Carlos Lopez

Summary

Publications

  1. doi request reprint Is it necessary to evaluate nuclei in HER2 FISH evaluation?
    Carlos Lopez
    Molecular Biology and Research Section, Hospital de Tortosa Verge de la Cinta, IISPV, URV, Tortosa, Spain
    Am J Clin Pathol 139:47-54. 2013
  2. pmc Validation of various adaptive threshold methods of segmentation applied to follicular lymphoma digital images stained with 3,3'-Diaminobenzidine&Haematoxylin
    Anna Korzyńska
    Nalecz Institute of Biocybernetics and Biomedical Engineering, Ks Trojdena 4 Str, Warsaw, Poland
    Diagn Pathol 8:48. 2013
  3. pmc Lipid-lowering drugs in ischaemic heart disease: a quasi-experimental uncontrolled before-and-after study of the effectiveness of clinical practice guidelines
    Rosa Dalmau
    ABS Tortosa Est, Institut Català de la Salut ICS, Institut Universitari d Investigació en Atenció Primària IDIAP Jordi Gol, Tortosa, Spain
    BMC Cardiovasc Disord 11:47. 2011
  4. doi request reprint Roundness variation in JPEG images affects the automated process of nuclear immunohistochemical quantification: correction with a linear regression model
    Carlos Lopez
    Department of Pathology, Hospital de Tortosa Verge de la Cinta, IISPV, C Esplanetes no 14, Tortosa 43500, Spain
    Histochem Cell Biol 132:469-77. 2009
  5. doi request reprint Automated quantification of nuclear immunohistochemical markers with different complexity
    Carlos Lopez
    Department of Pathology, Hospital de Tortosa Verge de la Cinta, Tarragona, Spain
    Histochem Cell Biol 129:379-87. 2008
  6. doi request reprint JPEG2000 for automated quantification of immunohistochemically stained cell nuclei: a comparative study with standard JPEG format
    Marylène Lejeune
    Molecular Biology and Research Section, Hospital de Tortosa Verge de la Cinta, IISPV, URV, c Esplanetes 14, 43500, Tortosa, Spain
    Virchows Arch 458:237-45. 2011
  7. doi request reprint Appraisal of immune response in lymphoproliferative syndromes: a systematic review
    Tomas Alvaro
    Department of Pathology, Hospital de Tortosa Verge de la Cinta, Tortosa, Spain
    Crit Rev Oncol Hematol 70:103-13. 2009
  8. ncbi request reprint Digital image analysis in breast cancer: an example of an automated methodology and the effects of image compression
    Carlos Lopez
    Unitat de Suport a la Recerca de la Gerencia Territorial Terres de l Ebre, IDIAP, Tortosa, Spain
    Stud Health Technol Inform 179:155-71. 2012
  9. doi request reprint Tumor-infiltrated immune response correlates with alterations in the apoptotic and cell cycle pathways in Hodgkin and Reed-Sternberg cells
    Tomas Alvaro
    Department of Pathology, Hospital de Tortosa Verge de la Cinta, Tortosa, Spain
    Clin Cancer Res 14:685-91. 2008
  10. ncbi request reprint The presence of STAT1-positive tumor-associated macrophages and their relation to outcome in patients with follicular lymphoma
    Tomas Alvaro
    Department of Pathology, Hospital de Tortosa Verge de la Cinta, C Esplanetes n 14, 43500 Tortosa, Spain
    Haematologica 91:1605-12. 2006

Collaborators

Detail Information

Publications12

  1. doi request reprint Is it necessary to evaluate nuclei in HER2 FISH evaluation?
    Carlos Lopez
    Molecular Biology and Research Section, Hospital de Tortosa Verge de la Cinta, IISPV, URV, Tortosa, Spain
    Am J Clin Pathol 139:47-54. 2013
    ..The proposed enhanced method substantially improves HER2 FISH assessment in breast cancer biopsy specimens because the evaluation of HER2/CEP17 copy numbers is more representative, easier, and faster than the conventional method...
  2. pmc Validation of various adaptive threshold methods of segmentation applied to follicular lymphoma digital images stained with 3,3'-Diaminobenzidine&Haematoxylin
    Anna Korzyńska
    Nalecz Institute of Biocybernetics and Biomedical Engineering, Ks Trojdena 4 Str, Warsaw, Poland
    Diagn Pathol 8:48. 2013
    ..The Sauvola and the Bernsen methods gives complementary results what will be exploited when the new method of virtual tissue slides segmentation be develop...
  3. pmc Lipid-lowering drugs in ischaemic heart disease: a quasi-experimental uncontrolled before-and-after study of the effectiveness of clinical practice guidelines
    Rosa Dalmau
    ABS Tortosa Est, Institut Català de la Salut ICS, Institut Universitari d Investigació en Atenció Primària IDIAP Jordi Gol, Tortosa, Spain
    BMC Cardiovasc Disord 11:47. 2011
    ..Secondary objectives are to assess the improvement of the prescription profile of these LLDs, to assess cardiovascular morbimortality and the professional profile and participant centre characteristics that govern the control of LDL-C...
  4. doi request reprint Roundness variation in JPEG images affects the automated process of nuclear immunohistochemical quantification: correction with a linear regression model
    Carlos Lopez
    Department of Pathology, Hospital de Tortosa Verge de la Cinta, IISPV, C Esplanetes no 14, Tortosa 43500, Spain
    Histochem Cell Biol 132:469-77. 2009
    ..Our results demonstrate that it is possible to carry out unbiased automated immunohistochemical nuclear quantification in compressed DIs with a methodology that could be easily incorporated in different systems of digital image analysis...
  5. doi request reprint Automated quantification of nuclear immunohistochemical markers with different complexity
    Carlos Lopez
    Department of Pathology, Hospital de Tortosa Verge de la Cinta, Tarragona, Spain
    Histochem Cell Biol 129:379-87. 2008
    ..In conclusion, this new automated procedure is an objective, faster and reproducible method that has an excellent level of accuracy, even with digital images with a high complexity...
  6. doi request reprint JPEG2000 for automated quantification of immunohistochemically stained cell nuclei: a comparative study with standard JPEG format
    Marylène Lejeune
    Molecular Biology and Research Section, Hospital de Tortosa Verge de la Cinta, IISPV, URV, c Esplanetes 14, 43500, Tortosa, Spain
    Virchows Arch 458:237-45. 2011
    ..These data suggest that JPEG2000 could give rise to an efficient means of storage, reducing file size and storage capacity, without compromise on the immunohistochemical analytical quality...
  7. doi request reprint Appraisal of immune response in lymphoproliferative syndromes: a systematic review
    Tomas Alvaro
    Department of Pathology, Hospital de Tortosa Verge de la Cinta, Tortosa, Spain
    Crit Rev Oncol Hematol 70:103-13. 2009
    ....
  8. ncbi request reprint Digital image analysis in breast cancer: an example of an automated methodology and the effects of image compression
    Carlos Lopez
    Unitat de Suport a la Recerca de la Gerencia Territorial Terres de l Ebre, IDIAP, Tortosa, Spain
    Stud Health Technol Inform 179:155-71. 2012
    ..Moreover, the results demonstrate that with correction factors, it is possible to carry out unbiased automated quantifications on IHC nuclear markers in compressed DIs...
  9. doi request reprint Tumor-infiltrated immune response correlates with alterations in the apoptotic and cell cycle pathways in Hodgkin and Reed-Sternberg cells
    Tomas Alvaro
    Department of Pathology, Hospital de Tortosa Verge de la Cinta, Tortosa, Spain
    Clin Cancer Res 14:685-91. 2008
    ..To analyze tumor-microenvironment relationships in Hodgkin lymphoma (HL) as potential determinants in the decision-making process related to the alterations in cell cycle and apoptotic pathways of Hodgkin/Reed-Sternberg (H/RS) cells...
  10. ncbi request reprint The presence of STAT1-positive tumor-associated macrophages and their relation to outcome in patients with follicular lymphoma
    Tomas Alvaro
    Department of Pathology, Hospital de Tortosa Verge de la Cinta, C Esplanetes n 14, 43500 Tortosa, Spain
    Haematologica 91:1605-12. 2006
    ..The aim of this study was to determine the extent to which macrophages are present in FL and to investigate the expression of STAT1 in these cells...
  11. pmc Quantification of diverse subcellular immunohistochemical markers with clinicobiological relevancies: validation of a new computer-assisted image analysis procedure
    Marylène Lejeune
    Department of Pathology, Hospital de Tortosa Verge de la Cinta, Tortosa, Spain
    J Anat 212:868-78. 2008
    ..Our semi-automated computerized method eliminates the major causes of observer variability and may be considered a valid alternative to manual microscopic quantification for diagnostic, prognostic and therapeutic purposes...
  12. ncbi request reprint Immunohistochemical patterns of reactive microenvironment are associated with clinicobiologic behavior in follicular lymphoma patients
    Tomas Alvaro
    Department of Pathology, Hospital Verge de la Cinta, Tortosa, Spain
    J Clin Oncol 24:5350-7. 2006
    ..Recent molecular data have suggested that non-neoplastic cells are powerful modulators that may confer a selective advantage or disadvantage on the outcome of follicular lymphoma (FL) patients...