John S Lubel

Summary

Publications

  1. doi request reprint Angiotensin-(1-7), an alternative metabolite of the renin-angiotensin system, is up-regulated in human liver disease and has antifibrotic activity in the bile-duct-ligated rat
    John S Lubel
    Department of Medicine, The University of Melbourne, Austin Health and Northern Health, Vic, Australia
    Clin Sci (Lond) 117:375-86. 2009
  2. pmc Portal pressure responses and angiotensin peptide production in rat liver are determined by relative activity of ACE and ACE2
    Chandana B Herath
    Department of Medicine, The University of Melbourne, Austin Repatriation Hospital, Heidelberg Heights, Victoria, Australia
    Am J Physiol Gastrointest Liver Physiol 297:G98-G106. 2009
  3. doi request reprint Liver disease and the renin-angiotensin system: recent discoveries and clinical implications
    John S Lubel
    Department of Medicine, The University of Melbourne, Austin and Northern Health, Melbourne, Victoria, Australia
    J Gastroenterol Hepatol 23:1327-38. 2008
  4. ncbi request reprint Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis
    Chandana B Herath
    Department of Medicine, The University of Melbourne, Austin Health, Heidelberg, Vic, Australia
    J Hepatol 47:387-95. 2007

Detail Information

Publications4

  1. doi request reprint Angiotensin-(1-7), an alternative metabolite of the renin-angiotensin system, is up-regulated in human liver disease and has antifibrotic activity in the bile-duct-ligated rat
    John S Lubel
    Department of Medicine, The University of Melbourne, Austin Health and Northern Health, Vic, Australia
    Clin Sci (Lond) 117:375-86. 2009
    ..In conclusion, Ang-(1-7) is up-regulated in human liver disease and has antifibrotic actions in a rat model of cirrhosis. The ACE2/Ang-(1-7)/mas receptor axis represents a potential target for antifibrotic therapy in humans...
  2. pmc Portal pressure responses and angiotensin peptide production in rat liver are determined by relative activity of ACE and ACE2
    Chandana B Herath
    Department of Medicine, The University of Melbourne, Austin Repatriation Hospital, Heidelberg Heights, Victoria, Australia
    Am J Physiol Gastrointest Liver Physiol 297:G98-G106. 2009
    ..NEP has the ability to generate large amounts of Ang-(1-7) in the BDL liver from Ang I only when ACE2 activity is greatly decreased or inhibited...
  3. doi request reprint Liver disease and the renin-angiotensin system: recent discoveries and clinical implications
    John S Lubel
    Department of Medicine, The University of Melbourne, Austin and Northern Health, Melbourne, Victoria, Australia
    J Gastroenterol Hepatol 23:1327-38. 2008
    ..The present review focuses on the novel components and pathways of the RAS with particular reference to their potential contribution towards the pathophysiology of liver disease...
  4. ncbi request reprint Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis
    Chandana B Herath
    Department of Medicine, The University of Melbourne, Austin Health, Heidelberg, Vic, Australia
    J Hepatol 47:387-95. 2007
    ..We examined the expression of these novel components of the renin angiotensin system (RAS) and the production and vasoactive effects of angiotensin-(1-7) in the bile duct ligated (BDL) rat...