Richard F Loeser

Summary

Publications

  1. pmc Disease progression and phasic changes in gene expression in a mouse model of osteoarthritis
    Richard F Loeser
    Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    PLoS ONE 8:e54633. 2013
  2. pmc Aging processes and the development of osteoarthritis
    Richard F Loeser
    Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Curr Opin Rheumatol 25:108-13. 2013
  3. pmc Aging and osteoarthritis
    Richard F Loeser
    Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Curr Opin Rheumatol 23:492-6. 2011
  4. pmc The Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationale
    Stephen P Messier
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC, USA
    BMC Musculoskelet Disord 10:93. 2009
  5. pmc Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis
    John D Cravero
    Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Arthritis Rheum 60:492-500. 2009
  6. doi request reprint Inflammatory biomarkers and physical function in older, obese adults with knee pain and self-reported osteoarthritis after intensive weight-loss therapy
    Gary D Miller
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC 27109 7868, USA
    J Am Geriatr Soc 56:644-51. 2008
  7. pmc Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes
    Raghunatha R Yammani
    Department of Internal Medicine, Section of Molecular Medicine, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Arthritis Res Ther 14:R23. 2012
  8. ncbi request reprint Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the Arthritis, Diet, and Activity Promotion Trial
    Stephen P Messier
    Claude D Pepper Older Americans Independence Center, Wake Forest University, Winston Salem, NC 27109, USA
    Arthritis Rheum 50:1501-10. 2004
  9. pmc Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes
    Raghunatha R Yammani
    Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Arthritis Rheum 60:792-800. 2009
  10. pmc Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways
    Weihong Yin
    Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Biol Chem 284:31972-81. 2009

Collaborators

Detail Information

Publications29

  1. pmc Disease progression and phasic changes in gene expression in a mouse model of osteoarthritis
    Richard F Loeser
    Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    PLoS ONE 8:e54633. 2013
    ..This implies that the response to an OA intervention will depend on the timing of the intervention. The quiescent period at 8 weeks may be due to the maturation of the osteophytes which are thought to temporarily stabilize the joint...
  2. pmc Aging processes and the development of osteoarthritis
    Richard F Loeser
    Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Curr Opin Rheumatol 25:108-13. 2013
    ..The most recent literature in this area was reviewed in order to update investigators on the status of the field...
  3. pmc Aging and osteoarthritis
    Richard F Loeser
    Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Curr Opin Rheumatol 23:492-6. 2011
    ..Osteoarthritis is strongly linked to aging but the mechanisms for this link are incompletely understood. The recent literature was reviewed to find studies providing new insights into the connection between aging and osteoarthritis...
  4. pmc The Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationale
    Stephen P Messier
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC, USA
    BMC Musculoskelet Disord 10:93. 2009
    ..This article describes the intervention, the empirical evidence to support it, and test-retest reliability data...
  5. pmc Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis
    John D Cravero
    Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Arthritis Rheum 60:492-500. 2009
    ..This study was undertaken to determine if TRB3 is expressed in chondrocytes, and whether the chondrocyte response to IGF-1 is reduced by TRB3...
  6. doi request reprint Inflammatory biomarkers and physical function in older, obese adults with knee pain and self-reported osteoarthritis after intensive weight-loss therapy
    Gary D Miller
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC 27109 7868, USA
    J Am Geriatr Soc 56:644-51. 2008
    ..To describe the relationships between proinflammatory biomarkers and self-reported and performance-based physical function and to examine the effect of weight loss on these markers of inflammation...
  7. pmc Extracellular nicotinamide phosphoribosyltransferase (NAMPT/visfatin) inhibits insulin-like growth factor-1 signaling and proteoglycan synthesis in human articular chondrocytes
    Raghunatha R Yammani
    Department of Internal Medicine, Section of Molecular Medicine, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Arthritis Res Ther 14:R23. 2012
    ..The purpose of the present study was to determine the role of extracellular nicotinamide phosphoribosyltransferase (eNAMPT/visfatin), a newly described adipokine, in regulating IGF-1 function in chondrocytes...
  8. ncbi request reprint Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the Arthritis, Diet, and Activity Promotion Trial
    Stephen P Messier
    Claude D Pepper Older Americans Independence Center, Wake Forest University, Winston Salem, NC 27109, USA
    Arthritis Rheum 50:1501-10. 2004
    ....
  9. pmc Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes
    Raghunatha R Yammani
    Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Arthritis Rheum 60:792-800. 2009
    ..The aim of this study was to examine the mechanism of S100A4 secretion by chondrocytes...
  10. pmc Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways
    Weihong Yin
    Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Biol Chem 284:31972-81. 2009
    ....
  11. pmc Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice
    Richard F Loeser
    Molecular Medicine, Wake Forest University, Winston Salem, NC 27157, USA
    Arthritis Rheum 64:705-17. 2012
    ..To better understand the contribution of age to the development of osteoarthritis (OA)...
  12. pmc NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments
    Judit I Pulai
    Department of Internal Medicine, Section of Rheumatology, Rush Medical College, Chicago, IL 60612, USA
    J Immunol 174:5781-8. 2005
    ..Targeting the signaling pathways activated by FN-f may be an effective means of inhibiting production of multiple mediators of cartilage destruction...
  13. pmc Human articular chondrocytes produce IL-7 and respond to IL-7 with increased production of matrix metalloproteinase-13
    David Long
    Section of Molecular Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, North Carolina 27157, USA
    Arthritis Res Ther 10:R23. 2008
    ..The purpose of this study was to discover novel mediators of cartilage destruction using fibronectin fragments as a stimulus...
  14. ncbi request reprint Intensive weight loss program improves physical function in older obese adults with knee osteoarthritis
    Gary D Miller
    Department of Health and Exercise Science, Wake Forest University, Winston Salem, NC 27109, USA
    Obesity (Silver Spring) 14:1219-30. 2006
    ..Physical function and body composition in older obese adults with knee osteoarthritis (OA) were examined after intensive weight loss...
  15. pmc Increased matrix metalloproteinase-13 production with aging by human articular chondrocytes in response to catabolic stimuli
    Christopher B Forsyth
    Department of Internal Medicine, Rush Medical College, Rush University Medical Center, Chicago, Illinois, USA
    J Gerontol A Biol Sci Med Sci 60:1118-24. 2005
    ..These results demonstrate a significant age-related increase in chondrocyte catabolic responsiveness which could contribute to the development of osteoarthritis in older adults...
  16. pmc Basic fibroblast growth factor inhibits the anabolic activity of insulin-like growth factor 1 and osteogenic protein 1 in adult human articular chondrocytes
    Richard F Loeser
    Section of Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Arthritis Rheum 52:3910-7. 2005
    ..To determine the effects of basic fibroblast growth factor (bFGF) on the chondrocyte anabolic activity promoted by insulin-like growth factor 1 (IGF-1) and osteogenic protein 1 (OP-1)...
  17. ncbi request reprint Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial
    Barbara J Nicklas
    Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Clin Nutr 79:544-51. 2004
    ..Persistent, low-grade inflammation is an independent predictor of several chronic diseases and all-cause mortality...
  18. pmc Rac1 is required for matrix metalloproteinase 13 production by chondrocytes in response to fibronectin fragments
    David L Long
    Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Arthritis Rheum 65:1561-8. 2013
    ..The objective of this study was to determine the role of the small GTPase Rac1 in chondrocyte signaling stimulated by FN fragments, which results in MMP-13 production...
  19. pmc Age-related changes in the musculoskeletal system and the development of osteoarthritis
    Richard F Loeser
    Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Clin Geriatr Med 26:371-86. 2010
    ..Understanding the basic mechanisms by which aging affects joint tissues should provide new targets for slowing or preventing the development of OA...
  20. pmc Sumoylation and nuclear translocation of S100A4 regulate IL-1beta-mediated production of matrix metalloproteinase-13
    Keally J Miranda
    Section of Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Biol Chem 285:31517-24. 2010
    ..Nuclear S100A4 was bound to the promoter region of MMP-13 in IL-1β-treated cells. Thus, we demonstrate a novel mechanism for sumoylated S100A4 as a regulator of expression of the MMP-13 gene...
  21. pmc Why is osteoarthritis an age-related disease?
    A Shane Anderson
    Section of Rheumatology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Best Pract Res Clin Rheumatol 24:15-26. 2010
    ..The ability to slow progression of OA in older adults will have enormous public health implications given the ageing of our population and the increase in other OA risk factors such as obesity...
  22. pmc Ionizing radiation causes active degradation and reduces matrix synthesis in articular cartilage
    Jeffrey S Willey
    Department of Radiation Oncology, Wake Forest School of Medicine, Winston Salem, North Carolina 27106, USA
    Int J Radiat Biol 89:268-77. 2013
    ..The aim of this study was to determine if radiation can reduce cartilage matrix production, induce cartilage degradation, or interfere with the anabolic effects of IGF-1...
  23. ncbi request reprint Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products
    Raghunatha R Yammani
    Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Arthritis Rheum 54:2901-11. 2006
    ....
  24. ncbi request reprint Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span
    William E Sonntag
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157 1083, USA
    Endocrinology 146:2920-32. 2005
    ....
  25. pmc Mitogen-activated protein kinases as therapeutic targets in osteoarthritis
    Richard F Loeser
    Department of Internal Medicine, Section of Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Curr Opin Rheumatol 20:581-6. 2008
    ..The therapeutic potential of MAP kinase inhibition in osteoarthritis was reviewed...
  26. ncbi request reprint Cell death in osteoarthritis
    Marcello Del Carlo
    Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Curr Rheumatol Rep 10:37-42. 2008
    ..Inhibition of cell death in OA likely will not be a sole therapeutic target but rather a desired effect of interventions designed to reverse the catabolic-anabolic imbalance occurring in OA joint tissues...
  27. ncbi request reprint The Arthritis, Diet and Activity Promotion Trial (ADAPT): design, rationale, and baseline results
    Gary D Miller
    Department of Health and Exercise Science Wake Forest University, Winston Salem, North Carolina 27109, USA
    Control Clin Trials 24:462-80. 2003
    ..The results from ADAPT will provide approaches clinicians should recommend for behavioral therapies that effectively reduce the incidence of disability associated with knee OA...
  28. pmc Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathway
    Richard F Loeser
    Department of Internal Medicine, Rush Medical College, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Biol Chem 278:24577-85. 2003
    ..studies have identified a novel pathway for the MAP kinase regulation of MMP-13 production which involves FN-f stimulation of the alpha5beta1 integrin and activation of the nonreceptor tyrosine kinase PYK2 by PKC, most likely PKCdelta..
  29. ncbi request reprint Integrins and cell signaling in chondrocytes
    Richard F Loeser
    Department of Internal Medicine, Section of Rheumatology, Rush Medical College of Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Biorheology 39:119-24. 2002
    ..A better understanding of chondrocyte integrin signaling is needed to define the mechanisms by which the ECM regulates chondrocyte function...