C S Lieber

Summary

Publications

  1. ncbi Prevention and treatment of liver fibrosis based on pathogenesis
    C S Lieber
    Alcohol Research and Treatment Center, Bronx Veterans Affairs Medical Center and Mount Sinai School of Medicine, New York 10468, USA
    Alcohol Clin Exp Res 23:944-9. 1999
  2. ncbi Alcoholic liver injury: pathogenesis and therapy in 2001
    C S Lieber
    Mount Sinai School of Medicine, Alcohol Research and Treatment Center, Section of Liver Disease and Nutrition, Bronx Veterans Affairs Medical Center, Bronx, NY 10468, USA
    Pathol Biol (Paris) 49:738-52. 2001
  3. ncbi DLPC decreases TGF-beta1-induced collagen mRNA by inhibiting p38 MAPK in hepatic stellate cells
    Qi Cao
    Alcohol Research and Treatment Center, Bronx Veterans Affairs Medical Center and Mount Sinai School of Medicine, Bronx, New York 10468, USA
    Am J Physiol Gastrointest Liver Physiol 283:G1051-61. 2002
  4. ncbi Hepatitis C and alcohol
    Charles S Lieber
    J Clin Gastroenterol 36:100-2. 2003
  5. ncbi II. Veterans Affairs Cooperative Study of polyenylphosphatidylcholine in alcoholic liver disease
    Charles S Lieber
    Bronx Veterans Affairs Medical Center and the Mount Sinai School of Medicine, New York 10468, USA
    Alcohol Clin Exp Res 27:1765-72. 2003
  6. ncbi Alcoholic liver disease: new insights in pathogenesis lead to new treatments
    C S Lieber
    Alcohol Research and Treatment Center, Bronx Veterans Affairs Medical Center and Mount Sinai School of Medicine, NY 10468, USA
    J Hepatol 32:113-28. 2000
  7. ncbi Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis
    Charles S Lieber
    Bronx Veterans Affairs Medical Center, Bronx, NY 10468, USA
    Alcohol 34:9-19. 2004
  8. ncbi Model of nonalcoholic steatohepatitis
    Charles S Lieber
    Section of Liver Disease and Nutrition, Bronx VA Medical Center and Mt Sinai School of Medicine, New York 10468, USA
    Am J Clin Nutr 79:502-9. 2004
  9. ncbi The unexpected outcomes of medical research: serendipity and the microsomal ethanol oxidizing system
    Charles S Lieber
    Section of Liver Disease and Nutrition, Alcohol Research, Bronx Veterans Affairs Medical Center 151 2 and Mt Sinai School of Medicine, 130 West Kingsbridge Road, Bronx, NY 10468 3922, USA
    J Hepatol 40:198-202. 2004
  10. ncbi New concepts of the pathogenesis of alcoholic liver disease lead to novel treatments
    Charles S Lieber
    Section of Liver Disease and Nutrition, Bronx VA Medical Center and Mt Sinai School of Medicine, 151 2, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Curr Gastroenterol Rep 6:60-5. 2004

Collaborators

Detail Information

Publications73

  1. ncbi Prevention and treatment of liver fibrosis based on pathogenesis
    C S Lieber
    Alcohol Research and Treatment Center, Bronx Veterans Affairs Medical Center and Mount Sinai School of Medicine, New York 10468, USA
    Alcohol Clin Exp Res 23:944-9. 1999
    ....
  2. ncbi Alcoholic liver injury: pathogenesis and therapy in 2001
    C S Lieber
    Mount Sinai School of Medicine, Alcohol Research and Treatment Center, Section of Liver Disease and Nutrition, Bronx Veterans Affairs Medical Center, Bronx, NY 10468, USA
    Pathol Biol (Paris) 49:738-52. 2001
    ....
  3. ncbi DLPC decreases TGF-beta1-induced collagen mRNA by inhibiting p38 MAPK in hepatic stellate cells
    Qi Cao
    Alcohol Research and Treatment Center, Bronx Veterans Affairs Medical Center and Mount Sinai School of Medicine, Bronx, New York 10468, USA
    Am J Physiol Gastrointest Liver Physiol 283:G1051-61. 2002
    ..DLPC, an innocuous phospholipid, may be considered for prevention and treatment of liver fibrosis...
  4. ncbi Hepatitis C and alcohol
    Charles S Lieber
    J Clin Gastroenterol 36:100-2. 2003
  5. ncbi II. Veterans Affairs Cooperative Study of polyenylphosphatidylcholine in alcoholic liver disease
    Charles S Lieber
    Bronx Veterans Affairs Medical Center and the Mount Sinai School of Medicine, New York 10468, USA
    Alcohol Clin Exp Res 27:1765-72. 2003
    ..Our aims were to determine the effectiveness of PPC in preventing or reversing liver fibrosis in heavy drinkers and to assess the extent of liver injury associated with the reduced drinking achieved in these patients...
  6. ncbi Alcoholic liver disease: new insights in pathogenesis lead to new treatments
    C S Lieber
    Alcohol Research and Treatment Center, Bronx Veterans Affairs Medical Center and Mount Sinai School of Medicine, NY 10468, USA
    J Hepatol 32:113-28. 2000
    ..Finally, abstinence from excessive drinking is always indicated; it is difficult to achieve but agents that oppose alcohol craving are becoming available and they should be used more extensively...
  7. ncbi Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis
    Charles S Lieber
    Bronx Veterans Affairs Medical Center, Bronx, NY 10468, USA
    Alcohol 34:9-19. 2004
    ..Progress in the understanding of the pathogenesis of alcoholic fatty liver and its progression to inflammation and fibrosis has resulted in prospects for their better prevention and treatment...
  8. ncbi Model of nonalcoholic steatohepatitis
    Charles S Lieber
    Section of Liver Disease and Nutrition, Bronx VA Medical Center and Mt Sinai School of Medicine, New York 10468, USA
    Am J Clin Nutr 79:502-9. 2004
    ..Obesity and diabetes are frequently associated with nonalcoholic steatohepatitis (NASH), but studies have been hampered by the absence of a suitable experimental model...
  9. ncbi The unexpected outcomes of medical research: serendipity and the microsomal ethanol oxidizing system
    Charles S Lieber
    Section of Liver Disease and Nutrition, Alcohol Research, Bronx Veterans Affairs Medical Center 151 2 and Mt Sinai School of Medicine, 130 West Kingsbridge Road, Bronx, NY 10468 3922, USA
    J Hepatol 40:198-202. 2004
  10. ncbi New concepts of the pathogenesis of alcoholic liver disease lead to novel treatments
    Charles S Lieber
    Section of Liver Disease and Nutrition, Bronx VA Medical Center and Mt Sinai School of Medicine, 151 2, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Curr Gastroenterol Rep 6:60-5. 2004
    ..The anti-inflammatory corticosteroids and colchicine yielded mixed results. Finally, replacing long-chain with medium-chain triglycerides opposed the fatty liver experimentally and clinically...
  11. ncbi Silymarin retards the progression of alcohol-induced hepatic fibrosis in baboons
    Charles S Lieber
    Section of Liver Disease and Nutrition, Bronx VA Medical Center and Mount Sinai School of Medicine, Bronx, New York 10468, USA
    J Clin Gastroenterol 37:336-9. 2003
    ..For strict control, this was assessed in non-human primates. STUDY Twelve baboons were fed alcohol with or without silymarin for 3 years with a nutritionally adequate diet...
  12. ncbi S-adenosyl-L-methionine: its role in the treatment of liver disorders
    Charles S Lieber
    Mount Sinai School of Medicine, Alcohol Research Center, Section of Liver Disease and Nutrition, Bronx Veterans Affairs Medical Center, NY 10468, USA
    Am J Clin Nutr 76:1183S-7S. 2002
    ..This was shown in alcohol-fed baboons and in other experimental models of liver injury and in clinical trials, some of which are reviewed in other articles in this issue...
  13. ncbi S-Adenosylmethionine: molecular, biological, and clinical aspects--an introduction
    Charles S Lieber
    Section of Liver Disease and Nutrition, Bronx VA Medical Center, Mount Sinai School of Medicine, NY 10468, USA
    Am J Clin Nutr 76:1148S-50S. 2002
    ..This symposium reviewed the biological and corresponding molecular aspects of SAMe metabolism and the clinical consequences of its deficiency or supplementation in various tissues...
  14. ncbi I. Veterans Affairs Cooperative Study of polyenylphosphatidylcholine in alcoholic liver disease: effects on drinking behavior by nurse/physician teams
    Charles S Lieber
    Bronx Veterans Affairs Medical Center and the Mount Sinai School of Medicine, New York 10468, USA
    Alcohol Clin Exp Res 27:1757-64. 2003
    ..An overall substantial and sustained reduction in drinking was observed. Hepatic histological and other findings are described in a companion article...
  15. ncbi S-Adenosyl-L-methionine and alcoholic liver disease in animal models: implications for early intervention in human beings
    Charles S Lieber
    Bronx Veterans Affairs Medical Center, NY 10468, USA
    Alcohol 27:173-7. 2002
    ....
  16. ncbi Metabolism of alcohol
    Charles S Lieber
    Bronx VA Medical Center 151 2, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Clin Liver Dis 9:1-35. 2005
    ..An additional system, containing cytochromes P-450 inducible by chronic alcohol feeding, was demonstrated in liver microsomes and found to be a major cause of hepatotoxicity...
  17. ncbi Pathogenesis and treatment of alcoholic liver disease: progress over the last 50 years
    C S Lieber
    Alcohol Research and Treatment Center, Section of Liver Disease and Nutrition, Bronx VA Medical Center, New York 10468, USA
    Rocz Akad Med Bialymst 50:7-20. 2005
    ..Similarly dilinoleoylphosphatidylcholine (DLPC), PPC's main component, also partially opposes the increase in CYP2E1 by ethanol. Hence, therapy with SAMe +DLPC is now being considered...
  18. ncbi Liver diseases by alcohol and hepatitis C: early detection and new insights in pathogenesis lead to improved treatment
    C S Lieber
    Section of Liver Disease and Nutrition, Alcohol Research and Treatment Center, Bronx Veterans Affairs Medical Center, 130 West Kingsbridge Rd, Bronx, NY 10468, USA
    Am J Addict 10:29-50. 2001
    ..Available antiviral agents are contraindicated in the alcoholic. Anti-inflammatory agents, such as steroids, may be selectively useful. Finally, anticraving agents, such as naltrexone or acamprosate, should be part of therapy...
  19. doi Value of fibrosis markers for staging liver fibrosis in patients with precirrhotic alcoholic liver disease
    Charles S Lieber
    James J Peters Veterans Affairs Medical Center, Bronx, New York 10468, USA
    Alcohol Clin Exp Res 32:1031-9. 2008
    ..Moreover, a diagnostic algorithm including 3 serum markers (TIMP1, PIIINP, HA) and age has been proposed to accurately detect fibrosis with acceptable levels of sensitivity/specificity in a chronic hepatitis C subgroup...
  20. doi Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1alpha in rats
    Charles S Lieber
    Section of Liver Diseases, James J Peters VA Medical Center, 130 West Kingsbridge Road 151 2, Bronx, NY 10468, USA
    Biochem Biophys Res Commun 370:44-8. 2008
    ..Since there is a pathophysiological link between SIRT1 and PGC-1alpha and mitochondrial energy, the implication of the study is that mitochondrial dysfunction due to alcohol abuse can be treated by dietary modifications...
  21. ncbi Beneficial effects versus toxicity of medium-chain triacylglycerols in rats with NASH
    Charles S Lieber
    Alcohol Research Center, James J Peters VA Medical Center, 130 West Kingsbridge Road 151 2, Bronx, NY 10468, USA
    J Hepatol 48:318-26. 2008
    ..Because of the similarity of the pathogenesis of alcohol-induced liver damage and non-alcoholic steatohepatitis (NASH), our aim was to assess whether MCT is also beneficial in NASH...
  22. ncbi Role of medium-chain triglycerides in the alcohol-mediated cytochrome P450 2E1 induction of mitochondria
    Charles S Lieber
    James J Peters VA Medical Center, Bronx, New York 10468, USA
    Alcohol Clin Exp Res 31:1660-8. 2007
    ..We now wondered whether the induction of mitochondrial CYP2E1 plays a role and whether liver injury could be avoided through mitochondrial intervention...
  23. ncbi Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968-1998)--a review
    C S Lieber
    Mount Sinai School of Medicine and Alcohol Research and Treatment Center, Section of Liver Disease and Nutrition, Bronx Veterans Affairs Medical Center, New York 10468, USA
    Alcohol Clin Exp Res 23:991-1007. 1999
    ..PPC (and its active component dilinoleoylphosphatidylcholine) also oppose hepatic oxidative stress and fibrosis. PPC is now being tested clinically for the prevention and treatment of liver disease in the alcoholic...
  24. ncbi Carbohydrate deficient transferrin in alcoholic liver disease: mechanisms and clinical implications
    C S Lieber
    Mount Sinai School of Medicine and Alcohol Research and Treatment Center, Bronx Veterans Affairs Medical Center, New York 10468, USA
    Alcohol 19:249-54. 1999
    ....
  25. doi Alcohol alters hepatic FoxO1, p53, and mitochondrial SIRT5 deacetylation function
    Charles S Lieber
    Section of Liver Disease and Nutrition, James J Peters VA Medical Center, 130 West Kingsbridge Road 151 2, Bronx, NY 10468, USA
    Biochem Biophys Res Commun 373:246-52. 2008
    ..Thus, alcohol consumption disrupts nuclear-mitochondrial interactions by post-translation protein modifications, which contribute to alteration of mitochondrial biogenesis through the newly discovered reduction of SIRT5...
  26. ncbi ALCOHOL: its metabolism and interaction with nutrients
    C S Lieber
    Mount Sinai School of Medicine and Alcohol Research and Treatment Center, Section of Liver Disease and Nutrition, Bronx Veterans Affairs Medical Center, Bronx, New York 10468, USA
    Annu Rev Nutr 20:395-430. 2000
    ..Corresponding clinical trials are ongoing...
  27. ncbi Dilinoleoylphosphatidylcholine decreases ethanol-induced cytochrome P4502E1
    M K Aleynik
    Alcohol Research and Treatment Center, Bronx Veterans Affairs Medical Center and Mount Sinai School of Medicine, Bronx, New York 10468, USA
    Biochem Biophys Res Commun 288:1047-51. 2001
    ..DLPC decreases ethanol-induced CYP2E1 and should be considered for the prevention of alcoholic liver disease...
  28. ncbi High levels of acetaldehyde in nonalcoholic liver injury after threonine or ethanol administration
    X L Ma
    Section of Liver Disease and Nutrition, Bronx Veterans Affairs Medical Center, New York, New York 10468
    Hepatology 10:933-40. 1989
    ..As a consequence, administration of ethanol (an exogenous source of acetaldehyde) resulted in striking elevations in the levels of acetaldehyde in carbon tetrachloride-treated rats.(ABSTRACT TRUNCATED AT 250 WORDS)..
  29. ncbi Azide inhibits human cytochrome P -4502E1, 1A2, and 3A4
    K S Salmela
    Alcohol Research and Treatment Center, Mount Sinai School of Medicine, New York, New York, USA
    Alcohol Clin Exp Res 25:253-60. 2001
    ..Therefore, azide should be avoided when measuring the MEOS activity because it may lead to underestimation, especially of CYP1A2- and CYP3A4-dependent ethanol oxidation...
  30. ncbi Polyenylphosphatidylcholine corrects the alcohol-induced hepatic oxidative stress by restoring s-adenosylmethionine
    Semyon I Aleynik
    Alcohol Research Center, Section of Liver Disease and Nutrition, Bronx VA Medical Center and Mount Sinai School of Medicine, New York, NY, USA
    Alcohol Alcohol 38:208-12. 2003
    ..Since the late stages of alcoholic liver injury are associated with decreased activity of methionine adenosyltransferase (MAT), we wondered whether this already occurs at the early stages and what is the mechanism involved...
  31. ncbi Interaction of ethanol with drugs, hepatotoxic agents, carcinogens and vitamins
    C S Lieber
    Alcohol Research and Treatment Center, Bronx VA Medical Center, New York 10468
    Alcohol Alcohol 25:157-76. 1990
    ....
  32. ncbi Molecular cloning and chromosomal localization of the ADH7 gene encoding human class IV (sigma) ADH
    H Yokoyama
    Alcohol Research Center, Bronx VA Medical Center, New York 10468, USA
    Genomics 31:243-5. 1996
    ..These data are consistent with the view that Class IV ADH is a member of the ADH family and is phylogenetically close to the other ADHs...
  33. ncbi Effect of beta-carotene on hepatic cytochrome P-450 in ethanol-fed rats
    I G Kessova
    Alcohol Research and Treatment Center, Bronx VA Medical Center, and Mount Sinai School of Medicine, New York, New York 10468, USA
    Alcohol Clin Exp Res 25:1368-72. 2001
    ..CONCLUSIONS: Beta-carotene potentiates the CYP2E1 induction by ethanol in rat liver and also increases CYP4A1, which may, at least in part, explain the associated hepatotoxicity...
  34. ncbi Cytokeratin 7 staining of hepatocytes predicts progression to more severe fibrosis in alcohol-fed baboons
    Chaoling Ren
    Alcohol Research Center, Veterans Affairs Medical Center, 130 West Kingsbridge Road 151 2, Bronx, NY 10468, USA
    J Hepatol 38:770-5. 2003
    ..Not all alcoholic patients develop severe liver disease with fibrosis progressing to cirrhosis. It is of practical importance to determine whether some markers can predict progression of liver fibrosis...
  35. ncbi Lycopene attenuates alcoholic apoptosis in HepG2 cells expressing CYP2E1
    Youqing Xu
    Section of Liver Disease and Nutrition, Alcohol Research and Treatment Center, Veterans Affairs Medical Center and Mt Sinai School of Medicine, 130 West Kingsbridge Road, Bronx, NY, USA
    Biochem Biophys Res Commun 308:614-8. 2003
    ..The parallelism between these effects suggests a causal link. Furthermore, these beneficial effects and the innocuity of lycopene now justify an in vivo trial...
  36. ncbi DLPC and SAMe prevent alpha1(I) collagen mRNA up-regulation in human hepatic stellate cells, whether caused by leptin or menadione
    Qi Cao
    Alcohol Research and Treatment Center, James J Peters Veterans Affairs Medical Center, 130 W Kingsbridge Road, Bronx, NY 10468, USA
    Biochem Biophys Res Commun 350:50-5. 2006
    ....
  37. ncbi Toxicity of beta-carotene and its exacerbation by acetaldehyde in HepG2 cells
    R Ni
    Liver Disease and Nutrition Section, Veterans Affairs Medical Center and Mount Sinai School of Medicine, Bronx, NY 10468-3992, USA
    Alcohol Alcohol 36:281-5. 2001
    ..In conclusion, this preliminary study indicates that beta-carotene is toxic to hepatocytes, especially when combined with acetaldehyde, the metabolite of ethanol...
  38. ncbi Characterization of the cytochrome P-450 monooxygenase system of hamster liver microsomes. Effects of prior treatment with ethanol and other xenobiotics
    C M Ardies
    Alcohol Research and Treatment Center, Bronx Veterans Administration Medical Center, NY 10468
    Biochem Pharmacol 36:3613-9. 1987
    ....
  39. ncbi Gender differences in pharmacokinetics of alcohol
    E Baraona
    Section of Liver Disease, Alcohol Research Center, Bronx Veterans Affairs and Mount Sinai Medical Centers, New York 10468, USA
    Alcohol Clin Exp Res 25:502-7. 2001
    ..The concentration-dependency of these effects may explain earlier discrepancies. The combined pharmacokinetic differences may increase the vulnerability of women to the effects of ethanol...
  40. ncbi Leptin stimulates tissue inhibitor of metalloproteinase-1 in human hepatic stellate cells: respective roles of the JAK/STAT and JAK-mediated H2O2-dependant MAPK pathways
    Qi Cao
    Alcohol Research and Treatment Center, Bronx Veterans Affairs Medical Center and Mount Sinai School of Medicine, Bronx, New York 10468, USA
    J Biol Chem 279:4292-304. 2004
    ..This process appears to be mediated by the JAK/STAT pathway via the leptin receptor long form and the H2O2-dependent p38 and ERK1/2 pathways via activated JAK...
  41. ncbi DLPC and SAMe combined prevent leptin-stimulated TIMP-1 production in LX-2 human hepatic stellate cells by inhibiting HO-mediated signal transduction
    Qi Cao
    Alcohol Research and Treatment Center, Bronx Veterans Affairs Medical Center and Mount Sinai School of Medicine, Bronx, NY 10468, USA
    Liver Int 26:221-31. 2006
    ..Because H2O2 mediates signal transduction-stimulating liver fibrogenesis, we investigated whether DLPC and SAMe attenuate the production of tissue inhibitor of metalloproteinase (TIMP)-1 by inhibiting H2O2 formation...
  42. ncbi The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role
    Charles S Lieber
    Mount Sinai School of Medicine, Section of Liver Disease and Nutrition and Alcohol Research Center, Bronx Veterans Affairs Medical Center, USA
    Drug Metab Rev 36:511-29. 2004
    ..PPC also opposes hepatic oxidative stress and fibrosis. It is now being tested clinically...
  43. ncbi Dilinoleoylphosphatidylcholine decreases acetaldehyde-induced TNF-alpha generation in Kupffer cells of ethanol-fed rats
    Qi Cao
    Alcohol Research and Treatment Center, Veterans Affairs Medical Center 151 2, Mount Sinai School of Medicine, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Biochem Biophys Res Commun 299:459-64. 2002
    ..Since increased TNF-alpha generation plays a pathogenic role in alcoholic liver disease, the DLPC action on Kupffer cells may explain, in part, its beneficial effects on liver cell injury after ethanol consumption...
  44. ncbi Dilinoleoylphosphatidylcholine prevents transforming growth factor-beta1-mediated collagen accumulation in cultured rat hepatic stellate cells
    Qi Cao
    Alcohol Research and Treatment Center, Bronx Veterans Affairs Medical Center, 130 W Kingsbridge Road, Bronx, NY 10468, USA
    J Lab Clin Med 139:202-10. 2002
    ..This effect of DLPC may explain, at least in part, the antifibrogenic action of PPC against alcoholic and other fibrotic disorders of the liver...
  45. ncbi Acarbose attenuates experimental non-alcoholic steatohepatitis
    Charles S Lieber
    Alcohol Research and Treatment Center, Section of Liver Disease and Nutrition, Veterans Affairs Medical Center 151 2, Mt Sinai School of Medicine, 130 West Kingsbridge Rd, Bronx, NY, USA
    Biochem Biophys Res Commun 315:699-703. 2004
    ..Because acarbose attenuates many of the hepatic alterations associated with experimental NASH, it is now indicated to determine whether it exerts similar beneficial effects in patients afflicted by this disease...
  46. doi Adipose differentiation-related protein is a reliable lipid droplet marker in alcoholic fatty liver of rats
    Ki M Mak
    Mount Sinai School of Medicine, New York, New York, USA
    Alcohol Clin Exp Res 32:683-9. 2008
    ..Because medium-chain triglycerides (MCT) reduce alcoholic hepatosteatosis, their effects on ADRP were also evaluated...
  47. ncbi Effects of alcohol consumption on eight circulating markers of liver fibrosis
    Yelena Ponomarenko
    Liver Disease and Nutrition Section, Veterans Affairs Medical Center and Mount Sinai School of Medicine, Bronx, NY 10468 3992, USA
    Alcohol Alcohol 37:252-5. 2002
    ..By contrast, TIMP-1, collagen VI, PIIINP, HA and MMP-2 did not significantly change. The mode of action of alcohol on these tests is unknown. These differences must be considered when using those measurements to assess liver fibrosis...
  48. ncbi Relationships between nutrition, alcohol use, and liver disease
    Charles S Lieber
    Mount Sinai School of Medicine, Bronx, New York, USA
    Alcohol Res Health 27:220-31. 2003
    ..New agents currently are being studied as promising nutritional supplements for alcoholics with liver disease...
  49. ncbi Leptin enhances alpha1(I) collagen gene expression in LX-2 human hepatic stellate cells through JAK-mediated H2O2-dependent MAPK pathways
    Qi Cao
    Alcohol Research and Treatment Center, Bronx Veterans Affairs Medical Center, and Mount Sinai School of Medicine, New York, NY, USA
    J Cell Biochem 97:188-97. 2006
    ..ERK1/2 stimulates alpha1(I) collagen promoter activity, whereas p38 stabilizes its mRNA. Accordingly, interference with leptin-induced oxidative stress by antioxidants provides an opportunity for the prevention of liver fibrosis...
  50. ncbi Dilinoleoylphosphatidylcholine is responsible for the beneficial effects of polyenylphosphatidylcholine on ethanol-induced mitochondrial injury in rats
    Khursheed P Navder
    Alcohol Research and Treatment Center, Bronx Veterans Affairs Medical Center and Mount Sinai School of Medicine, New York, New York 10468, USA
    Biochem Biophys Res Commun 291:1109-12. 2002
    ..These effects were equally prevented by either PPC or DLPC. In conclusion, DLPC fully reproduced PPC's protective action and may be effective in the prevention or delay of more severe liver damage...
  51. ncbi Aspartate aminotransferase to platelet ratio index in patients with alcoholic liver fibrosis
    Charles S Lieber
    James J Peters Veterans Affairs Medical Center, Alcohol Research and Treatment Center, Liver Diseases and Nutrition Section, Bronx, New York 10468, USA
    Am J Gastroenterol 101:1500-8. 2006
    ..To validate APRI in hepatitis C and to determine its usefulness in other liver diseases, we evaluated APRI in patients with liver fibrosis due to excessive alcohol consumption with or without viral hepatitis C...
  52. ncbi Alcohol and hepatitis C
    C S Lieber
    Section of Liver Disease and Nutrition, Alcohol Research Center, Bronx, USA
    Alcohol Res Health 25:245-54. 2001
    ..Because alcohol potentiates the fibrosis- and cancer-inducing actions of HCV, alcoholics are particularly vulnerable to HCV infection and most in need of treatment...
  53. ncbi Dilinoleoylphosphatidylcholine reproduces the antiapoptotic actions of polyenylphosphatidylcholine against ethanol-induced hepatocyte apoptosis
    Ki M Mak
    Alcohol Research and Treatment Center, Bronx Veterans Affairs Medical Center and Mount Sinai School of Medicine, New York 10468, USA
    Alcohol Clin Exp Res 27:997-1005. 2003
    ....
  54. ncbi Ethanol consumption increases nitric oxide production in rats, and its peroxynitrite-mediated toxicity is attenuated by polyenylphosphatidylcholine
    Enrique Baraona
    Alcohol Research Center, Bronx Veterans Affairs Medical Center, New York, New York 10468, USA
    Alcohol Clin Exp Res 26:883-9. 2002
    ..Nitric oxide generally mediates beneficial responses but becomes deleterious when coexistence with enhanced superoxide formation leads to the synthesis of peroxynitrite, a potent oxidant and nitrating agent...
  55. ncbi Leptin represses matrix metalloproteinase-1 gene expression in LX2 human hepatic stellate cells
    Qi Cao
    Alcohol Research and Treatment Center, James J Peters VA Medical Center, Bronx, and Mount Sinai School of Medicine, New York, NY 10029, USA
    J Hepatol 46:124-33. 2007
    ..LX-2 hepatic stellate cells produce increased amounts of collagen and tissue inhibitor of metalloproteinase (TIMP)-1 in response to leptin. The effect of leptin on MMP-1 production has not been reported...
  56. ncbi Lycopene attenuates arachidonic acid toxicity in HepG2 cells overexpressing CYP2E1
    Youqing Xu
    Alcohol Research and Treatment Center, Section of Liver Disease and Nutrition, Veterans Affairs Medical Center 151 2, Mt Sinai School of Medicine, 130 West Kingsbridge Rd, Bronx, NY, USA
    Biochem Biophys Res Commun 303:745-50. 2003
    ..This was due, at least in part, to inhibition of hydrogen peroxide production and of the resulting lipid peroxidation, confirming the potent anti-oxidant properties of lycopene and its suitability for clinical studies...
  57. ncbi Dilinoleoylphosphatidylcholine decreases LPS-induced TNF-alpha generation in Kupffer cells of ethanol-fed rats: respective roles of MAPKs and NF-kappaB
    Qi Cao
    Alcohol Research and Treatment Center, Veterans Affairs Medical Center and Mount Sinai School of Medicine, Bronx, NY 10468, USA
    Biochem Biophys Res Commun 294:849-53. 2002
    ..Both inhibitors reduced TNF-alpha generation. Thus, DLPC diminishes LPS-dependent TNF-alpha generation by inhibiting p38 and ERK1/2 activation; the latter leads to decreased NF-kappaB activation...
  58. ncbi Cytochrome P4502E1 primes macrophages to increase TNF-alpha production in response to lipopolysaccharide
    Qi Cao
    Alcohol Research Center, Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Am J Physiol Gastrointest Liver Physiol 289:G95-107. 2005
    ..Accordingly, CYP2E1 priming could explain the sensitization of Kupffer cells to LPS activation by ethanol, a critical early step in alcoholic liver disease...
  59. ncbi Molecular cloning of human class IV alcohol dehydrogenase cDNA
    H Yokoyama
    Alcohol Research Center, Bronx VA Medical Center, New York, NY
    Biochem Biophys Res Commun 203:219-24. 1994
    ..Northern hybridization analysis with the specific probe for the mRNA of this protein showed that it is expressed in the human stomach but not in the liver. These data indicate that the cDNA we cloned is that of human class IV ADH...
  60. ncbi Gastritis and Helicobacter pylori: forty years of antibiotic therapy
    C S Lieber
    Section of Liver Disease and Nutrition, Bronx VA Medical Center, NY 10468 3922, USA
    Digestion 58:203-10. 1997
    ..Broader studies and clinical applications of these earlier findings are now warranted...
  61. ncbi Alcohol and health: a drink a day won't keep the doctor away
    Charles S Lieber
    Alcohol Research and Treatment Center, Section of Liver Disease and Nutrition, Bronx VA Medical Center, New York 11468 3922, USA
    Cleve Clin J Med 70:945-6, 948, 951-3. 2003
    ..Those who are healthy and whose drinking history shows little risk of developing alcohol dependency may continue to drink moderate amounts. Heavy drinkers should be advised to quit...
  62. ncbi A trial of "standard" outpatient alcoholism treatment vs. a minimal treatment control
    William T Davis
    Alcohol Dependency Treatment Program, Department of Veterans Affairs Medical Center, 00MH, 130 W Kingsbridge Road, Bronx, NY 10468, USA
    J Subst Abuse Treat 23:9-19. 2002
    ..It is concluded that a ST approach is more helpful than MT in treating severely alcohol-dependent individuals who have not been able to cut down drinking on their own. Those already drinking less appeared to be helped by MT...
  63. ncbi The Research Society on Alcoholism
    Yedy Israel
    Alcohol Research Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Addiction 97:483-6. 2002
    ..RSA committees are active in presenting the most recent findings to the public and to elected representatives, and in making recommendations on areas of research that need funding...
  64. ncbi Mediation by nitric oxide of the stimulatory effects of ethanol on blood flow
    Enrique Baraona
    Sections of Liver Disease and Nutrition, Alcohol Research Center, Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Life Sci 70:2987-95. 2002
    ..All the stimulatory effects of ethanol on flow, as well as the rise in NO levels, were prevented by L-NMMA, incriminating NO as the mediator of the hemodynamic effects of ethanol oxidation, acting probably via acetate and adenosine...
  65. ncbi Dynamics of cytochrome P4502E1 activity in man: induction by ethanol and disappearance during withdrawal phase
    Carl M Oneta
    Division of Gastroenterology, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois CHUV et Policlinique Médicale Universitaire PMU, Lausanne, Switzerland
    J Hepatol 36:47-52. 2002
    ..However, the amount and duration of alcohol intake associated with CYP2E1 induction is not known but limited information is available on the disappearance of CYP2E1 following alcohol withdrawal...
  66. ncbi Inflammation and repair in viral hepatitis C
    Manuela G Neuman
    In Vitro Drug Safety and Biotechnology, Department of Pharmacology, Biophysics and Global Health, Institute of Drug Research, University of Toronto, Toronto, ON, Canada
    Dig Dis Sci 53:1468-87. 2008
    ..This review will also aim to describe the importance of IFN-alpha-based therapies in HCV infection, ways of monitoring them, and associated complications...
  67. ncbi Alcohol metabolism: role in toxicity and carcinogenesis
    Thomas M Badger
    Arkansas Children s Nutrition Center and Departments of Physiology and Biophysics, Pediatrics at the University of Arkansas for Medical Sciences, Little Rock, Arkansas 72211, USA
    Alcohol Clin Exp Res 27:336-47. 2003
    ....
  68. ncbi DLPC attenuates alcohol-induced cytotoxicity in HepG2 cells expressing CYP2E1
    Youqing Xu
    Liver Research Center, Beijing Friendship Hospital, Beijing, China
    Alcohol Alcohol 40:172-5. 2005
    ..Our aim was to determine whether this could be overcome by using dilinoleoylphosphatidylcholine (DLPC), an innocuous antioxidant extracted from soybeans...
  69. ncbi From alcohol toxicity to treatment
    Helmut K Seitz
    Department of Medicine, Salem Medical Center and Laboratory of Alcohol Research, Liver Disease and Nutrition, Heidelberg, Germany
    Alcohol Clin Exp Res 29:1341-50. 2005
    ..Lieber (USA) discussed the development of the understanding of the pathophysiology of alcoholic liver disease in the last 50 years. He emphasized the role of pathophysiology as an important prerequisite for better treatment strategies...
  70. ncbi SMART amplification maintains representation of relative gene expression: quantitative validation by real time PCR and application to studies of alcoholic liver disease in primates
    Devanshi Seth
    Drug Health Services and A W Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital and Centenary Institute of Cancer Medicine and Cell Biology, Camperdown, NSW 2050, Australia
    J Biochem Biophys Methods 55:53-66. 2003
    ....
  71. ncbi Alcohol and coronary heart disease
    Charles S Lieber
    N Engl J Med 348:1719-22; author reply 1719-22. 2003
  72. ncbi Alcoholic liver disease: from pathophysiology to therapy
    Helmut K Seitz
    Department of Medicine, Salem Medical Center, Heidelberg, Germany
    Alcohol Clin Exp Res 29:1276-81. 2005
  73. pmc Gene expression profiling of alcoholic liver disease in the baboon (Papio hamadryas) and human liver
    Devanshi Seth
    Drug Health Services, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Am J Pathol 163:2303-17. 2003
    ..The gene expression profile of ALD is dominated by alcohol metabolism and inflammation and differs from other liver diseases. Annexins may play a role in the progression of fibrosis in ALD...

Research Grants30

  1. DLPC Treatment of Alcoholic and Non-Alcoholic Fibrosis
    Charles Lieber; Fiscal Year: 2006
    ..abstract_text> ..
  2. ANTIVIRAL & ANTIFIBROTIC LIVER THERAPY OF HCV+ DRINKERS
    Charles Lieber; Fiscal Year: 2005
    ..Funds are requested for special laboratory tests, study nurses, travel to meetings, patient monitoring expenses and a core office. ..
  3. Liver Fibrosis, Inflammation & Oxidative Stress Markers
    Charles Lieber; Fiscal Year: 2006
    ..abstract_text> ..
  4. Antiviral/Antifibrotic Liver Therapy of Hepatitis C positive Alcohol Drinkers
    Charles Lieber; Fiscal Year: 2007
    ..Accordingly, support is requested for the completion of this novel approach for the treatment of HCV+ patients who become abstinent or who continue to consume alcohol moderately. ..
  5. INTERACTION OF ETHANOL WITH HEPATIC MICROSOMES
    Charles Lieber; Fiscal Year: 1992
    ..Our ultimate goal is to define in molecular terms some of the most far-reaching changes brought about by chronic ethanol consumption in the internal milieu of the body and the resulting response to the environment...
  6. DLPC TREATMENT OF ALCOHOLIC AND NON ALCOHOLIC FIBROSIS
    Charles Lieber; Fiscal Year: 2000
    ..If successful, the proposed studies will establish DLPC as the first safe and chemically defined agent capable of preventing the progression (and possibly of promoting the regression) of hepatic and pulmonary fibrosis. ..
  7. MECHANISM AND ROLE OF MICROSOMAL ETHANOL OXIDATION
    Charles Lieber; Fiscal Year: 2001
    ..Such information is aimed at elucidating key aspects of alcohol mediated pathology in a way which may eventually affect alcohol related medical complications, their prevention and treatment. ..
  8. Synergistic Nutraceutical Effects of DLPC and SAMe
    Charles Lieber; Fiscal Year: 2007
    ....