Brain imaging studies of cocaine abuse: implications for medication developmentE D London
The Brain Imaging Center, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Crit Rev Neurobiol 13:227-42. 1999
..The future directions of in vivo brain imaging to identify functional and structural alterations in the brains of cocaine abusers are discussed in relation to the development of medications to treat cocaine dependence...
- Orbitofrontal cortex and human drug abuse: functional imaging
E D London
Brain Imaging Center, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Cereb Cortex 10:334-42. 2000
....
- [125/123I]IPH: a radioiodinated analog of epibatidine for in vivo studies of nicotinic acetylcholine receptors
J L Musachio
Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Synapse 26:392-9. 1997
..123)I]IPH seems well suited for imaging studies of nAChRs and, to our knowledge, is the first SPECT agent that has allowed for the visualization of nAChRs in primate brain...
- Correlation of inhibitory potencies of putative antagonists for sigma receptors in brain and spleen
T P Su
Neuropharmacology Laboratory, National Institute on Drug Abuse, Baltimore, Maryland 21224
Eur J Pharmacol 148:467-70. 1988
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- 2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling
A O Koren
Brain Imaging Center, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
J Med Chem 41:3690-8. 1998
..The new ligands with high affinity for nAChRs may be of interest as pharmacological probes, potential medications, and candidates for developing radiohalogenated tracers to study nAChRs...
- Dose-dependent effects of D-N-allylnormetazocine on regional cerebral metabolic rates for glucose
A Della Puppa
Neuroimaging and Drug Action Section, National Institute on Drug Abuse, Baltimore, MD 21224
Brain Res 603:38-46. 1993
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Effect of nicotine on brain activation during performance of a working memory taskM Ernst
Brain Imaging Center and Clinical Pharmacology and Therapeutics Branch, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Proc Natl Acad Sci U S A 98:4728-33. 2001
..Furthermore, the lack of enhancement of activation after nicotine administration in smokers likely reflects tolerance...
- In vivo binding of [3H]d-N-allylnormetazocine and [3H]haloperidol to sigma receptors in the mouse brain
A D Weissman
Neuropharmacology Laboratory, National Institute on Drug Abuse, Baltimore, MD 21224
J Chem Neuroanat 3:347-54. 1990
..The results suggest that radiolabelled d-NANM and HAL may be useful for imaging sigma binding sites in vivo...
- Pharmacological characteristics and distributions of sigma- and phencyclidine receptors in the animal kingdom
T H Vu
Addiction Research Center, National Institute on Drug Abuse, Baltimore, MD 21224
J Neurochem 54:598-604. 1990
..The results suggest that sigma- and phencyclidine binding sites are evolutionarily old, as the characteristics of the two sites are well preserved over a range of vertebrate phyla...
- Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems
T P Su
Addiction Research Center, National Institute on Drug Abuse, Baltimore, MD 21224
Science 240:219-21. 1988
..The findings suggest that steroids are naturally occurring ligands for sigma receptors and raise the possibility that these sites mediate some aspects of steroid-induced mental disturbances and alterations in immune functions...
- Effects of triazolam on brain activity during episodic memory encoding: a PET study
M Z Mintzer
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Neuropsychopharmacology 25:744-56. 2001
..Results are discussed in relation to triazolam's effects on mnemonic versus attentional processes...
- Age-related decline in striatal volume in monkeys as measured by magnetic resonance imaging
J A Matochik
Brain Imaging Center, Neuroimaging Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Neurobiol Aging 21:591-8. 2000
..The current results provide normative data to assess potential interventions (e.g. caloric restriction) in the aging process...
- Extraordinary postmortem stability of kappa opioid receptors in guinea-pig brain
C Ori
Neuropharmacology Laboratory, National Institute on Drug Abuse, Baltimore, MD 21224
J Pharm Pharmacol 39:951-4. 1987
..Postmortem delays of up to 16 h did not alter the affinity or density of kappa binding sites. The remarkable stability of kappa receptors may greatly facilitate the study of this opioid receptor subtype in human brain...
- Divergent ontogeny of sigma and phencyclidine binding sites in the rat brain
M D Majewska
Addiction Research Center, National Institute on Drug Abuse, Baltimore, MD 21224
Brain Res Dev Brain Res 47:13-8. 1989
..The differences in developmental patterns provide evidence for distinctive properties of cerebral sigma and PCP binding sites...
- Drug abusers show impaired performance in a laboratory test of decision making
S Grant
Intramural Research Program, National Institute on Drug Abuse, Brain Imaging Center, 5500 Nathan Shock Drive, MD 21224, Baltimore, USA
Neuropsychologia 38:1180-7. 2000
..These findings indicate that the Gambling Task may be a useful model in laboratory studies of cognitive dysfunctions associated with drug abuse...
- Smoking history and nicotine effects on cognitive performance
M Ernst
Brain Imaging Center, National Institute on Drug Abuse, Baltimore, MD, USA
Neuropsychopharmacology 25:313-9. 2001
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- Peptide T and glucose metabolism in AIDS dementia complex
V L Villemagne
Brain Imaging Section, National Institute on Drug Abuse NIDA, National Institutes of Health NIH, Baltimore, Maryland 21224, USA
J Nucl Med 37:1177-80. 1996
..These preliminary observations suggest that functional neuroimaging techniques provide a useful tool in the evaluation of the response to treatment in ADC patients...
- Electrophysiological and binding studies on intact NCB-20 cells suggest presence of a low affinity sigma receptor
X Z Wu
Neuropharmacology Laboratory, National Institute on Drug Abuse, Baltimore, Maryland 21224
J Pharmacol Exp Ther 257:351-9. 1991
..abstract truncated at 250 words)..
- Selective loss of cerebral cortical sigma, but not PCP binding sites in schizophrenia
A D Weissman
Neuroscience Branch, National Institute on Drug Abuse, Baltimore, MD 21224
Biol Psychiatry 29:41-54. 1991
..These data provide the first evidence for alterations in sigma binding sites in schizophrenia, and suggest that selective sigma ligands may be useful in the treatment of the disorder...
- Cerebral glucose metabolism during opioid withdrawal following methylnaloxonium injection into the locus coeruleus
A S Kimes
Brain Imaging Center, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Brain Res 814:1-12. 1998
..The present data support the view that LC is a major substrate of opioid withdrawal in the brain, and they suggest that LC plays an important role in changing rCMRglc during opioid withdrawal induced by systemic naloxone administration...
- Synthesis and evaluation of N-[11C]methylated analogues of epibatidine as tracers for positron emission tomographic studies of nicotinic acetylcholine receptors
A G Horti
Brain Imaging Center, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, Maryland 21224
J Med Chem 41:4199-206. 1998
..2.1]heptane ([18F]FPH), which are highly specific nAChR probes. The initial brain uptake of the 11C analogues and the acute toxicity of the corresponding authentic nonlabeled compounds appeared to be related to their lipophilicity...
- Assessment of neurotoxicity from potential medications for drug abuse: ibogaine testing and brain imaging
F J Vocci
Medications Development Division, National Institute on Drug Abuse, Rockville, Maryland 20857, USA
Ann N Y Acad Sci 820:29-39; discussion 39-40. 1997
..This "harbinger of toxicity" approach would provide clinicians the critical data necessary for appropriate follow-up of subjects as well as the propriety of continuance of the clinical trials within the ibogaine project...
- Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task
K I Bolla
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Neuroimage 19:1085-94. 2003
..Compromised decision-making could contribute to the development of addiction and undermine attempts at abstinence...
- Autoradiographic evidence that prolonged withdrawal from intermittent cocaine reduces mu-opioid receptor expression in limbic regions of the rat brain
L G Sharpe
Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD 21224, USA
Synapse 37:292-7. 2000
..05). The mu-receptor may manifest, as do other neural markers (e.g., dopamine transporter, dopamine efflux), a biphasic temporal pattern with upregulation during early phases of cocaine withdrawal but a downregulation at later times...
- Effects of extracellular acetylcholine on muscarinic receptor binding assessed by [125I]dexetimide and a simple probe
P M Sanchez-Roa
Department of Environmental Health Sciences, Johns Hopkins University, Baltimore, MD 21205 2179, USA
Eur J Pharmacol 358:207-11. 1998
..These findings demonstrate that dynamic changes in extracellular acetylcholine can be evaluated by displacement of [125I]dexetimide binding in vivo using a simple probe system...
- Aging and caloric restriction in nonhuman primates: behavioral and in vivo brain imaging studies
D K Ingram
Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
Ann N Y Acad Sci 928:316-26. 2001
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