Xuebo Liu



  1. Mi Y, Zhang W, Tian H, Li R, Huang S, Li X, et al. EGCG evokes Nrf2 nuclear translocation and dampens PTP1B expression to ameliorate metabolic misalignment under insulin resistance condition. Food Funct. 2018;9:1510-1523 pubmed publisher
    ..Administration of an appropriate chemopreventive agent, such as EGCG, could potentially serve as an additional therapeutic intervention in the arsenal against obesity. ..
  2. Liu Z, Sun Y, Qiao Q, Zhao T, Zhang W, Ren B, et al. Sesamol ameliorates high-fat and high-fructose induced cognitive defects via improving insulin signaling disruption in the central nervous system. Food Funct. 2017;8:710-719 pubmed publisher
    ..This compelling evidence indicated that sesamol is a potential nutritional supplement to prevent unhealthy-diet-induced learning and memory loss. ..
  3. Wang J, Zou Q, Suo Y, Tan X, Yuan T, Liu Z, et al. Lycopene ameliorates systemic inflammation-induced synaptic dysfunction via improving insulin resistance and mitochondrial dysfunction in the liver-brain axis. Food Funct. 2019;10:2125-2137 pubmed publisher
    ..In conclusion, these results indicated that the supplementation of LYC might be a nutritional preventive strategy in systemic inflammation-induced synaptic dysfunction. ..
  4. Yuan T, Wu D, Sun K, Tan X, Wang J, Zhao T, et al. Anti-Fatigue Activity of Aqueous Extracts of Sonchus arvensis L. in Exercise Trained Mice. Molecules. 2019;24: pubmed publisher
    ..Therefore, SA could be a potential nutraceutical for improving exercise performance and alleviating physical fatigue. ..
  5. Liu R, Zhang J, Zhao C, Duan X, McClements D, Liu X, et al. Formation and Characterization of Lactoferrin-Hyaluronic Acid Conjugates and Their Effects on the Storage Stability of Sesamol Emulsions. Molecules. 2018;23: pubmed publisher
    ..Optimum stability of the emulsion was obtained at a LF-to-HA molar ratio of 2:1. Our results suggest that LF-HA conjugates may be effective emulsifiers for use in food stuffs and other applications. ..
  6. Wang J, Wang Z, Li B, Qiang Y, Yuan T, Tan X, et al. Lycopene attenuates western-diet-induced cognitive deficits via improving glycolipid metabolism dysfunction and inflammatory responses in gut-liver-brain axis. Int J Obes (Lond). 2018;: pubmed publisher
    ..These findings indicate that LYC might be a nutritional strategy for western diet-induced dysfunction of the central nervous system. ..
  7. Ren B, Yuan T, Diao Z, Zhang C, Liu Z, Liu X. Protective effects of sesamol on systemic oxidative stress-induced cognitive impairments via regulation of Nrf2/Keap1 pathway. Food Funct. 2018;9:5912-5924 pubmed publisher
    ..In conclusion, these results revealed that sesamol could be a potential neuroprotective agent during aging process due to its beneficial effects on liver-brain axis. ..
  8. Tan X, Ye J, Liu W, Zhao B, Shi X, Zhang C, et al. Acrylamide aggravates cognitive deficits at night period via the gut-brain axis by reprogramming the brain circadian clock. Arch Toxicol. 2019;93:467-486 pubmed publisher
    ..Above all, the present research discovered that ACR is a potential circadian-depressing compound that influences cognitive function in mice brain. ..
  9. Qi G, Wu W, Mi Y, Shi R, Sun K, Li R, et al. Tea polyphenols direct Bmal1-driven ameliorating of the redox imbalance and mitochondrial dysfunction in hepatocytes. Food Chem Toxicol. 2018;122:181-193 pubmed publisher
    ..Our study revealed that TP, as a Bmal1-enhancing natural compound, alleviated redox imbalance via strengthening Keap1/Nrf2 antioxidant defense pathway and ameliorating mitochondrial dysfunction in a Bmal1-dependent manner. ..

More Information


  1. Mi Y, Liu X, Tian H, Liu H, Li J, Qi G, et al. EGCG stimulates the recruitment of brite adipocytes, suppresses adipogenesis and counteracts TNF-?-triggered insulin resistance in adipocytes. Food Funct. 2018;9:3374-3386 pubmed publisher
    ..These findings indicate that EGCG is capable of suppressing adipogenesis and evoking white adipocyte beiging and therefore it may potentially serve as a novel approach to combat obesity. ..
  2. Qi G, Mi Y, Wang Y, Li R, Huang S, Li X, et al. Neuroprotective action of tea polyphenols on oxidative stress-induced apoptosis through the activation of the TrkB/CREB/BDNF pathway and Keap1/Nrf2 signaling pathway in SH-SY5Y cells and mice brain. Food Funct. 2017;8:4421-4432 pubmed publisher
  3. Liu Q, Wang Y, Xiao C, Wu W, Liu X. Metabolism of chicoric acid by rat liver microsomes and bioactivity comparisons of chicoric acid and its metabolites. Food Funct. 2015;6:1928-35 pubmed publisher
    ..Finally, the pharmacological activities of chicoric acid were significantly stronger than those of its metabolites within a certain concentration range. ..
  4. Liu Z, Song G, Zou C, Liu G, Wu W, Yuan T, et al. Acrylamide induces mitochondrial dysfunction and apoptosis in BV-2 microglial cells. Free Radic Biol Med. 2015;84:42-53 pubmed publisher
    ..ACR-mediated mitochondrial dysfunction along with a more oxidized redox status seems to be critical events leading to activation of the intrinsic apoptotic pathway and inflammatory responses. ..
  5. Qi G, Guo R, Tian H, Li L, Liu H, Mi Y, et al. Nobiletin protects against insulin resistance and disorders of lipid metabolism by reprogramming of circadian clock in hepatocytes. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:549-562 pubmed publisher
    ..Overall, NOB may serve as a nutritional preventive strategy in recovering metabolic disorders relevant to circadian clock. ..
  6. Yuan L, Wang J, Wu W, Liu Q, Liu X. Effect of isoorientin on intracellular antioxidant defence mechanisms in hepatoma and liver cell lines. Biomed Pharmacother. 2016;81:356-62 pubmed publisher
    ..All of these results demonstrated, for the first time, that ISO possesses a notable hepatoprotective effect, which might be mediated through the respiratory chain complexes and phase II detoxifying enzyme activities. ..
  7. Mi Y, Xiao C, Du Q, Wu W, Qi G, Liu X. Momordin Ic couples apoptosis with autophagy in human hepatoblastoma cancer cells by reactive oxygen species (ROS)-mediated PI3K/Akt and MAPK signaling pathways. Free Radic Biol Med. 2016;90:230-42 pubmed publisher
    ..Those results suggest that momordin Ic has great potential as a nutritional preventive strategy in cancer therapy. ..
  8. Qi G, Yang L, Xiao C, Shi J, Mi Y, Liu X. Nutrient values and bioactivities of the extracts from three fern species in China: a comparative assessment. Food Funct. 2015;6:2918-29 pubmed publisher
    ..Ching as valuable sources of nutrients and natural antioxidants, and among which Athyrium multidentatum (Doll.) Ching has potential anticancer properties. ..
  9. Wang J, Li L, Wang Z, Cui Y, Tan X, Yuan T, et al. Supplementation of lycopene attenuates lipopolysaccharide-induced amyloidogenesis and cognitive impairments via mediating neuroinflammation and oxidative stress. J Nutr Biochem. 2018;56:16-25 pubmed publisher
  10. Cui Y, Lu P, Song G, Liu Q, Zhu D, Liu X. Involvement of PI3K/Akt, ERK and p38 signaling pathways in emodin-mediated extrinsic and intrinsic human hepatoblastoma cell apoptosis. Food Chem Toxicol. 2016;92:26-37 pubmed publisher
    ..Additionally, there was a cross-talk between PI3K/Akt and MAPKs pathways in emodin-induced apoptosis. ..
  11. Qi G, Mi Y, Fan R, Zhao B, Ren B, Liu X. Tea polyphenols ameliorates neural redox imbalance and mitochondrial dysfunction via mechanisms linking the key circadian regular Bmal1. Food Chem Toxicol. 2017;110:189-199 pubmed publisher
    ..Hence, TP may serve as a nutritional preventive strategy in the recovery of oxidative stress-related neurodegenerative disease via modulating circadian clock. ..
  12. Zhu D, Zhang X, Niu Y, Diao Z, Ren B, Li X, et al. Cichoric acid improved hyperglycaemia and restored muscle injury via activating antioxidant response in MLD-STZ-induced diabetic mice. Food Chem Toxicol. 2017;107:138-149 pubmed publisher
    ..In general, CA is a natural food-derived compound with the potential application for regulating glucose homeostasis and improving diabetes and its complications. ..
  13. Qi G, Liu Z, Fan R, Yin Z, Mi Y, Ren B, et al. Athyrium multidentatum (Doll.) Ching extract induce apoptosis via mitochondrial dysfunction and oxidative stress in HepG2 cells. Sci Rep. 2017;7:2275 pubmed publisher
    ..Further in vivo experiments demonstrated that AMC significantly suppressed the tumor growth, suggesting that AMC may be a novel promising agent for hepatocellular carcinoma treatment. ..
  14. Zhao B, Ren B, Guo R, Zhang W, Ma S, Yao Y, et al. Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway. Food Chem Toxicol. 2017;109:505-516 pubmed publisher
    ..Therefore, these results illustrated that LYC could ameliorate oxidative stress induced neuroinflammation and cognitive impairment possibly via mediating Nrf2/NF-κB transcriptional pathway. ..
  15. Mi Y, Qi G, Fan R, Qiao Q, Sun Y, Gao Y, et al. EGCG ameliorates high-fat- and high-fructose-induced cognitive defects by regulating the IRS/AKT and ERK/CREB/BDNF signaling pathways in the CNS. FASEB J. 2017;31:4998-5011 pubmed publisher
    ..Mi, Y., Qi, G., Fan, R., Qiao, Q., Sun, Y., Gao, Y., Liu, X. EGCG ameliorates high-fat- and high-fructose-induced cognitive defects by regulating the IRS/AKT and ERK/CREB/BDNF signaling pathways in the CNS. ..
  16. Xiao C, He P, Han J, Tang M, Wang Z, Mi Y, et al. 1,3-Dichloro-2-propanol evokes inflammation and apoptosis in BV-2 microglia via MAPKs and NF-κB signaling pathways mediated by reactive oxygen species. Toxicol Lett. 2018;284:103-112 pubmed publisher
    ..Overall, these results presented here suggested that 1,3-DCP has neurotoxic effect on BV-2 microglia mainly via MAPKs and NF-κB pathways mediated by ROS. ..
  17. Mi Y, Qi G, Fan R, Ji X, Liu Z, Liu X. EGCG ameliorates diet-induced metabolic syndrome associating with the circadian clock. Biochim Biophys Acta Mol Basis Dis. 2017;1863:1575-1589 pubmed publisher
    ..This study is the first to provide compelling evidences that EGCG may ameliorate diet-induced metabolic misalignment by regulating the rhythmic expression of the circadian clock genes in the liver and fat. ..
  18. Liu Q, Chen Y, Shen C, Xiao Y, Wang Y, Liu Z, et al. Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-?B. FASEB J. 2017;31:1494-1507 pubmed publisher
    ..Liu, Q., Chen, Y., Shen, C., Xiao, Y., Wang, Y., Liu, Z., Liu, X. Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-?B. ..