Gérard Lucotte

Summary

Publications

  1. ncbi request reprint More about the Viking hypothesis of origin of the delta32 mutation in the CCR5 gene conferring resistance to HIV-1 infection
    Gérard Lucotte
    Centre de Neurogénétique Moléculaire, 44 rue Monge, 75005 Paris, France
    Infect Genet Evol 3:293-5. 2003
  2. ncbi request reprint North African genes in Iberia studied by Y-chromosome DNA haplotype 5
    G Lucotte
    International Institute of Anthropology, Paris, France
    Hum Biol 73:763-9. 2001
  3. doi request reprint Near fixation of 374l allele frequencies of the skin pigmentation gene SLC45A2 in Africa
    Gérard Lucotte
    Institute of Molecular Anthropology, 44 Monge Street, 75005, Paris, France
    Biochem Genet 51:655-65. 2013
  4. ncbi request reprint A European allele map of the C282Y mutation of hemochromatosis: Celtic versus Viking origin of the mutation?
    Gérard Lucotte
    International Institute of Anthropology, Paris, France
    Blood Cells Mol Dis 31:262-7. 2003
  5. ncbi request reprint Duplex PCR-RFLP for simultaneous detection of factor V Leiden and prothrombin G20210A
    G Lucotte
    Centre de Neurogénétique Moléculaire, 44 rue Monge, 75005 Paris, France
    Mol Cell Probes 17:267-9. 2003
  6. ncbi request reprint CCR5-Delta32 allele frequencies in Ashkenazi Jews
    G Lucotte
    Center of Neurogenetics, Paris, France
    Genet Test 7:333-7. 2003
  7. ncbi request reprint The population distribution of the Met allele at the PRNP129 polymorphism (a high risk factor for Creutzfeldt-Jakob disease) in various regions of France and in West Europe
    Gérard Lucotte
    Centre de Neurogénétique Moléculaire, 44 rue Monge, Paris 75005, France
    Infect Genet Evol 5:141-4. 2005
  8. ncbi request reprint The 35delG mutation in the connexin 26 gene (GJB2) associated with congenital deafness: European carrier frequencies and evidence for its origin in ancient Greece
    Gérard Lucotte
    Institute of Molecular Anthropology, 75005 Paris, France
    Genet Test 9:20-5. 2005
  9. ncbi request reprint High prevalences of carriers of the 35delG mutation of connexin 26 in the Mediterranean area
    Gérard Lucotte
    Center of Molecular Neurogenetics, 44 rue Monge, 75005 Paris, France
    Int J Pediatr Otorhinolaryngol 71:741-6. 2007
  10. ncbi request reprint Mutations of the noggin (NOG) and of the activin A type I receptor (ACVR1) genes in a series of twenty-seven French fibrodysplasia ossificans progressiva (FOP) patients
    G Lucotte
    Center of Molecular Neurogenetics, 75005 Paris, France
    Genet Couns 20:53-62. 2009

Collaborators

  • Isao Yuasa
  • Géraldine Mercier
  • Florent Dieterlen
  • Nathalie Gerard
  • Nathalie Change
  • Benoit Funalot
  • O Santt
  • F Jovelin
  • William C Nichols
  • Jordi Perez-Tur
  • Sala Berriche
  • Annie Aouizérate
  • Christian Bathelier
  • H Baranova
  • Y J Bignon
  • E Albuisson
  • S Berthaud
  • Stephane Panserat
  • F Huetz
  • M Mariotti

Detail Information

Publications34

  1. ncbi request reprint More about the Viking hypothesis of origin of the delta32 mutation in the CCR5 gene conferring resistance to HIV-1 infection
    Gérard Lucotte
    Centre de Neurogénétique Moléculaire, 44 rue Monge, 75005 Paris, France
    Infect Genet Evol 3:293-5. 2003
    ..We constructed an allele map of delta32 frequencies in Europe; the map is in accordance to the Vikings hypothesis of the origin of the mutation and his dissemination during the eighth to the tenth centuries...
  2. ncbi request reprint North African genes in Iberia studied by Y-chromosome DNA haplotype 5
    G Lucotte
    International Institute of Anthropology, Paris, France
    Hum Biol 73:763-9. 2001
    ..2% in Portugal, 12.1% in Catalonia, and 11.3% in the Basque Country; such a cline of decreasing frequency of haplotype 5 from the south to the north in Iberia clearly establishes a gene flow from North Africa towards Iberia...
  3. doi request reprint Near fixation of 374l allele frequencies of the skin pigmentation gene SLC45A2 in Africa
    Gérard Lucotte
    Institute of Molecular Anthropology, 44 Monge Street, 75005, Paris, France
    Biochem Genet 51:655-65. 2013
    ..Almost all the African populations located below 16° of latitude are fixed for the 374l allele. Peul, Toucouleur, and Soninké populations have 374l allele frequencies of 0.06, 0.03, and 0.03, respectively...
  4. ncbi request reprint A European allele map of the C282Y mutation of hemochromatosis: Celtic versus Viking origin of the mutation?
    Gérard Lucotte
    International Institute of Anthropology, Paris, France
    Blood Cells Mol Dis 31:262-7. 2003
    ..The highest European frequencies are observed in the Celtic populations in Ireland, in the United Kingdom, and in France, but elevated frequencies are also observed in Scandinavia...
  5. ncbi request reprint Duplex PCR-RFLP for simultaneous detection of factor V Leiden and prothrombin G20210A
    G Lucotte
    Centre de Neurogénétique Moléculaire, 44 rue Monge, 75005 Paris, France
    Mol Cell Probes 17:267-9. 2003
    ..This method is simple an inexpensive, and readily adaptable to the routine in a clinical molecular diagnostic laboratory other that our own...
  6. ncbi request reprint CCR5-Delta32 allele frequencies in Ashkenazi Jews
    G Lucotte
    Center of Neurogenetics, Paris, France
    Genet Test 7:333-7. 2003
    ..20, p < 0.03). Founder effect and genetic drift are proposed to explain the elevated values observed in Ashkenazi Jews and those originating from Lithuania...
  7. ncbi request reprint The population distribution of the Met allele at the PRNP129 polymorphism (a high risk factor for Creutzfeldt-Jakob disease) in various regions of France and in West Europe
    Gérard Lucotte
    Centre de Neurogénétique Moléculaire, 44 rue Monge, Paris 75005, France
    Infect Genet Evol 5:141-4. 2005
    ..We hypothesise that high Met 129 frequencies populations may be at higher risk for Creutzfeldt-Jakob disease...
  8. ncbi request reprint The 35delG mutation in the connexin 26 gene (GJB2) associated with congenital deafness: European carrier frequencies and evidence for its origin in ancient Greece
    Gérard Lucotte
    Institute of Molecular Anthropology, 75005 Paris, France
    Genet Test 9:20-5. 2005
    ..It is probable that the 35delG mutation originated in ancient Greece and was subsequently propagated in other Mediterranean countries (especially in Italy) during recent historical times...
  9. ncbi request reprint High prevalences of carriers of the 35delG mutation of connexin 26 in the Mediterranean area
    Gérard Lucotte
    Center of Molecular Neurogenetics, 44 rue Monge, 75005 Paris, France
    Int J Pediatr Otorhinolaryngol 71:741-6. 2007
    ..The aim of this study is to determinate the percentage of carriers in seven populations of the Mediterranean area and to compare prevalence of the mutation in seventeen other published populations in the same area...
  10. ncbi request reprint Mutations of the noggin (NOG) and of the activin A type I receptor (ACVR1) genes in a series of twenty-seven French fibrodysplasia ossificans progressiva (FOP) patients
    G Lucotte
    Center of Molecular Neurogenetics, 75005 Paris, France
    Genet Couns 20:53-62. 2009
    ..Mutations 274G>C, 283G>A and 617G>A segregate with the trait in five different FOP families, some members of them being partially affected by the disease...
  11. doi request reprint A decreasing gradient of 374F allele frequencies in the skin pigmentation gene SLC45A2, from the north of West Europe to North Africa
    Gérard Lucotte
    Institute of Molecular Anthropology, 44 rue Monge, Paris, France
    Biochem Genet 48:26-33. 2010
    ..869). The results confirm that the distribution of the 374F allele may reflect the ultraviolet radiation level and can be associated with skin color variation in these regions...
  12. pmc A rare variant of the mtDNA HVS1 sequence in the hairs of Napoléon's family
    Gérard Lucotte
    Institute of Molecular Anthropology, Paris, France
    Investig Genet 1:7. 2010
    ..This 16184C→T variant could be used for genetic verification to authenticate any doubtful material and determine whether it should indeed be attributed to Napoléon...
  13. ncbi request reprint Y-chromosome DNA haplotypes in Jews: comparisons with Lebanese and Palestinians
    Gérard Lucotte
    International Institute of Anthropology, Paris, France
    Genet Test 7:67-71. 2003
    ..These results confirm similarities in the Y-haplotype frequencies in Lebanese, Palestinian, and Sephardic Jewish men, three Near-Eastern populations sharing a common geographic origin...
  14. ncbi request reprint Frequencies of 32 base pair deletion of the (Delta 32) allele of the CCR5 HIV-1 co-receptor gene in Caucasians: a comparative analysis
    Gérard Lucotte
    Center of Molecular Neurogenetics, 44 rue Monge, Paris 5ème, France
    Infect Genet Evol 1:201-5. 2002
    ..Possibly variola virus has discriminated the Delta 32 carriers in Europe since the eighth century AD, explaining the high frequency of the Delta 32 allele in Europe today...
  15. ncbi request reprint Paternal European ancestry in French Polynesia detected by Y-chromosome haplotypes
    Gérard Lucotte
    International Institute of Anthropology, Paris, France
    Hum Biol 75:129-33. 2003
    ..The mean haplotype (45.6%) in French Polynesia is haplotype XV, a typical western European haplotype. Such an elevated frequency of European haplotypes is due to male gene flow from Europeans in French Polynesia...
  16. ncbi request reprint Meta-analysis of GJB2 mutation 35delG frequencies in Europe
    G Lucotte
    International Institute of Anthropology, Paris, France
    Genet Test 5:149-52. 2001
    ..527)...
  17. ncbi request reprint Distribution of the CCR5 gene 32-basepair deletion in West Europe. A hypothesis about the possible dispersion of the mutation by the Vikings in historical times
    G Lucotte
    International Institute of Anthropology, Paris, France
    Hum Immunol 62:933-6. 2001
    ....
  18. ncbi request reprint A rare case of a patient heterozygous for the hemochromatosis mutation C282Y and homozygous for H63D
    G Lucotte
    Center of Molecular Neurogenetics, Paris, France
    Blood Cells Mol Dis 27:892-3. 2001
    ..The C282Y and H63D mutations in the "cis" phase may thus account for some very rare cases...
  19. ncbi request reprint [Y-chromosome haplotypes in Corsica]
    Gérard Lucotte
    Institut international d anthropologie, 75016 Paris, France
    C R Biol 325:191-6. 2002
    ..Distribution of haplotypes can be explained by Corsican history and geography...
  20. ncbi request reprint Brief communication: Y-chromosome haplotypes in Egypt
    G Lucotte
    International Institute of Anthropology, Paris, France
    Am J Phys Anthropol 121:63-6. 2003
    ..9%). Haplotype V is a characteristic Arab haplotype, with a northern geographic distribution in Egypt in the Nile River Valley. Haplotype IV, characteristic of sub-Saharan populations, shows a southern geographic distribution in Egypt...
  21. ncbi request reprint North African genes in Iberia studied by Y-chromosome DNA haplotype V
    G Lucotte
    International Institute of Anthropology, Paris, France
    Hum Immunol 62:885-8. 2001
    ..8% in Andalusia, 36.2% in Portugal, 12.1% in Catalonia, and 11.3% in Basques; such a cline of decreasing haplotype V frequencies from the South to the North in Iberia clearly establishes a North African toward Iberian gene flow...
  22. doi request reprint Genetic screening of the G2019S mutation of the LRRK2 gene in Southwest European, North African, and Sephardic Jewish subjects
    Nathalie Change
    Center of Molecular Neurogenetics, Paris, France
    Genet Test 12:333-9. 2008
    ....
  23. ncbi request reprint Population distribution of the methionine allele at the PRNP codon 129 polymorphism in Europe and the Middle East
    Géraldine Mercier
    Institute of Molecular Anthropology, 44 rue Monge, 75005 Paris, France
    Hum Biol 80:181-90. 2008
    ..77) and longitude (r = 0.69). The geographic map of methionine allele frequencies indicates an east-west gradient of decreasing methionine allele values from the Middle East to Western Europe...
  24. ncbi request reprint Y-chromosome DNA haplotype XI in Eastern Europe
    Gérard Lucotte
    International Institute of Anthropology, Paris, France
    Hum Biol 75:405-10. 2003
    ..9%), and Hungary (40.7%). Percentages of haplotype XI geographic distribution show a gradient of decreasing frequency from these areas of higher percentages toward southeastern and more western countries in Europe...
  25. ncbi request reprint North African Berber and Arab influences in the western Mediterranean revealed by Y-chromosome DNA haplotypes
    Nathalie Gerard
    Institute of Molecular Anthropology, 44 rue Monge, 75005 Paris, France
    Hum Biol 78:307-16. 2006
    ..8%) and Andalusia (15.5%). In Iberia there is a gradient of decreasing frequencies in latitude for both subhaplotypes Va and Vb, related to eight centuries of Muslim domination (8th to 15th centuries) in southern Iberia...
  26. ncbi request reprint Connexin 26 mutation 35delG: prevalence of carriers in various regions in France
    Géraldine Mercier
    Center of Molecular Neurogenetics, 44 rue Monge, 75005 Paris, France
    Int J Pediatr Otorhinolaryngol 69:1187-90. 2005
    ..The prevalence of carriers varies, with a mean value proportion of 1/30 in Mediterranean countries. The aim of this study is to determinate the percentage of carriers in several regions of the Mediterranean coast in France...
  27. ncbi request reprint Haplotype XV of the Y-chromosome is the main haplotype in West-Europe
    Florent Dieterlen
    Institute of Molecular Anthropology, Paris, France
    Biomed Pharmacother 59:269-72. 2005
    ..This study demonstrates that the geographic distribution of Y-chromosome variation for p49a,f TaqI haplotype XV reveals an important genetic identity for populations that live in the Occidental part of Europe...
  28. ncbi request reprint Roles of gender, age at onset and environmental risk in the frequency of CYP2D6-deficient alleles in patients with Parkinson's disease
    Nathalie Gerard
    INSERM U458, Laboratory of Pharmacogenetics, Paris, France
    Eur Neurol 48:114-5. 2002
  29. ncbi request reprint Genetic screening for two LRRK2 mutations in French patients with idiopathic Parkinson's disease
    Benoit Funalot
    INSERM U 573, Centre Paul Broca, Paris, France
    Genet Test 10:290-3. 2006
    ..One of our patients was of Berberian (North Africa) origin. Our 2 patients displayed genetic profiles consistent with the same ancestral haplotype as previously reported for carriers of the LRRK2 G2019S mutation...
  30. ncbi request reprint Interaction between GSTM1-null and CYP2D6-deficient alleles in the pathogenesis of Parkinson's disease
    O Santt
    Center of Molecular Neurogenetics, Paris, France
    Eur J Neurol 11:247-51. 2004
    ..18; P = 0.076). Such a combination of polymorphic peculiarities in studied metabolic genes might represent additional risk factor for development of sporadic PD...
  31. ncbi request reprint Frequency analysis and allele map in favor of the celtic origin of the C282Y mutation of hemochromatosis
    G Lucotte
    International Institute of Anthropology, Paris, France
    Blood Cells Mol Dis 27:549-56. 2001
    ..Prog. Med. Genet. 4, 135-168, 1980) concerning a Celtic origin of the hereditary hemochromatosis mutation...
  32. ncbi request reprint Population genetics of factor V Leiden in Europe
    G Lucotte
    International Institute of Anthropology, 1 place d Iéna, Paris 16ème, France
    Blood Cells Mol Dis 27:362-7. 2001
    ..Based on these findings, an interpretation is proposed of the history of factor V Leiden expansion in Europe during the Neolithic period, from a probable Anatolian center of origin in Turkey...
  33. ncbi request reprint Taq I restriction polymorphism of HLA class-I genes, and hybridization with HLA-A and HLA-B specific probes
    F Huetz
    , CNTS Institut, Paris, France
    Exp Clin Immunogenet 4:1-7. 1987
    ..For each of these two loci, a frequent polymorphism was described, which correlated with serologic haplotypes in several families studied...
  34. ncbi request reprint Molecular basis of the TaqI p49a,f polymorphism in the DYS1 locus containing DAZ genes
    F Jovelin
    Centre de Neurogénétique Moléculaire, 44 rue Monge, 75005 Paris, France
    Mol Hum Reprod 9:509-16. 2003
    ..Most of the codon changes caused by TaqI site losses located in the exons of the four DAZ genes have potentially high selective values...