Francesca Fang Liao

Summary

Publications

  1. pmc Differential regulation of BACE1 expression by oxidative and nitrosative signals
    Young Don Kwak
    Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, 874 Union Avenue, Memphis TN, 38163, USA
    Mol Neurodegener 6:17. 2011
  2. pmc NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration
    Young Don Kwak
    Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, 874 Union Avenue, Memphis TN, 38163, USA
    Mol Neurodegener 5:49. 2010
  3. pmc Hsp90 chaperone inhibitor 17-AAG attenuates Aβ-induced synaptic toxicity and memory impairment
    Yaomin Chen
    Neurodegenerative Disease Research Program, Sanford Burnham Medical Research Institute, La Jolla, California 92037, Department of Pharmacology and Anatomy and Neurobiology, University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee 38163, and Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
    J Neurosci 34:2464-70. 2014
  4. pmc Upregulation of the E3 ligase NEDD4-1 by oxidative stress degrades IGF-1 receptor protein in neurodegeneration
    Young Don Kwak
    Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee 38163, USA
    J Neurosci 32:10971-81. 2012
  5. doi request reprint Metabolic stress modulates Alzheimer's β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons
    Ruishan Wang
    Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, 874 Union Avenue, Memphis, TN 38163, USA
    Cell Metab 17:685-94. 2013
  6. pmc Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment
    Xing Lin Tan
    Departments of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue Crowe 401, Memphis, TN, 38163, USA
    Mol Neurodegener 10:24. 2015
  7. pmc NEDD4-mediated HSF1 degradation underlies α-synucleinopathy
    Eunhee Kim
    Department of Pharmacology and Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 874 Union Avenue Crowe 401, Memphis, TN 38163, USA
    Hum Mol Genet 25:211-22. 2016
  8. pmc Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling
    Tao Ma
    Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee 38163, USA
    J Neurosci 29:11226-36. 2009
  9. pmc Insulin signaling in sporadic Alzheimer's disease
    Francesca Fang Liao
    Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
    Sci Signal 2:pe36. 2009
  10. doi request reprint Genetic variability to diet-induced hippocampal dysfunction in BXD recombinant inbred (RI) mouse strains
    Yueqiang Xue
    Department of Pharmacology, USA
    Behav Brain Res 292:83-94. 2015

Research Grants

  1. New Roles for sAPP in Neuroprotection and Neurogenesis
    Francesca Fang Liao; Fiscal Year: 2010

Collaborators

Detail Information

Publications12

  1. pmc Differential regulation of BACE1 expression by oxidative and nitrosative signals
    Young Don Kwak
    Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, 874 Union Avenue, Memphis TN, 38163, USA
    Mol Neurodegener 6:17. 2011
    ..abstract:..
  2. pmc NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration
    Young Don Kwak
    Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, 874 Union Avenue, Memphis TN, 38163, USA
    Mol Neurodegener 5:49. 2010
    ..However the molecular signals and mechanism underlying PTEN loss are unknown...
  3. pmc Hsp90 chaperone inhibitor 17-AAG attenuates Aβ-induced synaptic toxicity and memory impairment
    Yaomin Chen
    Neurodegenerative Disease Research Program, Sanford Burnham Medical Research Institute, La Jolla, California 92037, Department of Pharmacology and Anatomy and Neurobiology, University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee 38163, and Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
    J Neurosci 34:2464-70. 2014
    ....
  4. pmc Upregulation of the E3 ligase NEDD4-1 by oxidative stress degrades IGF-1 receptor protein in neurodegeneration
    Young Don Kwak
    Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee 38163, USA
    J Neurosci 32:10971-81. 2012
    ..Together, our work identifies a novel molecular mechanism for ROS-upregulated NEDD4-1 and the subsequently reduced IGF-1Rβ signaling in neurodegeneration...
  5. doi request reprint Metabolic stress modulates Alzheimer's β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons
    Ruishan Wang
    Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, 874 Union Avenue, Memphis, TN 38163, USA
    Cell Metab 17:685-94. 2013
    ..The interference on the BACE1 gene identified here represents a unique noncanonical mechanism of PPARγ-PGC-1 in transcriptional repression in neurons in response to metabolic signals that may involve recruitment of corepressor NCoR...
  6. pmc Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment
    Xing Lin Tan
    Departments of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue Crowe 401, Memphis, TN, 38163, USA
    Mol Neurodegener 10:24. 2015
    ..Since there are no reports of complete eNOS deficiency in humans, we used heterozygous eNOS(+/-) mice to mimic partial deficiency of eNOS, and determine its impact on cerebrovascular pathology and perfusion of cerebral vessels...
  7. pmc NEDD4-mediated HSF1 degradation underlies α-synucleinopathy
    Eunhee Kim
    Department of Pharmacology and Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 874 Union Avenue Crowe 401, Memphis, TN 38163, USA
    Hum Mol Genet 25:211-22. 2016
    ..Together with the finding that preserving HSF1 can alleviate α-synuclein toxicity, this study strongly suggests that aberrant HSF1 degradation is a key neurodegenerative mechanism underlying α-synucleinopathy. ..
  8. pmc Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling
    Tao Ma
    Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee 38163, USA
    J Neurosci 29:11226-36. 2009
    ..Altogether, our study provides novel insights into statin-mediated neuronal excitoprotection through both cholesterol-dependent and -independent mechanisms and links them to calpain-mediated neuronal death...
  9. pmc Insulin signaling in sporadic Alzheimer's disease
    Francesca Fang Liao
    Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
    Sci Signal 2:pe36. 2009
    ..Indeed, insulin and insulin sensitizers have been shown to improve cognitive and memory functions in animal models of AD, as well as in AD patients...
  10. doi request reprint Genetic variability to diet-induced hippocampal dysfunction in BXD recombinant inbred (RI) mouse strains
    Yueqiang Xue
    Department of Pharmacology, USA
    Behav Brain Res 292:83-94. 2015
    ..The obesity-prone and obesity-resistant lines we have identified should be highly useful to study the molecular genetics of diet-induced cognitive decline...
  11. pmc Soluble beta-amyloid peptides, but not insoluble fibrils, have specific effect on neuronal microRNA expression
    Jing Jing Li
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 9:e90770. 2014
    ..In addition, the repression of miR-107 expression by the sAβ containing 7PA2 CM is likely involved multiple mechanisms and multiple players including NMDA receptor, N-terminally truncated Aβ and reactive oxygen species (ROS). ..

Research Grants1

  1. New Roles for sAPP in Neuroprotection and Neurogenesis
    Francesca Fang Liao; Fiscal Year: 2010
    ..Our study will reveal novel physiological functions of APP/sAPPa as well as the underlying molecular mechanisms, and should shed light on potential therapeutic windows for sAPPa in the future. ..