Jean Pierre Louboutin

Summary

Publications

  1. pmc Preexisting immunity to adenovirus in rhesus monkeys fails to prevent vector-induced toxicity
    Andrei N Varnavski
    Institute for Human Gene Therapy and Department of Molecular and Cellular Engineering, University of Pennsylvania and The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Virol 76:5711-9. 2002
  2. pmc Role of CCR5 and its ligands in the control of vascular inflammation and leukocyte recruitment required for acute excitotoxic seizure induction and neural damage
    Jean Pierre Louboutin
    Department of Pathology, Jefferson Medical College, 1020 Locust St, Rm 251, Philadelphia, PA 19107, USA
    FASEB J 25:737-53. 2011
  3. ncbi request reprint HIV-1 gp120-induced injury to the blood-brain barrier: role of metalloproteinases 2 and 9 and relationship to oxidative stress
    Jean Pierre Louboutin
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Neuropathol Exp Neurol 69:801-16. 2010
  4. doi request reprint Dopaminergic neurotoxicity of HIV-1 gp120: reactive oxygen species as signaling intermediates
    Lokesh Agrawal
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA
    Brain Res 1306:116-30. 2010
  5. doi request reprint HIV-1 gp120 neurotoxicity proximally and at a distance from the point of exposure: protection by rSV40 delivery of antioxidant enzymes
    Jean Pierre Louboutin
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Neurobiol Dis 34:462-76. 2009
  6. ncbi request reprint Relationship between the chemokine receptor CCR5 and microglia in neurological disorders: consequences of targeting CCR5 on neuroinflammation, neuronal death and regeneration in a model of epilepsy
    Jean Pierre Louboutin
    Department of Pathology, Jefferson Medical College, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    CNS Neurol Disord Drug Targets 12:815-29. 2013
  7. ncbi request reprint Ethanol protects from injury due to ischemia and reperfusion by increasing vascularity via vascular endothelial growth factor
    Jean Pierre Louboutin
    Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Alcohol 46:441-54. 2012
  8. ncbi request reprint Gene delivery of antioxidant enzymes inhibits human immunodeficiency virus type 1 gp120-induced expression of caspases
    J P Louboutin
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, United States
    Neuroscience 214:68-77. 2012
  9. pmc Blood-brain barrier abnormalities caused by HIV-1 gp120: mechanistic and therapeutic implications
    Jean Pierre Louboutin
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street Room 255 Philadelphia, PA 19107, USA
    ScientificWorldJournal 2012:482575. 2012
  10. doi request reprint Intracisternal rSV40 administration provides effective pan-CNS transgene expression
    J P Louboutin
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA
    Gene Ther 19:114-8. 2012

Detail Information

Publications41

  1. pmc Preexisting immunity to adenovirus in rhesus monkeys fails to prevent vector-induced toxicity
    Andrei N Varnavski
    Institute for Human Gene Therapy and Department of Molecular and Cellular Engineering, University of Pennsylvania and The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Virol 76:5711-9. 2002
    ..Furthermore, preexisting immunity appears to induce a vector-specific inhibitory effect on erythroid progenitor development in the bone marrow that is not found when naive animals are challenged with vector...
  2. pmc Role of CCR5 and its ligands in the control of vascular inflammation and leukocyte recruitment required for acute excitotoxic seizure induction and neural damage
    Jean Pierre Louboutin
    Department of Pathology, Jefferson Medical College, 1020 Locust St, Rm 251, Philadelphia, PA 19107, USA
    FASEB J 25:737-53. 2011
    ..Controls received unrelated SV(BUGT) vectors. Decrease in CCR5 in circulating cells strongly protected from excitotoxin-induced seizures, BBB leakage, CNS injury, and inflammation, and facilitated neurogenic repair...
  3. ncbi request reprint HIV-1 gp120-induced injury to the blood-brain barrier: role of metalloproteinases 2 and 9 and relationship to oxidative stress
    Jean Pierre Louboutin
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Neuropathol Exp Neurol 69:801-16. 2010
    ....
  4. doi request reprint Dopaminergic neurotoxicity of HIV-1 gp120: reactive oxygen species as signaling intermediates
    Lokesh Agrawal
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA
    Brain Res 1306:116-30. 2010
    ..These findings may help explain why DN loss and Parkinson's-like dysfunction predominate in neuroAIDS and may apply to other neurodegenerative diseases involving the SN...
  5. doi request reprint HIV-1 gp120 neurotoxicity proximally and at a distance from the point of exposure: protection by rSV40 delivery of antioxidant enzymes
    Jean Pierre Louboutin
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Neurobiol Dis 34:462-76. 2009
    ..Thus, SN dopaminergic neurons are highly sensitive to HIV-1 gp120-induced neurotoxicity, and antioxidant gene delivery, even at a distance, is protective...
  6. ncbi request reprint Relationship between the chemokine receptor CCR5 and microglia in neurological disorders: consequences of targeting CCR5 on neuroinflammation, neuronal death and regeneration in a model of epilepsy
    Jean Pierre Louboutin
    Department of Pathology, Jefferson Medical College, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    CNS Neurol Disord Drug Targets 12:815-29. 2013
    ....
  7. ncbi request reprint Ethanol protects from injury due to ischemia and reperfusion by increasing vascularity via vascular endothelial growth factor
    Jean Pierre Louboutin
    Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Alcohol 46:441-54. 2012
    ..Finally, ethanol consumption protected myocardium following experimental ischemia/reperfusion...
  8. ncbi request reprint Gene delivery of antioxidant enzymes inhibits human immunodeficiency virus type 1 gp120-induced expression of caspases
    J P Louboutin
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, United States
    Neuroscience 214:68-77. 2012
    ..Thus, HIV-1 gp120 increased caspases expression in the CP. Prior antioxidant enzyme treatment mitigated production of these caspases, probably by reducing ROS levels...
  9. pmc Blood-brain barrier abnormalities caused by HIV-1 gp120: mechanistic and therapeutic implications
    Jean Pierre Louboutin
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street Room 255 Philadelphia, PA 19107, USA
    ScientificWorldJournal 2012:482575. 2012
    ....
  10. doi request reprint Intracisternal rSV40 administration provides effective pan-CNS transgene expression
    J P Louboutin
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA
    Gene Ther 19:114-8. 2012
    ..Thus, intracisternal administration of antioxidant-carrying rSV40 vectors may be useful in treating widespread CNS diseases such as HIV-1-associated neurocognitive disorders characterized by oxidative stress...
  11. ncbi request reprint S-protein is expressed in necrotic fibers in Duchenne muscular dystrophy and polymyositis
    Jean Pierre Louboutin
    Department of Medicine, Division of Medical Genetics, University of Pennsylvania School of Medicine, Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104 4268, USA
    Muscle Nerve 27:575-81. 2003
    ....
  12. ncbi request reprint A rat model of human immunodeficiency virus 1 encephalopathy using envelope glycoprotein gp120 expression delivered by SV40 vectors
    Jean Pierre Louboutin
    Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Neuropathol Exp Neurol 68:456-73. 2009
    ....
  13. ncbi request reprint Rat bone marrow progenitor cells transduced in situ by rSV40 vectors differentiate into multiple central nervous system cell lineages
    Jean Pierre Louboutin
    Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, 1020 Locust Street, Philadelphia, Pennsylvania 19107, USA
    Stem Cells 24:2801-9. 2006
    ..6%), as determined by double immunostaining for FLAG and lineage markers. These data suggest that one or more populations of cells resident within adult bone marrow can migrate to the brain and differentiate into CNS-specific cells...
  14. ncbi request reprint In vivo gene transfer to the CNS using recombinant SV40-derived vectors
    Jean Pierre Louboutin
    Thomas Jefferson University, Department of Pathology, Anatomy and Cell Biology, 1020 Locust Street, Room 255, Philadelphia, PA 19107, USA
    Expert Opin Biol Ther 8:1319-35. 2008
    ..Gene transfer to the CNS has been approached using various vectors...
  15. ncbi request reprint Strategies for CNS-directed gene delivery: in vivo gene transfer to the brain using SV40-derived vectors
    J P Louboutin
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Gene Ther 14:939-49. 2007
    ..SV40-derived vectors may, thus, be useful for long-term gene expression in the brain, whether locally by intraparenchymal administration or diffusely by intraventricular injection, with or without mannitol...
  16. ncbi request reprint Delivering genes to the organ-localized immune system: long-term results of direct intramarrow transduction
    Jean Pierre Louboutin
    Department of Pathology, Jefferson Medical College, Philadelphia, PA 19107, USA
    J Gene Med 9:843-51. 2007
    ....
  17. ncbi request reprint HIV-1 gp120-induced neuroinflammation: relationship to neuron loss and protection by rSV40-delivered antioxidant enzymes
    Jean Pierre Louboutin
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Room 255, Philadelphia, PA 19107, USA
    Exp Neurol 221:231-45. 2010
    ..Thus, gp120-induced CNS injury, neuron loss and inflammation may be mitigated by antioxidant gene delivery...
  18. doi request reprint Blood-brain barrier abnormalities caused by exposure to HIV-1 gp120--protection by gene delivery of antioxidant enzymes
    Jean Pierre Louboutin
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Neurobiol Dis 38:313-25. 2010
    ..Thus: acute and chronic exposure to gp120 disrupts the BBB; gp120-mediated BBB abnormalities are related to lesions of brain microvessels; and gp120 is directly toxic to brain endothelial cells...
  19. doi request reprint Gene transfer to the cerebellum
    Jean Pierre Louboutin
    Department of Pathology, Jefferson Medical College, Thomas Jefferson University, 1020 Locust Street, Room 255, Philadelphia, PA 19107, USA
    Cerebellum 9:587-97. 2010
    ..No inflammatory or other reaction was detected at any time. Thus, SV40-derived vectors can deliver effective, safe, and durable transgene expression to the cerebellum...
  20. doi request reprint Efficient CNS gene delivery by intravenous injection
    Jean Pierre Louboutin
    Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Nat Methods 7:905-7. 2010
    ..Intravenous injection of rSV40s, particularly with mannitol pretreatment, resulted in extensive expression of multiple transgenes throughout the CNS...
  21. doi request reprint Bone marrow-derived cells migrate to line the vessels of the CNS: opportunities for gene delivery to CNS vasculature
    J P Louboutin
    Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Neuroscience 195:215-23. 2011
    ..Intramarrow gene delivery may provide an avenue to deliver genes to the vascular endothelium of the CNS...
  22. doi request reprint HIV-1 gp120 upregulates matrix metalloproteinases and their inhibitors in a rat model of HIV encephalopathy
    Jean Pierre Louboutin
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Eur J Neurosci 34:2015-23. 2011
    ..Thus, HIV-1 gp120 upregulated TIMP-1 and TIMP-2 in the CP. Prior antioxidant enzyme treatment mitigated production of these TIMPs, probably by reducing MMP expression...
  23. ncbi request reprint Protecting neurons from HIV-1 gp120-induced oxidant stress using both localized intracerebral and generalized intraventricular administration of antioxidant enzymes delivered by SV40-derived vectors
    J P Louboutin
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Gene Ther 14:1650-61. 2007
    ..These findings suggest the potential utility of both localized and widespread gene delivery in treating neuroAIDS and other CNS diseases characterized by excessive oxidative stress...
  24. doi request reprint HIV-1 Tat neurotoxicity: a model of acute and chronic exposure, and neuroprotection by gene delivery of antioxidant enzymes
    Lokesh Agrawal
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Neurobiol Dis 45:657-70. 2012
    ....
  25. ncbi request reprint Toll-like receptor 4 mediates innate immune responses to Haemophilus influenzae infection in mouse lung
    Xiaorong Wang
    Institute for Human Gene Therapy, Department of Molecular and Cellular Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 168:810-5. 2002
    ..influenzae in the lung. This suggests that the airway epithelia might contribute to sensing of H. influenzae infection and signaling the innate immune response...
  26. ncbi request reprint Preventing HIV-1 Tat-induced neuronal apoptosis using antioxidant enzymes: mechanistic and therapeutic implications
    Lokesh Agrawal
    Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Room 251, 1020 Locust Street, Philadelphia, PA 19107, USA
    Virology 363:462-72. 2007
    ..Tat therefore activates multiple signaling pathways, in one of which superoxide acts as an intermediate while the other utilizes peroxide. Gene delivery to protect neurons from Tat must therefore target both...
  27. ncbi request reprint Correction of the dystrophic phenotype by in vivo targeting of muscle progenitor cells
    Gary P Kobinger
    Gene Therapy Program, Division of Medical Genetics, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Hum Gene Ther 14:1441-9. 2003
    ..This study shows that progenitor cells can be genetically engineered in vivo and subsequently proliferate into terminally differentiated tissue carrying the genetic graft in a way that stably corrects function...
  28. ncbi request reprint Transduction of satellite cells after prenatal intramuscular administration of lentiviral vectors
    Tippi C MacKenzie
    The Children s Institute for Surgical Science, Children s Hospital of Philadelphia, Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104 4318, USA
    J Gene Med 7:50-8. 2005
    ..In this study we performed experiments to further define the morphology and function of these cells...
  29. ncbi request reprint Lymphocyte adhesion to CCR5 ligands is reduced by anti-CCR5 gene delivery
    Elena Marusich
    Department of Pathology, Jefferson Medical College, Thomas Jefferson University, 1020 Locust Street, Philadelphia, Pennsylvania 19107, USA
    J Neurol Sci 308:25-7. 2011
    ..These data suggest that reducing CCR5 in peripheral blood mononuclear cells (PBMCs) might alter their adhesion to the microvasculature and their participation in inflammatory processes...
  30. ncbi request reprint Long-term gene expression in dividing and nondividing cells using SV40-derived vectors
    David S Strayer
    Department of Pathology and Cell Biology, Jefferson Medical College, Philadelphia, PA, USA
    Mol Biotechnol 34:257-70. 2006
    ....
  31. ncbi request reprint Pharmacologically regulated regeneration of functional human pancreatic islets
    Gary P Kobinger
    Gene Therapy Program, Division of Medical Genetics, Department of Medicine, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    Mol Ther 11:105-11. 2005
    ..This strategy has the potential to reduce the quantity of human islets required for treatment of patients with Type I diabetes...
  32. pmc Human airway epithelial cells sense Pseudomonas aeruginosa infection via recognition of flagellin by Toll-like receptor 5
    Zhe Zhang
    Gene Therapy Program, Division of Medical Genetics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Infect Immun 73:7151-60. 2005
    ..These findings demonstrate that the airway epithelial receptor TLR5 senses P. aeruginosa through its flagellin protein, which may have an important role in the initiation of the host inflammatory reaction to clear the invading pathogen...
  33. pmc Preterminal host dendritic cells in irradiated mice prime CD8+ T cell-mediated acute graft-versus-host disease
    Yi Zhang
    Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Clin Invest 109:1335-44. 2002
    ..These results indicate that, although host DCs disappear rapidly after allogeneic bone marrow transplantation, they prime donor T cells before their disappearance and play a critical role in triggering donor CD8+ T cell-mediated GVHD...
  34. ncbi request reprint Gene therapy with novel adeno-associated virus vectors substantially diminishes atherosclerosis in a murine model of familial hypercholesterolemia
    Corinna Lebherz
    Gene Therapy Program, Division of Medical Genetics, The University of Pennsylvania School of Medicine, Pennsylvania, USA
    J Gene Med 6:663-72. 2004
    ..We recently isolated a new family of vectors based on adeno-associated viruses (AAVs) isolated from nonhuman primates, which enable efficient and stable transgene expression following in vivo gene delivery to liver...
  35. ncbi request reprint Gene transfer into skeletal muscle using novel AAV serotypes
    Jean Pierre Louboutin
    Gene Therapy Program, Department of Medicine, Division of Medical Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Gene Med 7:442-51. 2005
    ..Recently, novel AAVs (AAV7 and AAV8) were isolated from rhesus macaques...
  36. ncbi request reprint Airway epithelia regulate expression of human beta-defensin 2 through Toll-like receptor 2
    Xiaorong Wang
    Department of Medicine, Medical Genetics Division, University of Pennsylvania School of Medicine, Philadelphia, USA
    FASEB J 17:1727-9. 2003
    ..These data provide convincing evidence that up-regulation of hBD2 can be induced through hTLR2-mediated NFkappaB/IkappaB pathway in the human airway epithelial cells...
  37. ncbi request reprint In vivo quantitative noninvasive imaging of gene transfer by single-photon emission computerized tomography
    Alberto Auricchio
    Department of Medicine, and The Wistar Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Hum Gene Ther 14:255-61. 2003
    ..This should be useful to monitor gene transfer in the settings of gene therapy...
  38. ncbi request reprint APCs in the liver and spleen recruit activated allogeneic CD8+ T cells to elicit hepatic graft-versus-host disease
    Yi Zhang
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 169:7111-8. 2002
    ..Thus, tissue-resident APCs control the local recruitment of allo-reactive donor T cells and the subsequent development of acute GVHD...
  39. ncbi request reprint Transduction of human islets with pseudotyped lentiviral vectors
    Gary P Kobinger
    Gene Therapy Program, Division of Medical Genetics, Department of Medicine, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    Hum Gene Ther 15:211-9. 2004
    ..Overall, our study describes an improved methodology for achieving safe and efficient gene transfer into cells of human islets...
  40. ncbi request reprint Novel adenoviral vectors coding for GFP-tagged wtCFTR and deltaF508-CFTR: characterization of expression and electrophysiological properties in A549 cells
    Horia Vais
    Division of Medical Genetics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Pflugers Arch 449:278-87. 2004
    ..The data show that high levels of functional GFP-tagged CFTR channels can be expressed with these adenoviral vector constructs...
  41. pmc The p38 mitogen-activated protein kinase signaling pathway is coupled to Toll-like receptor 5 to mediate gene regulation in response to Pseudomonas aeruginosa infection in human airway epithelial cells
    Zhe Zhang
    Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Infect Immun 75:5985-92. 2007
    ..These results demonstrate a role for p38 MAPK signaling in gene regulation in response to P. aeruginosa via TLR5...