Ex-utero intrapartum therapyKenneth W Liechty
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
Semin Fetal Neonatal Med 15:34-9. 2010
....
Fetal tendon wound size modulates wound gene expression and subsequent wound phenotypeBenjamin J Herdrich
The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Wound Repair Regen 18:543-9. 2010
..This model allows the process of regenerative healing to be examined without the confounding variable of gestational age...
- Inhibition of stromal cell-derived factor-1α further impairs diabetic wound healing
Dustin M Bermudez
Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Vasc Surg 53:774-84. 2011
..We hypothesized that SDF-1α is a critical component of the normal wound-healing response and that inhibition of SDF-1α would further delay the wound-healing process...
- Predicting the severity of congenital high airway obstruction syndrome
Jessica L Roybal
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, PA 19104 4318, USA
J Pediatr Surg 45:1633-9. 2010
..In our relatively large series of CHAOS patients, we have observed a spectrum of clinical severity. The aim of this study was to identify the prenatal characteristics of CHAOS predictive of a milder postnatal course...
- Prenatal ultrasonographic gastrointestinal abnormalities in fetuses with gastroschisis do not correlate with postnatal outcomes
Andrea T Badillo
The Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Pediatr Surg 43:647-53. 2008
..The purpose of this study was to correlate prenatal identification of additional gastrointestinal sonographic abnormalities with postnatal clinical outcome...
- Prenatal course and postnatal management of peripheral bronchial atresia: association with congenital cystic adenomatoid malformation of the lung
William H Peranteau
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Fetal Diagn Ther 24:190-6. 2008
....
- Outcomes after postnatal resection of prenatally diagnosed asymptomatic cystic lung lesions
ANTHONY Y TSAI
The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Pediatr Surg 43:513-7. 2008
..On the other hand, malignant degeneration, pneumonia, and pneumothorax are known consequences of cystic lung lesions. This study aims to assess the safety of resection for asymptomatic lung lesions that were diagnosed before birth...
- Impaired biomechanical properties of diabetic skin implications in pathogenesis of diabetic wound complications
Dustin M Bermudez
Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Am J Pathol 178:2215-23. 2011
....
Liver position and lung-to-head ratio for prediction of extracorporeal membrane oxygenation and survival in isolated left congenital diaphragmatic herniaHolly L Hedrick
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA, USA
Am J Obstet Gynecol 197:422.e1-4. 2007
..The purpose of this study was to determine the ability of liver position and lung-to-head ratio to predict outcome in isolated left congenital diaphragmatic hernia...
- Amniotic fluid levels of glial fibrillary acidic protein in fetal rats with retinoic acid induced myelomeningocele: a potential marker for spinal cord injury
Enrico Danzer
Children s Center for Fetal Research, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Am J Obstet Gynecol 204:178.e1-11. 2011
....
- IL-10 overexpression decreases inflammatory mediators and promotes regenerative healing in an adult model of scar formation
William H Peranteau
Department of Surgery, The Center for Fetal Research, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
J Invest Dermatol 128:1852-60. 2008
..We conclude that lentivirus-mediated overexpression of IL-10 decreases the inflammatory response to injury, creating an environment conducive for regenerative adult wound healing...
- Severe pulmonary hypoplasia associated with giant cervical teratomas
Kenneth W Liechty
Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Pediatr Surg 41:230-3. 2006
..Despite obtaining airway control, a subset of these patients will die because of pulmonary hypoplasia. When counseling patients with large cervical masses it is important to discuss potential pulmonary hypoplasia in these patients...
- Effect of maternal betamethasone administration on prenatal congenital cystic adenomatoid malformation growth and fetal survival
William H Peranteau
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Fetal Diagn Ther 22:365-71. 2007
..To evaluate the effect of prenatal steroid treatment on the growth of congenital cystic adenomatoid malformations (CCAM) and survival in affected fetuses not amenable to other percutaneous ultrasound-guided prenatal interventions...
- Effect of interleukin-10 overexpression on the properties of healing tendon in a murine patellar tendon model
Eric T Ricchetti
McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PA, USA
J Hand Surg Am 33:1843-52. 2008
..The objective of this study is to investigate the effect of IL-10 overexpression on the properties of adult healing tendon using a well-established murine model of tendon injury and a lentiviral-mediated method of IL-10 overexpression...
- Survival in primary congenital pulmonary lymphangiectasia with hydrops fetalis
Pablo Laje
Department of General Surgery, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Fetal Diagn Ther 24:225-9. 2008
..The different aspects of the management of congenital pulmonary lymphangiectasia are discussed in this report, together with a review of the literature...
- Stromal progenitor cells promote leukocyte migration through production of stromal-derived growth factor 1alpha: a potential mechanism for stromal progenitor cell-mediated enhancement of cellular recruitment to wounds
Andrea T Badillo
The Center for Fetal Research at The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Pediatr Surg 43:1128-33. 2008
..We hypothesized that SPC-enhanced tissue repair is, in part, because of SPC-mediated recruitment of circulating cells to areas of tissue injury. To test this, we examined the migration of leukocytes in response to SPC in vitro...
- Age and pro-inflammatory cytokine production: wound-healing implications for scar-formation and the timing of genital surgery in boys
Dustin M Bermudez
Hospital of the University of Pennsylvania, 3400 Spruce Street, Department of Surgery Education, Philadelphia, PA 19104, USA
J Pediatr Urol 7:324-31. 2011
..We believe that these age-related differences may explain the greater risk of complications following repair in older boys...
- Pregnancy outcomes following bipolar umbilical cord cauterization for selective termination in complicated monochorionic multiple gestations
John G Ilagan
Center for Fetal Diagnosis and Treatment at the Children s Hospital of Philadelphia, Department of Surgery and Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Fetal Diagn Ther 23:153-8. 2008
..To review pregnancy and childhood outcomes following selective termination by ultrasound guided bipolar umbilical cord cauterization (UCC) in complicated monochorionic multifetal pregnancies...
- Prospective, interdisciplinary follow-up of children with prenatally diagnosed giant omphalocele: short-term neurodevelopmental outcome
Enrico Danzer
The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Pediatr Surg 45:718-23. 2010
..The objective of this study is to determine the short-term neurodevelopmental outcome in infants with giant omphalocele (GO)...
- Regenerative healing following foetal myocardial infarction
Benjamin J Herdrich
The University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Eur J Cardiothorac Surg 38:691-8. 2010
..Understanding the mechanisms involved in foetal myocardial regeneration may lead to applications to alter the adult response following myocardial infarction...
- Diminished type III collagen promotes myofibroblast differentiation and increases scar deposition in cutaneous wound healing
Susan W Volk
Department of Clinical Studies and Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
Cells Tissues Organs 194:25-37. 2011
..The effect of Col3 expression on myofibroblast differentiation and scar formation in this model suggests a previously undefined role for this ECM protein in tissue regeneration and repair...
- Stromal progenitor cell therapy corrects the wound-healing defect in the ischemic rabbit ear model of chronic wound repair
Susan W Volk
Department of Clinical Studies, School of Veterinary Medicine, The University of Pennsylvania, Philadelphia, Pennyslvania, USA
Wound Repair Regen 15:736-47. 2007
..Treatment of ischemic wounds with SPCs can dramatically improve wound healing and provides a rationale for further studies focused on SPCs as a potential cellular therapy in impaired wound healing...
- Postnatal management and outcome of prenatally diagnosed lung lesions
Pablo Laje
Children s Hospital of Philadelphia, PA 19104, USA
Prenat Diagn 28:612-8. 2008
....
- Lentiviral gene transfer of SDF-1alpha to wounds improves diabetic wound healing
Andrea T Badillo
The Center for Fetal Research at The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Surg Res 143:35-42. 2007
..We hypothesized that lentiviral-mediated increased production of SDF-1alpha in the wound environment could also improve diabetic wound healing...
- Wilms' tumor arising within a mediastinal teratoma
Andrea T Badillo
Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Pediatr Surg 41:e1-5. 2006
..We report the case of an 18-year-old man with a Wilms' tumor arising within a mediastinal teratoma and discuss the management of this extremely rare lesion...
- Postnatal management of prenatally diagnosed abdominal masses and anomalies
Todd E Heaton
The Center for Fetal Research, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Prenat Diagn 28:656-66. 2008
..The purpose of this chapter is to review our current understanding of prenatally diagnosed intra-abdominal lesions, and describe the current guidelines for the postnatal management and subsequent outcome for these lesions...
- Cystic adenomatoid malformation of the lung: review of genetics, prenatal diagnosis, and in utero treatment
R Douglas Wilson
Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4399, USA
Am J Med Genet A 140:151-5. 2006
..In the appropriate situation, this maternal fetal surgery approach for CCAM is life-saving for the affected fetus with acceptable maternal morbidity risks in the present and future pregnancies...
- Treatment of diabetic wounds with fetal murine mesenchymal stromal cells enhances wound closure
Andrea T Badillo
The Center for Fetal Research at The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Cell Tissue Res 329:301-11. 2007
..Possible mechanisms of this effect include augmented local growth-factor production, improved neovascularization, enhanced cellular recruitment to wounds, and improved wound contraction...
- Pulmonary vascular malformations
Kenneth W Liechty
Center for Fetal Research, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Semin Pediatr Surg 17:9-16. 2008
..This paper will review the components of these lesions, their associated anomalies, the diagnosis and natural history, and finally, current concepts in the management of pulmonary vascular malformations...
