- Independent association of drug-resistant hypertension to reduced sleep duration and efficiency
Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute of the Mount Sinai Hospital, Toronto, Ontario, Canada
Am J Hypertens 23:174-9. 2010
..The objective of this study was to test the hypothesis that short sleep duration is associated with resistant hypertension (RH) independently of OSA, which can itself disrupt and shorten sleep...
- Transforming hypertension management using mobile health technology for telemonitoring and self-care support
Alexander G Logan
Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute of the Mount Sinai Hospital, Department of Medicine of the Mount Sinai Hospital and the University of Toronto, Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada Electronic address
Can J Cardiol 29:579-85. 2013
..Nonetheless, the inability of most electronic medical record systems to receive and process information from mobile devices continues to be a major impediment in realizing the full potential of mHealth technology...
- Effect of home blood pressure telemonitoring with self-care support on uncontrolled systolic hypertension in diabetics
Alexander G Logan
Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 435 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
Hypertension 60:51-7. 2012
..Home blood pressure monitoring alone had no effect on blood pressure. Promoting patient self-care may have negative psychological effects...
- Hypertension in aging patients
Alexander G Logan
Mount Sinai Hospital, 435 600 University Avenue, Toronto, ON M5G 1X5, Canada
Expert Rev Cardiovasc Ther 9:113-20. 2011
..Future management will likely focus on intervening earlier to prevent accelerated vascular aging and irreversible arterial damage...
- Relationship between overnight rostral fluid shift and obstructive sleep apnea in drug-resistant hypertension
Mount Sinai Hospital, Toronto, Ontario, Canada
Hypertension 56:1077-82. 2010
..Our findings support the concept that fluid redistribution centrally during sleep accounts for the high prevalence of obstructive sleep apnea in drug-resistant hypertension...
- Sleep apnea and cardiovascular disease
Alexander G Logan
Mount Sinai Hospital, 435 600 University Avenue, Toronto, ON, M5G 1X5, Canada
Curr Hypertens Rep 12:182-8. 2010
- Suppression of central sleep apnea by continuous positive airway pressure and transplant-free survival in heart failure: a post hoc analysis of the Canadian Continuous Positive Airway Pressure for Patients with Central Sleep Apnea and Heart Failure Trial
University of Toronto, Toronto, Ontario, Canada
Circulation 115:3173-80. 2007
..This stratified analysis of CANPAP tested the hypothesis that suppression of CSA below this threshold by CPAP would improve left ventricular ejection fraction and heart transplant-free survival...
- Mobile phone-based remote patient monitoring system for management of hypertension in diabetic patients
Alexander G Logan
Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
Am J Hypertens 20:942-8. 2007
..The objectives of this study were to develop and pilot-test a home BP tele-management system that actively engages patients in the process of care...
- The price of obstructive sleep apnea-hypopnea: hypertension and other ill effects
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Division of Nephrology, Mount Sinai Hospital and University Health Network, and Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Am J Hypertens 22:474-83. 2009
- Nocturnal blood pressure profiles among normotensive, controlled hypertensive and refractory hypertensive subjects
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
Can J Cardiol 25:e312-6. 2009
..Nocturnal blood pressure abnormalities are independently associated with an increased risk of death and cardiovascular disease. It is unclear, however, whether they are related to the presence or severity of hypertension...
- Attitudes of primary care physicians and their patients about home blood pressure monitoring in Ontario
Alexander G Logan
Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Department of Family and Community Medicine, University of Toronto, Canada
J Hypertens 26:446-52. 2008
..Guidelines recommend home blood pressure monitoring (HBPM) to improve blood pressure control, but the attitudes of primary care physicians and their hypertensive patients towards its use are not known...
- Influence of lower body positive pressure on upper airway cross-sectional area in drug-resistant hypertension
Prosserman Center for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Hypertension 61:240-5. 2013
- Telemanagement of hypertension: a qualitative assessment of patient and physician preferences
Nancy V D Halifax
Centre for Global eHealth Innovation, University Health Network, Mount Sinai Hospital, Toronto, Ontario
Can J Cardiol 23:591-4. 2007
..Major design flaws and high operating costs, however, have hindered its adoption by physicians and patients...
- Relationship between self-reported sleep duration and changes in circadian blood pressure
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Am J Hypertens 22:1205-11. 2009
..The relationship, however, between these two entities remains unclear. This study was undertaken to determine whether abnormal sleep duration is associated with nondipping status and elevated morning surge...
- The cost effectiveness of ACE inhibitors as first-line antihypertensive therapy
Alain J Nordmann
The Programme in Clinical Epidemiology and Health Care Research, University of Toronto, Toronto, Ontario, Canada
Pharmacoeconomics 21:573-85. 2003
..Current hypertension guidelines differ in their recommendations for first-line antihypertensive therapy...
- Ethnic differences in relative risk of idiopathic calcium nephrolithiasis in North America
Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
J Urol 178:1992-7; discussion 1997. 2007
..We determined the relative risk of calcium nephrolithiasis among people of different ethnic backgrounds living in the same geographic region...
- Sympathoadrenal mechanisms in the pathogenesis of sleep apnea-related hypertension
Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
Curr Hypertens Rep 11:212-6. 2009
..Taken together, these findings strengthen the claim that the sympathoadrenal pressor system is essential for the development of the hypertensive state in individuals with OSAH...
- Effect of continuous positive airway pressure on sleep structure in heart failure patients with central sleep apnea
University of Toronto, Toronto, ON, Canada
Sleep 32:91-8. 2009
..If so, they should diminish in frequency when CSA is attenuated. We therefore sought to determine whether attenuation of CSA by CPAP reduces arousal frequency...
- Incidence and risk factors for cardiovascular events and death in pediatric renal transplant patients: a single center long-term outcome study
Susan M Koshy
Division of Nephrology, Department of Pediatrics, SickKids Hospital, Toronto, ON, Canada
Pediatr Transplant 13:1027-33. 2009
..The rates of developing CV disease and dying prematurely are extraordinarily high in PRTx, underscoring the need for early and aggressive intervention to reduce the burden of suffering in this patient population...
- Continuous positive airway pressure for central sleep apnea and heart failure
T Douglas Bradley
Department of Medicine, University of Toronto, Toronto
N Engl J Med 353:2025-33. 2005
- Association between refractory hypertension and obstructive sleep apnea
Sleep Research Laboratory of the Toronto Rehabilitation Institute, Toronto, Ontario, Canada
J Hypertens 27:1439-45. 2009
..Rapid eye movement (REM) sleep deprivation can raise blood pressure in animals. However, a potential relationship of OSA and REM sleep time with RHT has not been examined...
- Balloon angioplasty or medical therapy for hypertensive patients with atherosclerotic renal artery stenosis? A meta-analysis of randomized controlled trials
Alain J Nordmann
Department of Medicine, University Health Network, Toronto, Ontario, Canada
Am J Med 114:44-50. 2003
..The optimal treatment for hypertensive patients with atherosclerotic renal artery stenosis is controversial. We performed a meta-analysis comparing the effects of balloon angioplasty and medical therapy in these patients...
- Relationship of systolic BP to obstructive sleep apnea in patients with heart failure
Don D Sin
Sleep Research Laboratory, Toronto Rehabilitation Institute, ON, Canada
Chest 123:1536-43. 2003
..Our objective was to determine whether OSA would be associated with elevated daytime BP in medically treated patients with CHF...
- High urinary calcium excretion and genetic susceptibility to hypertension and kidney stone disease
Department of Medicine, Division of Nephrology, Mount Sinai Hospital, Room 435, 600 University Avenue, Toronto, Ont M5G1X5, Canada
J Am Soc Nephrol 17:2567-75. 2006
..Although an environmental effect cannot be excluded fully, our findings suggest that the disturbance in calcium metabolism in hypertension and KSD has a genetic basis...
- Molecular variants of the thiazide-sensitive Na+-Cl- cotransporter in hypertensive families
Andras P Keszei
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
J Hypertens 25:2074-81. 2007
..The thiazide-sensitive Na-Cl cotransporter (TSC) is involved in the fine regulation of sodium excretion by the kidney, and an increase in its activity causes salt-sensitive hypertension and hypercalciuria...
- Lifestyle modifications to prevent and manage hypertension for exercise physiologists and fitness professionals
Veronica K Jamnik
Kinesiology and Health Sci, York Univ, Bethune College, Toronto, ON
Can J Appl Physiol 30:754-61. 2005
- Heterogeneity in IBD allele sharing among covariate-defined subgroups: issues and findings for affected relatives
Shelley B Bull
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ont, Canada
Hum Hered 56:94-106. 2003
..In this report, we highlight issues that arise in studies of families with affected relatives...
- Transforming growth factor beta-1 (TGFB1) and peak bone mass: association between intragenic polymorphisms and quantitative ultrasound of the heel
Dept of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada
BMC Musculoskelet Disord 6:29. 2005
..However, a comprehensive look at multiple SNPs at this locus for their association with indices of peak bone mass has not been reported...
- Familial aggregation of diabetes and hypertension in a case-control study of colorectal neoplasia
Paula M Brauer
Department of Public Health Sciences, University of Toronto, Ontario, Canada
Am J Epidemiol 156:702-13. 2002
..Family studies are needed to understand the contribution of specific environmental and genetic factors in accounting for the disease aggregations...
- Can nocturnal hypertension predict cardiovascular risk?
Samuel Lunenfeld Research Institute, Division of Nephrology, Mount Sinai Hospital
Integr Blood Press Control 2:25-37. 2009
- Urinary potassium is a clinically useful test to detect a poor quality diet
Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada
J Nutr 139:743-9. 2009
..Urinary K(+) provides a summary measure of diet quality, is significantly related to BMI, blood pressure, and heart rate, and may be useful clinically to detect poor dietary habits and monitor response to dietary interventions...