Human macrophage host defense against Mycobacterium tuberculosisPhilip T Liu
Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, United States
Curr Opin Immunol 20:371-6. 2008
..Further understanding these defense mechanisms in human tuberculosis will help the development of new interventional strategies to prevent and treat disease...
Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responsesPhilip T Liu
Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
PLoS ONE 4:e5810. 2009
..Therefore, these data identify a novel mechanism of host defense requiring the induction of IL-1beta in synergy with vitamin D activation, for the TLR-induced antimicrobial pathway against an intracellular pathogen...
CD209(+) macrophages mediate host defense against Propionibacterium acnesPhilip T Liu
Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
J Immunol 180:4919-23. 2008
..acnes-mediated differentiation of the CD209(+) subset. Therefore, the differentiation of monocytes into CD209(+) macrophages and CD1b(+) dendritic cells distinctly mediate the innate immune response to P. acnes...
- T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism
Kristina Edfeldt
Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 107:22593-8. 2010
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- Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
Philip T Liu
Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095, USA
Science 311:1770-3. 2006
..These data support a link between TLRs and vitamin D-mediated innate immunity and suggest that differences in ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection...
- Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages
Mario Fabri
Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles UCLA, Los Angeles, CA 90095, USA
Sci Transl Med 3:104ra102. 2011
..The present findings underscore the importance of adequate amounts of vitamin D in all human populations for sustaining both innate and acquired immunity against infection...
- Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism
Jürgen Schauber
Division of Dermatology, University of California, San Diego, and VA San Diego Healthcare System, San Diego, California, USA
J Clin Invest 117:803-11. 2007
..Thus, we demonstrate what we believe to be a previously unexpected role for vitamin D3 in innate immunity, enabling keratinocytes to recognize and respond to microbes and to protect wounds against infection...
- Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin
Philip T Liu
Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Immunol 179:2060-3. 2007
..These data demonstrate that cathelicidin is required for the 1,25D(3)-triggered antimicrobial activity against intracellular M. tuberculosis...
- IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway
Stephan R Krutzik
Division of Dermatology, David Geffen School of Medicine at University of California Los Angeles, CA 90095, USA
J Immunol 181:7115-20. 2008
..Therefore, IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway...
- TLR activation of Langerhans cell-like dendritic cells triggers an antiviral immune response
Claudia N Renn
Division of Dermatology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA
J Immunol 177:298-305. 2006
..Finally, CXCL9 colocalized with LCs in skin biopsy specimens from viral infections. Together, our data suggest that LCs exhibit a direct antiviral activity that is dependent on type I IFN as part of the innate immune system...
- Cord blood vitamin D status impacts innate immune responses
Valencia P Walker
Department of Pediatrics, Division of Neonatology and Developmental Biology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095, USA
J Clin Endocrinol Metab 96:1835-43. 2011
....
- MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy
Philip T Liu
Orthopaedic Hospital Research Center, University of California Los Angeles, Los Angeles, California, USA
Nat Med 18:267-73. 2012
..leprae to upregulate hsa-mir-21 targets multiple genes associated with the immunologically localized disease form, providing an effective mechanism to escape from the vitamin D-dependent antimicrobial pathway...
- All-trans retinoic acid shifts Propionibacterium acnes-induced matrix degradation expression profile toward matrix preservation in human monocytes
H Ray Jalian
Division of Dermatology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
J Invest Dermatol 128:2777-82. 2008
..These data indicate that P. acnes-induced MMPs and TIMPs may be involved in acne pathogenesis and that retinoic acid modulates MMP and TIMP expression, shifting from a matrix-degradative phenotype to a matrix-preserving phenotype...
- Therapeutic implications of the TLR and VDR partnership
Philip T Liu
Division of Dermatology, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
Trends Mol Med 13:117-24. 2007
..Owing to their capability to combat a wide array of pathogens, TLRs are attractive therapeutic targets. However, additional knowledge about their antimicrobial mechanisms is needed...
- TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells
Stephan R Krutzik
Division of Dermatology, University of California at Los Angeles, 611 Charles Young Drive East, 536 Boyer Hall, Los Angeles, CA 90095, USA
Nat Med 11:653-60. 2005
..Thus, TLR-induced differentiation of monocytes into either macrophages or dendritic cells seems to crucially influence effective host defenses in human infectious disease...
- Immune blood biomarkers of Alzheimer disease patients
Hripsime Avagyan
Department of Orthopaedic Surgery, UCLA Orthopaedic Hospital Research Center, Los Angeles, CA 90095, United States
J Neuroimmunol 210:67-72. 2009
..The significance of abnormal results in aged persons should be investigated by prospective studies to determine the risk of AD...
- Cutting edge: all-trans retinoic acid down-regulates TLR2 expression and function
Philip T Liu
Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at University of California, Los Angeles, USA
J Immunol 174:2467-70. 2005
..Agents that target TLR expression and function represent a novel strategy to treat inflammation in humans...
- TGF-alpha regulates TLR expression and function on epidermal keratinocytes
Lloyd S Miller
Division of Dermatology, Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Immunol 174:6137-43. 2005
..These findings provide evidence that TGF-alpha up-regulates TLR expression and function, augmenting host defense mechanisms at epithelial surfaces...
- IL-17A is increased in the serum and in spinal cord CD8 and mast cells of ALS patients
Milan Fiala
Department of Medicine, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, 650 Charles E, Young Dr, South, Los Angeles, CA 90095 1735, USA
J Neuroinflammation 7:76. 2010
..Immune modulation of chronic inflammation may be a new approach to sALS...
- Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin
Milan Fiala
Department of Medicine, Greater Los Angeles Veterans Affairs Medical Center, and School of Medicine, University of California Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 104:12849-54. 2007
..Thus, bisdemethoxycurcumin may correct immune defects of AD patients and provide a previously uncharacterized approach to AD immunotherapy...
- Toll-like receptors induce a phagocytic gene program through p38
Sean E Doyle
Dept. of Microbiology, Immunology and Molecular Genetics, University of California-Los Angeles, 8-240 Factor Building, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
J Exp Med 199:81-90. 2004
..Taken together, our data describe an evolutionarily conserved mechanism by which TLRs can specifically promote phagocytic clearance of bacteria during infection...
