Fei Liu

Summary

Publications

  1. ncbi request reprint Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease
    Fei Liu
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Biol Chem 280:1790-6. 2005
  2. pmc CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer's disease
    Nana Jin
    Jiangsu Key Laboratory of Neuroregeneration, Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Nucleic Acids Res 41:3240-56. 2013
  3. pmc Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A
    Wei Qian
    Jiangsu Key Laboratory of Neuroregeneration, Department of Biochemistry, Medical School, Nantong University, Nantong, Jiangsu, PR China
    Nucleic Acids Res 39:6161-71. 2011
  4. ncbi request reprint Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, 10314, USA
    J Biol Chem 280:37755-62. 2005
  5. ncbi request reprint Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York 10314, USA
    Eur J Neurosci 22:1942-50. 2005
  6. ncbi request reprint Hyperphosphorylation of tau and protein phosphatases in Alzheimer disease
    F Liu
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Panminerva Med 48:97-108. 2006
  7. pmc PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    FEBS Lett 580:6269-74. 2006
  8. pmc Mechanisms of tau-induced neurodegeneration
    Khalid Iqbal
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314, USA
    Acta Neuropathol 118:53-69. 2009
  9. pmc Differential effects of an O-GlcNAcase inhibitor on tau phosphorylation
    Yang Yu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America
    PLoS ONE 7:e35277. 2012
  10. ncbi request reprint Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island 10314, USA
    FEBS Lett 530:209-14. 2002

Collaborators

Detail Information

Publications72

  1. ncbi request reprint Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease
    Fei Liu
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Biol Chem 280:1790-6. 2005
    ..These results suggest that tau is probably a physiological substrate of PP5 and that the abnormal hyperphosphorylation of tau in AD might result in part from the decreased PP5 activity in the diseased brains...
  2. pmc CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer's disease
    Nana Jin
    Jiangsu Key Laboratory of Neuroregeneration, Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Nucleic Acids Res 41:3240-56. 2013
    ..These findings suggest that overactivation of calpain I caused by calcium overload proteolyses CREB, resulting in a reduction of GLUT3 expression and consequently impairing glucose uptake and metabolism in AD brain...
  3. pmc Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A
    Wei Qian
    Jiangsu Key Laboratory of Neuroregeneration, Department of Biochemistry, Medical School, Nantong University, Nantong, Jiangsu, PR China
    Nucleic Acids Res 39:6161-71. 2011
    ....
  4. ncbi request reprint Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, 10314, USA
    J Biol Chem 280:37755-62. 2005
    ..These findings suggest that the overactivation of calpain I and calcineurin may mediate the role of calcium homeostatic disturbance in the neurodegeneration of AD...
  5. ncbi request reprint Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York 10314, USA
    Eur J Neurosci 22:1942-50. 2005
    ..Our findings indicate that PP2A is the major tau phosphatase that regulates its phosphorylation at multiple sites in human brain. The abnormal hyperphosphorylation of tau is partially due to a downregulation of PP2A activity in AD brain...
  6. ncbi request reprint Hyperphosphorylation of tau and protein phosphatases in Alzheimer disease
    F Liu
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Panminerva Med 48:97-108. 2006
    ....
  7. pmc PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    FEBS Lett 580:6269-74. 2006
    ..These studies reveal the nature of the inter-regulation of tau phosphorylation by the three major tau kinases...
  8. pmc Mechanisms of tau-induced neurodegeneration
    Khalid Iqbal
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314, USA
    Acta Neuropathol 118:53-69. 2009
    ..AD is multifactorial and heterogeneous and involves more than one etiopathogenic mechanism...
  9. pmc Differential effects of an O-GlcNAcase inhibitor on tau phosphorylation
    Yang Yu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America
    PLoS ONE 7:e35277. 2012
    ....
  10. ncbi request reprint Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island 10314, USA
    FEBS Lett 530:209-14. 2002
    ..These data suggest that aberrant glycosylation of tau in AD might be involved in neurofibrillary degeneration by promoting abnormal hyperphosphorylation by cdk5 and GSK-3beta...
  11. pmc Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain
    Zhihou Liang
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA
    J Neurochem 103:2462-70. 2007
    ....
  12. pmc Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome
    Zhihou Liang
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314 6399, USA
    J Alzheimers Dis 13:295-302. 2008
    ..Our results indicate that PP2A is down-regulated in DS brain and suggest that this down-regulation might be involved in the abnormal hyperphosphorylation and accumulation of tau...
  13. pmc Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Rd, Staten Island, New York 10314, USA
    FASEB J 22:3224-33. 2008
    ..These findings strongly suggest a novel mechanism by which the overexpression of Dyrk1A in DS brain causes neurofibrillary degeneration via hyperphosphorylating tau...
  14. pmc Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome
    Jerzy Wegiel
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Neuropathol Exp Neurol 70:36-50. 2011
    ..These data support the hypothesis that phosphorylation of ASF by overexpressed DYRK1A may contribute to alternative splicing of exon 10, increased expression of 3R tau, and early onset of neurofibrillary degeneration in DS...
  15. pmc A non-transgenic mouse model (icv-STZ mouse) of Alzheimer's disease: similarities to and differences from the transgenic model (3xTg-AD mouse)
    Yanxing Chen
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, NY 10314, USA
    Mol Neurobiol 47:711-25. 2013
    ....
  16. pmc O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Proc Natl Acad Sci U S A 101:10804-9. 2004
    ....
  17. pmc Brain glucose transporters, O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer's disease
    Ying Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA
    J Neurochem 111:242-9. 2009
    ..These results suggest that T2DM may contribute to the increased risk for AD by impairing brain glucose uptake/metabolism and, consequently, down-regulation of O-GlcNAcylation, which facilitates abnormal hyperphosphorylation of tau...
  18. pmc Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Eur J Neurosci 26:3429-36. 2007
    ..These studies reveal the differential regulation of tau's biological activity and self-aggregation by phosphorylation at various sites/regions...
  19. pmc Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease
    Gustavo Basurto-Islas
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314 6399, USA
    J Biol Chem 288:17495-507. 2013
    ..These findings suggest the involvement of brain acidosis in the etiopathogenesis of Alzheimer disease, and asparaginyl endopeptidase-I2(PP2A)-protein phosphatase 2A-Tau hyperphosphorylation pathway as a therapeutic target...
  20. pmc Developmental regulation of protein O-GlcNAcylation, O-GlcNAc transferase, and O-GlcNAcase in mammalian brain
    Ying Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America
    PLoS ONE 7:e43724. 2012
    ..These studies provide fundamental knowledge of age-dependent protein modification by O-GlcNAc and will help guide future studies on the role of O-GlcNAcylation in the mammalian brain...
  21. pmc Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    Brain 132:1820-32. 2009
    ..Thus, restoration of brain tau O-GlcNAcylation and protein phosphatase 2A activity may offer promising therapeutic targets for treating Alzheimer's disease...
  22. pmc Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorial
    Khalid Iqbal
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York, NY 10314, USA
    Biochem Soc Trans 38:962-6. 2010
    ..Restoration of PP2A activity by inhibition of the cleavage of I(2)(PP2A)/SET offers a promising therapeutic opportunity in AD with this aetiopathogenic mechanism...
  23. pmc The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome
    Jerzy Wegiel
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Acta Neuropathol 116:391-407. 2008
    ....
  24. ncbi request reprint Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5
    Cheng Xin Gong
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Neurochem 88:298-310. 2004
    ..These results suggest that PP5 plays a role in the dephosphorylation of tau and might be involved in the molecular pathogenesis of Alzheimer's disease...
  25. pmc Brain gene expression of a sporadic (icv-STZ Mouse) and a familial mouse model (3xTg-AD mouse) of Alzheimer's disease
    Yanxing Chen
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America
    PLoS ONE 7:e51432. 2012
    ..The present study provides important fundamental knowledge of these two AD mouse models and will help guide future studies using these two mouse models for the development of AD drugs...
  26. pmc Dysregulation of tau phosphorylation in mouse brain during excitotoxic damage
    Zhihou Liang
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314 6399, USA
    J Alzheimers Dis 17:531-9. 2009
    ....
  27. pmc Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2(PP2A)/SET
    Lisette Arnaud
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    FEBS Lett 585:2653-9. 2011
    ..The C-terminal acidic region in I(2CTF) and Val 92 in I(2NTF) are essential for their association with PP2Ac and inhibition of the phosphatase activity...
  28. pmc Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases
    Yang Yu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA
    J Neurochem 108:1480-94. 2009
    ..These studies provide new insight into the developmental regulation of site-specific tau phosphorylation and identify the likely sites required for the abnormal hyperphosphorylation of tau in AD...
  29. doi request reprint Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes
    Ying Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    J Pathol 225:54-62. 2011
    ..Our findings provide novel insight into the molecular mechanism by which type 2 diabetes mellitus increases the risk for developing cognitive impairment and dementia in Alzheimer's disease...
  30. pmc Inhibition of protein synthesis alters protein degradation through activation of protein kinase B (AKT)
    Chun Ling Dai
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Biol Chem 288:23875-83. 2013
    ..This study reveals a novel regulation of protein degradation and calls for caution in blocking protein biosynthesis to study the half-life of proteins. ..
  31. pmc Regulation between O-GlcNAcylation and phosphorylation of neurofilament-M and their dysregulation in Alzheimer disease
    Yanqiu Deng
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Rd, Staten Island, NY 10314, USA
    FASEB J 22:138-45. 2008
    ....
  32. ncbi request reprint Tau pathology in Alzheimer disease and other tauopathies
    Khalid Iqbal
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, USA
    Biochim Biophys Acta 1739:198-210. 2005
    ..Inhibition of this tau abnormality is one of the most promising therapeutic approaches to AD and other tauopathies...
  33. pmc Intracerebroventricular Streptozotocin Exacerbates Alzheimer-Like Changes of 3xTg-AD Mice
    Yanxing Chen
    Department of Neurochemistry, Inge Grundke Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314 6399, USA
    Mol Neurobiol 49:547-62. 2014
    ..These findings provide experimental evidence of the role of metabolic insult in AD. ..
  34. ncbi request reprint Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation
    Cheng Xin Gong
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, USA
    J Alzheimers Dis 9:1-12. 2006
    ..Further studies of this mechanism are likely to offer a novel therapeutic target for preventing and treating AD...
  35. pmc Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease
    Ying Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    FEBS Lett 582:359-64. 2008
    ....
  36. ncbi request reprint Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice
    Bin Li
    Department of Neurochemistry, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    FEBS Lett 584:3359-65. 2010
    ..P21 induced enhancement of neurogenesis and maturation of newly born neurons in the granular cell layer and subgranular zone of the dentate gyrus...
  37. pmc Alzheimer disease therapeutics: focus on the disease and not just plaques and tangles
    Khalid Iqbal
    Department of Neurochemistry, Inge Grundke Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA Electronic address
    Biochem Pharmacol 88:631-9. 2014
    ..Treatment of AD will require both inhibition of neurodegeneration and regeneration of the brain. ..
  38. ncbi request reprint Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain
    Yu Huang
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, New York 10314 6399, USA
    Eur J Neurosci 20:3489-97. 2004
    ..Our findings suggest that AC might play a role in controlling neuronal apoptosis and that AC-mediated signalling pathways might be involved in the molecular mechanism of AD...
  39. ncbi request reprint Role of glycosylation in hyperphosphorylation of tau in Alzheimer's disease
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    FEBS Lett 512:101-6. 2002
    ..These results suggest that the glycosylation of tau is an early abnormality that can facilitate the subsequent abnormal hyperphosphorylation of tau in AD brain...
  40. doi request reprint Beneficial effect of a CNTF tetrapeptide on adult hippocampal neurogenesis, neuronal plasticity, and spatial memory in mice
    Julie Blanchard
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    J Alzheimers Dis 21:1185-95. 2010
    ..Overall, these findings demonstrated the therapeutic potential of Peptide 6c for regeneration of the brain and improvement of cognition...
  41. pmc Diverse regulation of AKT and GSK-3β by O-GlcNAcylation in various types of cells
    Jianhua Shi
    Department of Biochemistry, Soochow University Medical School, Soochow, China
    FEBS Lett 586:2443-50. 2012
    ..These results suggest protein-specific and cell type-specific regulation of AKT and GSK-3β by O-GlcNAcylation. Therefore, studies on the roles of AKT and GSK-3β O-GlcNAcylation should be done in a tissue- and cell type-specific manner...
  42. ncbi request reprint NF-kappaB precursor, p105, and NF-kappaB inhibitor, IkappaBgamma, are both elevated in Alzheimer disease brain
    Yu Huang
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, USA
    Neurosci Lett 373:115-8. 2005
    ..Our findings suggest that the NF-kappaB pathway might be involved in the molecular mechanism of AD...
  43. ncbi request reprint [Simultaneous determination of six flavonoids in Flos Chrysanthemi Indici by RP-HPLC]
    Fei Liu
    School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
    Zhongguo Zhong Yao Za Zhi 34:2067-70. 2009
    ..To develop an HPLC method for the determination of luteolin-7-O-glycoside, apigenin-7-O-glycoside, linarin, luteolin, apigenin and acacetin in Flos Chrysanthemi Indici simultaneously...
  44. ncbi request reprint [Diagnosis and surgical management of adult Hirschsprung disease]
    Shu qing Ding
    The Third Affiliated Hospital of Nanjing University of Chinese Traditional Medicine, Nanjing 210001, China
    Zhonghua Wei Chang Wai Ke Za Zhi 9:53-5. 2006
    ..To investigate the diagnosis and surgical treatment of adult Hirschsprung disease (AHD)...
  45. doi request reprint In vivo kinematic determination of total knee arthroplasty from squatting to standing
    Fei Liu
    Midlands Orthopaedics, 1910 Blanding St, Columbia, SC 29201, USA
    Knee 16:116-20. 2009
    ..There was little statistical difference of their kinematic patterns during this activity between the LPS fixed and mobile TKA implants...
  46. pmc Expression of granulocyte colony stimulating factor receptor in human colorectal cancer
    X Yang
    Medical College, Nanjing University, Jingsu, China
    Postgrad Med J 81:333-7. 2005
    ....
  47. ncbi request reprint The role of factor XI in a dilute thromboplastin assay of extrinsic coagulation pathway
    R He
    Department of Physiology, Hunan Medical University, Changsha, PR China
    Thromb Haemost 85:1055-9. 2001
    ....
  48. ncbi request reprint Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5
    F Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Neuroscience 115:829-37. 2002
    ..The combined impact of this modulation may be to make tau more susceptible to becoming abnormally hyperphosphorylated...
  49. ncbi request reprint Antioxidative activity of natural products from plants
    T B Ng
    Department of Biochemistry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT
    Life Sci 66:709-23. 2000
    ..Obviously, the aromatic hydroxyl group is very important for antioxidative effects of the compounds. None of the compounds tested exerted an obvious pro-oxidant effect...
  50. doi request reprint Microtubule-associated protein tau as a therapeutic target in Alzheimer's disease
    Khalid Iqbal
    New York State Institute for Basic Research in Developmental Disabilities, Department of Neurochemistry, Inge Grundke Iqbal Research Floor, 1050 Forest Hill Road, Staten Island, NY 10314, USA 1 718 494 5259
    Expert Opin Ther Targets 18:307-18. 2014
    ..Alzheimer's disease (AD) is a major public health problem in modern society and as yet, other than a few symptomatic drugs, there is no disease-modifying treatment for this disease available...
  51. ncbi request reprint Post-translational modifications of tau protein in Alzheimer's disease
    C X Gong
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    J Neural Transm 112:813-38. 2005
    ..Analyses of the current advances in tau modifications suggest that intervention addressing these abnormalities may offer promising therapeutic opportunities to prevent and treat neurofibrillary degeneration of AD and other tauopathies...
  52. pmc Tau exon 10 alternative splicing and tauopathies
    Fei Liu
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    Mol Neurodegener 3:8. 2008
    ....
  53. ncbi request reprint BDNF-Akt-Bcl2 antiapoptotic signaling pathway is compromised in the brain of autistic subjects
    Ashfaq M Sheikh
    Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, New York, New York 10314, USA
    J Neurosci Res 88:2641-7. 2010
    ..These results suggest that down-regulation of the BDNF-Akt-Bcl2 antiapoptotic signaling pathway in the autistic brain could be one of the underlying mechanisms responsible for the pathogenesis of autism...
  54. ncbi request reprint [Effect of specific siRNA targeting against bcr-abl chimeric gene on chronic myelogenous leukemia cells]
    Sha Wang
    Department of Hematology, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    Zhonghua Yi Xue Za Zhi 85:198-202. 2005
    ..To investigate the effect of specific small interfering RNA (siRNA) targeting against bcr-abl chimeric gene on the biological traits of chronic myelogenous leukemia (CML) cells...
  55. ncbi request reprint A kinetic model of transcription initiation by RNA polymerase
    Xiao chuan Xue
    Center for Advanced Study, Tsinghua University, Beijing 100084, China
    J Mol Biol 378:520-9. 2008
    ....
  56. ncbi request reprint Fluoride-assisted regioselective conversion of functionalized furans to alpha-substituted gamma-hydroxybutenolides using singlet oxygen
    Santoshkumar N Patil
    Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, New South Wales 2109, Australia
    J Org Chem 72:6305-8. 2007
    ..A facile synthesis of alpha-substituted gamma-hydroxybutenolides from 3-furfural was achieved using a Baylis-Hillman reaction followed by singlet oxygen oxidation. The regioselectivity of this conversion was controlled by using TBAF...
  57. doi request reprint Microtubule-associated protein tau in development, degeneration and protection of neurons
    Jian Zhi Wang
    Pathophysiology Department, Hubei Provincial Key Laboratory of Neurological Diseases, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China
    Prog Neurobiol 85:148-75. 2008
    ..The primary aim of this review is to summarize the latest developments and perspectives in our understanding about the roles of tau, especially hyperphosphorylation, in the development, degeneration and protection of neurons...
  58. ncbi request reprint The transcription co-repressor TLE1 interacted with the intracellular region of gpl30 through its Q domain
    Fei Liu
    Department of Immunology, 4th Military Medical University, Xi an City, Shannxi Province, PR China
    Mol Cell Biochem 232:163-7. 2002
    ..The interaction between gp130 and TLE1 indicated that molecules of TLE family might play a role in gp 130 signaling...
  59. ncbi request reprint Activity-based identification of secreted serine proteases of the filamentous fungus, Ophiostoma
    Caiyan Wu
    Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW, Australia
    Biotechnol Lett 29:937-43. 2007
    ..This use of a chemical probe led to the rapid discovery of subtilisin-like serine protease of Ophiostoma. Two hypothetical proteins were also captured, with one being a probable endopeptidase K type of protease...
  60. ncbi request reprint [Clinicopathological features of typical and non-typical hereditary non-polyposis colorectal cancer and their germline mutation of hMLH1 and hMSH2]
    Long Cui
    Department of Colorectal Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    Zhonghua Wai Ke Za Zhi 41:112-5. 2003
    ..To study the clinicopathological features of the Chinese hereditary non-polyposis colorectal cancer and its germline mutation of hMLH(1) and hMSH(2)...
  61. ncbi request reprint Phenobarbital responsiveness as a uniquely sensitive indicator of hepatocyte differentiation status: requirement of dexamethasone and extracellular matrix in establishing the functional integrity of cultured primary rat hepatocytes
    Jaspreet S Sidhu
    Department of Environmental Health, University of Washington, Seattle, WA 98105, USA
    Exp Cell Res 292:252-64. 2004
    ..These studies further establish the PB gene induction response as an exceptionally sensitive indicator of hepatocyte differentiation status...
  62. ncbi request reprint Relations of the type and branch of surface N-glycans to cell adhesion, migration and integrin expressions
    Ying Zhang
    Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry, School of Medicine, Fudan University, Shanghai, China
    Mol Cell Biochem 260:137-46. 2004
    ..This findings suggest that both the structure of N-glycan and the expression of integrin on cell surface are two of the important factors in the determination of cell adhesion to Fn, a complex biological process...
  63. ncbi request reprint Cloning, enzyme characterization of recombinant human Eg5 and the development of a new inhibitor
    Lei Yang
    School of Life Science and Technology, China Pharmaceutical University, Nanjing, China
    Biol Pharm Bull 31:1397-402. 2008
    ..These results indicate that CPUYL064 could be developed as a new, potent mitotic arrest compound...
  64. pmc Monte Carlo simulation for single RNA unfolding by force
    Fei Liu
    Center for Advanced Study, Tsinghua University, Beijing, China
    Biophys J 88:76-84. 2005
    ..The reaction rate constants for the folding and unfolding are calculated. Our results show that the agreement between the simulation and the experimental measurements is satisfactory...
  65. ncbi request reprint Two-pathway four-state kinetic model of thioredoxin-catalyzed reduction of single forced disulfide bonds
    Xiaochuan Xue
    Center for Advanced Study, Tsinghua University, Beijing 100084, China
    Phys Rev E Stat Nonlin Soft Matter Phys 77:050903. 2008
    ..The very recent experiment favors our model...
  66. ncbi request reprint Pharmacophore identification of KSP inhibitors
    Fei Liu
    Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China
    Bioorg Med Chem Lett 17:722-6. 2007
    ..965. The results of our study provide a valuable tool in designing new leads with desired biological activity by virtual screening...
  67. ncbi request reprint Unfolding single RNA molecules by mechanical force: a stochastic kinetic method
    Fei Liu
    Center for Advanced Study, Tsinghua University, Beijing 100084, People s Republic of China
    Phys Rev E Stat Nonlin Soft Matter Phys 70:040901. 2004
    ..The extension-force curves in equilibrium and kinetic reaction rate constants for folding and unfolding are calculated. Our results show that the agreement between simulation and experimental measurements is satisfactory...
  68. ncbi request reprint Single molecule Michaelis-Menten equation beyond quasistatic disorder
    Xiaochuan Xue
    Center for Advanced Study, Tsinghua University, Beijing 100084, China
    Phys Rev E Stat Nonlin Soft Matter Phys 74:030902. 2006
    ..In particular, by employing the decoupling approximation we demonstrate analytically that the classic Michaelis-Menten equation is still an excellent approximation in the presence of general dynamic disorder...
  69. ncbi request reprint Dynamic disorder in receptor-ligand forced dissociation experiments
    Fei Liu
    Center for Advanced Study, Tsinghua University, Beijing 100084, China
    Phys Rev E Stat Nonlin Soft Matter Phys 73:010901. 2006
    ....
  70. ncbi request reprint [The role of the immunohistochemistry for hMLH1 and hMSH2 with detection of microsatellite instability to identify the kindreds with hereditary nonpolyposis colorectal cancer]
    Hei ying Jin
    Department of Colorectal Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    Zhonghua Wai Ke Za Zhi 41:809-11. 2003
    ....
  71. ncbi request reprint Chemoenzymatic approaches for streamlined detection of active site modifications on thiotemplate assembly lines using mass spectrometry
    Shaun M McLoughlin
    Department of Chemistry, University of Illinois, Urbana, Illinois 61801, USA
    Biochemistry 44:14159-69. 2005
    ..Also, the use of the affinity reporter, biotin-maleimidyl-S-coenzyme A, permitted the isolation of intact synthetases at high purity via removal of contaminating Escherichia coli proteins...
  72. ncbi request reprint Rh-catalyzed highly enantioselective formation of functionalized cyclopentanes and cyclopentanones
    Fei Liu
    College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, P R China
    Org Biomol Chem 5:3531-4. 2007
    ..were obtained from readily available starting materials in high yields and selectivities. Both regioselectivities and enantioselectivities are excellent: only 1,4-dienes were observed and in over 99% ee...