Lin Liu

Summary

Publications

  1. ncbi request reprint An essential role for functional telomeres in mouse germ cells during fertilization and early development
    Lin Liu
    Department of Immunology and Oncology, National Centre of Biotechnology, Madrid, E 28049, Spain
    Dev Biol 249:74-84. 2002
  2. pmc Association of telomere instability with senescence of porcine cells
    Guangzhen Ji
    State Key Laboratory of Medicinal Chemical Biology College of Life Sciences, Nankai University, Tianjin 300071, China
    BMC Cell Biol 13:36. 2012
  3. pmc Isolation of mouse mesenchymal stem cells with normal ploidy from bone marrows by reducing oxidative stress in combination with extracellular matrix
    Guokuan Fan
    School of Life Science, Sun Yat Sen University, Guangzhou, China
    BMC Cell Biol 12:30. 2011
  4. ncbi request reprint Telomere lengthening early in development
    Lin Liu
    Laboratory for Reproductive Medicine, Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Nat Cell Biol 9:1436-41. 2007
  5. ncbi request reprint Defective cohesin is associated with age-dependent misaligned chromosomes in oocytes
    Lin Liu
    Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Reprod Biomed Online 16:103-12. 2008
  6. doi request reprint Telomere susceptibility to cigarette smoke-induced oxidative damage and chromosomal instability of mouse embryos in vitro
    Junjiu Huang
    Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Free Radic Biol Med 48:1663-76. 2010
  7. doi request reprint Delay in oocyte aging in mice by the antioxidant N-acetyl-L-cysteine (NAC)
    Jinmiao Liu
    Department of Cell Biology and Genetics, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China
    Hum Reprod 27:1411-20. 2012
  8. ncbi request reprint Noninvasive imaging of spindle dynamics during mammalian oocyte activation
    Paula A A S Navarro
    Department of Obstetrics and Gynecology, Women and Infants Hospital, Brown University, Providence, Rhode Island, USA
    Fertil Steril 83:1197-205. 2005
  9. doi request reprint Isolation and culture of primary bovine embryonic stem cell colonies by a novel method
    Shanbo Cao
    School of Life Science, Sun Yat Sen University, Guangzhou, China
    J Exp Zool A Ecol Genet Physiol 311:368-76. 2009
  10. doi request reprint Birth of parthenote mice directly from parthenogenetic embryonic stem cells
    Zhisheng Chen
    School of Life Science, Sun Yet Sen University, Guangzhou, China
    Stem Cells 27:2136-45. 2009

Collaborators

Detail Information

Publications70

  1. ncbi request reprint An essential role for functional telomeres in mouse germ cells during fertilization and early development
    Lin Liu
    Department of Immunology and Oncology, National Centre of Biotechnology, Madrid, E 28049, Spain
    Dev Biol 249:74-84. 2002
    ....
  2. pmc Association of telomere instability with senescence of porcine cells
    Guangzhen Ji
    State Key Laboratory of Medicinal Chemical Biology College of Life Sciences, Nankai University, Tianjin 300071, China
    BMC Cell Biol 13:36. 2012
    ..We attempted to investigate telomere characteristics of porcine cells using telomere Q-FISH method...
  3. pmc Isolation of mouse mesenchymal stem cells with normal ploidy from bone marrows by reducing oxidative stress in combination with extracellular matrix
    Guokuan Fan
    School of Life Science, Sun Yat Sen University, Guangzhou, China
    BMC Cell Biol 12:30. 2011
    ....
  4. ncbi request reprint Telomere lengthening early in development
    Lin Liu
    Laboratory for Reproductive Medicine, Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Nat Cell Biol 9:1436-41. 2007
    ....
  5. ncbi request reprint Defective cohesin is associated with age-dependent misaligned chromosomes in oocytes
    Lin Liu
    Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Reprod Biomed Online 16:103-12. 2008
    ..This natural ageing mouse model shows that defective cohesin coincides with increased incidence of chromosome misalignment and precocious separations of sister chromatids...
  6. doi request reprint Telomere susceptibility to cigarette smoke-induced oxidative damage and chromosomal instability of mouse embryos in vitro
    Junjiu Huang
    Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Free Radic Biol Med 48:1663-76. 2010
    ..These data further extend our understanding of mechanisms underlying smoke-induced oxidative damage to include telomere dysfunction and chromosomal instability...
  7. doi request reprint Delay in oocyte aging in mice by the antioxidant N-acetyl-L-cysteine (NAC)
    Jinmiao Liu
    Department of Cell Biology and Genetics, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China
    Hum Reprod 27:1411-20. 2012
    ..Using mice as models, we tested the hypothesis that reducing oxidative stress by NAC might prevent or delay ovarian aging in vivo...
  8. ncbi request reprint Noninvasive imaging of spindle dynamics during mammalian oocyte activation
    Paula A A S Navarro
    Department of Obstetrics and Gynecology, Women and Infants Hospital, Brown University, Providence, Rhode Island, USA
    Fertil Steril 83:1197-205. 2005
    ..To develop a method to evaluate spindle dynamics in living oocytes and in karyoplasts during the initial stages of activation and after pharmacological disruption of cytoskeleton...
  9. doi request reprint Isolation and culture of primary bovine embryonic stem cell colonies by a novel method
    Shanbo Cao
    School of Life Science, Sun Yat Sen University, Guangzhou, China
    J Exp Zool A Ecol Genet Physiol 311:368-76. 2009
    ....
  10. doi request reprint Birth of parthenote mice directly from parthenogenetic embryonic stem cells
    Zhisheng Chen
    School of Life Science, Sun Yet Sen University, Guangzhou, China
    Stem Cells 27:2136-45. 2009
    ..This is the first demonstration that pESCs are capable of full-term development and can differentiate into all cell types and functional organs in the body...
  11. pmc Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells
    Fang Wang
    College of Life Sciences, Nankai University, Tianjin 300071, China
    Cell Res 22:757-68. 2012
    ..These findings may also relate to the cloning field where these mechanisms could be responsible for telomere heterogeneity after nuclear reprogramming by somatic cell nuclear transfer...
  12. doi request reprint Correlation of expression and methylation of imprinted genes with pluripotency of parthenogenetic embryonic stem cells
    Chao Li
    School of Life Science, Sun Yat Sen University, Guangzhou 510275, China
    Hum Mol Genet 18:2177-87. 2009
    ....
  13. pmc Association of telomere length with authentic pluripotency of ES/iPS cells
    Junjiu Huang
    School of Life Sciences, Sun Yat Sen University, Guangzhou 510275, China
    Cell Res 21:779-92. 2011
    ....
  14. doi request reprint Resveratrol protects against age-associated infertility in mice
    Mengyuan Liu
    Department of Cell Biology and Genetics, State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China
    Hum Reprod 28:707-17. 2013
    ..Does resveratrol counteract age-associated infertility in a mouse model of reproductive aging?..
  15. doi request reprint Genome-wide gene expression profiling reveals aberrant MAPK and Wnt signaling pathways associated with early parthenogenesis
    Na Liu
    College of Life Sciences, Nankai University, Tianjin 300071, China
    J Mol Cell Biol 2:333-44. 2010
    ....
  16. ncbi request reprint Imaging meiotic spindles by polarization light microscopy: principles and applications to IVF
    David Keefe
    Department of Obstetrics and Gynecology, Division of Reproductive Medicine and Infertility, Women and Infants Hospital, 101 Dudley Street, Providence, RI 02905, USA
    Reprod Biomed Online 7:24-9. 2003
    ..A time-lapse video of a mouse oocyte imaged by polscope may be purchased for viewing on the internet at www.rbmonline.com/Article/824 (free to web subscribers)...
  17. doi request reprint Generation of pluripotent stem cells from eggs of aging mice
    Junjiu Huang
    Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa, FL 33647, USA
    Aging Cell 9:113-25. 2010
    ....
  18. doi request reprint Transplantation of parthenogenetic embryonic stem cells ameliorates cardiac dysfunction and remodelling after myocardial infarction
    Yi Liu
    State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin, PR 300071, China
    Cardiovasc Res 97:208-18. 2013
    ..Here we investigated whether pESCs could repair myocardial infarction (MI), in comparison to embryonic stem cells (ESCs)...
  19. ncbi request reprint Arsenite induces aberrations in meiosis that can be prevented by coadministration of N-acetylcysteine in mice
    Paula A A S Navarro
    Department of Obstetrics and Gynecology, Women and Infants Hospital, Brown University, Providence, Rhode Island, USA
    Fertil Steril 85:1187-94. 2006
    ..To evaluate in vitro effects of arsenite and of arsenite plus N-acetylcysteine on mouse oocyte meiosis...
  20. pmc Germline competency of parthenogenetic embryonic stem cells from immature oocytes of adult mouse ovary
    Zhong Liu
    School of Life Science, Sun Yat Sen University, Guangzhou 510275, China
    Hum Mol Genet 20:1339-52. 2011
    ..This may indicate differences in differentiation potentially to the germline. The mechanisms for acquisition of pluripotency and germline competency of IVM pESCs from immature oocytes remain to be determined...
  21. ncbi request reprint Nuclear transfer methods to study aging
    Lin Liu
    Department of Obstetrics and Gynecology, Women and Infants Hospital, Brown Medical School, Providence, RI, USA
    Methods Mol Biol 371:191-207. 2007
    ..Then, nuclear transfer is used at the zygote stage to study nuclear and cytoplasmic abnormality and apoptosis in early development...
  22. pmc Robust measurement of telomere length in single cells
    Fang Wang
    Department of Obstetrics and Gynecology, New York University Langone Medical Center, NY 10016, USA
    Proc Natl Acad Sci U S A 110:E1906-12. 2013
    ..This method will facilitate understanding of telomere heterogeneity and its role in tumorigenesis, aging, and associated diseases...
  23. doi request reprint Conservation and characterization of unique porcine interstitial telomeric sequences
    Guangzhen Ji
    State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China
    Sci China Life Sci 55:1029-37. 2012
    ..Further understanding of the function and regulation of pig ITSs may provide new clues for evolution and chromosomal instability...
  24. pmc Influences of lamin A levels on induction of pluripotent stem cells
    Bingfeng Zuo
    State Key Laboratory of Medicinal Chemical Biology, Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, Tianjin 300071, China Tianjin Oxford Joint Laboratory of Gene Therapy, Tianjin Research Centre of Basic Medical Science, Tianjin Medical University, Tianjin 300070, China
    Biol Open 1:1118-27. 2012
    ..These findings may have implications in enhancing rejuvenation of senescent or older cells by iPS technology and manipulating lamin A levels...
  25. ncbi request reprint Telomerase deficiency impairs differentiation of mesenchymal stem cells
    Lin Liu
    Department of Obstetrics and Gynecology, Women and Infants Hospital, Brown University School of Medicine, Providence, RI 02905, USA
    Exp Cell Res 294:1-8. 2004
    ..This work may be significant for further potentiating adult stem cells for use in tissue engineering and gene therapy and for understanding the significance of telomerase expression in the process of cell differentiation...
  26. ncbi request reprint Nuclear origin of aging-associated meiotic defects in senescence-accelerated mice
    Lin Liu
    Department of Obstetrics and Gynecology, Brown Medical School and Women and Infants Hospital, Providence, Rhode Island 02905, USA
    Biol Reprod 71:1724-9. 2004
    ..Our results demonstrate that both nuclear and cytoplasmic factors contribute to the meiotic defects of the old SAM oocytes and that the nuclear compartment plays the predominant role in the etiology of aging-related meiotic defects...
  27. pmc Irregular telomeres impair meiotic synapsis and recombination in mice
    Lin Liu
    Department of Obstetrics and Gynecology, Brown Medical School, Women and Infants Hospital, Providence, RI 02905, USA
    Proc Natl Acad Sci U S A 101:6496-501. 2004
    ..These findings imply that functional telomeres are important in mammalian meiotic synapsis and recombination...
  28. ncbi request reprint Checkpoint for DNA integrity at the first mitosis after oocyte activation
    Lin Liu
    Department of Obstetrics and Gynecology, Brown University, Women and Infants Hospital, Providence, Rhode Island, USA
    Mol Reprod Dev 62:277-88. 2002
    ..Further, we found a mechanism of cytoskeletal involvement in the process of cytofragmentation. In addition, possible implication of the present findings in somatic cell cloning and human clinical embryology is discussed...
  29. pmc Requirement of functional telomeres for metaphase chromosome alignments and integrity of meiotic spindles
    Lin Liu
    Department of Obstetrics and Gynecology, Women and Infants Hospital, Brown University, Providence, RI 02905, USA
    EMBO Rep 3:230-4. 2002
    ..Rather, functional telomeres may be involved in mediating metaphase chromosome alignment and maintaining functional spindles during meiotic division...
  30. ncbi request reprint Telomeres and reproductive aging
    David L Keefe
    Department of Ob Gyn, University of South Florida, Tampa, FL 33606, USA
    Reprod Fertil Dev 21:10-4. 2009
    ..Telomere dysfunction resulting from oxidative stress, a DNA damage response or aberrant telomere recombination may contribute to reproductive aging-associated meiotic defects, miscarriage and infertility...
  31. ncbi request reprint The telomere theory of reproductive senescence in women
    David L Keefe
    University of South Florida, Department of Obstetrics and Gynecology, Tampa, Florida 33606, USA
    Curr Opin Obstet Gynecol 18:280-5. 2006
    ..A unifying theory of reproductive aging, based on telomere shortening, is proposed...
  32. doi request reprint Atypical PKC, regulated by Rho GTPases and Mek/Erk, phosphorylates Ezrin during eight-cell embryocompaction
    Hongjie Liu
    The State Key Laboratory of Medicinal Chemical Biology, the 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics and College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China
    Dev Biol 375:13-22. 2013
    ..Our data also suggested that aPKC might be the Ezrin kinase during eight-cell embryo compaction...
  33. doi request reprint Generation of porcine-induced pluripotent stem cells by using OCT4 and KLF4 porcine factors
    Kai Liu
    State Key Laboratory of Medicinal Chemical Biology, Department of Cell Biology and Genetics, College of Life Sciences, Nankai University, Tianjin 300071, China
    Cell Reprogram 14:505-13. 2012
    ..These attempts represent the first step toward generating truly pluripotent porcine iPSCs with fewer exogenous genes and less integration...
  34. pmc Telomeres and human reproduction
    Keri Horan Kalmbach
    Department of Obstetrics and Gynecology, New York University, Langone Medical Center, New York City, New York, USA
    Fertil Steril 99:23-9. 2013
    ..Additionally, growing evidence links altered telomere biology to endometriosis and gynecologic cancers, thus future studies should examine the role of telomeres in pathologies of the reproductive tract...
  35. doi request reprint Quantitative proteomics analysis of parthenogenetically induced pluripotent stem cells
    Zhe Hu
    Department of Cell Biology and Genetics, Key Laboratory of Bioactive Materials of Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China
    Protein Cell 2:631-46. 2011
    ..The germline competent IVM pES cells may be applicable for germ cell renewal in aging ovaries if oocytes are retrieved at a younger age...
  36. ncbi request reprint Oxidative stress contributes to arsenic-induced telomere attrition, chromosome instability, and apoptosis
    Lin Liu
    Department of Obstetrics and Gynecology, Women and Infants Hospital, Brown University, Providence, Rhode Island 02905, USA
    J Biol Chem 278:31998-2004. 2003
    ..Together, these findings may explain why arsenic can initiate oxidative stress and telomere erosion, leading to apoptosis and anti-tumor therapy on the one hand and chromosome instability and carcinogenesis on the other...
  37. ncbi request reprint Germline stem cells and neo-oogenesis in the adult human ovary
    Yifei Liu
    College of Life Sciences, Sun Yat Sen University, Guangzhou 510275, China
    Dev Biol 306:112-20. 2007
    ..If postnatal oogenesis is confirmed in mice, then this species would represent an exception to the rule that neo-oogenesis does not occur in adults...
  38. ncbi request reprint Ageing-associated aberration in meiosis of oocytes from senescence-accelerated mice
    Lin Liu
    Department of Obstetrics and Gynecology, Brown University, Women and Infants Hospital, Providence, RI 02905, USA
    Hum Reprod 17:2678-85. 2002
    ..The senescence-accelerated mouse (SAM) has been shown to exhibit ageing-associated mitochondrial dysfunction and oxidative stress, and early decline in fertility...
  39. ncbi request reprint In vivo effects of arsenite on meiosis, preimplantation development, and apoptosis in the mouse
    Paula A A S Navarro
    Department of Obstetrics and Gynecology, Women and Infants Hospital, Brown University, Providence, Rhode Island 02905, USA
    Biol Reprod 70:980-5. 2004
    ..These data suggest that arsenite causes meiotic aberrations, which may contribute to decreased cleavage and preimplantation development, as well as increased apoptosis...
  40. doi request reprint Reprogramming- and pluripotency-associated membrane proteins in mouse stem cells revealed by label-free quantitative proteomics
    Jie Hao
    Tianjin State Laboratory of Protein Science, College of Life Sciences, Nankai University, Tianjin 300071, China
    J Proteomics 86:70-84. 2013
    ..Moreover, knock-down of glucose transporter 3 in ESCs impaired the beating function of ESC-derived cardiomyocytes, suggesting its potential role in mediating stem cell differentiation...
  41. doi request reprint Efficient production of mice from embryonic stem cells injected into four- or eight-cell embryos by piezo micromanipulation
    Junjiu Huang
    Department of Obstetrics and Gynecology, University of South Florida College of Medicine, 12901 Bruce B Downs Boulevard, Tampa, Florida 33612, USA
    Stem Cells 26:1883-90. 2008
    ....
  42. ncbi request reprint MicroRNA-125a/b-5p inhibits endothelin-1 expression in vascular endothelial cells
    Dong Li
    Department of Pharmacology and School of Pharmacy, Second Military Medical University, Shanghai, China
    J Hypertens 28:1646-54. 2010
    ..Endothelin-1 (ET-1) is considered to be one of the most potent and long-lasting vasoconstrictive peptides, but the mechanisms on the regulation of ET-1 expression are not fully understood...
  43. pmc Telomere length reprogramming in embryos and stem cells
    Keri Kalmbach
    Department of Obstetrics and Gynecology, New York University Langone Medical Center, 180 Varick Street, No 761, New York, NY 10014, USA
    Biomed Res Int 2014:925121. 2014
    ....
  44. ncbi request reprint Current progress and prospects of induced pluripotent stem cells
    Lingyi Chen
    Key Laboratory of Bioactive Materials of Ministry of Education, College of Life Sciences, Nankai University, Tianjin, 300071, China
    Sci China C Life Sci 52:622-36. 2009
    ..Current problems that need to be addressed and the prospects for iPS research are also discussed...
  45. doi request reprint Telomere shortening and DNA damage of embryonic stem cells induced by cigarette smoke
    Junjiu Huang
    Department of Biochemistry, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat Sen University, Guangzhou 510275, China
    Reprod Toxicol 35:89-95. 2013
    ..Notably, a sub-proportion of ESCs during passages is selected to resist to smoke-induced oxidative damage to telomeres...
  46. doi request reprint Effects of cigarette smoke on fertilization and embryo development in vivo
    Junjiu Huang
    Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa, Florida 33606, USA
    Fertil Steril 92:1456-65. 2009
    ..To determine the effects of smoking on eggs and subsequent embryo development by maternal exposure to cigarette smoke...
  47. doi request reprint Cloning and expression analysis of six small heat shock protein genes in the common cutworm, Spodoptera litura
    Ying Shen
    Guangdong Provincial Key Lab of Biotechnology for Plant Development, School of Life Sciences, South China Normal University, Guangzhou, Guangdong 510631, China
    J Insect Physiol 57:908-14. 2011
    ..4 may have no direct relationship with either thermal response or development...
  48. ncbi request reprint Haploidy but not parthenogenetic activation leads to increased incidence of apoptosis in mouse embryos
    Lin Liu
    Department of Obstetrics and Gynecology, Women and Infants Hospital, Brown University, Providence, Rhode Island 02905, USA
    Biol Reprod 66:204-10. 2002
    ..These results suggest that haploidy can lead to an increased incidence of apoptosis. Moreover, the initiation of apoptosis during preimplantation development does not require the paternal genome...
  49. doi request reprint Exogenous Nanog alleviates but is insufficient to reverse embryonic stem cells differentiation induced by PI3K signaling inhibition
    Na Liu
    State Key Laboratory of Experimental Hematology, Institute of Hematology, National Research Center for Stem Cell Engineering and Technology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
    J Cell Biochem 106:1041-7. 2009
    ..Exogenous Nanog sustains mouse ES cells pluripotency independent of LIF, and alleviates the differentiation induced by LY294002. But it is insufficient to totally reverse the differentiation...
  50. doi request reprint SDF-1/CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis, migration and cytokine secretion
    Xiaolei Liu
    The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science, Nankai University, Tianjin 300071, China
    Protein Cell 2:845-54. 2011
    ..These protective effects were partially inhibited by AMD3100, an antagonist of CXCR4.We conclude that the SDF-1/CXCR4 axis is critical for MSC survival, migration and cytokine secretion...
  51. ncbi request reprint Apoptosis recruits two-pore domain potassium channels used for homeostatic volume regulation
    James R Trimarchi
    Laboratory for Reproductive Medicine, Lillie Bldg, Marine Biological Laboratory, 7 MBL St, Woods Hole, MA 02543, USA
    Am J Physiol Cell Physiol 282:C588-94. 2002
    ..We propose that K(2P) channels are the pathway by which K+ effluxes during AVD and RVD and that apoptosis co-opts mechanisms more routinely employed for homeostatic cell volume regulation...
  52. ncbi request reprint [Differential expression of miR-21, miR-126, miR-143, miR-373 in normal cervical tissue, cervical cancer tissue and Hela cell]
    Lin Liu
    Department of Obstetrics and Gynecology, First Affiliated Hospital of Medical College of Xi an Jiaotong University, Xi an 710061, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 43:536-9. 2012
    ..To investigate the differential expression of miR-21, miR-126, miR-143 and miR-373 in normal cervical tissue, cervical cancer tissue and Hela cell...
  53. pmc Peroxisome Proliferator-activated receptor γ activation by ligands and dephosphorylation induces proprotein convertase subtilisin kexin type 9 and low density lipoprotein receptor expression
    Yajun Duan
    State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin300071, China
    J Biol Chem 287:23667-77. 2012
    ..Our results indicate that although PPARγ activation increased PCSK9 expression, PPARγ activation induced LDLR and CYP7A1 expression that enhanced LDL cholesterol metabolism...
  54. doi request reprint Mouse embryos stressed by physiological levels of osmolarity become arrested in the late 2-cell stage before entry into M phase
    Fang Wang
    School of Life Sciences, Sun Yat Sen University, Guangzhou, China
    Biol Reprod 85:702-13. 2011
    ..Thus, embryos become arrested late in the G(2) stage of the second embryonic cell cycle when stressed by physiological osmolarity in the absence of organic osmolytes...
  55. ncbi request reprint Fate of centrosomes following somatic cell nuclear transfer (SCNT) in bovine oocytes
    Yunping Dai
    State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing
    Reproduction 131:1051-61. 2006
    ..Addressing these fundamental problems may enhance production of normal clones...
  56. ncbi request reprint Telomere length predicts embryo fragmentation after in vitro fertilization in women--toward a telomere theory of reproductive aging in women
    David L Keefe
    Dept of Ob Gyn, Brown University, Woman and Infants Hospital, 101 Dudley St, Providence, RI 02905, USA
    Am J Obstet Gynecol 192:1256-60; discussion 1260-1. 2005
    ..Ethical constraints limit study of human embryos to nondestructive assays, such as morphologic evaluation under transmission optics, but cytoplasmic fragmentation is a reliable marker of apoptosis...
  57. ncbi request reprint Trans-differentiation of alveolar epithelial type II cells to type I cells involves autocrine signaling by transforming growth factor beta 1 through the Smad pathway
    Manoj Bhaskaran
    Department of Physiological Sciences, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    J Biol Chem 282:3968-76. 2007
    ....
  58. ncbi request reprint [Effect of PLK1 gene silence on cell cycle, proliferation and drug resistance in K562/A02 cells]
    Lin Liu
    Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 14:241-6. 2006
    ..8%. It is concluded that PLK1 gene silence can inhibit K562/A02 cell proliferation, induce cell cycle arrest at G2/M, and increase intracellular ADM accumulation, so that enhance cell sensitivity to ADM...
  59. ncbi request reprint Effect of polo-like kinase 1 gene silence on cell cycle and drug resistance in K562/A02 cell
    Lin Liu
    Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Chin Med J (Engl) 119:605-8. 2006
  60. ncbi request reprint Mitochondrial dysfunction leads to telomere attrition and genomic instability
    Lin Liu
    Department of Ob Gyn, Brown University and Women and Infants Hospital, Providence, RI 02905, USA
    Aging Cell 1:40-6. 2002
    ..This work links mitochondrial dysfunction and genomic instability and may provide new therapeutic strategies to combat certain mitochondrial and aging-associated pathologies...
  61. ncbi request reprint Severe cholestasis induced by cholic acid feeding in knockout mice of sister of P-glycoprotein
    Renxue Wang
    British Columbia Cancer Research Center, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Hepatology 38:1489-99. 2003
    ..In conclusion, the spgp(-/-) mice provide a unique model to investigate molecular pathways associated with cholestasis and related diseases...
  62. ncbi request reprint [Expression and significance of telomerase reverse transcriptase and its regulators in non-small cell lung carcinoma]
    Tao Xiang Chen
    Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, PR China
    Ai Zheng 23:273-7. 2004
    ....
  63. ncbi request reprint Effect of ploidy and parental genome composition on expression of Oct-4 protein in mouse embryos
    Lin Liu
    Department of Obstetrics Gynecology, Women and Infants Hospital, Brown Medical School, Providence, RI 02905, USA
    Gene Expr Patterns 4:433-41. 2004
    ..Similar profiles of Oct-4 expression observed in embryos with different ploidy and genome composition, are suggestive of Oct-4 being necessary but not sufficient for developmental potency...
  64. ncbi request reprint Crystal structure of human coactosin-like protein
    Lin Liu
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, People s Republic of China
    J Mol Biol 344:317-23. 2004
    ..These two sites are quite close, which might prevent F-actin and 5-Lipoxygenase from binding to coactosin simultaneously...
  65. doi request reprint Polo-like kinase 1 as a new target for non-Hodgkin's lymphoma treatment
    Lin Liu
    Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Oncology 74:96-103. 2008
    ..The study was devised to detect expression of polo-like kinase 1 (PLK1) in non-Hodgkin's lymphoma (NHL) and assess its value as a new target for NHL treatment...
  66. ncbi request reprint [Relationships among expressions of hTERT, MDR1, MRP mRNA, and C-myc protein in non-small cell lung cancer]
    Li Li
    Department of Pathology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430 071, P R China
    Ai Zheng 24:53-7. 2005
    ..This study was to investigate relations among expressions of hTERT, MDR1, MRP mRNA, and C-myc protein in non-small cell lung cancer (NSCLC)...
  67. ncbi request reprint Effects of oocyte activation and sperm preparation on the development of porcine embryos derived from in vitro-matured oocytes and intracytoplasmic sperm injection
    Jian Hui Tian
    Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100094, PR China
    Theriogenology 66:439-48. 2006
    ..In conclusion, various methods of oocyte activation and sperm preparation significantly affected the developmental capacity of early porcine embryos derived from IVM and ICSI...
  68. ncbi request reprint Characterization of protein kinase C theta activation loop autophosphorylation and the kinase domain catalytic mechanism
    Robert Czerwinski
    Department of Chemical and Screening Sciences, Wyeth Research, 87 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA
    Biochemistry 44:9563-73. 2005
    ..These results should aid the design and discovery of PKCtheta antagonists as therapeutics for modulating T-cell-mediated immune and respiratory diseases...
  69. ncbi request reprint Expression of PLK1 and survivin in diffuse large B-cell lymphoma
    Lin Liu
    Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Leuk Lymphoma 48:2179-83. 2007
    ..The results suggest that there is a significant relationship between over expression of PLK1, the clinical features and survival time. Compared with survivin, PLK1 seems to be a better independent prognostic factor for DLBCL...
  70. ncbi request reprint [Expression of multidrug resistance-associated gene in non-small cell lung cancer and its correlations with telomerase reverse transcriptase and genes related to apoptosis]
    Xing Feng Yao
    Zhonghua Bing Li Xue Za Zhi 34:110-1. 2005