Rudolf Lucas

Summary

Publications

  1. pmc A computational study of the oligosaccharide binding sites in the lectin-like domain of Tumor Necrosis Factor and the TNF-derived TIP peptide
    Alexander Dulebo
    University of South Bohemia in Ceske Budejovice, Faculty of Science, Czech Republic
    Curr Pharm Des 18:4236-43. 2012
  2. pmc Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability
    Rudolf Lucas
    Vascular Biology Center and Dept of Pharmacology and Toxicology, Georgia Health Sciences University, 1459 Laney Walker Blvd, Augusta, GA 30912 2500, USA
    Am J Respir Cell Mol Biol 47:445-53. 2012
  3. pmc Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema
    Rudolf Lucas
    Vascular Biology Center and Department of Pharmacology and Toxicology, Georgia Health Sciences University, Augusta, GA 30912, USA
    Proc Natl Acad Sci U S A 109:2084-9. 2012
  4. pmc Extracellular beta-nicotinamide adenine dinucleotide (beta-NAD) promotes the endothelial cell barrier integrity via PKA- and EPAC1/Rac1-dependent actin cytoskeleton rearrangement
    Nagavedi S Umapathy
    Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Cell Physiol 223:215-23. 2010
  5. pmc The lectin-like domain of TNF protects from listeriolysin-induced hyperpermeability in human pulmonary microvascular endothelial cells - a crucial role for protein kinase C-alpha inhibition
    Chenling Xiong
    Medical College of Georgia, Augusta, GA, USA
    Vascul Pharmacol 52:207-13. 2010
  6. doi request reprint Harvesting, identification and barrier function of human lung microvascular endothelial cells
    John D Catravas
    Medical College of Georgia, Augusta, GA 30912 2300, USA
    Vascul Pharmacol 52:175-81. 2010
  7. doi request reprint Application of alpha7 nicotinic acetylcholine receptor agonists in inflammatory diseases: an overview
    Mario B Marrero
    Vascular Biology Center, Medical College of Georgia, Augusta, Georgia, USA
    Pharm Res 28:413-6. 2011
  8. pmc β-Nicotinamide adenine dinucleotide attenuates lipopolysaccharide-induced inflammatory effects in a murine model of acute lung injury
    Nagavedi Siddaramappa Umapathy
    Vascular Biology Center and Section of Pulmonary and Critical Care Medicine, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    Exp Lung Res 38:223-32. 2012
  9. pmc Mini-review: novel therapeutic strategies to blunt actions of pneumolysin in the lungs
    Rudolf Lucas
    Vascular Biology Center, Georgia Regents University, Augusta, GA 30912, USA
    Toxins (Basel) 5:1244-60. 2013
  10. pmc The Dual Role of TNF in Pulmonary Edema
    Guang Yang
    Vascular Biology Center and Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA, 30912, USA
    J Cardiovasc Dis Res 1:29-36. 2010

Collaborators

Detail Information

Publications18

  1. pmc A computational study of the oligosaccharide binding sites in the lectin-like domain of Tumor Necrosis Factor and the TNF-derived TIP peptide
    Alexander Dulebo
    University of South Bohemia in Ceske Budejovice, Faculty of Science, Czech Republic
    Curr Pharm Des 18:4236-43. 2012
    ....
  2. pmc Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability
    Rudolf Lucas
    Vascular Biology Center and Dept of Pharmacology and Toxicology, Georgia Health Sciences University, 1459 Laney Walker Blvd, Augusta, GA 30912 2500, USA
    Am J Respir Cell Mol Biol 47:445-53. 2012
    ..These results identify PKC-α and arginase I as potential upstream and downstream therapeutic targets in PLY-induced pulmonary endothelial dysfunction...
  3. pmc Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema
    Rudolf Lucas
    Vascular Biology Center and Department of Pharmacology and Toxicology, Georgia Health Sciences University, Augusta, GA 30912, USA
    Proc Natl Acad Sci U S A 109:2084-9. 2012
    ..These findings point toward a protective role of the GHRH signaling pathway in PLY-induced permeability edema...
  4. pmc Extracellular beta-nicotinamide adenine dinucleotide (beta-NAD) promotes the endothelial cell barrier integrity via PKA- and EPAC1/Rac1-dependent actin cytoskeleton rearrangement
    Nagavedi S Umapathy
    Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Cell Physiol 223:215-23. 2010
    ..With these results, we conclude that beta-NAD regulates the pulmonary EC barrier integrity via small GTPase Rac1- and MLCP- dependent signaling pathways...
  5. pmc The lectin-like domain of TNF protects from listeriolysin-induced hyperpermeability in human pulmonary microvascular endothelial cells - a crucial role for protein kinase C-alpha inhibition
    Chenling Xiong
    Medical College of Georgia, Augusta, GA, USA
    Vascul Pharmacol 52:207-13. 2010
    ..These results indicate that the lectin-like domain of TNF has a potential therapeutic value in protecting from LLO-induced pulmonary endothelial hyperpermeability...
  6. doi request reprint Harvesting, identification and barrier function of human lung microvascular endothelial cells
    John D Catravas
    Medical College of Georgia, Augusta, GA 30912 2300, USA
    Vascul Pharmacol 52:175-81. 2010
    ..These HLMVEC present an in-house-derived alternative to commercially available human cells for the study of mechanisms contributing to ALI and ARDS...
  7. doi request reprint Application of alpha7 nicotinic acetylcholine receptor agonists in inflammatory diseases: an overview
    Mario B Marrero
    Vascular Biology Center, Medical College of Georgia, Augusta, Georgia, USA
    Pharm Res 28:413-6. 2011
    ..In this brief commentary we will discuss some of the latest advances and discoveries in the treatment of these inflammatory diseases, making use of alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonists...
  8. pmc β-Nicotinamide adenine dinucleotide attenuates lipopolysaccharide-induced inflammatory effects in a murine model of acute lung injury
    Nagavedi Siddaramappa Umapathy
    Vascular Biology Center and Section of Pulmonary and Critical Care Medicine, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    Exp Lung Res 38:223-32. 2012
    ..NAD treatment down-regulated the mRNA levels of the proinflammatory cytokines. These findings suggest that β-NAD could be investigated as a therapeutic option against bacterial toxin-induced lung inflammation and ALI in mice...
  9. pmc Mini-review: novel therapeutic strategies to blunt actions of pneumolysin in the lungs
    Rudolf Lucas
    Vascular Biology Center, Georgia Regents University, Augusta, GA 30912, USA
    Toxins (Basel) 5:1244-60. 2013
    ..Such treatments could reduce the potentially lethal complications occurring after antibiotic treatment of patients with severe pneumonia. ..
  10. pmc The Dual Role of TNF in Pulmonary Edema
    Guang Yang
    Vascular Biology Center and Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA, 30912, USA
    J Cardiovasc Dis Res 1:29-36. 2010
    ..oxygen species (ROS);myosin light chain (MLC);pneumolysin (PLY);listeriolysin (LLO);interleukin (IL);bronchoalveolar lavage fluids (BALF);Bacillus Calmette-Guerin (BCG);TNF receptor type 1 (TNFR1); TNF receptor type 2 (TNF-R2);..
  11. pmc αVβ3 integrin regulates macrophage inflammatory responses via PI3 kinase/Akt-dependent NF-κB activation
    Alexander S Antonov
    Vascular Biology Center, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Cell Physiol 226:469-76. 2011
    ..We hypothesize that αVβ3 activation can maintain chronic inflammatory processes in pathological conditions and that the loss of αVβ3 ligation will allow macrophages to escape from the inflammatory state...
  12. doi request reprint Cytokine profiling of young overweight and obese female African American adults with prediabetes
    Rudolf Lucas
    Vascular Biology Center, Georgia Regents University, Augusta, GA, United States Department of Pharmacology and Toxicology, Georgia Regents University, Augusta, GA, United States Division of Pulmonary Medicine, Georgia Regents University, Augusta, GA, United States Electronic address
    Cytokine 64:310-5. 2013
    ..Our data also call for further investigations in animal models and population cohorts to establish the roles of a variety of pro-inflammatory cytokines in the early development of obesity-related T2D. ..
  13. pmc P2Y receptors as regulators of lung endothelial barrier integrity
    Evgeny Zemskov
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912, USA
    J Cardiovasc Dis Res 2:14-22. 2011
    ..Here, we present an overview of recently identified P2Y receptor agonists that enhance the pulmonary endothelial barrier and inhibit and/or reverse endothelial barrier disruption...
  14. ncbi request reprint Endothelial cell-based methods for the detection of cyanobacterial anti-inflammatory and wound-healing promoting metabolites
    Christoph Wiesner
    Vascular Biology Center, Medical College of Georgia, Augusta, GA30909, USA
    Drug Metab Lett 1:254-60. 2007
    ..We therefore describe here the use of human endothelial cell-based in vitro assays for the detection of anti-inflammatory and wound-healing metabolites from cyanobacteria...
  15. pmc Adenosine A1 receptors promote vasa vasorum endothelial cell barrier integrity via Gi and Akt-dependent actin cytoskeleton remodeling
    Siddaramappa Nagavedi Umapathy
    Vascular Biology Center, Georgia Regents University, Augusta, Georgia, United States of America
    PLoS ONE 8:e59733. 2013
    ..Thus, we aimed to determine the role of adenosine in barrier regulation of VVEC isolated from the pulmonary arteries of normoxic (VVEC-Co) or chronically hypoxic (VVEC-Hyp) neonatal calves...
  16. pmc Novel mechanisms of endothelial dysfunction in diabetes
    Guang Yang
    Department of Vascular Biology Center, Medical College of Georgia, Augusta, GA, USA
    J Cardiovasc Dis Res 1:59-63. 2010
    ..In this review article, some recent developments that could improve the knowledge of diabetes-induced endothelial dysfunction are discussed...
  17. doi request reprint An alpha7 nicotinic acetylcholine receptor-selective agonist reduces weight gain and metabolic changes in a mouse model of diabetes
    Mario B Marrero
    Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Boulevard, Augusta, GA 30912, USA
    J Pharmacol Exp Ther 332:173-80. 2010
    ..The results show that alpha7 nAChRs play a central role in regulating biological parameters associated with diabetes and support the potential of targeting these receptors as a new therapeutic strategy for treatment...
  18. doi request reprint Regulators of endothelial and epithelial barrier integrity and function in acute lung injury
    Rudolf Lucas
    Vascular Biology Center, Medical College of Georgia, Augusta, GA 30912 2500, USA
    Biochem Pharmacol 77:1763-72. 2009
    ..Unraveling the mechanism of action of these agents could contribute to the development of novel therapeutic strategies to combat permeability edema...