Research Topics
| Robert LivingstonSummaryAffiliation: Adaptive TCR Location: Seattle, U.S.A. URL: adaptivetcr.com Summary: 1999-2001 Post doctoral fellow, University of Washington, Molecular Biotechnology 2001-2007 Senior Research Scientist and program manager, University of Washington, Genome Sciences 2008-2009 Senior Research Scientist, University of Washington, Biology 2009-present Vice President of Research and Development, Adaptive TCR Inc., Seattle, WA Grants: Development of T-cell receptor repertoire profiling as a diagnostic for T1D, 2010, NIH SBIR Correlating TCR diversity to immune reconstitution after cord blood transplant, 2011, NIH SBIR Publications
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Detail Information
Publications
Sequence variation in the human T-cell receptor lociRachel Mackelprang
Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
Immunol Rev 190:26-39. 2002..This suggests that meaningful association studies in the TCR loci will require the analysis and typing of large marker sets to fully evaluate the role of TCR loci in common disease susceptibility in human populations...
Epidermolysis bullosa simplex: a keratin 5 mutation is a fully dominant allele in epidermal cytoskeleton functionK Stephens
Department of Medicine, University of Washington, Seattle 98195
Am J Hum Genet 56:577-85. 1995....- Integrating host genomics with surveillance for invasive bacterial diseasesDana C Crawford
Vanderbilt University, Nashville, Tennessee, USA
Emerg Infect Dis 14:1138-40. 2008..Using nDBS specimens, we resequenced CD46, putative host gene receptor for Neisseria meningitidis, and identified variants associated with susceptibility to this disease... - The environmental genome project: reference polymorphisms for drug metabolism genes and genome-wide association studiesMark J Rieder
Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
Drug Metab Rev 40:241-61. 2008..Herein, we review a subset of Phase I cytochrome P450 genes studied by the EGP, approaches to GWAS, and the sensitivity of available genotyping platforms to capture common sequence variation in this subset of drug metabolism genes... - Linkage disequilibrium in wild miceCathy C Laurie
Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
PLoS Genet 3:e144. 2007.... - Allelic spectrum of the natural variation in CRPDana C Crawford
Department of Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195 7730, USA
Hum Genet 119:496-504. 2006..Collectively, these data suggest that several different types re-sequencing and genotyping approaches may be required to fully understand the complete spectrum of alleles that impact human phenotypes... - Sequence diversity, natural selection and linkage disequilibrium in the human T cell receptor alpha/delta locusRachel Mackelprang
Department of Genome Sciences, University of Washington, 357730, Seattle, WA, 98195 7730, USA
Hum Genet 119:255-66. 2006..Furthermore, we explore signatures of natural selection across V genes. We find evidence of strong directional selection at this locus as evidenced by unusually high values of Fst... - Genomic regions exhibiting positive selection identified from dense genotype dataChristopher S Carlson
Department of Genome Sciences, University of Washington, Seattle, Washington 98195 7730, USA
Genome Res 15:1553-65. 2005.... - Comprehensive identification and characterization of diallelic insertion-deletion polymorphisms in 330 human candidate genesTushar R Bhangale
Department of Bioengineering, University of Washington, Seattle, WA 98195-7730, USA
Hum Mol Genet 14:59-69. 2005.... - Pattern of sequence variation across 213 environmental response genesRobert J Livingston
Department of Genome Sciences, University of Washington, Seattle, Washington 98195-7730, USA
Genome Res 14:1821-31. 2004..The implications for the use of these data in direct and indirect association studies of environmentally induced diseases are discussed... - Expression of a truncated keratin 5 may contribute to severe palmar--plantar hyperkeratosis in epidermolysis bullosa simplex patientsR J Livingston
Department of Pathology, University of Washington, Seattle, Washington 98195, USA
J Invest Dermatol 116:970-4. 2001..The remarkable occurrence of severe palmar--plantar hyperkeratosis in both patients suggests that the keratin 5 tail domain may have unrecognized, but important, normal functions in palmar-plantar tissues... - Autosomal dominant cyclic hematopoiesis: exclusion of linkage to the major hematopoietic regulatory gene cluster on chromosome 5S E Palmer
Department of Medicine, University of Washington, Seattle 98195
Hum Genet 93:195-7. 1994..Furthermore, the exclusion data provide evidence for rejecting the hypothesis that ADCH may be encoded by a new gene mapping within this cluster... - LPA and PLG sequence variation and kringle IV-2 copy number in two populationsDana C Crawford
Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232, USA
Hum Hered 66:199-209. 2008..African-descent populations have, on average, higher levels of Lp(a), suggesting other genetic factors contribute to Lp(a) level variability across populations...