Wen T, Wang Z, Li Y, Li Z, Che X, Fan Y, et al
. A Four-Factor Immunoscore System That Predicts Clinical Outcome for Stage II/III Gastric Cancer. Cancer Immunol Res. 2017;5:524-534 pubmed publisher
..Thus, this more comprehensive immunoscore system can provide more accurate prognoses and is an essential complement to the AJCC staging system for operable gastric cancer patients. Cancer Immunol Res; 5(7); 524-34. Â©2017 AACR. ..
Fang W, Qu X, Shi J, Li H, Guo X, Wu X, et al
. Cruciferous vegetables and colorectal cancer risk: a hospital-based matched case-control study in Northeast China. Eur J Clin Nutr. 2018;: pubmed publisher
..66; 95% CI: 0.48-0.92). No significant association was found between total cruciferous vegetable intake and colorectal cancer risk. However, specific types of cruciferous vegetables might have protective roles against colorectal cancer. ..
Wu Y, Wang K, Li Z, Liu Y, Izumi H, Uramoto H, et al
. Y-box binding protein 1 enhances DNA topoisomerase 1 activity and sensitivity to camptothecin via direct interaction. J Exp Clin Cancer Res. 2014;33:112 pubmed publisher
..Our findings suggest that nuclear YB-1 serves as an intracellular promoter of TOPO1 catalytic activity that enhances CPT sensitivity through its direct interaction with TOPO1. ..
Yang Z, Shi X, Li C, Wang X, Hou K, Li Z, et al
. Long non-coding RNA UCA1 upregulation promotes the migration of hypoxia-resistant gastric cancer cells through the miR-7-5p/EGFR axis. Exp Cell Res. 2018;368:194-201 pubmed publisher
..This study thus reveals a new mechanism by which a hypoxic microenvironment promotes tumor metastasis, and highlights UCA1 as a potential biomarker for predicting the metastasis of gastric cancer to guide clinical treatment. ..
Ma R, Xu L, Qu X, Che X, Zhang Y, Fan Y, et al
. AZ304, a novel dual BRAF inhibitor, exerts anti-tumour effects in colorectal cancer independently of BRAF genetic status. Br J Cancer. 2018;118:1453-1463 pubmed publisher
..The BRAF inhibitor AZ304 has broad spectrum antitumour activity, which is significantly enhanced by combination with Cetuximab in colorectal cancers in vitro and in vivo. ..
Wang J, Qu J, Li Z, Che X, Zhang J, Liu J, et al
. A Prognostic Model in Metastatic or Recurrent Gastric Cancer Patients with Good Performance Status Who Received First-Line Chemotherapy. Transl Oncol. 2016;9:256-61 pubmed publisher
Li H, Xu L, Li C, Zhao L, Ma Y, Zheng H, et al
. Ubiquitin ligase Cbl-b represses IGF-I-induced epithelial mesenchymal transition via ZEB2 and microRNA-200c regulation in gastric cancer cells. Mol Cancer. 2014;13:136 pubmed publisher
..001). Together, these findings demonstrate that the ubiquitin ligase Cbl-b represses IGF-I-induced EMT, likely through targeting IGF-IR for degradation and further inhibiting the Akt/ERK-miR-200c-ZEB2 axis in gastric cancer cells. ..
Li H, Batth I, Qu X, Xu L, Song N, Wang R, et al
. IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights. Mol Cancer. 2017;16:6 pubmed publisher
..Most importantly, we address several factors in the regulation of IGF-I/IGF-IR-associated EMT progression that may be potential predictive biomarkers in targeted therapy. ..
Xu L, Zhang Y, Qu X, Che X, Guo T, Cai Y, et al
. E3 Ubiquitin Ligase Cbl-b Prevents Tumor Metastasis by Maintaining the Epithelial Phenotype in Multiple Drug-Resistant Gastric and Breast Cancer Cells. Neoplasia. 2017;19:374-382 pubmed publisher
..These results suggest that Cbl-b is an important factor for maintenance of the epithelial phenotype and inhibition of cell migration in MDR gastric and breast cancer cells. ..