Robert Livingston

Summary

Affiliation: Adaptive TCR
Location: Seattle, U.S.A.
URL: adaptivetcr.com
Summary:
1999-2001 Post doctoral fellow, University of Washington, Molecular Biotechnology
2001-2007 Senior Research Scientist and program manager, University of Washington, Genome Sciences
2008-2009 Senior Research Scientist, University of Washington, Biology
2009-present Vice President of Research and Development, Adaptive TCR Inc., Seattle, WA
Grants:
Development of T-cell receptor repertoire profiling as a diagnostic for T1D, 2010, NIH SBIR
Correlating TCR diversity to immune reconstitution after cord blood transplant, 2011, NIH SBIR

Publications

  1. ncbi Sequence variation in the human T-cell receptor loci
    Rachel Mackelprang
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Immunol Rev 190:26-39. 2002
  2. pmc Epidermolysis bullosa simplex: a keratin 5 mutation is a fully dominant allele in epidermal cytoskeleton function
    K Stephens
    Department of Medicine, University of Washington, Seattle 98195
    Am J Hum Genet 56:577-85. 1995
  3. pmc Integrating host genomics with surveillance for invasive bacterial diseases
    Dana C Crawford
    Vanderbilt University, Nashville, Tennessee, USA
    Emerg Infect Dis 14:1138-40. 2008
  4. ncbi The environmental genome project: reference polymorphisms for drug metabolism genes and genome-wide association studies
    Mark J Rieder
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Drug Metab Rev 40:241-61. 2008
  5. pmc Linkage disequilibrium in wild mice
    Cathy C Laurie
    Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 3:e144. 2007
  6. pmc Allelic spectrum of the natural variation in CRP
    Dana C Crawford
    Department of Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195 7730, USA
    Hum Genet 119:496-504. 2006
  7. ncbi Sequence diversity, natural selection and linkage disequilibrium in the human T cell receptor alpha/delta locus
    Rachel Mackelprang
    Department of Genome Sciences, University of Washington, 357730, Seattle, WA, 98195 7730, USA
    Hum Genet 119:255-66. 2006
  8. pmc Genomic regions exhibiting positive selection identified from dense genotype data
    Christopher S Carlson
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195 7730, USA
    Genome Res 15:1553-65. 2005
  9. ncbi Comprehensive identification and characterization of diallelic insertion-deletion polymorphisms in 330 human candidate genes
    Tushar R Bhangale
    Department of Bioengineering, University of Washington, Seattle, WA 98195 7730, USA
    Hum Mol Genet 14:59-69. 2005
  10. pmc Pattern of sequence variation across 213 environmental response genes
    Robert J Livingston
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195 7730, USA
    Genome Res 14:1821-31. 2004

Detail Information

Publications13

  1. ncbi Sequence variation in the human T-cell receptor loci
    Rachel Mackelprang
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Immunol Rev 190:26-39. 2002
    ..This suggests that meaningful association studies in the TCR loci will require the analysis and typing of large marker sets to fully evaluate the role of TCR loci in common disease susceptibility in human populations...
  2. pmc Epidermolysis bullosa simplex: a keratin 5 mutation is a fully dominant allele in epidermal cytoskeleton function
    K Stephens
    Department of Medicine, University of Washington, Seattle 98195
    Am J Hum Genet 56:577-85. 1995
    ....
  3. pmc Integrating host genomics with surveillance for invasive bacterial diseases
    Dana C Crawford
    Vanderbilt University, Nashville, Tennessee, USA
    Emerg Infect Dis 14:1138-40. 2008
    ..Using nDBS specimens, we resequenced CD46, putative host gene receptor for Neisseria meningitidis, and identified variants associated with susceptibility to this disease...
  4. ncbi The environmental genome project: reference polymorphisms for drug metabolism genes and genome-wide association studies
    Mark J Rieder
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Drug Metab Rev 40:241-61. 2008
    ..Herein, we review a subset of Phase I cytochrome P450 genes studied by the EGP, approaches to GWAS, and the sensitivity of available genotyping platforms to capture common sequence variation in this subset of drug metabolism genes...
  5. pmc Linkage disequilibrium in wild mice
    Cathy C Laurie
    Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 3:e144. 2007
    ....
  6. pmc Allelic spectrum of the natural variation in CRP
    Dana C Crawford
    Department of Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195 7730, USA
    Hum Genet 119:496-504. 2006
    ..Collectively, these data suggest that several different types re-sequencing and genotyping approaches may be required to fully understand the complete spectrum of alleles that impact human phenotypes...
  7. ncbi Sequence diversity, natural selection and linkage disequilibrium in the human T cell receptor alpha/delta locus
    Rachel Mackelprang
    Department of Genome Sciences, University of Washington, 357730, Seattle, WA, 98195 7730, USA
    Hum Genet 119:255-66. 2006
    ..Furthermore, we explore signatures of natural selection across V genes. We find evidence of strong directional selection at this locus as evidenced by unusually high values of Fst...
  8. pmc Genomic regions exhibiting positive selection identified from dense genotype data
    Christopher S Carlson
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195 7730, USA
    Genome Res 15:1553-65. 2005
    ....
  9. ncbi Comprehensive identification and characterization of diallelic insertion-deletion polymorphisms in 330 human candidate genes
    Tushar R Bhangale
    Department of Bioengineering, University of Washington, Seattle, WA 98195 7730, USA
    Hum Mol Genet 14:59-69. 2005
    ....
  10. pmc Pattern of sequence variation across 213 environmental response genes
    Robert J Livingston
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195 7730, USA
    Genome Res 14:1821-31. 2004
    ..The implications for the use of these data in direct and indirect association studies of environmentally induced diseases are discussed...
  11. ncbi Expression of a truncated keratin 5 may contribute to severe palmar--plantar hyperkeratosis in epidermolysis bullosa simplex patients
    R J Livingston
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    J Invest Dermatol 116:970-4. 2001
    ..The remarkable occurrence of severe palmar--plantar hyperkeratosis in both patients suggests that the keratin 5 tail domain may have unrecognized, but important, normal functions in palmar-plantar tissues...
  12. ncbi Autosomal dominant cyclic hematopoiesis: exclusion of linkage to the major hematopoietic regulatory gene cluster on chromosome 5
    S E Palmer
    Department of Medicine, University of Washington, Seattle 98195
    Hum Genet 93:195-7. 1994
    ..Furthermore, the exclusion data provide evidence for rejecting the hypothesis that ADCH may be encoded by a new gene mapping within this cluster...
  13. pmc LPA and PLG sequence variation and kringle IV-2 copy number in two populations
    Dana C Crawford
    Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232, USA
    Hum Hered 66:199-209. 2008
    ..African-descent populations have, on average, higher levels of Lp(a), suggesting other genetic factors contribute to Lp(a) level variability across populations...