Research Topics

Kenneth Lundstrom

Summary

Publications

  1. Lundstrom K. RNA Viruses as Tools in Gene Therapy and Vaccine Development. Genes (Basel). 2019;10: pubmed publisher
    ..Several clinical trials on cancer patients have generated anti-tumor activity, prolonged survival, and even progression-free survival. ..
  2. Lundstrom K. Plasmid DNA-based Alphavirus Vaccines. Vaccines (Basel). 2019;7: pubmed publisher
    ..In addition to DNA-based delivery, immunization with recombinant alphavirus particles and RNA replicons has demonstrated efficacy in providing protection against lethal challenges by infectious agents and tumor cells. ..
  3. Lundstrom K. Self-Replicating RNA Viruses for RNA Therapeutics. Molecules. 2018;23: pubmed publisher
    ..The purpose of this review is to summarize the achievements of using self-replicating RNA viruses for RNA therapy based on preclinical animal studies and clinical trials in humans. ..
  4. Lundstrom K. Alphaviruses in gene therapy. Viruses. 2015;7:2321-33 pubmed publisher
    ..Recent discoveries of the strong association of RNA interference and disease have accelerated gene therapy based approaches, where alphavirus-based gene delivery can play an important role. ..
  5. Lundstrom K. Viral Vectors in Gene Therapy. Diseases. 2018;6: pubmed publisher
    ..A number of preclinical studies have demonstrated therapeutic and prophylactic efficacy in animal models and furthermore in clinical trials. Several viral vector-based drugs have also been globally approved. ..
  6. Lundstrom K. Semliki forest virus-based expression of recombinant GPCRs. Methods Enzymol. 2015;556:331-50 pubmed publisher
    ..Furthermore, the high preference for neuronal delivery of SFV particles has allowed functional and localization studies of recombinant proteins in hippocampal slice cultures, in primary neurons, and in vivo. ..
  7. Lundstrom K. Alphavirus vectors as tools in neuroscience and gene therapy. Virus Res. 2016;216:16-25 pubmed publisher
    ..Due to the strong local transient expression provided by alphavirus vectors a number of immunization and gene therapy approaches have demonstrated both therapeutic and prophylactic efficacy in various animal models. ..
  8. Lundstrom K. Alphavirus-Based Vaccines. Methods Mol Biol. 2016;1404:313-28 pubmed publisher
    ..Moreover, vaccines have been developed against alphaviruses causing epidemics such as Chikungunya virus. ..
  9. Lundstrom K. Replicon RNA Viral Vectors as Vaccines. Vaccines (Basel). 2016;4: pubmed
    ..Overall, immunization with self-replicating RNA viruses provides high transient expression levels of antigens resulting in generation of neutralizing antibody responses and protection against lethal challenges under safe conditions. ..

More Information

Publications13

  1. Lundstrom K. Alphavirus-Based Vaccines. Methods Mol Biol. 2017;1581:225-242 pubmed publisher
    ..As alphaviruses also cause epidemics, vaccines have been developed against Chikungunya virus. Despite the success in several animal smodels only a few clinical trials have been conducted in humans, so far. ..
  2. Lundstrom K. Oncolytic Alphaviruses in Cancer Immunotherapy. Vaccines (Basel). 2017;5: pubmed publisher
    ..Furthermore, preclinical evaluation demonstrated both prophylactic and therapeutic efficacy of oncolytic alphavirus administration. Clinical trials in humans have mainly been limited to safety studies so far. ..
  3. Ajbani S, Velhal S, Kadam R, Patel V, Lundstrom K, Bandivdekar A. Immunogenicity of virus-like Semliki Forest virus replicon particles expressing Indian HIV-1C gag, env and polRT genes. Immunol Lett. 2017;190:221-232 pubmed publisher
    ..The immunogenicity of VRPs was found to be higher as compared to that of RNA replicons and VRPs may therefore be promising preventive and therapeutic candidate vaccines for the control and management of HIV/AIDS. ..
  4. Lundstrom K, Pham H, Dinh L. Interaction of Plant Extracts with Central Nervous System Receptors. Medicines (Basel). 2017;4: pubmed publisher
    ..However, additional investigations related to plant extracts and their isolated compounds, as well as their application in animal models and the conducting of clinical trials, are required. ..