Francesca Fang Liao

Summary

Publications

  1. pmc Differential regulation of BACE1 expression by oxidative and nitrosative signals
    Young Don Kwak
    Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, 874 Union Avenue, Memphis TN, 38163, USA
    Mol Neurodegener 6:17. 2011
  2. pmc NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration
    Young Don Kwak
    Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, 874 Union Avenue, Memphis TN, 38163, USA
    Mol Neurodegener 5:49. 2010
  3. pmc Hsp90 chaperone inhibitor 17-AAG attenuates Aβ-induced synaptic toxicity and memory impairment
    Yaomin Chen
    Neurodegenerative Disease Research Program, Sanford Burnham Medical Research Institute, La Jolla, California 92037, Department of Pharmacology and Anatomy and Neurobiology, University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee 38163, and Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
    J Neurosci 34:2464-70. 2014
  4. pmc Upregulation of the E3 ligase NEDD4-1 by oxidative stress degrades IGF-1 receptor protein in neurodegeneration
    Young Don Kwak
    Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee 38163, USA
    J Neurosci 32:10971-81. 2012
  5. doi request reprint Metabolic stress modulates Alzheimer's β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons
    Ruishan Wang
    Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, 874 Union Avenue, Memphis, TN 38163, USA
    Cell Metab 17:685-94. 2013
  6. doi request reprint Insulin signaling in sporadic Alzheimer's disease
    Francesca Fang Liao
    Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
    Sci Signal 2:pe36. 2009
  7. pmc Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling
    Tao Ma
    Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee 38163, USA
    J Neurosci 29:11226-36. 2009
  8. pmc Soluble beta-amyloid peptides, but not insoluble fibrils, have specific effect on neuronal microRNA expression
    Jing Jing Li
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 9:e90770. 2014

Research Grants

  1. New Roles for sAPP in Neuroprotection and Neurogenesis
    Francesca Fang Liao; Fiscal Year: 2006
  2. PTEN, Cell Cycle and Neurofibrillary Degeneration
    Francesca Fang Liao; Fiscal Year: 2009
  3. New Roles for sAPP in Neuroprotection and Neurogenesis
    Francesca Fang Liao; Fiscal Year: 2009
  4. PTEN, Cell Cycle and Neurofibrillary Degeneration
    Francesca Fang Liao; Fiscal Year: 2010
  5. New Roles for sAPP in Neuroprotection and Neurogenesis
    Francesca Fang Liao; Fiscal Year: 2010

Collaborators

  • Huaxi Xu
  • Bin Wang
  • Eliezer Masliah
  • Zhijun Luo
  • Yun Wu Zhang
  • Li Liu
  • Hansruedi Bueler
  • Young Don Kwak
  • Jing Jing Li
  • Yaomin Chen
  • Ruishan Wang
  • Shiyong Diao
  • Tao Ma
  • Yueqiang Xue
  • Scott A Heldt
  • Ling Qiang Zhu
  • Georgia Dolios
  • Rong Wang
  • Kazuko Sakata
  • Dan Liu
  • Robert W Williams
  • Lianteng Zhi
  • Edwards A Park
  • Narayan R Bhat
  • Raymond Xu
  • Jung Joon Sung
  • Qiyue Deng
  • Janet Hsu
  • Stuart A Lipton
  • Xue Zhang
  • Yongbo Zhao
  • Zhangmin Yang
  • Robert Thompson

Detail Information

Publications9

  1. pmc Differential regulation of BACE1 expression by oxidative and nitrosative signals
    Young Don Kwak
    Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, 874 Union Avenue, Memphis TN, 38163, USA
    Mol Neurodegener 6:17. 2011
    ..abstract:..
  2. pmc NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration
    Young Don Kwak
    Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, 874 Union Avenue, Memphis TN, 38163, USA
    Mol Neurodegener 5:49. 2010
    ..However the molecular signals and mechanism underlying PTEN loss are unknown...
  3. pmc Hsp90 chaperone inhibitor 17-AAG attenuates Aβ-induced synaptic toxicity and memory impairment
    Yaomin Chen
    Neurodegenerative Disease Research Program, Sanford Burnham Medical Research Institute, La Jolla, California 92037, Department of Pharmacology and Anatomy and Neurobiology, University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee 38163, and Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
    J Neurosci 34:2464-70. 2014
    ....
  4. pmc Upregulation of the E3 ligase NEDD4-1 by oxidative stress degrades IGF-1 receptor protein in neurodegeneration
    Young Don Kwak
    Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee 38163, USA
    J Neurosci 32:10971-81. 2012
    ..Together, our work identifies a novel molecular mechanism for ROS-upregulated NEDD4-1 and the subsequently reduced IGF-1Rβ signaling in neurodegeneration...
  5. doi request reprint Metabolic stress modulates Alzheimer's β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons
    Ruishan Wang
    Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, 874 Union Avenue, Memphis, TN 38163, USA
    Cell Metab 17:685-94. 2013
    ..The interference on the BACE1 gene identified here represents a unique noncanonical mechanism of PPARγ-PGC-1 in transcriptional repression in neurons in response to metabolic signals that may involve recruitment of corepressor NCoR...
  6. doi request reprint Insulin signaling in sporadic Alzheimer's disease
    Francesca Fang Liao
    Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
    Sci Signal 2:pe36. 2009
    ..Indeed, insulin and insulin sensitizers have been shown to improve cognitive and memory functions in animal models of AD, as well as in AD patients...
  7. pmc Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling
    Tao Ma
    Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee 38163, USA
    J Neurosci 29:11226-36. 2009
    ..Altogether, our study provides novel insights into statin-mediated neuronal excitoprotection through both cholesterol-dependent and -independent mechanisms and links them to calpain-mediated neuronal death...
  8. pmc Soluble beta-amyloid peptides, but not insoluble fibrils, have specific effect on neuronal microRNA expression
    Jing Jing Li
    Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 9:e90770. 2014
    ..In addition, the repression of miR-107 expression by the sAβ containing 7PA2 CM is likely involved multiple mechanisms and multiple players including NMDA receptor, N-terminally truncated Aβ and reactive oxygen species (ROS). ..

Research Grants6

  1. New Roles for sAPP in Neuroprotection and Neurogenesis
    Francesca Fang Liao; Fiscal Year: 2006
    ..Our study will reveal novel physiological functions of APP/sAPPa as well as the underlying molecular mechanisms, and should shed light on potential therapeutic windows for sAPPa in the future. ..
  2. PTEN, Cell Cycle and Neurofibrillary Degeneration
    Francesca Fang Liao; Fiscal Year: 2009
    ..This work should have great impact on exploring a new class of cell cycle inhibitors in future preventive and treatment strategies of AD once these concepts are validated. ..
  3. New Roles for sAPP in Neuroprotection and Neurogenesis
    Francesca Fang Liao; Fiscal Year: 2009
    ..Our study will reveal novel physiological functions of APP/sAPPa as well as the underlying molecular mechanisms, and should shed light on potential therapeutic windows for sAPPa in the future. ..
  4. PTEN, Cell Cycle and Neurofibrillary Degeneration
    Francesca Fang Liao; Fiscal Year: 2010
    ..This work should have great impact on exploring a new class of cell cycle inhibitors in future preventive and treatment strategies of AD once these concepts are validated. ..
  5. New Roles for sAPP in Neuroprotection and Neurogenesis
    Francesca Fang Liao; Fiscal Year: 2010
    ..Our study will reveal novel physiological functions of APP/sAPPa as well as the underlying molecular mechanisms, and should shed light on potential therapeutic windows for sAPPa in the future. ..