Stacy Loeb

Summary

Publications

  1. ncbi request reprint Accuracy of prostate weight estimation by digital rectal examination versus transrectal ultrasonography
    Stacy Loeb
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    J Urol 173:63-5. 2005
  2. doi request reprint Complications after prostate biopsy: data from SEER-Medicare
    Stacy Loeb
    Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 186:1830-4. 2011
  3. pmc Prostate cancer risk alleles and their associations with other malignancies
    Phillip R Cooper
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Urology 78:970.e15-20. 2011
  4. doi request reprint PSA and beyond: the past, present, and future of investigative biomarkers for prostate cancer
    Jeffrey Tosoian
    The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    ScientificWorldJournal 10:1919-31. 2010
  5. pmc Genetic prostate cancer risk assessment: common variants in 9 genomic regions are associated with cumulative risk
    Brian T Helfand
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    J Urol 184:501-5. 2010
  6. ncbi request reprint Overdiagnosis and overtreatment of prostate cancer
    Stacy Loeb
    Department of Urology, New York University, New York, NY, USA Electronic address
    Eur Urol 65:1046-55. 2014
  7. ncbi request reprint Systematic review of complications of prostate biopsy
    Stacy Loeb
    Department of Urology, New York University, New York, NY, USA Electronic address
    Eur Urol 64:876-92. 2013
  8. doi request reprint Population based study of use and determinants of active surveillance and watchful waiting for low and intermediate risk prostate cancer
    Stacy Loeb
    Department of Urology, New York University, New York, New York Electronic address
    J Urol 190:1742-9. 2013
  9. ncbi request reprint Point: Impact of prostate-specific antigen velocity on management decisions and recommendations
    Stacy Loeb
    Department of Urology, New York University, New York, New York, USA
    J Natl Compr Canc Netw 11:281-5. 2013
  10. pmc Is repeat prostate biopsy associated with a greater risk of hospitalization? Data from SEER-Medicare
    Stacy Loeb
    Department of Urology, New York University, New York, New York 10016, USA
    J Urol 189:867-70. 2013

Detail Information

Publications93

  1. ncbi request reprint Accuracy of prostate weight estimation by digital rectal examination versus transrectal ultrasonography
    Stacy Loeb
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    J Urol 173:63-5. 2005
    ..We evaluated the relative accuracy of these weight estimates by comparing them to prostate weight following radical retropubic prostatectomy (RRP)...
  2. doi request reprint Complications after prostate biopsy: data from SEER-Medicare
    Stacy Loeb
    Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 186:1830-4. 2011
    ..We determined the risk of serious complications requiring hospitalization. We hypothesized that with emerging multidrug resistant organisms there may be an increasing risk of infectious complications...
  3. pmc Prostate cancer risk alleles and their associations with other malignancies
    Phillip R Cooper
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Urology 78:970.e15-20. 2011
    ..CaP has been associated with other common malignancies. Recently, numerous single nucleotide polymorphisms (SNPs) have been associated with CaP susceptibility...
  4. doi request reprint PSA and beyond: the past, present, and future of investigative biomarkers for prostate cancer
    Jeffrey Tosoian
    The James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    ScientificWorldJournal 10:1919-31. 2010
    ....
  5. pmc Genetic prostate cancer risk assessment: common variants in 9 genomic regions are associated with cumulative risk
    Brian T Helfand
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    J Urol 184:501-5. 2010
    ..We performed cumulative risk assessment incorporating all 9 genetic variants and determined the relationship of the new variants to clinicopathological tumor features...
  6. ncbi request reprint Overdiagnosis and overtreatment of prostate cancer
    Stacy Loeb
    Department of Urology, New York University, New York, NY, USA Electronic address
    Eur Urol 65:1046-55. 2014
    ..Although prostate cancer (PCa) screening reduces the incidence of advanced disease and mortality, trade-offs include overdiagnosis and resultant overtreatment...
  7. ncbi request reprint Systematic review of complications of prostate biopsy
    Stacy Loeb
    Department of Urology, New York University, New York, NY, USA Electronic address
    Eur Urol 64:876-92. 2013
    ..Prostate biopsy is commonly performed for cancer detection and management. The benefits and risks of prostate biopsy are germane to ongoing debates about prostate cancer screening and treatment...
  8. doi request reprint Population based study of use and determinants of active surveillance and watchful waiting for low and intermediate risk prostate cancer
    Stacy Loeb
    Department of Urology, New York University, New York, New York Electronic address
    J Urol 190:1742-9. 2013
    ..We also examined factors associated with selection of deferred management, which might provide insight into the rational diffusion of this important management strategy...
  9. ncbi request reprint Point: Impact of prostate-specific antigen velocity on management decisions and recommendations
    Stacy Loeb
    Department of Urology, New York University, New York, New York, USA
    J Natl Compr Canc Netw 11:281-5. 2013
    ..Among men already diagnosed with prostate cancer, PSA kinetics may also be helpful in predicting prognosis after definitive therapy...
  10. pmc Is repeat prostate biopsy associated with a greater risk of hospitalization? Data from SEER-Medicare
    Stacy Loeb
    Department of Urology, New York University, New York, New York 10016, USA
    J Urol 189:867-70. 2013
    ..We determined whether repeat biopsies are associated with an increased risk of hospitalization compared to the initial biopsy...
  11. doi request reprint Does benign prostatic hyperplasia treatment with alpha-blockers affect prostate cancer risk?
    Stacy Loeb
    Department of Urology, New York University, New York, New York, USA
    Curr Opin Urol 23:2-4. 2013
    ..To determine whether alpha-blockers, commonly used for the treatment of benign prostatic hyperplasia, are associated with prostate cancer risk...
  12. doi request reprint Risk of localized and advanced prostate cancer among immigrants versus native-born Swedish men: a nation-wide population-based study
    Stacy Loeb
    Department of Urology, New York University, New York, NY 10016, USA
    Cancer Causes Control 24:383-90. 2013
    ..Our hypothesis was that lower PSA-testing uptake among foreign-born men would result in lower rates of localized disease, and similar or higher risk of metastatic disease...
  13. doi request reprint Long-term radical prostatectomy outcomes among participants from the European Randomized Study of Screening for Prostate Cancer (ERSPC) Rotterdam
    Stacy Loeb
    Department of Urology, New York University, New York, NY, USA
    BJU Int 110:1678-83. 2012
    ..Our data suggests that radical prostatectomy is also associated with improved outcomes in men with screen-detected prostate cancer...
  14. doi request reprint Infectious complications and hospital admissions after prostate biopsy in a European randomized trial
    Stacy Loeb
    Department of Urology, New York University, New York, NY, USA
    Eur Urol 61:1110-4. 2012
    ..Studies from the United States and Canada have recently reported increasing numbers of hospitalizations for infectious complications after PNB...
  15. doi request reprint Distribution of PSA velocity by total PSA levels: data from the Baltimore Longitudinal Study of Aging
    Stacy Loeb
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Urology 77:143-7. 2011
    ..35 and >2.0 ng/mL/y have been associated with an increased risk of prostate cancer (CaP) death more than 10 years and 1 year before diagnosis, respectively. It is unknown how frequently PSAVs of this magnitude occur in community men...
  16. pmc PSA doubling time versus PSA velocity to predict high-risk prostate cancer: data from the Baltimore Longitudinal Study of Aging
    Stacy Loeb
    Department of Urology, The Johns Hopkins University School of Medicine, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Eur Urol 54:1073-80. 2008
    ..Less is known about the relative utility of pretreatment PSA doubling time (PSA DT) to predict tumor aggressiveness...
  17. pmc Prostate-specific antigen screening: pro
    Stacy Loeb
    Brady Urological Institute, Johns Hopkins Medical Institutions, 600 N Wolfe Street, Baltimore, MD 21231, USA
    Curr Opin Urol 20:185-8. 2010
    ..Nevertheless, PSA testing has become increasingly controversial. In this review, we will present the evidence supporting the role of PSA in prostate cancer screening...
  18. ncbi request reprint Bone mineral content and prostate cancer risk: data from the Baltimore Longitudinal Study of Aging
    Stacy Loeb
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, and the National Institute on Ageing, National Institutes of Health Clinical Research Branch, Baltimore, MD, USA
    BJU Int 106:28-31. 2010
    ..Aetiology (inception cohort) Level of Evidence 2b...
  19. doi request reprint A case of gastrointestinal stromal tumor diagnosed on prostate biopsy
    Stacy Loeb
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Nat Clin Pract Urol 6:54-7. 2009
    ..Four years after the initial presentation, the patient presented to a tertiary institution with worsened symptoms...
  20. doi request reprint Single nucleotide polymorphisms and the likelihood of prostate cancer at a given prostate specific antigen level
    Stacy Loeb
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 182:101-4; discussion 105. 2009
    ..Prostate specific antigen is used for prostate cancer screening but its specificity is limited. Specificity might be increased by considering genotype associated prostate specific antigen levels...
  21. ncbi request reprint Should prostate specific antigen be adjusted for body mass index? Data from the Baltimore Longitudinal Study of Aging
    Stacy Loeb
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 182:2646-51. 2009
    ..We examined the relationship between body mass index and prostate specific antigen by age in men without prostate cancer in a longitudinal aging study to determine whether prostate specific antigen must be adjusted for body mass index...
  22. doi request reprint Can we stop prostate specific antigen testing 10 years after radical prostatectomy?
    Stacy Loeb
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 186:500-5. 2011
    ..We examined predictors of late biochemical recurrence, and the relationship between timing of biochemical recurrence and long-term survival outcomes...
  23. pmc Does perineural invasion on prostate biopsy predict adverse prostatectomy outcomes?
    Stacy Loeb
    James Buchanan Brady Urological Institute and the Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    BJU Int 105:1510-3. 2010
    ....
  24. doi request reprint Risk factors, prevention and early detection of prostate cancer
    Stacy Loeb
    Brady Urological Institute, Johns Hopkins Medical Institutions, 600 N Wolfe Street, Marburg 1, Baltimore, MD 21287, USA
    Prim Care 36:603-21. 2009
    ..The current screening strategies using prostate-specific antigen and digital rectal examination are also discussed, as well as the limitations of these protocols and potential methods for improving early detection...
  25. pmc Progression after radical prostatectomy for men in their thirties compared to older men
    Stacy Loeb
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    BJU Int 101:1503-6. 2008
    ..To assess the biochemical outcome after radical prostatectomy (RP) specifically for men aged 30-39 years, as previous studies suggest that prostate cancer in young men might be more aggressive...
  26. doi request reprint Prostate volume changes over time: results from the Baltimore Longitudinal Study of Aging
    Stacy Loeb
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 182:1458-62. 2009
    ..Although there is an abundance of literature describing prostatic enlargement in association with benign prostatic hyperplasia, less is known about the phenomenon of prostate atrophy...
  27. doi request reprint Baseline prostate-specific antigen testing at a young age
    Stacy Loeb
    Department of Urology, New York University School of Medicine, New York, NY, USA
    Eur Urol 61:1-7. 2012
    ..Prostate cancer screening is highly controversial, including the age to begin prostate-specific antigen (PSA) testing. Several studies have evaluated the usefulness of baseline PSA measurements at a young age...
  28. pmc Does prostate growth confound prostate specific antigen velocity? Data from the Baltimore longitudinal study of aging
    Stacy Loeb
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions and National Institute on Aging, National Institutes of Health Clinical Research Branch, Baltimore, Maryland, USA
    J Urol 180:1314-7; discussion 1317. 2008
    ..Thus, we investigated the relationship between changes in prostate size and prostate specific antigen changes in a large cohort of men without prostate cancer...
  29. ncbi request reprint Prostate specific antigen velocity in men with total prostate specific antigen less than 4 ng/ml
    Stacy Loeb
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 178:2348-52; discussion 2352-3. 2007
    ..However, both of these frequently cited thresholds were determined largely in groups of men with a prostate specific antigen greater than 4 ng/ml...
  30. ncbi request reprint Prostate-specific antigen kinetics during follow-up are an unreliable trigger for intervention in a prostate cancer surveillance program
    Ashley E Ross
    Departments of Urology and Pathology, The Johns Hopkins University School of Medicine, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, MD, USA
    J Clin Oncol 28:2810-6. 2010
    ....
  31. ncbi request reprint Prostate specific antigen at the initial diagnosis of metastasis to bone in patients after radical prostatectomy
    Stacy Loeb
    Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 184:157-61. 2010
    ..This information would be useful in determining when to initiate androgen deprivation therapy...
  32. ncbi request reprint Risk of prostate cancer for young men with a prostate specific antigen less than their age specific median
    Stacy Loeb
    Department of Urology, Georgetown University School of Medicine, Washington, DC, USA
    J Urol 177:1745-8. 2007
    ..Although this suggests the need for close followup of men in their 40s with a prostate specific antigen level greater than 0.7 ng/ml, the appropriate screening strategy for men with a level less than the age specific median is unclear...
  33. ncbi request reprint Under diagnosis and over diagnosis of prostate cancer
    Theresa Graif
    Department of Urology, Northwestern Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Urol 178:88-92. 2007
    ..We quantified the rates of over and under diagnosis of prostate cancer in 2 large patient cohorts during the last 15 years...
  34. pmc Is statin use associated with prostate cancer aggressiveness?
    Stacy Loeb
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    BJU Int 105:1222-5. 2010
    ....
  35. doi request reprint Outcomes of radical prostatectomy for patients with clinical stage T1a and T1b disease
    Brian T Helfand
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    BJU Int 104:304-9. 2009
    ....
  36. doi request reprint Prospective multicenter evaluation of the Beckman Coulter Prostate Health Index using WHO calibration
    Stacy Loeb
    Department of Urology, New York University Langone Medical Center, New York, New York, USA
    J Urol 189:1702-6. 2013
    ..The Beckman CoulterĀ® Prostate Health Index and [-2]proPSA are newly approved serum markers associated with prostate cancer risk and aggressiveness. We studied the influence of assay standardization on these markers...
  37. ncbi request reprint Prostate specific antigen velocity threshold for predicting prostate cancer in young men
    Stacy Loeb
    Department of Urology, Georgetown University School of Medicine, Washington, DC, USA
    J Urol 177:899-902. 2007
    ..Prostate specific antigen velocity 0.75 ng/ml yearly has been proposed to distinguish prostate cancer from benign prostate conditions. However, this threshold might be too high in young men with lower total prostate specific antigen...
  38. pmc Preoperative prostate specific antigen doubling time is not a useful predictor of biochemical progression after radical prostatectomy
    Stacy Loeb
    Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 183:1816-21. 2010
    ..Less is known about the usefulness of preoperative prostate specific antigen doubling time for the initial prediction of prostatectomy outcomes...
  39. pmc Association of [-2]proPSA with biopsy reclassification during active surveillance for prostate cancer
    Jeffrey J Tosoian
    Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 188:1131-6. 2012
    ..Thus, we examined the relationship between [-2]proPSA and biopsy results in men enrolled in an active surveillance program...
  40. pmc What is the true number needed to screen and treat to save a life with prostate-specific antigen testing?
    Stacy Loeb
    Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Clin Oncol 29:464-7. 2011
    ..Our objective was to re-examine the effect of varying follow-up times on NNS and NNT using data extrapolated from the ERSPC report...
  41. doi request reprint Outcomes in patients with Gleason score 8-10 prostate cancer: relation to preoperative PSA level
    Barry B McGuire
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    BJU Int 109:1764-9. 2012
    ..A proportion of these tumours produce little PSA. This study demonstrates that among Gleason 8-10 prostate cancers, some of the worst survival outcomes are associated with the lowest PSA levels...
  42. ncbi request reprint Characteristics of prostate cancer detected by digital rectal examination only
    Onisuru T Okotie
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Urology 70:1117-20. 2007
    ..To examine clinical and pathologic features and postoperative survival outcomes of men with prostate cancer detected by digital rectal examination (DRE) alone, elevated prostate-specific antigen (PSA) level alone, or abnormalities in both...
  43. pmc Prostate specific antigen testing among the elderly--when to stop?
    Edward M Schaeffer
    Department of Urology, The Johns Hopkins University School of Medicine, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland, USA
    J Urol 181:1606-14; discussion 1613-4. 2009
    ..We evaluated the relationship between prostate specific antigen and the risk of aggressive prostate cancer developing in men of various ages...
  44. ncbi request reprint Lymphovascular invasion in radical prostatectomy specimens: prediction of adverse pathologic features and biochemical progression
    Stacy Loeb
    Department of Urology, Georgetown University School of Medicine, Washington, DC, USA
    Urology 68:99-103. 2006
    ..However, limited data are available concerning the relationship between LVI and preoperative screening characteristics, pathologic tumor features, and patient prognosis...
  45. doi request reprint Accuracy of PCA3 measurement in predicting short-term biopsy progression in an active surveillance program
    Jeffrey J Tosoian
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 183:534-8. 2010
    ..We assessed the relationship between PCA3 and prostate biopsy results in men in a surveillance program...
  46. ncbi request reprint Comparison of methods for calculating prostate specific antigen velocity
    XiaoYing Yu
    Department of Urology, Northwestern University, Feinberg School of Medicine, Northwestern Medical Faculty Foundation, 675 N Saint Clair Street, Chicago, IL 60611, USA
    J Urol 176:2427-31; discussion 2431. 2006
    ....
  47. ncbi request reprint Improved stage and grade-specific progression-free survival rates after radical prostatectomy in the PSA era
    Naresh V Desireddi
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Urology 70:950-5. 2007
    ..Our objective was to examine differences in PFS after radical prostatectomy between the pre-PSA era (before 1992) and the PSA era, controlling for tumor stage and grade...
  48. pmc Correlation between serum prostate-specific antigen and cancer volume in prostate glands of different sizes
    Gustavo F Carvalhal
    Department of Urology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Urology 76:1072-6. 2010
    ..Although early studies showed a strong correlation between PSA and tumor volume, it has been suggested that PSA is no longer a valid marker for prostate cancer and only correlates with prostate size...
  49. pmc External validation of the cancer of the prostate risk assessment (CAPRA) score in a single-surgeon radical prostatectomy series
    Stacy Loeb
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21224, USA
    Urol Oncol 30:584-9. 2012
    ..Our objective was to perform an external validation of the CAPRA score as a predictor of 5-year progression-free survival (PFS) in a single-surgeon radical retropubic prostatectomy (RRP) series...
  50. pmc A multicenter study of [-2]pro-prostate specific antigen combined with prostate specific antigen and free prostate specific antigen for prostate cancer detection in the 2.0 to 10.0 ng/ml prostate specific antigen range
    William J Catalona
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Urol 185:1650-5. 2011
    ....
  51. pmc Significance of preoperative PSA velocity in men with low serum PSA and normal DRE
    Danil V Makarov
    Department of Urology and The Section on Value and Comparative Effectiveness, New York University School of Medicine, New York, NY, USA
    World J Urol 29:11-4. 2011
    ..However, less is known about the utility of this PSAV cutpoint for the prediction of treatment outcomes among men undergoing radical prostatectomy (RP)...
  52. ncbi request reprint Use of 2.6 ng/ml prostate specific antigen prompt for biopsy in men older than 60 years
    Robert B Nadler
    Department of Urology, Feinberg School of Medicine, Northwestern University Medical Faculty Foundation, 675 North Saint Clair Street, Chicago, IL 60611, USA
    J Urol 174:2154-7, discussion 2157. 2005
    ..There has been recent investigation into lowering the PSA prompt for biopsy, especially in men younger than 60 years. We determined how a lower cutoff would perform in men older than 60 years...
  53. ncbi request reprint Does body mass index affect preoperative prostate specific antigen velocity or pathological outcomes after radical prostatectomy?
    Stacy Loeb
    Department of Urology, Georgetown University School of Medicine, Washington, DC, USA
    J Urol 177:102-6; discussion 106. 2007
    ..We examined the associations among obesity, prostate specific antigen velocity and adverse tumor features in men treated with radical prostatectomy...
  54. doi request reprint PSA velocity is associated with gleason score in radical prostatectomy specimen: marker for prostate cancer aggressiveness
    Stacy Loeb
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Urology 72:1116-20; discussion 1120. 2008
    ..To our knowledge, the relationship between preoperative PSAV and Gleason score in the radical prostatectomy specimen has not been formally demonstrated...
  55. doi request reprint Population based study of predictors of adverse pathology among candidates for active surveillance with Gleason 6 prostate cancer
    Annelies Vellekoop
    Department of Urology, New York University and Manhattan Veterans Affairs Medical Center, New York, New York Electronic address
    J Urol 191:350-7. 2014
    ..We studied trends and predictors of upgrading and up staging among men with Gleason 6 prostate cancer who were potential candidates for active surveillance in a population based cohort...
  56. pmc Prostate cancer imaging trends after a nationwide effort to discourage inappropriate prostate cancer imaging
    Danil V Makarov
    US Department of Veterans Affairs, New York University, New York, NY, USA
    J Natl Cancer Inst 105:1306-13. 2013
    ..We sought to determine the temporal and regional effects of this effort on prostate cancer imaging rates...
  57. doi request reprint The impact of anatomical radical retropubic prostatectomy on cancer control: the 30-year anniversary
    Jeffrey K Mullins
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 188:2219-24. 2012
    ..We report oncological outcomes of the longest running series of nerve sparing radical retropubic prostatectomy on the 30th anniversary of the inaugural operation...
  58. ncbi request reprint The relationship between prostate volume and prostate-specific antigen variability: data from the Baltimore Longitudinal Study of Aging and the Johns Hopkins Active Surveillance Program
    John H Nichols
    School of Medicine, Johns Hopkins, Baltimore, MD, USA
    BJU Int 109:1304-8. 2012
    ..The results of the study suggest that baseline PSA, not prostate volume, is the primary driver of PSA variability in these populations...
  59. doi request reprint Relationship of prostate-specific antigen velocity to histologic findings in a prostate cancer screening program
    Scott E Eggener
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Urology 71:1016-9. 2008
    ..We evaluated the relationship of PSAV to histologic findings on biopsy and assessed whether PSAV provides independent predictive information...
  60. doi request reprint Long-term rates of undetectable PSA with initial observation and delayed salvage radiotherapy after radical prostatectomy
    Stacy Loeb
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Eur Urol 54:88-94. 2008
    ..Less is known about the relative advantages and disadvantages of initial observation with delayed salvage radiation therapy (SRT)...
  61. pmc Number of prostate cancer risk alleles may identify possibly 'insignificant' disease
    Brian T Helfand
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    BJU Int 106:1602-6. 2010
    ..To determine whether the cumulative effects of five prostate cancer risk alleles (three single-nucleotide polymorphisms [SNPs] on chromosome 8Q24 and two SNPs on chromosome 17a) could help to identify possibly 'insignificant' disease...
  62. ncbi request reprint Baseline prostate-specific antigen compared with median prostate-specific antigen for age group as predictor of prostate cancer risk in men younger than 60 years old
    Stacy Loeb
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Urology 67:316-20. 2006
    ..Limited data are available concerning the extent to which the initial prostate-specific antigen (PSA) measurement in men younger than age 60 predicts for the risk of prostate cancer (CaP) and how this compares to other known risk factors...
  63. ncbi request reprint Use of prostate-specific antigen velocity to follow up patients with isolated high-grade prostatic intraepithelial neoplasia on prostate biopsy
    Stacy Loeb
    Department of Urology, Georgetown University School of Medicine, Washington, DC, USA
    Urology 69:108-12. 2007
    ..Thus, our objective was to identify the clinical factors that could help predict which men with isolated HG-PIN were at the greatest risk of subsequent CaP detection...
  64. ncbi request reprint Pathological features after radical prostatectomy in potential candidates for active monitoring
    Christopher R Griffin
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Urol 178:860-3; discussion 863. 2007
    ..When counseling patients with low grade prostate cancer about treatment options, it is useful to know the results of surgical treatment in this population...
  65. doi request reprint Combined prostate-specific antigen density and biopsy features to predict "clinically insignificant" prostate cancer
    Stacy Loeb
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Urology 72:143-7. 2008
    ..In this study, we examined the ability of PSAD and biopsy features to predict pathologic outcomes in a contemporary RRP population...
  66. pmc Characteristics of prostate cancers detected at prostate specific antigen levels less than 2.5 ng/ml
    Joshua J Meeks
    Department of Urology, Northwestern Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Urol 181:2515-8; discussion 2518-9. 2009
    ..However, limited published data describe the tumor features of prostate cancer detected at low prostate specific antigen levels (less than 2.5 ng/ml)...
  67. pmc Does diabetes mellitus modify the association between 17q12 risk variant and prostate cancer aggressiveness?
    Stacy Loeb
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    BJU Int 104:1200-3. 2009
    ..Specifically, we sought to evaluate for effect modification between DM, a newly discovered prostate cancer susceptibility locus on chromosome 17q12 (single nucleotide polymorphism rs4430796) and prostate cancer features...
  68. ncbi request reprint Benign prostate glands at the bladder neck margin in robotic vs open radical prostatectomy
    Stacy Loeb
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    BJU Int 105:1446-9. 2010
    ....
  69. pmc What are the outcomes of radical prostatectomy for high-risk prostate cancer?
    Stacy Loeb
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2101, USA
    Urology 76:710-4. 2010
    ..These patients are often treated with combined radiation and androgen deprivation therapy, and less is known about the long-term survival in this population after radical prostatectomy (RP)...
  70. pmc Prostate-specific antigen velocity (PSAV) risk count improves the specificity of screening for clinically significant prostate cancer
    Stacy Loeb
    Department of Urology, New York University School of Medicine, New York, NY, USA
    BJU Int 109:508-13; discussion 513-4. 2012
    ..e. the number of times PSAV exceeds a specific threshold) could increase the specificity of screening for prostate cancer and potentially life-threatening tumours...
  71. ncbi request reprint Viewpoint: expanding prostate cancer screening
    William J Catalona
    Northwestern Feinberg School of Medicine, Department of Urology, Chicago, Illinois 60611, USA
    Ann Intern Med 144:441-3. 2006
    ..They recommend screening for risk assessment for average-risk men beginning at age 40 years, screening selected healthy men older than age 70 years, and lowering the PSA threshold for considering biopsy to 2.5 ng/mL for all men...
  72. doi request reprint Comparison of prostate specific antigen velocity in screened versus referred patients with prostate cancer
    Joshua J Meeks
    Department of Urology, Northwestern Feinberg School of Medicine, Chicago, Illinois, USA
    J Urol 179:1340-3. 2008
    ..We compared the prostate specific antigen velocity profile between patients with prostate cancer in whom the tumor was detected in a formal screening study and those who were referred for treatment...
  73. doi request reprint Is the utility of prostate-specific antigen velocity for prostate cancer detection affected by age?
    Stacy Loeb
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    BJU Int 101:817-21. 2008
    ..To determine whether prostate-specific antigen velocity (PSAV) is useful for prostate cancer detection in men from different age groups, and whether the same PSAV thresholds can reasonably be applied to all men aged >or=40 years...
  74. ncbi request reprint The association between total prostate specific antigen concentration and prostate specific antigen velocity
    XiaoYing Yu
    Department of Urology, Northwestern Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Urol 177:1298-302; discussion 1301-2. 2007
    ..Because prostate specific antigen and prostate specific antigen velocity contain much of the same predictive information, our objective was to further examine the relationship between them...
  75. doi request reprint Is prostate-specific antigen surveillance necessary in men with benign prostate pathology following radical cystoprostatectomy for bladder cancer?
    Trinity J Bivalacqua
    James Buchanan Brady Urologic Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Urol Int 85:466-9. 2010
    ..The purpose of our study was to analyze the postoperative PSA characteristics of men without prostate cancer who underwent a RCP for bladder cancer...
  76. doi request reprint Tumor characteristics of carriers and noncarriers of the deCODE 8q24 prostate cancer susceptibility alleles
    Brian T Helfand
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    J Urol 179:2197-201; discussion 2202. 2008
    ..In this study we examine the differences in clinical and pathological tumor features between carriers and noncarriers of these 8q24 alleles in patients with prostate cancer...
  77. doi request reprint Exclusion of inflammation in the differential diagnosis of an elevated prostate-specific antigen (PSA)
    Stacy Loeb
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Urol Oncol 27:64-6. 2009
    ..This article reviews the evidence about elevations in PSA due to prostatitis and describes the controversy over the optimal approach to reduce its confounding impact on prostate cancer screening...
  78. pmc Interpretation of the prostate-specific antigen history in assessing life-threatening prostate cancer
    Anna E Kettermann
    Department of Urology, The Johns Hopkins University School of Medicine, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, MD, USA
    BJU Int 106:1284-90; discussion 1290-2. 2010
    ..e. PSA velocity (PSAV). This longitudinal approach might also be extendible to other biomarkers...
  79. pmc Treatment outcomes of radical prostatectomy in potential candidates for 3 published active surveillance protocols
    C Shad Thaxton
    Department of Urology, Northwestern Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Urology 75:414-8. 2010
    ..AS protocols are designed to spare the potential morbidity of treatment to patients with low-risk prostate cancer (PCa)...
  80. pmc Can prostate specific antigen velocity thresholds decrease insignificant prostate cancer detection?
    Stacy Loeb
    Department of Urology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Urol 183:112-6. 2010
    ..Because PSA kinetics were previously linked to prostate cancer specific mortality, we determined whether prostate specific antigen velocity is associated with clinically significant prostate cancer...
  81. doi request reprint Delay of surgery in men with low risk prostate cancer
    Daniel O'Brien
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    J Urol 185:2143-7. 2011
    ..We determined the impact of surgical delay on radical prostatectomy outcomes specifically in low risk patients...
  82. ncbi request reprint Pathological characteristics of prostate cancer detected through prostate specific antigen based screening
    Stacy Loeb
    Department of Urology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
    J Urol 175:902-6. 2006
    ..However, it is uncertain to what extent clinically insignificant tumors are being diagnosed and treated. In a large, community based population we determined the pathological characteristics of screening detected cancers...
  83. ncbi request reprint Intermediate-term potency, continence, and survival outcomes of radical prostatectomy for clinically high-risk or locally advanced prostate cancer
    Stacy Loeb
    Department of Urology, Georgetown University School of Medicine, Washington, DC, USA
    Urology 69:1170-5. 2007
    ..We examined the intermediate-term cancer control and quality-of-life outcomes after radical retropubic prostatectomy (RRP) in selected patients...
  84. ncbi request reprint Prostate specific antigen assay standardization bias could affect clinical decision making
    Stacy Loeb
    Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 180:1959-62; discussion 1962-3. 2008
    ..Most commercial prostate specific antigen assays are standardized to the WHO 90:10 standard or aligned with the original Hybritech assay with potentially disparate results...
  85. pmc Pathological outcomes associated with the 17q prostate cancer risk variants
    Brian T Helfand
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Urol 181:2502-7. 2009
    ..Less is known about tumor pathological features in carriers of these variants...
  86. pmc Reducing blood loss in open radical retropubic prostatectomy with prophylactic periprostatic sutures
    Gustavo F Carvalhal
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    BJU Int 105:1650-3. 2010
    ..To determine whether the placement of small-calibre, rapidly absorbed prophylactic periprostatic sutures before the mobilization of the prostate could reduce blood loss during open retropubic radical prostatectomy (RRP)...
  87. pmc [-2]Proenzyme prostate specific antigen is more accurate than total and free prostate specific antigen in differentiating prostate cancer from benign disease in a prospective prostate cancer screening study
    Brian V Le
    Department of Urology, Northwestern University, Chicago, Illinois 60611, USA
    J Urol 183:1355-9. 2010
    ..We examined the usefulness of this isoform in a prospective prostate cancer screening study...
  88. doi request reprint Thoracic complications of urologic laparoscopy: correlation between radiographic findings and clinical manifestations
    Lee C Zhao
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    J Endourol 22:607-14. 2008
    ....
  89. doi request reprint What to do with an abnormal PSA test
    Stacy Loeb
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Oncologist 13:299-305. 2008
    ..This review describes the evolution of prostate cancer screening and provides clinical insights into the informed use of PSA and its adjunctive measurements...
  90. doi request reprint Tertiary Gleason patterns and biochemical recurrence after prostatectomy: proposal for a modified Gleason scoring system
    Bruce J Trock
    Department of Urology, The Johns Hopkins Hospital, Baltimore, Maryland 21231, USA
    J Urol 182:1364-70. 2009
    ..We investigated the relationship between the tertiary Gleason component in radical prostatectomy specimens and biochemical recurrence in what is to our knowledge the largest single institution cohort to date...
  91. ncbi request reprint Open radical retropubic prostatectomy
    Stacy Loeb
    Department of Urology, Georgetown University School of Medicine, Washington, D C 20037, USA
    Urol Oncol 25:494-8. 2007
    ..Additional experience with these methods and long-term follow-up data are necessary to determine whether the cancer control and functional outcomes meet the standards of open radical prostatectomy...
  92. ncbi request reprint Making prostate-specific antigen testing more effective
    William J Catalona
    Department of Urology, Northwestern Feinberg School of Medicine, Chicago, IL, USA
    Urol Oncol 24:177-9. 2006
  93. doi request reprint The case for open radical prostatectomy
    Edward M Schaeffer
    Johns Hopkins Medical Institution, Brady Urological Institute, 600 North Wolfe Street, Marburg 145, Baltimore, MD 21287, USA
    Urol Clin North Am 37:49-55, Table of Contents. 2010
    ..Although there are many differences between the 2 approaches, the common goal is to optimize oncologic and functional outcomes. This article highlights the background, techniques, and outcomes of open and robotic prostatectomy...