Christine Lochner

Summary

Publications

  1. ncbi Heterogeneity of obsessive-compulsive disorder: a literature review
    Christine Lochner
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Harv Rev Psychiatry 11:113-32. 2003
  2. ncbi Hoarding in obsessive-compulsive disorder: clinical and genetic correlates
    Christine Lochner
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    J Clin Psychiatry 66:1155-60. 2005
  3. ncbi Obsessive-compulsive spectrum disorders: a multidimensional approach
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    Psychiatr Clin North Am 29:343-51. 2006
  4. ncbi Corrigendum to "gender in obsessive-compulsive disorder: clinical and genetic findings" [Eur. Neuropsychopharmacol. 14 (2004) 105-113]
    Christine Lochner
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Eur Neuropsychopharmacol 14:437-45. 2004
  5. ncbi Gender in obsessive-compulsive disorder: clinical and genetic findings
    Christine Lochner
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, P O Box 19063, Tygerberg 7505, Cape Town, South Africa
    Eur Neuropsychopharmacol 14:105-13. 2004
  6. ncbi Cluster analysis of obsessive-compulsive spectrum disorders in patients with obsessive-compulsive disorder: clinical and genetic correlates
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg, 7505, Cape Town, South Africa
    Compr Psychiatry 46:14-9. 2005
  7. ncbi Early- versus late-onset obsessive-compulsive disorder: investigating genetic and clinical correlates
    Sian M J Hemmings
    MRC Unit on Anxiety and Stress Disorders, University of Stellenbosch, Medical School, PO Box 19063, Tygerberg 7505, South Africa
    Psychiatry Res 128:175-82. 2004
  8. ncbi Genetic correlates in trichotillomania--A case-control association study in the South African Caucasian population
    Sian M J Hemmings
    MRC US Centre for Molecular and Cellular Biology, University of Stellenbosch, Tygerberg, South Africa
    Isr J Psychiatry Relat Sci 43:93-101. 2006
  9. ncbi Investigating the role of dopaminergic and serotonergic candidate genes in obsessive-compulsive disorder
    Sian M J Hemmings
    MRC US Centre for Molecular and Cellular Biology, University of Stellenbosch, P O Box 19063, 7505, Tygerberg, South Africa
    Eur Neuropsychopharmacol 13:93-8. 2003
  10. doi Comorbid obsessive-compulsive personality disorder in obsessive-compulsive disorder (OCD): a marker of severity
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    Prog Neuropsychopharmacol Biol Psychiatry 35:1087-92. 2011

Detail Information

Publications45

  1. ncbi Heterogeneity of obsessive-compulsive disorder: a literature review
    Christine Lochner
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Harv Rev Psychiatry 11:113-32. 2003
    ..The heterogeneity of OCD has important clinical and research implications...
  2. ncbi Hoarding in obsessive-compulsive disorder: clinical and genetic correlates
    Christine Lochner
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    J Clin Psychiatry 66:1155-60. 2005
    ..The clinical and genetic correlates of hoarding in OCD therefore deserve additional investigation...
  3. ncbi Obsessive-compulsive spectrum disorders: a multidimensional approach
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    Psychiatr Clin North Am 29:343-51. 2006
    ..As further progress is made in understanding the cognitive-affective neuroscience of OCD and related conditions, constructs about obsessive-compulsive spectrum disorders will become increasingly sharp...
  4. ncbi Corrigendum to "gender in obsessive-compulsive disorder: clinical and genetic findings" [Eur. Neuropsychopharmacol. 14 (2004) 105-113]
    Christine Lochner
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Eur Neuropsychopharmacol 14:437-45. 2004
    ..There is increasing recognition that obsessive-compulsive disorder (OCD) is not a homogeneous entity. It has been suggested that gender may contribute to the clinical and biological heterogeneity of OCD...
  5. ncbi Gender in obsessive-compulsive disorder: clinical and genetic findings
    Christine Lochner
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, P O Box 19063, Tygerberg 7505, Cape Town, South Africa
    Eur Neuropsychopharmacol 14:105-13. 2004
    ..There is increasing recognition that obsessive-compulsive disorder (OCD) is not a homogeneous entity. It has been suggested that gender may contribute to the clinical and biological heterogeneity of OCD...
  6. ncbi Cluster analysis of obsessive-compulsive spectrum disorders in patients with obsessive-compulsive disorder: clinical and genetic correlates
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg, 7505, Cape Town, South Africa
    Compr Psychiatry 46:14-9. 2005
    ..Comorbidity of the putative OCSDs in OCD has, however, not often been systematically investigated...
  7. ncbi Early- versus late-onset obsessive-compulsive disorder: investigating genetic and clinical correlates
    Sian M J Hemmings
    MRC Unit on Anxiety and Stress Disorders, University of Stellenbosch, Medical School, PO Box 19063, Tygerberg 7505, South Africa
    Psychiatry Res 128:175-82. 2004
    ..These data support a role for the dopaminergic system, which may be relevant to the development of early-onset OCD...
  8. ncbi Genetic correlates in trichotillomania--A case-control association study in the South African Caucasian population
    Sian M J Hemmings
    MRC US Centre for Molecular and Cellular Biology, University of Stellenbosch, Tygerberg, South Africa
    Isr J Psychiatry Relat Sci 43:93-101. 2006
    ..Some have argued, however, that TTM is an obsessive-compulsive spectrum disorder (OCSD). There is some evidence that both disorders (OCD and TTM) are mediated by serotonergic (5-HT) and dopaminergic pathways...
  9. ncbi Investigating the role of dopaminergic and serotonergic candidate genes in obsessive-compulsive disorder
    Sian M J Hemmings
    MRC US Centre for Molecular and Cellular Biology, University of Stellenbosch, P O Box 19063, 7505, Tygerberg, South Africa
    Eur Neuropsychopharmacol 13:93-8. 2003
    ..Although no statistically significant genotypic or allelic associations were detected, the data yielded interesting preliminary results that warrant further discussion and investigation...
  10. doi Comorbid obsessive-compulsive personality disorder in obsessive-compulsive disorder (OCD): a marker of severity
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    Prog Neuropsychopharmacol Biol Psychiatry 35:1087-92. 2011
    ..It remains unclear, however, whether OCPD in OCD represents a distinct subtype of OCD or whether it is simply a marker of severity in OCD...
  11. ncbi Dissociative experiences in obsessive-compulsive disorder and trichotillomania: clinical and genetic findings
    Christine Lochner
    Medical Research Council Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenboch, Cape Town, South Africa
    Compr Psychiatry 45:384-91. 2004
    ..g., lower age) and comorbidity profile (e.g., increased incidence of impulse dyscontrol disorders). Additional work is necessary before conclusions about the role of monoaminergic systems in mediating such dissociation can be drawn...
  12. doi Investigating SAPAP3 variants in the etiology of obsessive-compulsive disorder and trichotillomania in the South African white population
    Leigh Boardman
    Division of Molecular Biology and Human Genetics, Department Biomedical Sciences, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa
    Compr Psychiatry 52:181-7. 2011
    ..Results from a recent knockout animal model suggest that SAP90/PSD95-associated protein 3 (SAPAP3) may be involved in the pathophysiology of both disorders...
  13. ncbi Investigating the possible effects of trauma experiences and 5-HTT on the dissociative experiences of patients with OCD using path analysis and multiple regression
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    Neuropsychobiology 56:6-13. 2007
    ..Here, two different but related statistical techniques (multiple regression and partial least squares), confirmed that physical neglect and the 5-HTT genotype jointly play a role in predicting dissociation in OCD...
  14. ncbi Cluster analysis of obsessive-compulsive symptomatology: identifying obsessive-compulsive disorder subtypes
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    Isr J Psychiatry Relat Sci 45:164-76. 2008
    ..There is increasing evidence that obsessive-compulsive disorder (OCD) is a heterogeneous disorder. Different clinical subtypes may be characterized by differing pathophysiological mechanisms and treatment outcomes...
  15. doi Chronic hair-pulling: phenomenology-based subtypes
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    J Anxiety Disord 24:196-202. 2010
    ..Future work, incorporating further investigation of the role of gender and psychobiological and treatment outcomes, is needed before definitive conclusions about hair-pulling subtypes can be drawn...
  16. ncbi Genetics and personality traits in patients with social anxiety disorder: a case-control study in South Africa
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    Eur Neuropsychopharmacol 17:321-7. 2007
    ..to compare differences in temperament dimensions between carriers of different (dominant vs. recessive) alleles for selected polymorphisms in SAD patients...
  17. pmc Obsessive-compulsive disorder and trichotillomania: a phenomenological comparison
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    BMC Psychiatry 5:2. 2005
    ..Nevertheless, there is evidence of important differences between these two disorders. Some authors have conceptualized the disorders as lying on an OCD spectrum of conditions...
  18. doi DSM-5 field survey: hair-pulling disorder (trichotillomania)
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    Depress Anxiety 29:1025-31. 2012
    ....
  19. doi Selective attention to fearful faces during pregnancy
    Annerine Roos
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, Stellenbosch University, P O Box 19063, Tygerberg 7505, South Africa
    Prog Neuropsychopharmacol Biol Psychiatry 37:76-80. 2012
    ....
  20. doi The validity of DSM-IV-TR criteria B and C of hair-pulling disorder (trichotillomania): evidence from a clinical study
    Christine Lochner
    Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    Psychiatry Res 189:276-80. 2011
    ..Our study does not provide convincing support for the inclusion of the current diagnostic criteria B and C for TTM in DSM-5...
  21. ncbi Obsessive compulsive disorder--prevalence in Xhosa-speaking schizophrenia patients
    Dana J H Niehaus
    Department of Psychiatry, Stellenbosch University, Tygerberg, W Cape
    S Afr Med J 95:120-2. 2005
    ..No concordance for OCD was noted in the sibship group. Our findings differ from those in other parts of the world, and if replicated, might suggest unique protective environmental or genetic factors for OCD in certain ethnic groups...
  22. doi Changes in regional brain volumes in social anxiety disorder following 12 weeks of treatment with escitalopram
    Naseema Cassimjee
    Department of Psychiatry, University of Stellenbosch, PO Box 19063, Tygerberg 7505, South Africa
    Metab Brain Dis 25:369-74. 2010
    ..These preliminary findings require replication to determine their reliability, and extension to determine whether or not they are disorder specific...
  23. ncbi Investigating the role of the brain-derived neurotrophic factor (BDNF) val66met variant in obsessive-compulsive disorder (OCD)
    Sian M J Hemmings
    MRC US Centre for Molecular and Cellular Biology, University of Stellenbosch, Tygerberg, South Africa
    World J Biol Psychiatry 9:126-34. 2008
    ..The present investigation forms part of ongoing research to elucidate the genetic components involved in the aetiology of OCD and OCD-related characteristics...
  24. doi Grey matter abnormalities in social anxiety disorder: a pilot study
    Supriya Syal
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    Metab Brain Dis 27:299-309. 2012
    ..Additional work is needed to investigate the causal mechanisms involved in such structural abnormalities in SAD...
  25. pmc Evidence for fractional anisotropy and mean diffusivity white matter abnormalities in the internal capsule and cingulum in patients with obsessive-compulsive disorder
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    J Psychiatry Neurosci 37:193-9. 2012
    ..In this study, we used diffusion tensor imaging (DTI) to examine white matter integrity in specific regions of interest (ROIs) in patients with OCD...
  26. doi Differential effects of escitalopram challenge on disgust processing in obsessive-compulsive disorder
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    Behav Brain Res 226:274-80. 2012
    ....
  27. ncbi Does work on obsessive-compulsive spectrum disorders contribute to understanding the heterogeneity of obsessive-compulsive disorder?
    Christine Lochner
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, South Africa
    Prog Neuropsychopharmacol Biol Psychiatry 30:353-61. 2006
    ..Here, we consider the different dimensions on which obsessive-compulsive spectrum (OCSDs) lie, and focus on how the concepts from this literature may help understand the heterogeneity of obsessive-compulsive disorder (OCD)...
  28. ncbi BDNF Val66Met modifies the risk of childhood trauma on obsessive-compulsive disorder
    Sîan Megan Joanna Hemmings
    Department of Psychiatry, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa Electronic address
    J Psychiatr Res 47:1857-63. 2013
    ..024). To our knowledge, this is one of the first studies to investigate gene-environment interactions in OCD, and the findings indicate the importance of collating genetic and environmental variables in future studies...
  29. doi White matter integrity in hair-pulling disorder (trichotillomania)
    Annerine Roos
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, Stellenbosch University, PO Box 19063, Tygerberg 7505, South Africa
    Psychiatry Res 211:246-50. 2013
    ..Our findings suggest that white matter integrity in fronto-striatal-thalamic pathways in HPD is related to symptom duration and severity. The molecular basis of measures of white matter integrity in HPD deserves further exploration...
  30. ncbi DSM-5 field survey: skin picking disorder
    Christine Lochner
    South African Medical Research Council, Research Unit on Anxiety and Stress Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa
    Ann Clin Psychiatry 24:300-4. 2012
    ..It is timely to consider including SPD in DSM-5. The aim of this field survey was to investigate possible diagnostic criteria for SPD...
  31. ncbi Quetiapine augmentation of serotonin reuptake inhibitors in treatment-refractory obsessive-compulsive disorder: is response to treatment predictable?
    Paul D Carey
    Department of Psychiatry, University of Stellenbosch, Tygerberg
    Int Clin Psychopharmacol 27:321-5. 2012
    ..Other factors are, however, also likely to play an important role in predicting outcome...
  32. ncbi Trichotillomania and skin-picking: a phenomenological comparison
    Christine Lochner
    Department of Psychiatry, MRC Unit on Stress and Anxiety Disorder, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Depress Anxiety 15:83-6. 2002
    ..Future work to assess the implications of overlap for clinical evaluation and intervention in the two conditions may be useful...
  33. ncbi Escitalopram in obsessive-compulsive disorder: response of symptom dimensions to pharmacotherapy
    Dan J Stein
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    CNS Spectr 13:492-8. 2008
    ..The response of OCD symptom dimensions to 12 weeks of treatment with escitalopram or placebo was investigated...
  34. doi Altered prefrontal cortical function during processing of fear-relevant stimuli in pregnancy
    Annerine Roos
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, P O Box 19063, Tygerberg 7505, South Africa
    Behav Brain Res 222:200-5. 2011
    ....
  35. doi Obsessive-compulsive spectrum disorders in obsessive-compulsive disorder and other anxiety disorders
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Stellenbosch, South Africa
    Psychopathology 43:389-96. 2010
    ..There has been debate about whether obsessive-compulsive disorder (OCD) should be classified as one of the anxiety disorders, or should rather be categorized with obsessive-compulsive spectrum conditions...
  36. ncbi Topiramate in the treatment of trichotillomania: an open-label pilot study
    Christine Lochner
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    Int Clin Psychopharmacol 21:255-9. 2006
    ..These results suggest that topiramate may be useful in the treatment of TTM. Future studies should investigate the efficacy of topiramate in an appropriately powered randomized placebo-controlled trial...
  37. doi Psychometric properties of the Multidimensional Scale of Perceived Social Support in youth
    Belinda Bruwer
    Department of Psychiatry, University of Stellenbosch, Cape Town 7505, South Africa
    Compr Psychiatry 49:195-201. 2008
    ..The psychometric properties of the MSPSS have been demonstrated in diverse samples, although its reproducibility in the South African youth has not yet been investigated...
  38. ncbi Should OCD be classified as an anxiety disorder in DSM-V?
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Cape Town, South Africa
    Depress Anxiety 27:495-506. 2010
    ..If this change is made, the name of this category should be changed to reflect this proposed change...
  39. ncbi Trichotillomania (hair pulling disorder), skin picking disorder, and stereotypic movement disorder: toward DSM-V
    Dan J Stein
    Department of Psychiatry, University of Cape Town, Rondebosch, Cape Town, South Africa
    Depress Anxiety 27:611-26. 2010
    ....
  40. ncbi Disability and quality of life in post-traumatic stress disorder: impact of drug treatment
    Soraya Seedat
    MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa
    Pharmacoeconomics 24:989-98. 2006
    ..Further investigation of the relationship of QOL to PTSD symptom severity, disability, treatment outcome and cost, among the different drug treatment modalities, is clearly needed...
  41. ncbi Quality of life in anxiety disorders: a comparison of obsessive-compulsive disorder, social anxiety disorder, and panic disorder
    Christine Lochner
    MRC Unit on Anxiety Disorders, Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa
    Psychopathology 36:255-62. 2003
    ..There is growing recognition that the anxiety disorders are disabling disorders associated with substantial morbidity and impaired quality of life (QOL). Nevertheless, there have been few studies comparing QOL across these conditions...
  42. ncbi Comorbidity of obsessive-compulsive disorder and substance use disorder: a new heuristic
    Natalie L Cuzen
    Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa
    Hum Psychopharmacol 29:89-93. 2014
    ..Here, we review the current evidence for comorbidity across clinical and epidemiological studies, and propose a new heuristic for substance use comorbidity in OCD, based on a hypothetical threshold of OCD severity...
  43. ncbi Childhood trauma in obsessive-compulsive disorder, trichotillomania, and controls
    Christine Lochner
    MRC Unit on Stress and Anxiety Disorders, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Depress Anxiety 15:66-8. 2002
    ....
  44. ncbi Consumer advocacy meetings: an innovative therapeutic tool
    Christine Lochner
    South African Medical Research Council Research Unit on Anxiety and Stress Disorders, Department of Psychiatry, Stellenbosch University, Matieland, Stellenbosch, South Africa
    Ann Clin Psychiatry 25:91-6. 2013
    ..The annual TLC retreat is an educational event focused on experiential learning and building a supportive community...
  45. ncbi Prevalence of obsessive compulsive disorder in first- and multi-episode male patients with schizophrenia-spectrum disorders
    Liezl Koen
    S Afr Med J 93:517-8. 2003