Yan Lu

Summary

Publications

  1. pmc Spinal cord injury-induced attenuation of GABAergic inhibition in spinal dorsal horn circuits is associated with down-regulation of the chloride transporter KCC2 in rat
    Yan Lu
    Department of Anaesthesiology, Xijing Hospital, The Fourth Military Medical University, Xi an, 710032, China
    J Physiol 586:5701-15. 2008
  2. doi request reprint A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia
    Yan Lu
    Department of Anesthesiology and Pain Management, Xijing Hospital, Fourth Military Medical University, Xian, People s Republic of China
    J Clin Invest 123:4050-62. 2013
  3. doi request reprint Neuroprotective effect of WIN 55,212-2 pretreatment against focal cerebral ischemia through activation of extracellular signal-regulated kinases in rats
    Bo Hu
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, Shaanxi Province, China
    Eur J Pharmacol 645:102-7. 2010
  4. pmc SirT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain
    Wenjun Yan
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an, China
    J Cereb Blood Flow Metab 33:396-406. 2013
  5. ncbi request reprint Subanesthetic dose of isoflurane protects against zymosan-induced generalized inflammation and its associated acute lung injury in mice
    Jinglan Mu
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, People s Republic of China
    Shock 34:183-9. 2010
  6. doi request reprint Activation of cholinergic anti-inflammatory pathway contributes to the protective effects of 100% oxygen inhalation on zymosan-induced generalized inflammation in mice
    Zishen Zhang
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, PR China
    J Surg Res 174:e75-83. 2012
  7. doi request reprint Sevoflurane postconditioning attenuates spinal cord reperfusion injury through free radicals-mediated up-regulation of antioxidant enzymes in rabbits
    Qiang Wang
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an, China
    J Surg Res 169:292-300. 2011
  8. doi request reprint Intracerebroventricular injection of human prostatic acid phosphatase has potent neuroprotective effects against transient focal cerebral ischemia in rats
    Yue Yang
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xian, 710032, China
    Neurosci Lett 504:321-4. 2011
  9. doi request reprint Autophagy activation is involved in neuroprotection induced by hyperbaric oxygen preconditioning against focal cerebral ischemia in rats
    Wenjun Yan
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    Brain Res 1402:109-21. 2011
  10. ncbi request reprint Electroacupuncture pretreatment ameliorates hypergravity-induced impairment of learning and memory and apoptosis of hippocampal neurons in rats
    Shufang Feng
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, China
    Neurosci Lett 478:150-5. 2010

Collaborators

Detail Information

Publications16

  1. pmc Spinal cord injury-induced attenuation of GABAergic inhibition in spinal dorsal horn circuits is associated with down-regulation of the chloride transporter KCC2 in rat
    Yan Lu
    Department of Anaesthesiology, Xijing Hospital, The Fourth Military Medical University, Xi an, 710032, China
    J Physiol 586:5701-15. 2008
    ..The resulting disinhibition unmasks normally ineffective SDH neuronal circuits and may contribute to the below-level central pain-related behaviours after incomplete SCI...
  2. doi request reprint A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia
    Yan Lu
    Department of Anesthesiology and Pain Management, Xijing Hospital, Fourth Military Medical University, Xian, People s Republic of China
    J Clin Invest 123:4050-62. 2013
    ..Disruption of this glycinergic inhibitory circuit after peripheral nerve injury has the potential to elicit mechanical allodynia, a cardinal symptom of neuropathic pain. ..
  3. doi request reprint Neuroprotective effect of WIN 55,212-2 pretreatment against focal cerebral ischemia through activation of extracellular signal-regulated kinases in rats
    Bo Hu
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, Shaanxi Province, China
    Eur J Pharmacol 645:102-7. 2010
    ..These findings suggest that the neuroprotective effect of WIN 55,212-2 pretreatment against focal cerebral ischemia is through the activation of extracellular signal-regulated kinases in rats...
  4. pmc SirT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain
    Wenjun Yan
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an, China
    J Cereb Blood Flow Metab 33:396-406. 2013
    ..Besides, SirT1 increased B-cell lymphoma 2 (Bcl-2) expression and decrease cleaved caspase 3. These results indicate that SirT1 mediates HBO-PC-induced tolerance to cerebral I/R through inhibition of apoptosis...
  5. ncbi request reprint Subanesthetic dose of isoflurane protects against zymosan-induced generalized inflammation and its associated acute lung injury in mice
    Jinglan Mu
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, People s Republic of China
    Shock 34:183-9. 2010
    ....
  6. doi request reprint Activation of cholinergic anti-inflammatory pathway contributes to the protective effects of 100% oxygen inhalation on zymosan-induced generalized inflammation in mice
    Zishen Zhang
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, PR China
    J Surg Res 174:e75-83. 2012
    ..However, the underlying mechanism is largely unknown. The present study was designed to explore the role of the cholinergic anti-inflammatory pathway in this animal model...
  7. doi request reprint Sevoflurane postconditioning attenuates spinal cord reperfusion injury through free radicals-mediated up-regulation of antioxidant enzymes in rabbits
    Qiang Wang
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an, China
    J Surg Res 169:292-300. 2011
    ..The present study examined the hypothesis that neuroprotection of sevoflurane postconditioning (PostC) against spinal cord reperfusion injury is associated with free radicals-mediated up-regulation of antioxidant enzymes in rabbits...
  8. doi request reprint Intracerebroventricular injection of human prostatic acid phosphatase has potent neuroprotective effects against transient focal cerebral ischemia in rats
    Yue Yang
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xian, 710032, China
    Neurosci Lett 504:321-4. 2011
    ..5 h after reperfusion. The present study suggested that PAP is a potential candidate for the prevention and treatment of cerebral ischemic injury, especially during perioperative period...
  9. doi request reprint Autophagy activation is involved in neuroprotection induced by hyperbaric oxygen preconditioning against focal cerebral ischemia in rats
    Wenjun Yan
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    Brain Res 1402:109-21. 2011
    ....
  10. ncbi request reprint Electroacupuncture pretreatment ameliorates hypergravity-induced impairment of learning and memory and apoptosis of hippocampal neurons in rats
    Shufang Feng
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, China
    Neurosci Lett 478:150-5. 2010
    ..These findings indicate that EA pretreatment provides a novel method to prevent the cognitive damage caused by +Gz, which could significantly protect neuronal damage and impairment of learning and memory...
  11. pmc Genistein Attenuates Brain Damage induced by Transient Cerebral Ischemia Through Up-regulation of ERK Activity in Ovariectomized Mice
    Shiquan Wang
    1 Department of Anesthesiology, Xijing Hospital, Forth Military Medical University, Xi an, China 4 Dr Shiquan Wang and Dr Haidong Wei equally contributed to this work
    Int J Biol Sci 10:457-65. 2014
    ..Our findings indicate that treatment with genistein can reduce the severity of subsequent stroke episodes, and that this beneficial function is associated with ERK activation. ..
  12. doi request reprint Electroacupuncture improves orthostatic tolerance in healthy individuals via improving cardiac function and activating the sympathetic system
    Jing Sun
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi, China
    Europace 15:127-34. 2013
    ..The aim of this study was to investigate whether electroacupuncture (EA) is a novel effective treatment in attenuating OI in healthy individuals...
  13. ncbi request reprint Excitatory synaptic transmission in the spinal substantia gelatinosa is under an inhibitory tone of endogenous adenosine
    Li Tian
    Pain Clinic, Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xian 710032, China
    Neurosci Lett 477:28-32. 2010
    ..The present results suggested that the background activity of A1 receptors in the spinal SG might be contributed to setting the physiological "noceceptive thresholds"...
  14. doi request reprint Mechanisms mediating propofol protection of pulmonary epithelial cells against lipopolysaccharide-induced cell death
    Xiaoxia Gu
    Department of Anaesthesiology, Guangdong Medical College, Zhanjiang, China
    Clin Exp Pharmacol Physiol 39:447-53. 2012
    ..The data indicate that propofol protects A549 cells against LPS-induced apoptosis, and probably autophagy, by blocking LPS-induced activation of ROS/caspase 9 pathways and upregulation of LC3 and beclin-1, respectively...
  15. doi request reprint Involvement of ERK 1/2 activation in electroacupuncture pretreatment via cannabinoid CB1 receptor in rats
    Juan Du
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    Brain Res 1360:1-7. 2010
    ..Our findings suggest that the ERK1/2 pathway might be involved in EA pretreatment-induced cerebral ischemic tolerance via cannabinoid CB1 receptor in rats...
  16. doi request reprint Effects of reactive oxygen species scavenger on the protective action of 100% oxygen treatment against sterile inflammation in mice
    Lichao Hou
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi Province, China
    Shock 33:646-54. 2010
    ..We thus conclude that ROS scavenger pretreatment partly abolishes the protective effects of 100% oxygen treatment on sterile inflammation in mice by regulating inflammatory cytokines as well as antioxidant enzymes...