Impact of YMDD mutations during lamivudine therapy in patients with chronic hepatitis BY F Liaw
Liver Research Unit, Chang Gung Memorial Hospital and University, Taipei, Taiwan
Antivir Chem Chemother 12:67-71. 2001
..New drugs and new strategies are needed to better achieve the goals of therapy and minimize the problem of YMDD mutants...
- Prednisolone priming enhances Th1 response and efficacy of subsequent lamivudine therapy in patients with chronic hepatitis B
Y F Liaw
Liver Research Unit Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan
Hepatology 32:604-9. 2000
..These results suggest that corticosteroid priming induced immune/ALT rebound greatly enhances response to lamivudine therapy in chronic hepatitis B. Confirmation by randomized controlled trial is needed...
- Treatment of chronic hepatitis B virus infection: who, when, what for and how
Y F Liaw
Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan
J Gastroenterol Hepatol 15:E31-3. 2000
..It is relevant and mandatory to coordinate all current knowledge to reach a consensus and to make guidelines for the treatment of chronic HBV infection in this region...
- Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B. Asia Hepatitis Lamivudine Study Group
Y F Liaw
Liver Research Unit, Chang Gung Memorial Hospital and University, Taipei, Taiwan
Gastroenterology 119:172-80. 2000
..One-year lamivudine therapy significantly suppressed hepatitis B virus (HBV) replication, improved hepatic necroinflammatory activity, and prevented progression of fibrosis. However, the effects of prolonged therapy are unknown...
- Case report: dramatic response to lamivudine therapy following corticosteroid priming in chronic hepatitis B
Y F Liaw
Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan
J Gastroenterol Hepatol 14:804-6. 1999
..If this dramatic response to lamivudine therapy after corticosteroid priming is confirmed by further studies, the regimens used in this particular case might become a powerful therapeutic tool for chronic HBV infection...
- Etiology of sporadic acute viral hepatitis in Taiwan: the role of hepatitis C virus, hepatitis E virus and GB virus-C/hepatitis G virus in an endemic area of hepatitis A and B
C M Chu
Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
J Med Virol 58:154-9. 1999
..Serum GBV-C/HGV RNA was detected in 3-4% of acute hepatitis non-A-E cases, suggesting its limited role in these cases...
- Switching to adefovir monotherapy after emergence of lamivudine-resistant mutations in patients with liver cirrhosis
Y F Liaw
Liver Research Unit, Lin Kou, Taiwan
J Viral Hepat 13:250-5. 2006
..To stop LAM and switch to ADV in patients with breakthrough is a reasonably safe and cost-effective approach...
- Comparison of long-term effects of lymphoblastoid interferon alpha and recombinant interferon alpha-2a therapy in patients with chronic hepatitis B
S M Lin
Liver Research Unit, Chang Gung University and Chang Gung Memorial Hospital, Taipei, Taiwan
J Viral Hepat 11:349-57. 2004
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- Low-level hepatitis C viremia and humoral immune response to NS4 in chronic hepatitis B virus-hepatitis C virus coinfection
C M Chu
Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University, Taipei, Taiwan
Scand J Gastroenterol 39:778-82. 2004
..The aim of this study was to investigate the effect of concurrent HBV infection on serum titers of HCV RNA and HCV antibody profiles in chronic HCV infection...
- Epidemiological characteristics, risk factors, and clinical manifestations of acute non-A-E hepatitis
C M Chu
Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
J Med Virol 65:296-300. 2001
..In conclusion, there is no obvious parenteral risk factor identified in acute non-A-E hepatitis. Clinical severity is similar to that of hepatitis C at least in hospitalized patients, but the rate of chronic evolution is much lower...
- Replication of hepatitis C virus in ascitic mononuclear cells with development of distinct viral quasispecies
C W Hsu
Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan
J Infect Dis 180:992-1000. 1999
..Minus-strand HCV-RNA was detectable in 5 of them. Our data suggest that HCV can replicate in the AMCs of patients with late-stage chronic HCV, which results in the development of distinct viral quasispecies...
High prevalence of TT virus infection in healthy children and adults and in patients with liver disease in TaiwanS Y Hsieh
Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Republic of Taiwan
J Clin Microbiol 37:1829-31. 1999
..These findings suggest that TTV is transmitted mainly via nonparenteral daily contact and frequently occurs very early in life and that TTV infection does not have a significant effect on liver disease...
- Viral superinfection in previously unrecognized chronic carriers of hepatitis B virus with superimposed acute fulminant versus nonfulminant hepatitis
C M Chu
Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
J Clin Microbiol 37:235-7. 1999
..3 versus 0%). Only 3. 6% of fulminant cases and 3.3% of nonfulminant controls were HGV RNA positive...
- Low-level viremia and intracellular expression of hepatitis B surface antigen (HBsAg) in HBsAg carriers with concurrent hepatitis C virus infection
C M Chu
Liver Research Unit, Chang Gung Memorial Hospital and Medical College, Taipei, Taiwan
J Clin Microbiol 36:2084-6. 1998
..HBsAg carriers with concurrent HCV infection thus have low-level viremia and intracellular HBsAg...
- Modulation of tumor necrosis factor receptors 1 and 2 in chronic hepatitis B and C: the differences and implications in pathogenesis
D I Tai
Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University, College of Medicine Taipei, Taiwan, ROC
J Biomed Sci 8:321-7. 2001
..However, the expression of TNFR-1 and 2 in liver was similar between CHB and CHC. These findings suggest that the TNFR signal transduction pathway is modulated differently in HBV and HCV infection...
- Reactivation of hepatitis C virus superinfection in a patient seropositive for hepatitis B e antigen
L W Chen
Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan
Infection 29:351-4. 2001
..Recognition of such a case suggests that the presence of de novo seroconversion of anti-HCV may indicate either reactivation or acute superinfection of HCV in a patient seropositive for hepatitis B e antigen...
- Sequential changes of hepatitis C virus antibody profiles during treatment of chronic hepatitis C of genotype 1b: pretreatment antibody response to E2/NS1 correlated sustained response
C M Chu
Liver Research Unit, Chang Gung Memorial Hospital, 199 Tung Hwa North Road, Taipei 105, Taiwan
Infection 32:153-6. 2004
..This study aimed to investigate the relation between hepatitis C virus (HCV) antibody profiles and response to therapy of chronic HCV infection of genotype 1b...
- Acute leukaemia in chronic hepatitis B patients with lamivudine therapy
R N Chien
Chang Gung Memorial Hospital, Taipei, Taiwan
Int J Clin Pract 58:1088-91. 2004
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- Basal core promoter mutation is associated with progression to cirrhosis rather than hepatocellular carcinoma in chronic hepatitis B virus infection
C M Chu
Liver Research Unit, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 199, Tung Hwa North Road, Taipei 10591, Taiwan
Br J Cancer 107:2010-5. 2012
..As most cases of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) have concurrent cirrhosis, viral factors identified to be associated with HCC might be related to cirrhosis rather than HCC...
Shorter durations and lower doses of peginterferon alfa-2a are associated with inferior hepatitis B e antigen seroconversion rates in hepatitis B virus genotypes B or CY F Liaw
Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
Hepatology 54:1591-9. 2011
....
- Amino acid substitutions in codons 9-11 of hepatitis C virus core protein lead to the synthesis of a short core protein product
C T Yeh
Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University School of Medicine, Taipei, Taiwan
J Gastroenterol Hepatol 15:182-91. 2000
..In this study, we aimed to investigate whether similar mutations existed in patients with chronic HCV infection and whether such mutations led to the expression of P16...
- Hepatitis B virus genotype B is associated with better response to thymosin alpha1 therapy than genotype C
R N Chien
Liver Research Unit, Chang Gung Memorial Hospital and University, Keelung, Taiwan
J Viral Hepat 13:845-50. 2006
..002). In conclusion, genotype, presence of precore mutation and Talpha-1 therapy were independent predictors to complete response. Genotype B, compared to genotype C, is associated with a higher response rate to T-alpha1 therapy...
- Identity of a novel swine hepatitis E virus in Taiwan forming a monophyletic group with Taiwan isolates of human hepatitis E virus
S Y Hsieh
Liver Research Unit, Chang Gung Memorial Hospital, School of Medicine, Chang Gung University, Taoyuan, Taiwan
J Clin Microbiol 37:3828-34. 1999
..7, 15, and 8%, respectively (for swine handlers versus controls, P = 0.048). Our findings may help provide an understanding of the modes of HEV transmission and may also raise potential public health concerns for HEV zoonosis...
- Clearance of the original hepatitis B virus YMDD-motif mutants with emergence of distinct lamivudine-resistant mutants during prolonged lamivudine therapy
C T Yeh
Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University School of Medicine, Taipei, Taiwan
Hepatology 31:1318-26. 2000
..These results suggested that distinct lamivudine-resistant mutants could emerge and replace the original YMDD-motif mutants as the cause of continuing chronic hepatitis during prolonged lamivudine therapy...
- Does increased body mass index with hepatic steatosis contribute to seroclearance of hepatitis B virus (HBV) surface antigen in chronic HBV infection?
C M Chu
Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
Int J Obes (Lond) 31:871-5. 2007
..This study aimed to test whether substantial amount of fatty infiltration in liver, which may interfere with cytoplasmic distribution of hepatitis B surface antigen (HBsAg), can contribute to HBsAg seroclearance in HBsAg carriers...
- Genome-wide hypomethylation in hepatocellular carcinogenesis
C H Lin
Liver Research Unit, Chang Gung Memorial Hospital, 199 Tung-Hua North Road, Taipei, Taiwan 155
Cancer Res 61:4238-43. 2001
..In addition, our results did not support the hypothesis of activation of transposable elements in HCC via genome-wide hypomethylation...
- Acute hepatitis C virus (HCV) infection in chronic carriers of hepatitis B virus (HBV): the impact of underlying active HBV replication on persistence of HCV infection and antibody responses to HCV
C M Chu
Liver Research Unit, Chang Gung University and Chang Gung Memorial Hospital, Taipei, Taiwan, ROC
Gut 51:95-9. 2002
..The aim of this study was to assess whether underlying chronic hepatitis B virus (HBV) infection interferes with persistence of hepatitis C virus (HCV) infection and humoral immune responses to HCV in acute HCV infection...
- Identification of a hepatic factor capable of supporting hepatitis C virus replication in a nonpermissive cell line
C T Yeh
Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taipei, Taiwan
J Virol 75:11017-24. 2001
..This factor belongs to a previously uncharacterized protein family. The physiological function of this protein awaits further study...
- Chronic hepatitis B virus infection acquired in childhood: special emphasis on prognostic and therapeutic implication of delayed HBeAg seroconversion
C M Chu
Liver Research Unit, Chang Gung Memorial Hospital and University, Taipei, Taiwan
J Viral Hepat 14:147-52. 2007
..Antiviral or immunomodulatory therapy should be considered seriously for these patients...
- Serial HBV DNA levels in patients with persistently normal transaminase over 10 years following spontaneous HBeAg seroconversion
Y C Chen
Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
J Viral Hepat 19:138-46. 2012
..These results suggest that 5 log(10) copies/mL (20,000 IU/mL) is a more appropriate cut-off HBV DNA level for inactive chronic HBV infection in the setting of PNALT...
- Polyadenylation of the mRNA of hepatitis delta virus is dependent on the structure of the nascent RNA and regulated by the small or large delta antigen
S Y Hsieh
Department of Microbiology and Immunology, Chang Gung College of Medicine and Technology, Taipei, Taiwan
Nucleic Acids Res 22:391-6. 1994
..We concluded that the HDV polyadenylation could be regulated by the structure of the nascent antigenomic RNA and by either the small or large HDAg...
- Unintentional rechallenge resulting in a causative relationship between ketoconazole and acute liver injury
R N Chien
Liver Research Unit, Chang-Gung Memorial Hospital, Taipei, Taiwan
Int J Clin Pract 57:829-30. 2003
..Clinicians should be aware of this cause and effect relationship between ketoconazole and acute liver injury, which can result in prompt severe acute liver injury after rechallenge...
- Aberrant caspase-activated DNase (CAD) transcripts in human hepatoma cells
S Y Hsieh
Liver Research Unit, Chang Gung Memorial Hospital, Taipei, Taiwan
Br J Cancer 88:210-6. 2003
..That mutations and aberrantly spliced transcripts for the CAD gene are frequently present in human HCC cells, especially in poorly differentiated HCC cells, suggests a significant role of CAD in human hepatocarcinogenesis...
- Hepatitis B virus DNA levels and outcomes in chronic hepatitis B
Chien Jen Chen
Genomics Research Center, Academia Sinica, National Taiwan University, Taipei, Taiwan
Hepatology 49:S72-84. 2009
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- Correlation of mutational analysis to clinical features in Taiwanese patients with Gilbert's syndrome
S Y Hsieh
Liver Research Unit, Chang Gung Memorial Hospital, and School of Medicine Chang Gung University, Taoyuan, Taiwan
Am J Gastroenterol 96:1188-93. 2001
..Concurrence of mutations of Gly71Arg and TATAA-box usually exerts a synergistic effect on hyperbilirubinemia. Pro229Gln, which is regularly linked to the TATAA-box mutation, may not have a significant effect on serum bilirubin levels...
- Increased incidence of fulminant hepatic failure in previously unrecognized HBsAg carriers with acute hepatitis independent of etiology
C M Chu
Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University, 199 Tung Hwa North Road, Taipei 105, Taiwan
Infection 33:136-9. 2005
..The etiology of acute hepatitis in HBsAg carriers was heterogeneous. This study aimed to correlate the incidence of fulminant hepatitis with the etiology in HBsAg carriers with acute hepatitis...
- Role of N-acetyltransferase polymorphisms in hepatitis B related hepatocellular carcinoma: impact of smoking on risk
M W Yu
Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
Gut 47:703-9. 2000
..Aromatic amines are potential hepatocarcinogens in humans. N-acetyltransferase (NAT) is involved in the metabolic activation and detoxification of these compounds...
- Aberrant transcripts of the cyclin-dependent kinase-associated protein phosphatase in hepatocellular carcinoma
C T Yeh
Liver Research Unit, Chang Gung Memorial Hospital and Chang Gung University School of Medicine, Taipei, Taiwan
Cancer Res 60:4697-700. 2000
..Using the yeast two-hybrid system, five of seven representative KAP mutants were shown to be defective in interacting with Cdk2. These data suggest a possible role of KAP mutations in multiple-step hepatocarcinogenesis...
