Research Topics

Zhi Qiang Liu



  1. Wei M, Liu Y, Pi Z, Li S, Hu M, He Y, et al. Systematically Characterize the Anti-Alzheimer's Disease Mechanism of Lignans from S. chinensis based on In-Vivo Ingredient Analysis and Target-Network Pharmacology Strategy by UHPLC⁻Q-TOF-MS. Molecules. 2019;24: pubmed publisher
    ..The results might serve as the basis for a fundamental strategy to explore effective therapeutic drugs to treat AD. ..
  2. Feng G, Liu S, Pi Z, Song F, Liu Z. Comprehensive characterization of in vivo metabolic profile of Polygalae radix based on ultra-high-performance liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2019;165:173-181 pubmed publisher
    ..This strategy not only provided a comprehensive insight into the chemical and metabolic profiles of PR but also presented a new perspective for the discovery of new drugs for medicinal application. ..
  3. Feng G, Sun Y, Liu S, Song F, Pi Z, Liu Z. Stepwise targeted matching strategy from in vitro to in vivo based on ultra-high performance liquid chromatography tandem mass spectrometry technology to quickly identify and screen pharmacodynamic constituents. Talanta. 2019;194:619-626 pubmed publisher
    ..It also can explicate the mechanism of action of TCM. Furthermore, this strategy is practicable to identify metabolites and screen PCs in other herbal medicines. ..
  4. Xu T, Pi Z, Song F, Liu S, Liu Z. Benzophenone used as the photochemical reagent for pinpointing C=C locations in unsaturated lipids through shotgun and liquid chromatography-mass spectrometry approaches. Anal Chim Acta. 2018;1028:32-44 pubmed publisher
    ..The proposed PB method has been implemented in shotgun and LC-MS lipidomics. To our best knowledge, this work is the first to report the integrated PB reaction with LC-MS lipidomics for identification of lipid isomers. ..
  5. Zheng Y, Feng G, Sun Y, Liu S, Pi Z, Song F, et al. Study on the compatibility interactions of formula Ding-Zhi-Xiao-Wan based on their main components transport characteristics across Caco-2 monolayers model. J Pharm Biomed Anal. 2018;159:179-185 pubmed publisher
    ..Herbal combination could remarkable improve the absorption of 18 compounds and the scientific rationality compatibility of DZXW formula was proved. ..
  6. Zhang X, Liu S, Xing J, Liu Z, Song F. Effect of type 2 diabetes mellitus on flavonoid pharmacokinetics and tissue distribution after oral administration of Radix Scutellaria extract in rats. Chin J Nat Med. 2018;16:418-427 pubmed publisher
    ..The results from the present study provided a crucial basis for a better understanding of in vivo anti-diabetic mechanism of action of the six flavonoids from Radix Scutellaria. ..
  7. Xu T, Liu S, Meng L, Pi Z, Song F, Liu Z. Bioactive heterocyclic alkaloids with diterpene structure isolated from traditional Chinese medicines. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1026:56-66 pubmed publisher
    ..Based on above review, the further researches are suggested. ..
  8. Zhang X, Pi Z, Zheng Z, Liu Z, Song F. Comprehensive investigation of in-vivo ingredients and action mechanism of iridoid extract from Gardeniae Fructus by liquid chromatography combined with mass spectrometry, microdialysis sampling and network pharmacology. J Chromatogr B Analyt Technol Biomed Life Sci. 2018;1076:70-76 pubmed publisher
    ..The results provide useful information for further study of pharmacology and in vivo mechanism of action of iridoid extract from the fruits of Gardeniae Fructus. ..
  9. He Y, Zhao X, Zhu S, Wei N, Sun J, Zhou Y, et al. In situ derivatization-ultrasound-assisted dispersive liquid-liquid microextraction for the determination of neurotransmitters in Parkinson's rat brain microdialysates by ultra high performance liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2016;1458:70-81 pubmed publisher
    ..Taken together, this in situ DUADLLME method was successfully applied for the simultaneous determination of six NTs in biological samples. ..

More Information


  1. Zhang Y, Pi Z, Song F, Liu Z. Ginsenosides attenuate d-galactose- and AlCl3-inducedspatial memory impairment by restoring the dysfunction of the neurotransmitter systems in the rat model of Alzheimer's disease. J Ethnopharmacol. 2016;194:188-195 pubmed publisher
    ..After effectively administrated, ginsenosides attenuate d-gal- and Al-induced spatial memory impairment. The possible mechanism of the beneficial effect is restoring the dysfunction of various neurotransmitters. ..
  2. Wei N, Zhao X, Zhu S, He Y, Zheng L, Chen G, et al. Determination of dopamine, serotonin, biosynthesis precursors and metabolites in rat brain microdialysates by ultrasonic-assisted in situ derivatization-dispersive liquid-liquid microextraction coupled with UHPLC-MS/MS. Talanta. 2016;161:253-264 pubmed publisher
    ..The developed method was successfully applied for the simultaneous determination of multiple neurotransmitters, their precursors and metabolites in brain microdialysates of normal and L-DOPA induced dyskinesias (LID) rats. ..
  3. Xu T, Li S, Sun Y, Pi Z, Liu S, Song F, et al. Systematically characterize the absorbed effective substances of Wutou Decoction and their metabolic pathways in rat plasma using UHPLC-Q-TOF-MS combined with a target network pharmacological analysis. J Pharm Biomed Anal. 2017;141:95-107 pubmed publisher
    ..The combining use of the T-NP method could discover potential drug targets and disclose the biological processes of WTD, which will open up a new approach in the study of TCM in future. ..
  4. Feng G, Liu S, Pi Z, Song F, Liu Z. Studies on the chemical and intestinal metabolic profiles of Polygalae Radix by using UHPLC-IT-MSn and UHPLC-Q-TOF-MS method coupled with intestinal bacteria incubation model in vitro. J Pharm Biomed Anal. 2018;148:298-306 pubmed publisher
    ..The obtained results would provide the methodological support for further studying the effective materials of the PR in vivo. ..
  5. Xu T, Feng G, Zhao B, Zhao J, Pi Z, Liu S, et al. A non-target urinary and serum metabolomics strategy reveals therapeutical mechanism of Radix Astragali on adjuvant-induced arthritis rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1048:94-101 pubmed publisher
    ..The present study demonstrates that urinary and serum metabolomics method could be a potentially powerful tool to understand the holistic therapeutic effect and the mechanisms of herb medicines. ..