Early intervention for asthma prevention in childrenAndrew H Liu
Division of Pediatric Allergy and Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, 1400 Jackson St, Denver, CO 80206, USA
Allergy Asthma Proc 23:289-93. 2002
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- Metropolitan endotoxin exposure, allergy and asthma
Benjamin J Song
Division of Pediatric Allergy and Immunology, National Jewish Medical Center, Denver, Colorado 80206, USA
Curr Opin Allergy Clin Immunol 3:331-5. 2003
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- Characterization of endotoxin and mouse allergen exposures in mouse facilities and research laboratories
Karin A Pacheco
Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
Ann Occup Hyg 50:563-72. 2006
..Endotoxin and mouse allergen are derived from the same animal source, but have different physicochemical attributes. It is not known if airborne exposures to these agents are correlated in the laboratory animal workplace...
- Hygiene theory and allergy and asthma prevention
Andrew H Liu
Division of Allergy and Clinical Immunology, Department of Pediatrics, National Jewish Medical and Research Center, University of Colorado School of Medicine, Denver, CO 80206, USA
Paediatr Perinat Epidemiol 21:2-7. 2007
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Status of asthma control in pediatric primary care: results from the pediatric Asthma Control Characteristics and Prevalence Survey Study (ACCESS)Andrew H Liu
Department of Pediatrics, National Jewish Health and University of Colorado Denver School of Medicine, Denver, CO, USA
J Pediatr 157:276-281.e3. 2010
..To estimate the prevalence of uncontrolled asthma in pediatric patients with asthma visiting their primary care provider for any medical reason...
National prevalence and risk factors for food allergy and relationship to asthma: results from the National Health and Nutrition Examination Survey 2005-2006Andrew H Liu
National Jewish Health and University of Colorado Denver School of Medicine, Denver, CO, USA
J Allergy Clin Immunol 126:798-806.e13. 2010
..The national prevalence and patterns of food allergy (FA) in the United States are not well understood...
- The Childhood Asthma Control Test: retrospective determination and clinical validation of a cut point to identify children with very poorly controlled asthma
Andrew H Liu
National Jewish Health and University of Colorado School of Medicine, Pediatrics Allergy and Immunology, Denver, CO 80206 2762, USA
J Allergy Clin Immunol 126:267-73, 273.e1. 2010
..However, new asthma management guidelines distinguish 3 levels of asthma control...
- Effect of animal contact and microbial exposures on the prevalence of atopy and asthma in urban vs rural children in India
Pudupakkam K Vedanthan
University of Colorado Health Sciences Center, Denver, USA
Ann Allergy Asthma Immunol 96:571-8. 2006
..Environmental factors, including microbial exposures and close animal contact, are implicated in the lower prevalence of asthma and allergy in rural vs urban children...
- Morbidity patterns among low-income wheezing infants
Mary D Klinnert
Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Pediatrics 112:49-57. 2003
..This study describes morbidity attributable to wheezing illness in a multi-ethnic sample of low-income infants younger than age 2, and examines biological, environmental, and psychosocial correlates of morbidity indexes...
- Outcome of a randomized multifaceted intervention with low-income families of wheezing infants
Mary D Klinnert
Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, G320, Denver, CO 80206, USA
Arch Pediatr Adolesc Med 161:783-90. 2007
..To evaluate the outcome of a secondary intervention conducted with infants at risk for asthma...
- Asthma outcomes: biomarkers
Stanley J Szefler
National Jewish Health, Denver, Colorado, USA
J Allergy Clin Immunol 129:S9-23. 2012
..Measurement of biomarkers has been incorporated within clinical research studies of asthma to characterize the population and associate the disease with environmental and therapeutic effects...
- Treatment of asthma with anti-immunoglobulin E monoclonal antibody
Andrew H Liu
Division of Pediatric Allergy and Clinical Immunology, National Jewish Medical and Research Center, University of Colorado School of Medicine, Denver, Colorado 80206, USA
Allergy Asthma Proc 27:S24-8. 2006
..There is good reason to have increasing comfort with omalizumab therapeutic trials, especially in those with severe asthma...
- Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial
Stanley J Szefler
National Jewish Health, Denver, CO, USA
Lancet 372:1065-72. 2008
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- Predictors of remitting, periodic, and persistent childhood asthma
Ronina A Covar
National Jewish Health, Denver, CO 80206, USA
J Allergy Clin Immunol 125:359-366.e3. 2010
..The course of mild to moderate persistent asthma in children is not clearly established...
- Optimizing childhood asthma management: the role of national institutes of health-sponsored study groups
Andrew H Liu
Department of Pediatric, Division of Allergy and Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
Allergy Asthma Proc 25:365-9. 2004
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- Neutrophilic airway inflammation and association with bacterial lipopolysaccharide in children with asthma and wheezing
Pia J Hauk
Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Pediatr Pulmonol 43:916-23. 2008
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- Bacterial DNA in house and farm barn dust
Sitesh R Roy
Division of Pediatric Allergy and Immunology, National Jewish Medical and Research Center, and the Department of Pediatrics, University of Colorado Health Sciences Center, 1400 Jackson Street, Denver, CO 80206, USA
J Allergy Clin Immunol 112:571-8. 2003
..DNA from farm barn dust augments the immune modulatory effects of endotoxin and may combine with exposure to other such naturally occurring microbial components to mitigate allergy and asthma development...
- Importance of the personal endotoxin cloud in school-age children with asthma
Nathan Rabinovitch
Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206, USA
J Allergy Clin Immunol 116:1053-7. 2005
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- Impulse oscillometry provides an effective measure of lung dysfunction in 4-year-old children at risk for persistent asthma
Alex Marotta
Division of Pediatric Allergy and Immunology, National Jewish Medical and Research Center, and the Department of Pediatrics, University of Colorado Health Sciences Center, Denver, 80206, USA
J Allergy Clin Immunol 112:317-22. 2003
..IOS is a useful diagnostic tool in early asthma development and might be a helpful objective outcome measure of early interventions...
- Successful school-based intervention for inner-city children with persistent asthma
Mark E Anderson
Department of Community Health Services, Denver Health, Denver, Colorado 80204, USA
J Asthma 41:445-53. 2004
..This study sought to determine the impact of the Kunsberg program on asthma utilization...
- Consider the child: how early should we treat?
Andrew H Liu
Department of Pediatrics, National Jewish Medical and Research Center, and University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
J Allergy Clin Immunol 113:S19-24. 2004
..This review will discuss recent clinical studies that exemplify early intervention and prevention strategies...
- Something old, something new: indoor endotoxin, allergens and asthma
Andrew H Liu
Division of Pediatric Allergy and Immunology, National Jewish Medical and Research Center, Denver, CO 80206, USA
Paediatr Respir Rev 5:S65-71. 2004
..These observations, consistent with the "Hygiene Hypothesis" of allergy and asthma, are an encouraging glimpse of the potential for early immune modulatory approaches to asthma therapy and prevention...
- Development and cross-sectional validation of the Childhood Asthma Control Test
Andrew H Liu
National Jewish Medical and Research Center and the University of Colorado School of Medicine, Denver, CO 80206, USA
J Allergy Clin Immunol 119:817-25. 2007
..For children younger than 12 years old with asthma, there are several quality-of-life instruments, clinical diaries, and questionnaires assessing symptoms; however, a validated tool for assessing asthma control is currently lacking...
- Sublingual immunotherapy for peanut allergy: a randomized, double-blind, placebo-controlled multicenter trial
David M Fleischer
Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
J Allergy Clin Immunol 131:119-27.e1-7. 2013
..There are presently no available therapeutic options for patients with peanut allergy...
- Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages
Elena Goleva
Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
J Allergy Clin Immunol 122:550-9.e3. 2008
..The cause of corticosteroid-resistant (CR) asthma is unknown...
- Unraveling the ecology of risks for early childhood asthma among ethnically diverse families in the southwest
Mary D Klinnert
National Jewish Medical and Research Center, Denver, Colo 80206, USA
Am J Public Health 92:792-8. 2002
..We describe the prevalence of asthma risk factors within racial/ethnic and language groups of infants participating in an intervention study for reducing chronic asthma...
- Biomarkers and childhood asthma: improving control today and tomorrow
Andrew H Liu
Department of Pediatric Allergy and Immunology, University of Colorado Health Sciences Center, Denver, CO, USA
Allergy Asthma Proc 26:249-54. 2005
..This article reconsiders the use of current and emerging measures of lung dysfunction, inflammation, and atopy in assessing tight control and long-term risk. Concluding emphasis will be placed on what can be implemented today...
- Advances in childhood asthma: hygiene hypothesis, natural history, and management
Andrew H Liu
National Jewish Medical and Research Center, and the University of Colorado Health Sciences Center, Denver, CO, USA
J Allergy Clin Immunol 111:S785-92. 2003
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- Airborne endotoxin predicts symptoms in non-mouse-sensitized technicians and research scientists exposed to laboratory mice
Karin A Pacheco
Department of Medicine, Division of Environmental and Occupational Health Sciences, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
Am J Respir Crit Care Med 167:983-90. 2003
..8, p = 0.003). We conclude that airborne endotoxin is associated with respiratory symptoms to mice in non-mouse-sensitized scientists and technicians...
- Leukotriene-E4 in human urine: Comparison of on-line purification and liquid chromatography-tandem mass spectrometry to affinity purification followed by enzyme immunoassay
Michael Armstrong
National Jewish Health, Department of Immunology, 1400 Jackson Street K924, Denver, CO 80206, USA
J Chromatogr B Analyt Technol Biomed Life Sci 877:3169-74. 2009
..Results from sample integrity experiments and preliminary values of urinary LTE(4) from healthy adults and children are reported...
- Innate microbial sensors and their relevance to allergy
Andrew H Liu
Pediatric Allergy and Immunology, National Jewish Health, Denver, CO 80206, USA
J Allergy Clin Immunol 122:846-58; quiz 858-60. 2008
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- Endotoxin, atopy and asthma
Amrutha D Holla
Division of Pediatric Allergy and Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Curr Opin Allergy Clin Immunol 2:141-5. 2002
..Indeed, infections have been associated with less atopy and asthma. Recent investigations have suggested that naturally-occurring non-infectious exposure to microbial components such as endotoxin might mitigate atopy and asthma as well...
