[DHPLC analysis of microsatellite instability in gastric cancer]Bing jian Lu
Department of Surgical Pathology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University Hangzhou 310 016, China
Yi Chuan 26:574-8. 2004
..Results obtained from DHPLC and gel electrophoresis were completely consistent. Thus, DHPLC analysis of Bat26 site may be a favorable method of detecting MSI-H status in gastric cancer, and be of clinical importance...
- [Germline polymorphisms of Bat26 and its significance in gastric cancer microsatellite instability]
Bing jian Lu
Deparment of Pathology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China
Zhejiang Da Xue Xue Bao Yi Xue Ban 34:353-7. 2005
..To detect the germline polymorphic variations of Bat26 in Chinese and its significance in microsatellite instability (MSI) study of gastric cancers...
- [Bioinformatic analysis of adenoma-normal mucosa SSH library of colon]
Bing jian Lu
Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou 310031, China
Yi Chuan 28:385-92. 2006
..The candidate genes in A-N library would be of great significance in disclosing the molecular mechanism underlying in colonic adenoma initiation and progression...
A transcriptome anatomy of human colorectal cancersBingjian Lu
Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, PR, 310031, China
BMC Cancer 6:40. 2006
..A practical approach is to mine a global transcriptome profile of disease from public database. New concepts of these diseases might emerge by landscaping this profile...
Analysis of SOX9 expression in colorectal cancerBingjian Lu
Department of Pathology, School of Medicine, Zhejiang University Department of Anatomical and Cellular Pathology, the Affiliated Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, China
Am J Clin Pathol 130:897-904. 2008
..05). The detection of SOX9 expression might contribute to predicting clinical outcomes for patients with colorectal cancer...
- SVM-T-RFE: a novel gene selection algorithm for identifying metastasis-related genes in colorectal cancer using gene expression profiles
Xiaobo Li
Department of Pathology, School of Medicine, Zhejiang University, Hangzhou 310058, People s Republic of China
Biochem Biophys Res Commun 419:148-53. 2012
..A fraction of selected genes have been reported to be associated with CRC development or metastasis...
- Identification of serum biomarkers for colorectal cancer metastasis using a differential secretome approach
Hua Xue
Department of Pathology and Pathophysiology, Affiliated Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, China
J Proteome Res 9:545-55. 2010
..Both trefoil factor 3 and growth/differentiation factor 15 could serve as potential biomarkers for the prediction of colorectal cancer metastasis...
- TaqMan low density array is roughly right for gene expression quantification in colorectal cancer
Bingjian Lu
Department of Pathology, School of Medicine, Zhejiang University, PR China
Clin Chim Acta 389:146-51. 2008
..TaqMan low density array (LDA) is promising for high throughput screening in functional genomics by simultaneously measuring mRNA expression of multiple genes. However, the reproducibility and reliability remain to be explored...
- Downregulation of Krüppel-like factor 9 in human colorectal cancer
Ling Kang
Department of Pathology and Pathophysiology, Affiliated Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, China
Pathol Int 58:334-8. 2008
..001) on tissue microarray. These results indicate that KLF9 may be involved in the carcinogenesis of human colorectal cancer...
- Association of matrix metalloproteinase-2 and -9 promoter polymorphisms with colorectal cancer in Chinese
Enping Xu
Department of Pathology and Pathophysiology, Center for Environmental Genomics, School of Medicine, Zhejiang University, and Department of Clinical Pathology, Sir Run Run Shaw Hospital, Hangzhou, China
Mol Carcinog 46:924-9. 2007
..Our results suggest that the presence of -1575G allele in the MMP-2 promoter region may be of significance in the assessment of colorectal cancer risk and invasive potential...
- Dynamic down-regulation of Krüppel-like factor 4 in colorectal adenoma-carcinoma sequence
Jing Xu
Department of Pathology, School of Medicine, Zhejiang University, Hangzhou, 310058, People s Republic of China
J Cancer Res Clin Oncol 134:891-8. 2008
..To explore the clinical significance of Krüppel-like factors 4 (KLF4) expression in colorectal cancer initiation and progression...
- Systemic analysis of the differential gene expression profile in a colonic adenoma-normal SSH library
Bingjian Lu
Department of Pathology and Pathophysiology, Zhejiang University, PR China
Clin Chim Acta 378:42-7. 2007
..In our previous study, we have developed an adenoma minus normal mucosa suppression subtractive hybridization (SSH) library and identified 109 differentially expressed clones...
- -8p12-23 and +20q are predictors of subtypes and metastatic pathways in colorectal cancer: construction of tree models using comparative genomic hybridization data
Xiaobo Li
Department of Pathology, School of Medicine, Zhejiang University, Hangzhou 310058, People s Republic of China
OMICS 15:37-47. 2011
..Particularly, the metastatic pathways we describe may provide pivotal clues for metastatic candidate genes, and thus impact on the prediction and intervention of metastatic colorectal cancer...
- Tumor suppressor gene insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) induces senescence-like growth arrest in colorectal cancer cells
Yu Ma
Department of Pathology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310058, China
Exp Mol Pathol 85:141-5. 2008
..Restoration of IGFBP-rP1 function might have potential therapeutic significance in colorectal cancer...
- Differential expression of mimecan and thioredoxin domain-containing protein 5 in colorectal adenoma and cancer: a proteomic study
YingHong Wang
Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, 310058, China
Exp Biol Med (Maywood) 232:1152-9. 2007
..Thus, the differentially expressed proteins might serve as potential biomarkers for colorectal cancer detection and intervention...
- The cancer secretome: a reservoir of biomarkers
Hua Xue
Department of Pathology, School of Medicine, Zhejiang University, PR China
J Transl Med 6:52. 2008
..Further improvements on strategies and technologies will continue to drive forward cancer secretome research and enable development of a wealth of clinically valuable cancer biomarkers...
- Secretagogin, a novel neuroendocrine marker, has a distinct expression pattern from chromogranin A
Maode Lai
Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, and Department of Surgical Pathology, The First Affiliated Hospital, Zhejiang, China
Virchows Arch 449:402-9. 2006
..We conclude that SCGN is a novel neuroendocrine marker that may be useful in routine surgical pathology practice...
- The association between metabolic abnormality and endometrial cancer: a large case-control study in China
Yan Zhang
Department of Clinical Pathology, Affiliated Women s Hospital, School of Medicine, Zhejiang University, PR China
Gynecol Oncol 117:41-6. 2010
..To investigate the association between insulin-resistance-related conditions (comprising the metabolic syndrome) and endometrial cancer risk in Chinese women...
- Serum insulin-like, growth factor binding protein-related protein 1 (IGFBP-rP1) and endometrial cancer risk in Chinese women
Yan Zhan
Department of Clinical Laboratory, the Affiliated Women s Hospital, School of Medicine, Zhejiang University, China
Int J Cancer 132:411-6. 2013
..13; 95% CI = 1.30-3.49; IGFBP-rP1: 0.57; 95% CI = 0.34-0.94). Hyperinsulinemia and high IGFBP-rP1 levels confer altered risks for endometrial carcinoma...
- No association between the polymorphisms in matrix metalloproteinase-1 and matrix metalloproteinase-3 promoter regions and colorectal cancer in Chinese
Enping Xu
Department of Pathology and Pathophysiology, Center for Environmental Genomics, School of Medicine, Zhejiang University, Hangzhou 310031, China
Dis Colon Rectum 49:1439-44. 2006
..In this study, we investigated whether these functional polymorphisms are associated with colorectal cancer in a Chinese population...
- Microwave heating of long-term formalin-fixed surgical pathology specimens improves quality of extracted DNA
Shanshui Wu
Department of Oncology, Quzhou Municipal Hospital, Quzhou, Zhejiang Province, PR China
Appl Immunohistochem Mol Morphol 20:512-7. 2012
..The successful fluorescence multiplex polymerase chain reaction-capillary electrophoresis analysis in these samples might facilitate MSI detection in clinical practice...
- Atypical epithelioid trophoblastic lesion with cyst and fistula formation after a cesarean section: a rare form of gestational trophoblastic disease
Yun Liang
Department of Surgical Pathology, the Affiliated Women s Hospital, School of Medicine, Zhejiang University, Zhejiang, P R China
Int J Gynecol Pathol 31:458-62. 2012
..The Ki67 indexes were 12.7% and 8.6%, respectively. We propose their description as atypical epithelioid trophoblastic lesions with cyst and fistula formation after a Cesarean section...
- Ovarian steroid cell tumor, not otherwise specified (NOS): an unusual case with myelolipoma
Xiaofei Zhang
Department of Surgical Pathology, Women s Reproductive Health Laboratory of Zhejiang Province, the Affiliated Women s Hospital, School of Medicine, Zhejiang University, 2 Xueshi Road, Hangzhou, Zhejiang, China
Int J Gynecol Pathol 30:460-5. 2011
..Lineage-specific markers including myeloid peroxidase were variably expressed in hematopoietic cells. This rare case will expand our appreciation of the spectrum and histogenesis of ovarian tumors...
- The expressions of bHLH gene HES1 and HES5 in advanced ovarian serous adenocarcinomas and their prognostic significance: a retrospective clinical study
Xinyu Wang
Women s Reproductive Health Laboratory of Zhejiang Province, Department of Gynecologic Oncology, Women s Hospital, School of Medicine, Zhejiang University, 310006 Hangzhou, China
J Cancer Res Clin Oncol 136:989-96. 2010
..The aim of the study is to investigate significance of the expression of HES1/HES5 protein, downstream effectors of Notch, in prognosis of the patients with advanced ovarian epithelial cancers...
