Alexandre Loupy

Summary

Publications

  1. doi request reprint Significance of C4d Banff scores in early protocol biopsies of kidney transplant recipients with preformed donor-specific antibodies (DSA)
    A Loupy
    Service de Transplantation Rénale et de Soins Intensifs, Hopital Necker, APHP, Paris, France
    Am J Transplant 11:56-65. 2011
  2. ncbi request reprint Complement-binding anti-HLA antibodies and kidney-allograft survival
    Alexandre Loupy
    Paris Translational Research Center for Organ Transplantation, INSERM Unité 970, Department of Kidney Transplantation, Hopital Necker, Universite Paris Descartes, and Assistance Publique Hôpitaux de Paris AP HP, Paris, France
    N Engl J Med 369:1215-26. 2013
  3. ncbi request reprint [Massive rhabdomyolysis revealing a McArdle disease]
    A Loupy
    Service des urgences néphrologiques et transplantation rénale, Hopital Tenon, 4, rue de la Chine, 75020 Paris, France
    Rev Med Interne 28:501-3. 2007
  4. doi request reprint Outcome of subclinical antibody-mediated rejection in kidney transplant recipients with preformed donor-specific antibodies
    A Loupy
    INSERM UMR 872, Universite Paris Descartes, Paris, France
    Am J Transplant 9:2561-70. 2009
  5. doi request reprint Combined posttransplant prophylactic IVIg/anti-CD 20/plasmapheresis in kidney recipients with preformed donor-specific antibodies: a pilot study
    Alexandre Loupy
    INSERM, U970, Paris Cardiovascular Research Center PARCC, Paris, France
    Transplantation 89:1403-10. 2010
  6. pmc Donor-specific antibodies accelerate arteriosclerosis after kidney transplantation
    Gary S Hill
    Laboratoire d Anatomie Pathologique, Hopital Europeen Georges Pompidou, APHP, Paris, France
    J Am Soc Nephrol 22:975-83. 2011
  7. ncbi request reprint Long-term outcome of third kidney transplants
    Alexandre Loupy
    Service de Transplantation Rénale et de Soins Intensifs, Hopital Necker, and Université René Descartes, Paris, France
    Nephrol Dial Transplant 22:2693-700. 2007
  8. pmc High-dosage intravenous immunoglobulin-associated macrovacuoles are associated with chronic tubulointerstitial lesion worsening in renal transplant recipients
    Guillaume Bollée
    Laboratoire d Anatomie Pathologique, Hopital Necker, APHP, and Université René Descartes, Paris, France
    Clin J Am Soc Nephrol 3:1461-8. 2008
  9. pmc Preexisting donor-specific HLA antibodies predict outcome in kidney transplantation
    Carmen Lefaucheur
    Département de Néphrologie et Transplantation Rénale, Hopital Saint Louis, Paris, France
    J Am Soc Nephrol 21:1398-406. 2010
  10. doi request reprint Antibody-mediated vascular rejection of kidney allografts: a population-based study
    Carmen Lefaucheur
    Nephrology and Kidney Transplantation, Saint Louis Hospital, Assistance Publique Hopitaux de Paris, INSERM U940, Paris, France
    Lancet 381:313-9. 2013

Collaborators

Detail Information

Publications27

  1. doi request reprint Significance of C4d Banff scores in early protocol biopsies of kidney transplant recipients with preformed donor-specific antibodies (DSA)
    A Loupy
    Service de Transplantation Rénale et de Soins Intensifs, Hopital Necker, APHP, Paris, France
    Am J Transplant 11:56-65. 2011
    ..However, C4d may not be a sufficiently sensitive indicator of activity, MI and DSA being more robust predictors of bad outcome...
  2. ncbi request reprint Complement-binding anti-HLA antibodies and kidney-allograft survival
    Alexandre Loupy
    Paris Translational Research Center for Organ Transplantation, INSERM Unité 970, Department of Kidney Transplantation, Hopital Necker, Universite Paris Descartes, and Assistance Publique Hôpitaux de Paris AP HP, Paris, France
    N Engl J Med 369:1215-26. 2013
    ..We investigated whether the complement-binding capacity of anti-HLA antibodies plays a role in kidney-allograft failure...
  3. ncbi request reprint [Massive rhabdomyolysis revealing a McArdle disease]
    A Loupy
    Service des urgences néphrologiques et transplantation rénale, Hopital Tenon, 4, rue de la Chine, 75020 Paris, France
    Rev Med Interne 28:501-3. 2007
    ..Typically, McArdle's disease is characterized by exercise intolerance with muscle cramps and myoglobinuria...
  4. doi request reprint Outcome of subclinical antibody-mediated rejection in kidney transplant recipients with preformed donor-specific antibodies
    A Loupy
    INSERM UMR 872, Universite Paris Descartes, Paris, France
    Am J Transplant 9:2561-70. 2009
    ..C4d-negative SAMR patients displayed an intermediate course between the no-SAMR group and the C4d+ SAMR group. Screening biopsies may be useful to recognize patients more likely to develop SAMR...
  5. doi request reprint Combined posttransplant prophylactic IVIg/anti-CD 20/plasmapheresis in kidney recipients with preformed donor-specific antibodies: a pilot study
    Alexandre Loupy
    INSERM, U970, Paris Cardiovascular Research Center PARCC, Paris, France
    Transplantation 89:1403-10. 2010
    ....
  6. pmc Donor-specific antibodies accelerate arteriosclerosis after kidney transplantation
    Gary S Hill
    Laboratoire d Anatomie Pathologique, Hopital Europeen Georges Pompidou, APHP, Paris, France
    J Am Soc Nephrol 22:975-83. 2011
    ..In conclusion, these data support the hypothesis that donor-specific antibodies dramatically accelerate post-transplant progression of arteriosclerosis...
  7. ncbi request reprint Long-term outcome of third kidney transplants
    Alexandre Loupy
    Service de Transplantation Rénale et de Soins Intensifs, Hopital Necker, and Université René Descartes, Paris, France
    Nephrol Dial Transplant 22:2693-700. 2007
    ....
  8. pmc High-dosage intravenous immunoglobulin-associated macrovacuoles are associated with chronic tubulointerstitial lesion worsening in renal transplant recipients
    Guillaume Bollée
    Laboratoire d Anatomie Pathologique, Hopital Necker, APHP, and Université René Descartes, Paris, France
    Clin J Am Soc Nephrol 3:1461-8. 2008
    ..Intravenous immunoglobulins (IVIg) may induce acute renal failure associated with tubular vacuolization. Although the use of IVIg is increasing in kidney transplantation, their impact on graft histology and function remains unknown...
  9. pmc Preexisting donor-specific HLA antibodies predict outcome in kidney transplantation
    Carmen Lefaucheur
    Département de Néphrologie et Transplantation Rénale, Hopital Saint Louis, Paris, France
    J Am Soc Nephrol 21:1398-406. 2010
    ..Quantification of HLA antibodies allows stratification of immunologic risk, which should help guide selection of acceptable grafts for sensitized patients...
  10. doi request reprint Antibody-mediated vascular rejection of kidney allografts: a population-based study
    Carmen Lefaucheur
    Nephrology and Kidney Transplantation, Saint Louis Hospital, Assistance Publique Hopitaux de Paris, INSERM U940, Paris, France
    Lancet 381:313-9. 2013
    ..We aimed to improve characterisation of different kidney-allograft rejection phenotypes, identify how each one is associated with anti-HLA antibodies, and investigate their distinct prognoses...
  11. doi request reprint Incidence of infectious complications in highly sensitized renal transplant recipients treated by rituximab: a case-controlled study
    Anne Scemla
    Department of Renal Transplantation, Assistance Publique Hopitaux de Paris, Hopital Necker, Paris, France
    Transplantation 90:1180-4. 2010
    ..Use of rituximab for various indications in renal transplantation is increasing. However, tolerance and complications associated with rituximab therapy remain controversial...
  12. pmc A clinicopathologic study of thrombotic microangiopathy in IgA nephropathy
    Khalil El Karoui
    Department of Pathology, Hopital Europeen Georges Pompidou, 21, rue Leblanc 75015, Paris, France
    J Am Soc Nephrol 23:137-48. 2012
    ..Although the pathophysiologic mechanisms involved remain undetermined, the current study rules out severe hypertension or advanced renal disease as sole causes...
  13. doi request reprint Kidney function following nephrectomy: similitude and discrepancies between kidney cancer and living donation
    Marc Olivier Timsit
    Universite Paris Descartes, Paris, France
    Urol Oncol 30:482-6. 2012
    ..We aimed to investigate if indication for nephrectomy (kidney cancer vs. living donation) was an independent risk factor for kidney function deterioration...
  14. doi request reprint The impact of donor-specific anti-HLA antibodies on late kidney allograft failure
    Alexandre Loupy
    Department of Kidney Transplantation, Necker Hospital, UMR S970, Paris, France
    Nat Rev Nephrol 8:348-57. 2012
    ..Therapies aimed at B cells, plasma cells and antibodies will be important therapeutic options to improve the length and quality of kidney allograft survival...
  15. doi request reprint Pathologic classification of antibody-mediated rejection correlates with donor-specific antibodies and endothelial cell activation
    Marion Tible
    Université Paris Descartes Médecine, Paris, France
    J Heart Lung Transplant 32:769-76. 2013
    ..This classification might benefit from new immunohistological markers and validation by others biomarkers, namely donor-specific antibodies (DSA)...
  16. ncbi request reprint Impact of surgical procedures and complications on outcomes of third and subsequent kidney transplants
    Alexandre Loupy
    Service de transplantation rénale, Hopital Necker, Paris, France
    Transplantation 83:385-91. 2007
    ..Surgical procedures and complications have rarely been described in patients receiving a third or subsequent renal transplant...
  17. doi request reprint Donor-estimated GFR as an appropriate criterion for allocation of ECD kidneys into single or dual kidney transplantation
    R Snanoudj
    Universite Paris Descartes, Paris, France
    Am J Transplant 9:2542-51. 2009
    ..Andres et al. and UNOS, did not indicate an improvement in 12-month eGFR compared to our allocation based on donor eGFR...
  18. doi request reprint Eculizumab in renal transplantation
    Christophe Legendre
    Sorbonne Paris Cité, Faculte de Medecine, Universite Paris Descartes, Paris, France
    Transplant Rev (Orlando) 27:90-2. 2013
    ....
  19. doi request reprint Accelerated arteriosclerosis: a form of transplant arteriopathy
    Gary S Hill
    Department of Pathology, Hopital Europeen Georges Pompidou, Hopital Necker, Paris, France
    Curr Opin Organ Transplant 15:11-5. 2010
    ..However, these latter lesions may present the appearance of banal arteriosclerosis, albeit more advanced expected on the basis of donor age. This review explores the distinctions to be drawn among these various descriptive terms...
  20. doi request reprint Influence of fractalkine receptor gene polymorphisms V249I-T280M on cancer occurrence after renal transplantation
    Cécile Courivaud
    INSERM, UMR645, Universite de Franche Comte, Etablissement Français du Sang, IFR133, Besancon, France
    Transplantation 95:728-32. 2013
    ..We hypothesized that a renal transplant recipient (RTR) carrying the homozygous I249M280 genotype could experience more cancer due to lower CX3CL1-dependent antitumorigenic effects...
  21. doi request reprint Focal segmental glomerulosclerosis plays a major role in the progression of IgA nephropathy. II. Light microscopic and clinical studies
    Khalil El Karoui
    Department of Pathology, Hopital Europeen Georges Pompidou, Paris, France
    Kidney Int 79:643-54. 2011
    ..Hence, interpreting IgAN in terms of FSGS emphasizes the role that podocyte lesions may play in the pathogenesis and progression of this disease...
  22. doi request reprint A simple clinico-histopathological composite scoring system is highly predictive of graft outcomes in marginal donors
    D Anglicheau
    Service de Transplantation Rénale et de Soins Intensifs, Hopital Necker, APHP, Paris, F 75015 France
    Am J Transplant 8:2325-34. 2008
    ..Instead, a simple and convenient composite score strongly predicts graft function and survival and may facilitate optimal allocation of marginal donors...
  23. pmc Tissue compartment analysis for biomarker discovery by gene expression profiling
    Antoine Disset
    UPMC Univ Paris 06, UMRS 872, Laboratoire de Génomique, Physiologie et Physiopathologie Rénales, Paris, France
    PLoS ONE 4:e7779. 2009
    ..As an alternate approach, we developed a tissue compartment analysis (TCA) method to assess the cell composition of tissue samples, and applied it to standardize data and to identify biomarkers...
  24. doi request reprint Bortezomib as the sole post-renal transplantation desensitization agent does not decrease donor-specific anti-HLA antibodies
    R Sberro-Soussan
    Universite Paris Descartes, Paris, France
    Am J Transplant 10:681-6. 2010
    ..These results underscore the need to evaluate this new desensitization agent properly in prospective, randomized and well-controlled studies...
  25. pmc PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor
    Alexandre Loupy
    INSERM UMRS 872, Centre de Recherche des Cordeliers, Paris, France
    J Clin Invest 122:3355-67. 2012
    ..These findings suggest that CaSR inhibitors may provide a new specific treatment for disorders related to impaired PTH secretion, such as primary hypoparathyroidism...
  26. doi request reprint Influence of cyclooxygenase-2 (COX-2) gene promoter polymorphism -765 on graft loss after renal transplantation
    C Courivaud
    INSERM, UMR645, F 25020, Besancon, France
    Am J Transplant 9:2752-7. 2009
    ..COX-2 gene promoter polymorphism at position -765 (G-->C) is associated with a higher rate of graft loss in RTRs. Such findings may be used to influence immunosuppressive strategies and optimize patient management...
  27. ncbi request reprint Posttransplant prophylactic intravenous immunoglobulin in kidney transplant patients at high immunological risk: a pilot study
    D Anglicheau
    Service de Transplantation Rénale et de Soins Intensifs, Hopital Necker, APHP, Paris, F 75015 France
    Am J Transplant 7:1185-92. 2007
    ..In conclusion, prophylactic IVIg in high-immunological risk patients is associated with good one-year outcomes, with adequate GFR and a profound decrease in PRA level, but a significant increase in allograft nephropathy...