The effects of neonatal isoflurane exposure in mice on brain cell viability, adult behavior, learning, and memoryAndreas W Loepke
Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Anesth Analg 108:90-104. 2009
..We examined the effects of neonatal isoflurane exposure and blood glucose on brain cell viability, spontaneous locomotor activity, as well as spatial learning and memory in mice...
- Cerebral oxygen saturation-time threshold for hypoxic-ischemic injury in piglets
C Dean Kurth
Department of Anesthesiology, Cincinnati Children s Hospital, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
Anesth Analg 108:1268-77. 2009
..We investigated the relationship between H-I duration at Sc(O2) 35%, a viability threshold which causes neurophysiological impairment, to neurological outcome...
- Desflurane, isoflurane, and sevoflurane provide limited neuroprotection against neonatal hypoxia-ischemia in a delayed preconditioning paradigm
John J McAuliffe
Department of Anesthesia, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3036, USA
Anesthesiology 111:533-46. 2009
..The authors used these agents in a delayed preconditioning model to test the hypothesis that they could provide neuroprotection against neonatal hypoxia-ischemia as assessed by a battery of behavioral tests...
The physiologic effects of isoflurane anesthesia in neonatal miceAndreas W Loepke
Department of Anesthesia, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Anesth Analg 102:75-80. 2006
..Use of 0.8 MAC isoflurane for evaluation of neuroprotection during hypoxia-ischemia requires mechanical ventilation and glucose supplementation in this model...
- Comparison of the neuroapoptotic properties of equipotent anesthetic concentrations of desflurane, isoflurane, or sevoflurane in neonatal mice
George K Istaphanous
Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Anesthesiology 114:578-87. 2011
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Abnormalities of granule cell dendritic structure are a prominent feature of the intrahippocampal kainic acid model of epilepsy despite reduced postinjury neurogenesisBrian L Murphy
Department of Anesthesia, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, U S A
Epilepsia 53:908-21. 2012
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- Anesthetics and sedatives: toxic or protective for the developing brain?
Christopher G Ward
Department of Anesthesia, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
Pharmacol Res 65:271-4. 2012
..The mechanisms and human applicability of anesthetic neurotoxicity and neuroprotection remain under intense investigation and this Perspectives article summarizes the current state of research...
- The impact of the perioperative period on neurocognitive development, with a focus on pharmacological concerns
George K Istaphanous
Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Best Pract Res Clin Anaesthesiol 24:433-49. 2010
..Moreover, this article outlines the putative mechanisms of anaesthetic neurotoxicity, and the phenomenon's implications for clinical practice in this rapidly emerging field...
- General anesthetics and the developing brain
George K Istaphanous
Department of Anesthesia, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Curr Opin Anaesthesiol 22:368-73. 2009
..This review presents recent developments in this rapidly emerging field...
- Heterogeneous integration of adult-generated granule cells into the epileptic brain
Brian L Murphy
Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Neurosci 31:105-17. 2011
..These data imply that newborn cells play complex--and potentially conflicting--roles in epilepsy...
- An assessment of the effects of general anesthetics on developing brain structure and neurocognitive function
Andreas W Loepke
Department of Anesthesia, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, USA
Anesth Analg 106:1681-707. 2008
..In the present review, we assess the evidence for the effects of commonly used anesthetics on neuronal structure and neurocognitive function in newborn humans and animals...
- Structural plasticity of dentate granule cell mossy fibers during the development of limbic epilepsy
Steve C Danzer
Department of Anesthesia, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
Hippocampus 20:113-24. 2010
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- Developmental neurotoxicity of sedatives and anesthetics: a concern for neonatal and pediatric critical care medicine?
Andreas W Loepke
Department of Anesthesia, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA
Pediatr Crit Care Med 11:217-26. 2010
..To evaluate the currently available evidence for the deleterious effects of sedatives and anesthetics on developing brain structure and neurocognitive function...
- Injury pattern of the neonatal brain after hypothermic low-flow cardiopulmonary bypass in a piglet model
Andreas W Loepke
Department of Anesthesia, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Institute of Pediatric Anesthesia, Cincinnati Children s Hospital Research Foundation, Ohio 45229, USA
Anesth Analg 101:340-8, table of contents. 2005
..Factors mitigating injury were higher arterial carbon dioxide, hematocrit, and blood glucose levels...
