Chun Yen Lin

Summary

Publications

  1. ncbi request reprint Patients younger than forty years old with hepatitis C virus genotype-1 chronic infection had treatment responses similar to genotype-2 infection and not related to interleukin-28B polymorphism
    Chun Yen Lin
    Division of Hepatology, Department of Gastroenterology and Hepatology, Linkou Medical Center, Chang Gung Memorial Hospital, Taiwan
    Ann Hepatol 12:62-9. 2013
  2. pmc Focused ultrasound-induced blood-brain barrier opening to enhance interleukin-12 delivery for brain tumor immunotherapy: a preclinical feasibility study
    Pin Yuan Chen
    Department of Neurosurgery, Chang Gung Memorial Hospital, Taoyuan, Linkou, Taiwan
    J Transl Med 13:93. 2015
  3. pmc Low-pressure pulsed focused ultrasound with microbubbles promotes an anticancer immunological response
    Hao Li Liu
    Department of Electrical Engineering, Chang Gung University, Taoyuan, Taiwan
    J Transl Med 10:221. 2012
  4. doi request reprint Various predictors of sustained virologic response in different age groups of patients with genotype-1 chronic hepatitis C
    Chun Yen Lin
    Departments of Gastroenterology and Hepatology Rheumatology, Allergy and Immunology, Linkou Medical Center, Chang Gung Memorial Hospital School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan
    J Clin Gastroenterol 47:794-9. 2013
  5. pmc IL28B SNP rs12979860 is a critical predictor for on-treatment and sustained virologic response in patients with hepatitis C virus genotype-1 infection
    Chun Yen Lin
    Department of Gastroenterology and Hepatology, Linkou Medical Center, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan
    PLoS ONE 6:e18322. 2011
  6. pmc MELD score can predict early mortality in patients with rebleeding after band ligation for variceal bleeding
    Wei Ting Chen
    Department of Hepato Gastroenterology, Linkou Medical Center, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan 333, Taipei, Taiwan, China
    World J Gastroenterol 17:2120-5. 2011
  7. ncbi request reprint A strong association between down-regulation of HLA-DR expression and the late mortality in patients with severe acute pancreatitis
    Yu Pin Ho
    Department of Gastroenterology and Hepatology, Linkou Medical Center, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan
    Am J Gastroenterol 101:1117-24. 2006
  8. pmc None of the six SNPs of IL28B could predict treatment responses in genotype 2 chronic HCV infected patients by propensity score matching analysis
    Wen Juei Jeng
    Division of Hepatology, Department of Gastroenterology and Hepatology, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    PLoS ONE 7:e48217. 2012
  9. doi request reprint Increased regulatory T cells in patients with liver cirrhosis correlated with hyperbilirubinemia and predict bacterial complications
    Chien Hao Huang
    Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan
    J Gastroenterol Hepatol 30:775-83. 2015
  10. pmc CD4⁺ T cells expressing latency-associated peptide and Foxp3 are an activated subgroup of regulatory T cells enriched in patients with colorectal cancer
    Jayashri Mahalingam
    College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan Department of Gastroenterology Hepatology, Linkou Medical Centre, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan
    PLoS ONE 9:e108554. 2014

Collaborators

  • Shi Ming Lin
  • Tse Ching Chen
  • Chau Ting Yeh
  • Cheng Hsun Chiu
  • Tzou Yien Lin
  • I Shyan Sheen
  • Ming Ling Chang
  • Miin Fu Chen
  • Wei Chen Lee
  • Hao Li Liu
  • Hsi Hsien Lin
  • Rong Nan Chien
  • Cho Li Yen
  • Yu Pin Ho
  • Wen Juei Jeng
  • Yung Chang Lin
  • Chien Hao Huang
  • Wei Ting Chen
  • Ching Tai Huang
  • Jayashri Mahalingam
  • Yu Yi Chu
  • Wei Teng
  • Jian He Fang
  • Po Jung Su
  • Jy Ming Chiang
  • Avijit Dutta
  • Pin Yuan Chen
  • Yi Cheng Chen
  • Hsin Yi Lai
  • Chien Chang Chen
  • Ching Chih Hu
  • Christopher Glenn Wallace
  • Li Yuan Chang
  • Chang Wen Huang
  • Ming Wei Lai
  • Yueh Chia He
  • Chiung Yin Huang
  • Han Yi Hsieh
  • Kuo Chen Wei
  • Chia Shiang Chang
  • Wei Chuan Lin
  • Yen Lin Kuo
  • Yuan Ji Day
  • Hai Ning Shi
  • Ren Chin Wu
  • Chiao Wen Kang
  • Chen Yu Hsu
  • Cheng Hung Chien
  • Shih Ming Jung
  • Man Shan Kong
  • Cheng Hao Weng
  • Hsiang Chen Yang
  • Wei Chao Huang
  • W Allan Walker
  • Hui Ching Tien
  • Jeng Yee Lin
  • Ji Yih Chen
  • Fu Chan Wei
  • Ping Chin Lai
  • Shu Chin Tseng
  • Shin Yi Ho
  • Ta Sen Yeh
  • Shiu Feng Huang
  • Cheng Shyong Wu

Detail Information

Publications25

  1. ncbi request reprint Patients younger than forty years old with hepatitis C virus genotype-1 chronic infection had treatment responses similar to genotype-2 infection and not related to interleukin-28B polymorphism
    Chun Yen Lin
    Division of Hepatology, Department of Gastroenterology and Hepatology, Linkou Medical Center, Chang Gung Memorial Hospital, Taiwan
    Ann Hepatol 12:62-9. 2013
    ..However, the treatment responses of the young patients had not been analyzed before. Therefore, we conducted this study to investigate the treatment responses of CHC patients younger than 40 years old (y/o)...
  2. pmc Focused ultrasound-induced blood-brain barrier opening to enhance interleukin-12 delivery for brain tumor immunotherapy: a preclinical feasibility study
    Pin Yuan Chen
    Department of Neurosurgery, Chang Gung Memorial Hospital, Taoyuan, Linkou, Taiwan
    J Transl Med 13:93. 2015
    ....
  3. pmc Low-pressure pulsed focused ultrasound with microbubbles promotes an anticancer immunological response
    Hao Li Liu
    Department of Electrical Engineering, Chang Gung University, Taoyuan, Taiwan
    J Transl Med 10:221. 2012
    ..Here we demonstrated that another form of focused ultrasound delivery, using low-pressure, pulsed-mode exposure in the presence of microbubbles (MBs), may also trigger an antitumor immunological response and inhibit tumor growth...
  4. doi request reprint Various predictors of sustained virologic response in different age groups of patients with genotype-1 chronic hepatitis C
    Chun Yen Lin
    Departments of Gastroenterology and Hepatology Rheumatology, Allergy and Immunology, Linkou Medical Center, Chang Gung Memorial Hospital School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan
    J Clin Gastroenterol 47:794-9. 2013
    ..However, variation of SVR predictors in different age groups was not explored before. We therefore conducted this study for investigating this issue...
  5. pmc IL28B SNP rs12979860 is a critical predictor for on-treatment and sustained virologic response in patients with hepatitis C virus genotype-1 infection
    Chun Yen Lin
    Department of Gastroenterology and Hepatology, Linkou Medical Center, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan
    PLoS ONE 6:e18322. 2011
    ..This study was to investigate the predictive power of IL28B SNPs for on-treatment responses and SVR in treatment-naïve patients with GT1-HCV chronic infection...
  6. pmc MELD score can predict early mortality in patients with rebleeding after band ligation for variceal bleeding
    Wei Ting Chen
    Department of Hepato Gastroenterology, Linkou Medical Center, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan 333, Taipei, Taiwan, China
    World J Gastroenterol 17:2120-5. 2011
    ..To investigate the outcomes, as well as risk factors for 6-wk mortality, in patients with early rebleeding after endoscopic variceal band ligation (EVL) for esophageal variceal hemorrhage (EVH)...
  7. ncbi request reprint A strong association between down-regulation of HLA-DR expression and the late mortality in patients with severe acute pancreatitis
    Yu Pin Ho
    Department of Gastroenterology and Hepatology, Linkou Medical Center, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan
    Am J Gastroenterol 101:1117-24. 2006
    ..However, the relationship between this parameter and late mortality of acute pancreatitis is still unclear. Therefore, we conducted this study in order to elucidate this issue...
  8. pmc None of the six SNPs of IL28B could predict treatment responses in genotype 2 chronic HCV infected patients by propensity score matching analysis
    Wen Juei Jeng
    Division of Hepatology, Department of Gastroenterology and Hepatology, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan
    PLoS ONE 7:e48217. 2012
    ..This study investigated the predictability of six single nucleotide polymorphisms (SNP) of IL28B on the treatment responses of PR in patients with CHC GT2...
  9. doi request reprint Increased regulatory T cells in patients with liver cirrhosis correlated with hyperbilirubinemia and predict bacterial complications
    Chien Hao Huang
    Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan
    J Gastroenterol Hepatol 30:775-83. 2015
    ..This paper aims to study the role of Treg cells in patients with liver cirrhosis and their correlations to bacterial complications...
  10. pmc CD4⁺ T cells expressing latency-associated peptide and Foxp3 are an activated subgroup of regulatory T cells enriched in patients with colorectal cancer
    Jayashri Mahalingam
    College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan Department of Gastroenterology Hepatology, Linkou Medical Centre, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan
    PLoS ONE 9:e108554. 2014
    ..The increased frequency of LAP⁺ Tregs in PBMCs of CRC patients suggests their potential role in controlling immune response to cancer and presents LAP as a marker of tumor-specific Tregs in CRC patients...
  11. doi request reprint Recurrence of spontaneous bacterial peritonitis in cirrhotic patients non-prophylactically treated with norfloxacin: serum albumin as an easy but reliable predictive factor
    Chien Hao Huang
    Department of Hepato Gastroenterology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan, ROC
    Liver Int 31:184-91. 2011
    ..Nonetheless, there are no definitive patient selection parameters identifying who would benefit from SID...
  12. pmc Predictors of mortality within 6 weeks after treatment of gastric variceal bleeding in cirrhotic patients
    Wei Teng
    From the Department of Gastroenterology and Hepatology WT, W TC, Y PH, W JJ, c hh, Y CC, s ml, C TC, c yl, I SS Division of Hepatology W TC, W JJ, c hh, Y CC, s ml, c yl, I SS, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou and Chang Gung University Y PH, s ml, C TC, c yl, Taoyuan, Taiwan
    Medicine (Baltimore) 93:e321. 2014
    ..001, 95% CI: 0.76-0.94) for determining 6 weeks mortality. Impaired renal function, deteriorated liver function with CTP score ≥ 9 as well as MELD score ≥ 18, rebleeding within 5 days, and ACLF are independent predictors of mortality...
  13. doi request reprint Predictors of changes in hemoglobin levels in patients with chronic hepatitis C treated with ribavirin plus pegylated interferon-α
    Ching Chih Hu
    Liver Research Unit, Chang Gung Memorial Hospital, Keelung, Taiwan
    Ren Fail 34:429-34. 2012
    ..The aim of this study was to evaluate the magnitude and frequency of change in Hb and determine the predictive risk factors for Hb decrease during this therapy...
  14. doi request reprint Tumor necrosis factor-α and interleukin-10 contribute to immunoparalysis in patients with acute pancreatitis
    Yu Pin Ho
    Department of Hepatogastroenterology, Linkou Medical Center, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan
    Hum Immunol 72:18-23. 2011
    ..Therefore, both TNF-α and IL-10 contributed to the development of immunoparalysis in patients with acute pancreatitis...
  15. doi request reprint LAP+CD4+ T cells are suppressors accumulated in the tumor sites and associated with the progression of colorectal cancer
    Jayashri Mahalingam
    Department of Gastroenterology Hepatology, Chang Gung University, Kweishan, Tayouan, Taiwan
    Clin Cancer Res 18:5224-33. 2012
    ..LAP(+)CD4(+) T cell is a recently identified subset of suppressor T cells. This study was designed to investigate their clinical relevance in patients with CRC...
  16. doi request reprint Adjuvant therapy for hepatocellular carcinoma after curative treatment
    Wen Juei Jeng
    Division of Hepatology, Liver Research Unit, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Taipei, Taiwan, ROC
    Dig Dis 32:747-54. 2014
    ..This review article will update the algorithms, novel medication or study drugs in the prevention of HCC after curative therapies...
  17. doi request reprint Activated but not resting regulatory T cells accumulated in tumor microenvironment and correlated with tumor progression in patients with colorectal cancer
    Yung Chang Lin
    Department of Hematology Oncology, Linkou Medical Center, Chang Gung Memorial Hospital, Kweishan, Tayouan, Taiwan
    Int J Cancer 132:1341-50. 2013
    ..In summary, we confirmed that activated T(reg) cells are a distinct subgroup with effector memory phenotype and fully functional regulatory activity against human colorectal cancer immunity...
  18. ncbi request reprint Expression of the HCRP1 mRNA in HCC as an independent predictor of disease-free survival after surgical resection
    Ming Wei Lai
    Department of Pediatric Gastroenterology, Chang Gung Memorial Hospital, Taipei, Taiwan
    Hepatol Res 39:164-76. 2009
    ..852; 95% CI, 1.131-3.032; P = 0.014) were included as independent predictors for disease-free survival. Conclusion: Expression of HCRP1 mRNA served as an independent predictor for postoperative disease-free survival in HCC patients...
  19. doi request reprint IL-10 inhibits neuraminidase-activated TGF-β and facilitates Th1 phenotype during early phase of infection
    Avijit Dutta
    Division of Infectious Diseases, Department of Medicine, Chang Gung Memorial Hospital, Chang Gung University, Kweishan, Taoyuan 33333, Taiwan
    Nat Commun 6:6374. 2015
    ..IL-10 then suppresses immune activation and aids in recovery from infection and inflammation. These results reveal a previously unrecognized function of Th1 cell-derived IL-10 in vivo. ..
  20. doi request reprint Oral inoculation of probiotics Lactobacillus acidophilus NCFM suppresses tumour growth both in segmental orthotopic colon cancer and extra-intestinal tissue
    Chien Chang Chen
    Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Chang Gung Children s Hospital, 12L, 5 Fu Hsing Street, Kwei Shan, Taoyuan 333, Taiwan, ROC
    Br J Nutr 107:1623-34. 2012
    ..The down-regulated expression of CXCR4 mRNA and MHC class I, as well as increasing apoptosis in tumour tissue, indicated that La may be associated with modulating the cellular response triggered by colon carcinogenesis...
  21. ncbi request reprint EMR2 receptor ligation modulates cytokine secretion profiles and cell survival of lipopolysaccharide-treated neutrophils
    Tzu Ying Chen
    Department of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan, Taiwan
    Chang Gung Med J 34:468-77. 2011
    ..In this study, we examined the effect of EMR2 ligation by its specific antibody on the cytokine expression profile and cell survival of lipopolysaccharide (LPS)-treated neutrophils...
  22. doi request reprint Hepatitis B virus-DNA level and basal core promoter A1762T/G1764A mutation in liver tissue independently predict postoperative survival in hepatocellular carcinoma
    Chau Ting Yeh
    Liver Research Center, Department of Hepato Gastroenterology, Chang Gung Memorial Hospital, Taipei, Taiwan
    Hepatology 52:1922-33. 2010
    ..005) and overall (P = 0.020) survival. A hot deletion region located between codons 107 and 141 of the pre-S sequence was identified for the short stretch pre-S deletion mutants...
  23. ncbi request reprint Endotoxemia contributes to the immune paralysis in patients with cirrhosis
    Chun Yen Lin
    Department of Hepatogastroenterology, Linkou Medical Center, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan
    J Hepatol 46:816-26. 2007
    ..However, the relationship between HLA-DR expression and cirrhosis is unclear...
  24. pmc Vascularized composite allograft rejection is delayed by intrajejunal treatment with donor splenocytes without concomitant immunosuppressants
    Christopher Glenn Wallace
    Department of Plastic Surgery, Chang Gung Memorial Hospital, Chang Gung University and Medical College, Taipei, Taiwan
    Clin Dev Immunol 2012:704063. 2012
    ..We studied its effects on recipient immune responses and VCA rejection...
  25. doi request reprint The indispensable role of CCR5 for in vivo suppressor function of tumor-derived CD103+ effector/memory regulatory T cells
    Li Yuan Chang
    College of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan
    J Immunol 189:567-74. 2012
    ..In conclusion, these results indicate that the potent in vivo suppression ability of CD103(+) Tregs is due to the tissue-migration ability through CCR5 expression...