2002
..This study evaluated the potential for an inspiratory impedance threshold valve (ITV) to improve 24-hour survival and neurological function in a pig model of cardiac arrest...
No assisted ventilation cardiopulmonary resuscitation and 24-hour neurological outcomes in a porcine model of cardiac arrestDemetris Yannopoulos
Division of Cardiology, University of Minnesota, Minneapolis, MN, USA
Crit Care Med 38:254-60. 2010
..To evaluate the effect of no assisted ventilation cardiopulmonary resuscitation on neurologically intact survival compared with ten positive pressure ventilations/minute cardiopulmonary resuscitation in a pig model of cardiac arrest...
- Comparison of a 10-breaths-per-minute versus a 2-breaths-per-minute strategy during cardiopulmonary resuscitation in a porcine model of cardiac arrest
Keith G Lurie
Department of Emergency Medicine, University of Minnesota, Minneapolis, Minnesota, USA
Respir Care 53:862-70. 2008
..Hyperventilation during cardiopulmonary resuscitation (CPR) is harmful...
- Ischemic postconditioning at the initiation of cardiopulmonary resuscitation facilitates functional cardiac and cerebral recovery after prolonged untreated ventricular fibrillation
Nicolas Segal
Cardiovascular Division, University of Minnesota, Minneapolis 55455 0341, USA
Resuscitation 83:1397-403. 2012
..We hypothesized that four 20-s pauses during the first 3 min of standard CPR would improve post resuscitation cardiac and neurological function, in a porcine model of prolonged untreated cardiac arrest...
- Effect of cough on heart rate and blood pressure in patients with "cough syncope"
David G Benditt
Cardiac Arrhythmia Center, Department of Medicine, Cardiovascular Division, University of Minnesota Medical School, Minneapolis, Minnesota, USA
Heart Rhythm 2:807-13. 2005
..quot;Cough syncope" is uncommon, and its mechanism remains controversial...
- Reducing ventilation frequency combined with an inspiratory impedance device improves CPR efficiency in swine model of cardiac arrest
Demetris Yannopoulos
Department of Medicine, University of Minnesota (DY, Minneapolis, MN 55455, USA
Resuscitation 61:75-82. 2004
..CONCLUSION: CPR efficiency can be optimized by changing the compression: ventilation ratio from 5:1 to 10:1 and with concurrent use of the inspiratory threshold device...
- Comparison of ventricular arrhythmia frequency in patients with ischemic cardiomyopathy versus nonischemic cardiomyopathy treated with implantable cardioverter defibrillators
Cengiz Ermis
Cardiac Arrhythmia Center, University of Minnesota Medical School, Minneapolis, MN, USA
Am J Cardiol 96:233-8. 2005
....
- Inspiratory impedance threshold device effects on hypotension in heat-stroked swine
Wolfgang G Voelckel
Minneapolis Medical Research Foundation, Cardiac Arrhythmia Center, Department of Emergency Medicine, Minneapolis, MN, USA
Aviat Space Environ Med 79:743-8. 2008
....
Controlled pauses at the initiation of sodium nitroprusside-enhanced cardiopulmonary resuscitation facilitate neurological and cardiac recovery after 15 mins of untreated ventricular fibrillationDemetris Yannopoulos
Cardiovascular Division, Department of Emergency Medicine, University of Minnesota, Minneapolis, MN, USA
Crit Care Med 40:1562-9. 2012
..The primary study end point was 24-hr survival with favorable neurologic function after 15 mins of untreated ventricular fibrillation...
- Sodium nitroprusside enhanced cardiopulmonary resuscitation prevents post-resuscitation left ventricular dysfunction and improves 24-hour survival and neurological function in a porcine model of prolonged untreated ventricular fibrillation
Jason Schultz
Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, MN 55455 0341, USA
Resuscitation 82:S35-40. 2011
..We hypothesize that SNPeCPR will improve post resuscitation left ventricular function and neurological function compared to standard (S) CPR after 15 min of untreated ventricular fibrillation in a porcine model of cardiac arrest...
- Impact of upgrade to cardiac resynchronization therapy on ventricular arrhythmia frequency in patients with implantable cardioverter-defibrillators
Cengiz Ermis
Cardiac Arrhythmia Center, University of Minnesota Medical School, Minneapolis, Minnesota, USA
J Am Coll Cardiol 46:2258-63. 2005
..Thus, apart from hemodynamic benefits, CRT may also ameliorate ventricular tachyarrhythmia susceptibility in HF patients...
- Comparison of catecholamine response during tilt-table-induced vasovagal syncope in patients <35 to those >65 years of age
Cengiz Ermis
Cardiac Arrhythmia Center, Department of Medicine, Cardiovascular Division, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Am J Cardiol 93:225-7. 2004
....
- Hemodynamic and respiratory effects of negative tracheal pressure during CPR in pigs
Demetris Yannopoulos
Department of Cardiology, Cardiac Arrhythmia Center, University of Minnesota, Minneapolis, MN, USA
Resuscitation 69:487-94. 2006
..The beneficial hemodynamic effects of ITPR-CPR were sustained at least 15 min without any compromise in oxygenation...
- Intrathoracic pressure regulation improves vital organ perfusion pressures in normovolemic and hypovolemic pigs
Demetris Yannopoulos
University of Minnesota, Division of Cardiology, MN, USA
Resuscitation 70:445-53. 2006
..The decrease in ICP was directly proportional to the reduction in intrathoracic pressure. The effects were more pronounced in severe hypovolemic and hypotensive states with more negative ETP pressure...
- Intrathoracic pressure regulation for intracranial pressure management in normovolemic and hypovolemic pigs
Demetris Yannopoulos
Department of Cardiology, University of Minnesota, Minneapolis, Minnesota, USA
Crit Care Med 34:S495-500. 2006
..The effect was most pronounced in the hypovolemic animals...
- Intrathoracic pressure regulation improves 24-hour survival in a porcine model of hypovolemic shock
Demetris Yannopoulos
Department of Cardiology, University of Minnesota, Minneapolis, Minnesota, USA
Anesth Analg 104:157-62. 2007
..We hypothesized that application of intermittent negative intrathoracic pressure in a pig model of severe hypovolemic hypotension would increase 24-h neurological intact survival rates...
- Reduced atrial tachyarrhythmia susceptibility after upgrade of conventional implanted pulse generator to cardiac resynchronization therapy in patients with heart failure
Demetris Yannopoulos
Cardiac Arrhythmia Center, Department of Medicine, Cardiovascular Division, University of Minnesota Medical School, the University of Minnesota Medical Center Fairview, Minneapolis, Minnesota, USA
J Am Coll Cardiol 50:1246-51. 2007
....
- Feasibility and effects of transcutaneous phrenic nerve stimulation combined with an inspiratory impedance threshold in a pig model of hemorrhagic shock
Nemer Samniah
Cardiac Arrhythmia Center, Department of Medicine/Cardiovascular Division, University of Minnesota Medical School, MMC 508, AHC, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Crit Care Med 31:1197-202. 2003
..CONCLUSIONS: This feasibility study suggests that phrenic nerve stimulation with the inspiratory threshold valve may improve cardiac preload and, subsequently, key hemodynamic variables in porcine model of severe hemorrhagic shock...
- Biventricular implantable cardioverter defibrillators improve survival compared with biventricular pacing alone in patients with severe left ventricular dysfunction
Cengiz Ermis
Cardiac Arrhythmia Center, University of Minnesota Medical School, Minneapolis, Minnesota, USA
J Cardiovasc Electrophysiol 15:862-6. 2004
..Furthermore, this benefit may be most apparent if other clinical factors do not preclude patient survival >1 year postimplant...
- Combination drug therapy with vasopressin, adrenaline (epinephrine) and nitroglycerin improves vital organ blood flow in a porcine model of ventricular fibrillation
Keith G Lurie
Cardiac Arrhythmia Center, Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
Resuscitation 54:187-94. 2002
..Addition of nitroglycerin to the combination of low dose epinephrine with vasopressin during cardiac arrest may be beneficial...
- Intrathoracic pressure regulator during continuous-chest-compression advanced cardiac resuscitation improves vital organ perfusion pressures in a porcine model of cardiac arrest
Demetris Yannopoulos
Department of Cardiology, Cardiac Arrhythmia Center, University of Minnesota, Minneapolis, MN, USA
Circulation 112:803-11. 2005
..CONCLUSIONS: Compared with STD-CPR, use of ITPR-CPR improved hemodynamics and short-term survival rates after cardiac arrest...
- Relationship of paroxysmal atrial tachyarrhythmias to volume overload: assessment by implanted transpulmonary impedance monitoring
Rajat Jhanjee
Cardiac Arrhythmia Center, Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA
Circ Arrhythm Electrophysiol 2:488-94. 2009
..The goal of this study was to determine whether periods of greater intrathoracic fluid congestion (as detected by OI) correspond with increased AT event frequency...
- Transient modification of baroreceptor response during tilt-induced vasovagal syncope
Nemer Samniah
Cardiac Arrhythmia Center, Cardiovascular Division, Department of Medicine, University of Minnesota, 420 Delaware Street SE, MMC 508, Minneapolis, MN 55455, USA
Europace 6:48-54. 2004
..This altered response may undermine the normal expected compensatory response to evolving systemic hypotension. The basis for this transient disturbance in baroreceptor responsiveness is currently unknown...
- Cardiorespiratory interactions and blood flow generation during cardiac arrest and other states of low blood flow
Gardar Sigurdsson
Cardiac Arrhythmia Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
Curr Opin Crit Care 9:183-8. 2003
....
- Sodium nitroprusside enhanced cardiopulmonary resuscitation improves survival with good neurological function in a porcine model of prolonged cardiac arrest
Demetris Yannopoulos
Department of Medicine, University of Minnesota, Minneapolis St Paul, MN, USA
Crit Care Med 39:1269-74. 2011
..The combination of active compression-decompression CPR+ITD+AB without SNP will be called "enhanced" or eCPR...
- Advances in cardiopulmonary resuscitation
Demetris Yannopoulos
Department of Medicine, Interventional Cardiology, University of Minnesota, 420 Delaware Street, MMC 508, Minneapolis, MN 55455, USA
Heart Fail Clin 7:251-68, ix. 2011
..Special emphasis is given to the basic simple ways to improve circulation, vital organ perfusion pressures, and the grave prognosis of sudden cardiac death...
- Effects of active compression-decompression cardiopulmonary resuscitation with the inspiratory threshold valve in a young porcine model of cardiac arrest
Wolfgang G Voelckel
Cardiac Arrhythmia Center, Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
Pediatr Res 51:523-7. 2002
..In conclusion, the combination of ACD + ITV CPR significantly increased both coronary perfusion pressure and vital organ blood flow after prolonged standard CPR in this young porcine model of ventricular fibrillation...
- Clinical and hemodynamic comparison of 15:2 and 30:2 compression-to-ventilation ratios for cardiopulmonary resuscitation
Demetris Yannopoulos
University of Minnesota, Minneapolis, MN, USA
Crit Care Med 34:1444-9. 2006
..CONCLUSIONS: These data strongly support the contention that a ratio of 30:2 is superior to 15:2 during manual CPR and that the ITD further enhances circulation with both C:V ratios...
- Evaluation of a prototypic inspiratory impedance threshold valve designed to enhance the efficiency of cardiopulmonary resuscitation
Keith G Lurie
Cardiac Arrhythmia Center, Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA
Respir Care 48:52-7. 2003
..Assess a prototype inspiratory impedance threshold valve (ITV) designed to enhance vital organ circulation during standard and active compression/decompression cardiopulmonary resuscitation (CPR)...
- Augmentation of ventricular preload during treatment of cardiovascular collapse and cardiac arrest
Keith G Lurie
Department of Medicine, Cardiovascular Division, Cardiac Arrhythmia Center, University of Minnesota, Minneapolis, MN, USA
Crit Care Med 30:S162-5. 2002
....
- Implantable diagnostic monitoring devices for evaluation of syncope, and tachy- and brady-arrhythmias
David G Benditt
Cardiac Arrhythmia Center, University of Minnesota Medical School, 420 Delaware Street SE, Minneapolis, MN 55455, USA
J Interv Card Electrophysiol 9:137-44. 2003
....
- Suppression of cautery-induced electromagnetic interference of cardiac implantable electrical devices by closely spaced bipolar sensing
Mithun Suresh
Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Anesth Analg 112:1358-61. 2011
..Because sensing by closely spaced electrodes (i.e., true bipolar) may be less susceptible to EMI, preoperative programming to a true bipolar mode may minimize the need for perioperative programming while preserving device function...
- Improved survival of cardiac transplantation candidates with implantable cardioverter defibrillator therapy: role of beta-blocker or amiodarone treatment
Cengiz Ermis
Cardiac Arrhythmia Center, Cardiovascular Division, University of Minnesota Medical School, Minneapolis, Minnesota 55436, USA
J Cardiovasc Electrophysiol 14:578-83. 2003
..003). CONCLUSION: ICD therapy is associated with improved survival in high-risk cardiac transplant candidates, and ICD benefit appears to be independent of concomitant treatment...
- Cardiac arrest, mild therapeutic hypothermia, and unanticipated cerebral recovery
Demetris Yannopoulos
Department of Medicine, Cardiovascular Division, University of Minnesota, Minneapolis, Minnesota 55455, USA
Neurologist 13:369-75. 2007
....
- Adrenal/renal contribution to circulating norepinephrine in posturally induced neurally mediated reflex syncope
Cengiz Ermis
Cardiac Arrhythmia Center, Department of Medicine, Cardiovascular Division, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Am J Cardiol 91:746-50. 2003
- Vital organ blood flow with the impedance threshold device
Tom P Aufderheide
Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Crit Care Med 34:S466-73. 2006
..Incorporation of the ITD into protocols that improve other aspects of the care of patients during cardiac arrest and after successful resuscitation should result in further benefit from the ITD...
- Reducing ventilation frequency during cardiopulmonary resuscitation in a porcine model of cardiac arrest
Demetris Yannopoulos
Minneapolis Medical Research Foundation, 914 South 8th Street, 3rd Floor, Minneapolis MN 55404, USA
Respir Care 50:628-35. 2005
....
- Emergency ventilatory management in hemorrhagic states: elemental or detrimental?
Paul E Pepe
Department of Surgery, University of Texas Southwestern Medical Center at Dallas, 75390 8579 USA
J Trauma 54:1048-55; discussion 1055-7. 2003
....
- Rapid induction of cerebral hypothermia is enhanced with active compression-decompression plus inspiratory impedance threshold device cardiopulmonary resusitation in a porcine model of cardiac arrest
Vijay Srinivasan
Department of Anesthesia and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
J Am Coll Cardiol 47:835-41. 2006
..3 +/- 2) than S-CPR pigs (17.4 +/- 3, p < 0.01). CONCLUSIONS: A rapid ice-cold saline infusion combined with ACD + ITD CPR during cardiac arrest induces cerebral hypothermia more rapidly immediately after ROSC than with S-CPR...
- Death by hyperventilation: a common and life-threatening problem during cardiopulmonary resuscitation
Tom P Aufderheide
Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Crit Care Med 32:S345-51. 2004
....
- Effects of an inspiratory impedance threshold device on blood pressure and short term survival in spontaneously breathing hypovolemic pigs
Gardar Sigurdsson
Hennepin County Medical Center, Minneapolis, MN, USA
Resuscitation 68:399-404. 2006
..Arterial oxygenation was not compromised in the ITD group. CONCLUSIONS: Use of an ITD improved blood pressure and short-term survival rates in a spontaneously breathing porcine model of hypovolemic hypotension...
- Hyperventilation-induced hypotension during cardiopulmonary resuscitation
Tom P Aufderheide
Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, USA
Circulation 109:1960-5. 2004
..Subsequent animal studies demonstrated that similar excessive ventilation rates resulted in significantly increased intrathoracic pressure and markedly decreased coronary perfusion pressures and survival rates...
- Effects of epinephrine and vasopressin in a piglet model of prolonged ventricular fibrillation and cardiopulmonary resuscitation
Wolfgang G Voelckel
Cardiac Arrhythmia Cente, Cardiovascular Division, Department of Medicine at the University of Minnesota, Minneapolis, MN, USA
Crit Care Med 30:957-62. 2002
..In stark contrast to asphyxial cardiac arrest, vasopressin alone or in combination with epinephrine appears to be of benefit after ventricular fibrillation in the pediatric porcine model...
- Vasopressor response in a porcine model of hypothermic cardiac arrest is improved with active compression-decompression cardiopulmonary resuscitation using the inspiratory impedance threshold valve
Claus Raedler
Department of Anesthesiology and Critical Care Medicine, Leopold Franzens University, Innsbruck, Austria
Anesth Analg 95:1496-502, table of contents. 2002
..Active compression-decompression CPR with the inspiratory threshold valve improved carotid blood flow (and coronary perfusion pressure with vasopressin) compared with standard CPR...
- Effects of incomplete chest wall decompression during cardiopulmonary resuscitation on coronary and cerebral perfusion pressures in a porcine model of cardiac arrest
Demetris Yannopoulos
Minneapolis Medical Research Foundation, 914 South 8th St, 3rd Floor, Minneapolis, MN 55404, USA
Resuscitation 64:363-72. 2005
..1, p = 0.045. CONCLUSIONS: Incomplete chest wall recoil during the decompression phase of CPR increases endotracheal pressure, impedes venous return and decreases mean arterial pressure, and coronary and cerebral perfusion pressures...
- Breathing through an inspiratory threshold device improves stroke volume during central hypovolemia in humans
Kathy L Ryan
U S Army Institute of Surgical Research, 3400 Rawley E Chambers Avenue, Fort Sam Houston, TX 78234 6315, USA
J Appl Physiol 104:1402-9. 2008
....
- Use of an inspiratory impedance threshold device on a facemask and endotracheal tube to reduce intrathoracic pressures during the decompression phase of active compression-decompression cardiopulmonary resuscitation
Patrick Plaisance
Department of Anesthesiology and Critical Care, , Paris, France
Crit Care Med 33:990-4. 2005
..Airway pressures with an ITD on either a facemask or ETT were similar. The ITD-facemask combination was practical and enables rapid deployment of this life-saving technology...
- Comparison of ventricular arrhythmia burden, therapeutic interventions, and survival, in patients < 75 and patients >or= 75 years of age treated with implantable cardioverter defibrillators
Cengiz Ermis
Cardiovascular Division, University of Akdeniz, Antalya, Turkey
Europace 9:270-4. 2007
..To address this question, we compared ICD-documented ventricular tachyarrhythmia burden in patients < 75 years of age (Group 1) and >or= 75 years of age (Group 2)...
- Comparison of standard cardiopulmonary resuscitation versus the combination of active compression-decompression cardiopulmonary resuscitation and an inspiratory impedance threshold device for out-of-hospital cardiac arrest
Benno B Wolcke
The Johannes Gutenberg University Medical School, Clinic of Anesthesiology, Mainz, Germany
Circulation 108:2201-5. 2003
..07). CONCLUSIONS: Compared with S-CPR, ACD+ITD CPR significantly improved short-term survival rates for patients with out-of-hospital cardiac arrest. Additional studies are needed to evaluate potential long-term benefits of ACD+ITD CPR...
- Level 1 cardiac arrest centers: learning from the trauma surgeons
Keith G Lurie
Acad Emerg Med 12:79-80. 2005
- Incomplete chest wall decompression: a clinical evaluation of CPR performance by EMS personnel and assessment of alternative manual chest compression-decompression techniques
Tom P Aufderheide
Department of Emergency Medicine, Medical College of Wisconsin, 9200W. Wisconsin Avenue, FEH Room 1870, Milwaukee, WI 53226, USA
Resuscitation 64:353-62. 2005
..These data support development and testing of more effective means to deliver manual as well as mechanical CPR...
- Clinical evaluation of an inspiratory impedance threshold device during standard cardiopulmonary resuscitation in patients with out-of-hospital cardiac arrest
Tom P Aufderheide
Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
Crit Care Med 33:734-40. 2005
..A larger clinical trial is underway to determine the potential longer term benefits of the impedance threshold device in cardiac arrest...
- Inspiratory resistance as a potential treatment for orthostatic intolerance and hemorrhagic shock
Victor A Convertino
US Army Institute of Surgical Research, Fort Sam Houston, TX 78234 6315, USA
Aviat Space Environ Med 76:319-25. 2005
..In this brief review, we present evidence which supports further consideration of using inspiratory resistance as a countermeasure against circulatory collapse associated with orthostatic instability and hemorrhagic shock...
- Effect of an inspiratory impedance threshold device on hemodynamics during conventional manual cardiopulmonary resuscitation
Ronald G Pirrallo
Medical College of Wisconsin, Department of Emergency Medicine, 9200 W Wisconsin Ave, FEH Room 1870, Milwaukee, WI 53226, USA
Resuscitation 66:13-20. 2005
..The objective of this study was to determine whether an ITD would improve blood pressure (BP) in patients receiving CPR for out-of-hospital cardiac arrest...
- Effects of inspiratory impedance on the carotid-cardiac baroreflex response in humans
Victor A Convertino
US Army Institute of Surgical Research, 3400 Rawley E Chambers Avenue Building 3611, Fort Sam Houston TX 78234 6315, USA
Clin Auton Res 14:240-8. 2004
..This resetting of the cardiac baroreflex may represent a mechanism that allows blood pressure to increase without a reflex-mediated reduction in HR...
- Treatment of hypotension in pigs with an inspiratory impedance threshold device: a feasibility study
Keith G Lurie
Cardiac Arrhythmia Center at the University of Minnesota, Minneapolis, MN 55455, USA
Crit Care Med 32:1555-62. 2004
..An inspiratory impedance threshold device was evaluated in spontaneously breathing animals with hypotension to determine whether it could help improve systemic arterial pressures when fluid replacement was not immediately available...
- Evaluation of an impedance threshold device in patients receiving active compression-decompression cardiopulmonary resuscitation for out of hospital cardiac arrest
Patrick Plaisance
Department of Anesthesiology and Critical Care, Lariboisiere University Hospital, 2 rue Ambroise Pare, 75010 Paris, France
Resuscitation 61:265-71. 2004
....
- Detrimental hemodynamic effects of assisted ventilation in hemorrhagic states
Paul E Pepe
Department of Surgery, and the School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA
Crit Care Med 32:S414-20. 2004
..Current ventilatory protocols for trauma resuscitation should be re-examined and considered a possible cause of worsened clinical outcomes and unrecognized confounded study results...
- Spontaneous gasping decreases intracranial pressure and improves cerebral perfusion in a pig model of ventricular fibrillation
Vijay Srinivasan
Department of Anesthesia and Critical Care Medicine, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, PA 19104, USA
Resuscitation 69:329-34. 2006
..The potential beneficial effect of gasping on cerebral perfusion may underlie the observed survival benefit, but mechanisms remain unknown...
- Inspiratory impedance effects on hemodynamic responses to orthostasis in normal subjects
Victor A Convertino
U S Army Institute of Surgical Research, 3400 Rawley E Chambers Avenue, Building 3611, Fort Sam Houston, TX 78234 6315, USA
Aviat Space Environ Med 77:486-93. 2006
..Breathing through an impedance threshold device (ITD) might prove effective as a countermeasure against post-spaceflight orthostatic hypotension since it increased blood pressure (BP) and cardiac output in supine human subjects...
- Human autonomic and cerebrovascular responses to inspiratory impedance
William H Cooke
Department of Health and Kinesiology, University of Texas at San Antonio (W.H.C, San Antonio, Texas, and Department of Emergency Medicine, Minneapolis Medical Research Foundation and Hennepin County Medical Center, Minneapolis, Minnesota, USA
J Trauma 60:1275-83. 2006
..Use of an active ITD in situations of acute central hypovolemia, such as during hemorrhage, may slow the progression to hemodynamic instability in bleeding patients who retain the ability to ventilate spontaneously and robustly...
- Incomplete chest wall decompression: a clinical evaluation of CPR performance by trained laypersons and an assessment of alternative manual chest compression-decompression techniques
Tom P Aufderheide
Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Resuscitation 71:341-51. 2006
..Complete chest wall recoil improves hemodynamics during CPR by generating relatively negative intrathoracic pressure, which draws venous blood back to the heart, providing cardiac preload prior to the next chest compression...
- Spontaneous breathing through an inspiratory impedance threshold device augments cardiac index and stroke volume index in a pediatric porcine model of hemorrhagic hypovolemia
Bradley S Marino
Cardiac Center at the Children's Hospital of Philadelphia and the Department of Pediatrics, University of Pennsylvania School of Medicine, USA
Crit Care Med 32:S398-405. 2004
..These beneficial effects of ITD-assisted breathing are not changed by the addition of positive end-expiratory pressures of 3 cm H2O...
