Buspirone-induced antinociception is mediated by L-type calcium channels and calcium/caffeine-sensitive pools in miceJian hui Liang
Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, 38 Xueyuan Road, 100083, Beijing, P R China
Psychopharmacology (Berl) 166:276-83. 2003
..It was of interest to investigate the involvement of extracellular/intracellular Ca(2+) in buspirone-induced antinociception...
- Potentiating effect of tramadol on methamphetamine-induced behavioral sensitization in mice
Jian hui Liang
Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, 38 Xueyuan Road, Beijing 100083, People s Republic of China
Psychopharmacology (Berl) 185:1-10. 2006
..Therefore, we hypothesized that there would be an interaction between TRAM and METH on behavioral sensitization induced by METH...
- Effects of antidepressants on the exploration, spontaneous motor activity and isolation-induced aggressiveness in mice
Jianhui Liang
National Institute on Drug Dependence, Peking University, Beijing 100083, China
Beijing Da Xue Xue Bao 35:54-60. 2003
..To study the role of different antidepressants on exploration, spontaneous motor activity and isolation-induced aggressiveness in mice, further to discuss different mechanisms of their anti-aggression...
- L-type calcium channel blockers enhance 5-HTP-induced antinociception in mice
Jian hui Liang
Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, Beijing 100083, China
Acta Pharmacol Sin 25:644-50. 2004
..To investigate the involvement of L-type Ca(2+) channels in antinociceptive action induced by the 5-HT precursor, 5-hydroxytryptophan (5-HTP)...
Septal nuclei critically mediate the development of behavioral sensitization to a single morphine injection in ratsQing Liu
National Institute on Drug Dependence, Peking University, Beijing 100191, PR China
Brain Res 1454:90-9. 2012
....
- Tramadol induces conditioned place preference in rats: interactions with morphine and buprenorphine
Min Zhang
National Institute on Drug Dependence, Peking University, Beijing 100191, PR China
Neurosci Lett 520:87-91. 2012
..These findings indicate that tramadol potentiates the rewarding effects of morphine or buprenorphine largely in an additive manner and support the general contention that tramadol has relatively low abuse liability...
- The phosphodiesterase-4 (PDE4) inhibitor rolipram decreases ethanol seeking and consumption in alcohol-preferring fawn-hooded rats
Rui Ting Wen
National Institute on Drug Dependence, Peking University, Beijing, China
Alcohol Clin Exp Res 36:2157-67. 2012
..Thus, it was of interest to determine whether PDE4 was involved in the regulation of alcohol use and abuse...
- Risperidone attenuates MK-801-induced hyperlocomotion in mice via the blockade of serotonin 5-HT 2A/2C receptors
Yun Ai Su
Institute of Mental Health, Peking University, No 51 Hua Yuan Bei Road, Beijing 100083, China
Eur J Pharmacol 564:123-30. 2007
..These findings indicate that risperidone attenuates MK-801-induced hyperlocomotion in mice by blocking serotonin 5-HT(2A/2C) receptors...
- Traditional Chinese medicine for treatment of alcoholism: from ancient to modern
Qing Liu
National Institute on Drug Dependence, Peking University, Beijing, P R China
Am J Chin Med 39:1-13. 2011
..decoctions and acupuncture...
- [The influence of psychoactive substance on histone acetylation modification]
Li Jing
Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, Beijing 100083, China
Sheng Li Ke Xue Jin Zhan 39:221-4. 2008
..The present review mainly presents the influence of several psychoactive substances, including cocaine, amphetamine, methamphetamine, morphine, and alcohol, on histone acetylation modification...
- Transcription and protein synthesis inhibitors reduce the induction of behavioural sensitization to a single morphine exposure and regulate Hsp70 expression in the mouse nucleus accumbens
Juan Luo
National Institute on Drug Dependence, Peking University, Beijing, PR China
Int J Neuropsychopharmacol 14:107-21. 2011
..Together, these findings suggest that induction of behavioural sensitization to a single morphine exposure requires new protein synthesis, potentially involving Hsp70 expression in the NAc of mice...
- Systemic administration of arecoline reduces ethanol-induced sleeping through activation of central muscarinic receptor in mice
Yan Ping Sun
National Institute on Drug Dependence, Peking University, Beijing, China
Alcohol Clin Exp Res 34:150-7. 2010
..The purpose of this study was to investigate the effects of arecoline on pentobarbital- and ethanol-induced hypnosis in mice...
- Calmodulin inhibitor trifluoperazine attenuates the development and expression of morphine-induced conditioned place preference in rats
Xiang-Feng Ye
Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100083, PR China
Eur J Pharmacol 486:265-71. 2004
..The action of trifluoperazine might be produced through its inhibition of calmodulin, but is probably not related to dopamine receptor blockade...
- Inhibition of methamphetamine-induced apoptosis by the calcium channel blocker verapamil in rat cerebellar neurons
Jun-Lan Zhou
National Institute on Drug Dependence, Peking University of Basic Medical School, Beijing 100083, China
Beijing Da Xue Xue Bao 36:361-5. 2004
..CONCLUSION: These results suggest that verapamil has a neuroprotective effect on MA-induced apoptosis, and that L-type voltage dependent calcium channel may be involved in the neurotoxitic effect of MA...
- Tramadol reduces the 5-HTP-induced head-twitch response in mice via the activation of mu and kappa opioid receptors
Hong-Lei Sun
National Institute on Drug Dependence, Peking University, Xue Yuan Road 38, Haidian District, Beijing 100083, PR China
Life Sci 72:1221-30. 2003
..Our findings show that mu and kappa opioid receptors, but not delta opioid receptor, play an important role in the regulation of serotonergic function in the CNS...
- L-type Ca(2+) channel blockers inhibit the development but not the expression of sensitization to morphine in mice
Qi Zhang
Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, 38 Xueyuan Road, Beijing 100083, PR China
Eur J Pharmacol 467:145-50. 2003
..These results indicate that blocking L-type Ca(2+) channel attenuates the locomotor-stimulating effects of morphine and inhibits the development but not the expression of morphine sensitization...
- Valproate prevents the induction, but not the expression of morphine sensitization in mice
Jun-Xu Li
Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, 38 Xueyuan Road, Beijing 100083, PR China
Behav Brain Res 152:251-7. 2004
..Our results indicated that GABA plays an important role in the induction, but not in the expression of morphine sensitization in mice...
- The GABA(B) receptor allosteric modulator CGP7930, like baclofen, reduces operant self-administration of ethanol in alcohol-preferring rats
Jian-hui Liang
Department of Neuropharmacology, National Institute of Drug Dependence, University of Peking, Beijing, P.R. China
Neuropharmacology 50:632-9. 2006
..These data demonstrate the potential of positive allosteric modulators of metabotropic GABA(B) receptors to regulate alcohol responding...
- Different effects of valproate on methamphetamine- and cocaine-induced behavioral sensitization in mice
Jun-Xu Li
Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, 38 Xueyuan Road, Beijing 100083, PR China
Behav Brain Res 161:125-32. 2005
..The present results supported that METH- and cocaine-induced behavioral sensitization possesses distinct neural mechanisms, which implies that valproate may have different modulatory effect on METH and cocaine addiction in humans...
- Nerve growth factor protects R2 cells against neurotoxicity induced by methamphetamine
Jun-Lan Zhou
Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, 38 Xueyuan Road, Beijing 100083, PR China
Toxicol Lett 150:221-7. 2004
..These results indicate that nerve growth factor may be useful for the treatment of methamphetamine users...
- [Effects of intragastric administration of thenorphine on morphine-induced behavioral sensitization in mice]
Wen-li Zhao
National Institute on Drug Dependence, Peking University, Beijing 100083, China
Yao Xue Xue Bao 39:961-5. 2004
..05 or P < 0.01). CONCLUSION: Thenorphine was shown to suppress the central nervous system and may be effective against the abuse and addiction to opioids...
- A new buprenorphine analogy, thenorphine, inhibits morphine-induced behavioral sensitization in mice
Wen-li Zhao
Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, Beijing, China
Acta Pharmacol Sin 25:1413-8. 2004
..05 or P<0.01). CONCLUSION: Thenorphine inhibited morphine-induced behavioral sensitization in mice, suggesting that thenorphine may be effective against the addiction of opioids...
- Effects of carbamazepine on morphine-induced behavioral sensitization in mice
Jun-Xu Li
Department of Neuropharmacology, National Institute on Drug Dependence, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100083, PR China
Brain Res 1019:77-83. 2004
..In clinic, the present results suggest that chronic use of carbamazepine might have abuse potential in opioid abusers...
- Effects of l-tetrahydropalmatine on locomotor sensitization to oxycodone in mice
Yan-li Liu
Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China
Acta Pharmacol Sin 26:533-8. 2005
..CONCLUSION: These results suggested that l-THP could attenuate the locomotor-stimulating effects of oxycodone and inhibit the development and expression of oxycodone behavioral sensitization...
