A J Lopez

Summary

Publications

  1. ncbi request reprint Alternative splicing of pre-mRNA: developmental consequences and mechanisms of regulation
    A J Lopez
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Annu Rev Genet 32:279-305. 1998
  2. ncbi request reprint Generation of alternative Ultrabithorax isoforms and stepwise removal of a large intron by resplicing at exon-exon junctions
    A R Hatton
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Mol Cell 2:787-96. 1998
  3. pmc Trans-acting factors required for inclusion of regulated exons in the Ultrabithorax mRNAs of Drosophila melanogaster
    J M Burnette
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennyslvania 15213, USA
    Genetics 151:1517-29. 1999
  4. pmc Evolutionary conservation of the structure and expression of alternatively spliced Ultrabithorax isoforms from Drosophila
    H M Bomze
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213
    Genetics 136:965-77. 1994
  5. pmc Functional differences between Ultrabithorax protein isoforms in Drosophila melanogaster: evidence from elimination, substitution and ectopic expression of specific isoforms
    V Subramaniam
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213
    Genetics 136:979-91. 1994
  6. ncbi request reprint Identification of fat-cell enhancer regions in Drosophila melanogaster
    J M Miller
    Department of Biological Sciences, University of Nevada, Las Vegas, 4505 Maryland Parkway, Box 454004, Las Vegas, Nevada 89154 4004, USA
    Insect Mol Biol 11:67-77. 2002
  7. ncbi request reprint CD-tagging: a new approach to gene and protein discovery and analysis
    J W Jarvik
    Carnegie Mellon University, Pittsburgh, PA, USA
    Biotechniques 20:896-904. 1996
  8. pmc Identification of target genes regulated by homeotic proteins in Drosophila melanogaster through genetic selection of Ultrabithorax protein-binding sites in yeast
    G S Mastick
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213
    Genetics 139:349-63. 1995
  9. pmc Immunochemical dissection of the Ultrabithorax homeoprotein family in Drosophila melanogaster
    A J Lopez
    Department of Biochemistry, Stanford University School of Medicine, CA 94305 5307
    Proc Natl Acad Sci U S A 88:9924-8. 1991

Collaborators

  • A R Hatton
  • J M Miller
  • V Subramaniam
  • J M Burnette
  • T Oligino
  • M Pazdera
  • D K Hoshizaki
  • J W Jarvik
  • H M Bomze
  • G S Mastick
  • C A Telmer
  • S A Adler
  • R McKay
  • K Donovan

Detail Information

Publications9

  1. ncbi request reprint Alternative splicing of pre-mRNA: developmental consequences and mechanisms of regulation
    A J Lopez
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Annu Rev Genet 32:279-305. 1998
    ..Cooperative and antagonistic effects integrated at regulatory elements are likely to be important for specificity and for finely tuned differences in cell-type-specific alternative splicing patterns...
  2. ncbi request reprint Generation of alternative Ultrabithorax isoforms and stepwise removal of a large intron by resplicing at exon-exon junctions
    A R Hatton
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Mol Cell 2:787-96. 1998
    ..Structural similarities predict the same process for mII. This resplicing mechanism avoids competition between distant splice sites for control of exon inclusion and allows removal of a 74 kb intron as a series of smaller fragments...
  3. pmc Trans-acting factors required for inclusion of regulated exons in the Ultrabithorax mRNAs of Drosophila melanogaster
    J M Burnette
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennyslvania 15213, USA
    Genetics 151:1517-29. 1999
    ..Deletion of at least five other loci caused significant reductions in the inclusion of mI and/or mII. Possible roles of identified factors are discussed in the context of the resplicing strategy for generation of alternative Ubx mRNAs...
  4. pmc Evolutionary conservation of the structure and expression of alternatively spliced Ultrabithorax isoforms from Drosophila
    H M Bomze
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213
    Genetics 136:965-77. 1994
    ..These findings argue for an important role of alternative splicing in Ubx function. We discuss the implications of these results for models of UBX protein function and the mechanism of alternative splicing...
  5. pmc Functional differences between Ultrabithorax protein isoforms in Drosophila melanogaster: evidence from elimination, substitution and ectopic expression of specific isoforms
    V Subramaniam
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213
    Genetics 136:979-91. 1994
    ..Additional observations suggest that UBX isoforms also differ in their ability to function in other tissues...
  6. ncbi request reprint Identification of fat-cell enhancer regions in Drosophila melanogaster
    J M Miller
    Department of Biological Sciences, University of Nevada, Las Vegas, 4505 Maryland Parkway, Box 454004, Las Vegas, Nevada 89154 4004, USA
    Insect Mol Biol 11:67-77. 2002
    ..This may be a common mechanism in insects to explain the origin of biochemically distinct regions of the larval/adult fat body...
  7. ncbi request reprint CD-tagging: a new approach to gene and protein discovery and analysis
    J W Jarvik
    Carnegie Mellon University, Pittsburgh, PA, USA
    Biotechniques 20:896-904. 1996
    ....
  8. pmc Identification of target genes regulated by homeotic proteins in Drosophila melanogaster through genetic selection of Ultrabithorax protein-binding sites in yeast
    G S Mastick
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213
    Genetics 139:349-63. 1995
    ..With appropriate modifications, this approach should be applicable to other transcriptional regulators in diverse organisms...
  9. pmc Immunochemical dissection of the Ultrabithorax homeoprotein family in Drosophila melanogaster
    A J Lopez
    Department of Biochemistry, Stanford University School of Medicine, CA 94305 5307
    Proc Natl Acad Sci U S A 88:9924-8. 1991
    ..These results support the hypothesis that alternative splicing and phosphorylation modulate developmentally specific functions of the Ubx gene...