Timmermans S, Van Montagu M, Libert C. Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains. Proc Natl Acad Sci U S A. 2017;114:9158-9163 pubmed publisher
..be) and allow a global, better interpretation of genetic background effects and a source of naturally defective alleles in these 36 sequenced classical and high-priority mouse inbred strains. ..
Timmermans S, Libert C. Easy Access to and Applications of the Sequences of All Protein-Coding Genes of All Sequenced Mouse Strains. Trends Genet. 2018;34:899-902 pubmed publisher
..We provide an insight into the advantages of using these databases. ..
Souffriau J, Eggermont M, Van Ryckeghem S, Van Looveren K, Van Wyngene L, Van Hamme E, et al
. A screening assay for Selective Dimerizing Glucocorticoid Receptor Agonists and Modulators (SEDIGRAM) that are effective against acute inflammation. Sci Rep. 2018;8:12894 pubmed publisher
..A screening pipeline for SEDIGRAM may assist the search for compounds that promote GR dimerization and limit overwhelming acute inflammatory responses. ..
Timmermans S, Souffriau J, Vandewalle J, Van Wyngene L, Van Looveren K, Vanderhaeghen T, et al
. Using the inbred mouse strain SPRET/EiJ to provide novel insights in inflammation and infection research. Mamm Genome. 2018;29:585-592 pubmed publisher
..Now that the genome of SPRET/EiJ has been sequenced, and other tools have become available, it is time to revisit this strain and emphasize its advantages and disadvantages as a research tool and a discovery platform. ..
Steeland S, PuimÃ¨ge L, Vandenbroucke R, Van Hauwermeiren F, Haustraete J, Devoogdt N, et al
. Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1. J Biol Chem. 2015;290:4022-37 pubmed publisher
..These results demonstrate the considerable potential of TROS and justify the evaluation of TROS in relevant disease animal models of both acute and chronic inflammation and eventually in patients. ..
Van Wyngene L, Vandewalle J, Libert C. Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?. EMBO Mol Med. 2018;10: pubmed publisher
..In this review, we concentrate on the pathological changes in metabolism, observed during sepsis, and the presumed underlying mechanisms, with a focus on the level of the organism and the interplay between different organ systems. ..
Steeland S, Libert C, Vandenbroucke R. A New Venue of TNF Targeting. Int J Mol Sci. 2018;19: pubmed publisher
..Here, we review the complications related to the use of conventional TNF inhibitors, together with the anti-TNF alternatives and the benefits of selective approaches in different diseases. ..
Steeland S, Vandenbroucke R, Libert C. Nanobodies as therapeutics: big opportunities for small antibodies. Drug Discov Today. 2016;21:1076-113 pubmed publisher
..In addition, we highlight their potential for use in the diagnosis and monitoring of diseases. Finally, we provide an extended overview of Nbs that are, or have been, involved in clinical trials. ..
De Bosscher K, Beck I, Ratman D, Berghe W, Libert C. Activation of the Glucocorticoid Receptor in Acute Inflammation: the SEDIGRAM Concept. Trends Pharmacol Sci. 2016;37:4-16 pubmed publisher